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Development, transcription factors, neurons, dopamine – Thomas Perlmann's Group

Our group is interested in how specific cell types of the central nervous system are generated and how they are maintained.

Our research

We are mostly focusing on neurons using dopamine as neurotransmitter and we are unraveling the signaling and transcriptional regulation that govern the specification, differentiation and maintenance of these cells. The studies have resulted in the identification of several transcription factors with key roles in these processes. The projects are focused on understanding functions in both early specification events and in maintenance of dopamine neurons in the adult brain. Moreover, we are also interested in regenerative medicine in relation to Parkinson’s disease and other brain disorders.

Link to lab website

Publications

Selected publications

  • Article: NATURE COMMUNICATIONS. 2019;10(1):581
    Tiklova K; Bjorklund AK; Lahti L; Fiorenzano A; Nolbrant S; Gillberg L; Volakakis N; Yokota C; Hilscher MM; Hauling T; Holmstrom F; Joodmardi E; Nilsson M; Parmar M; Perlmann T
  • Article: CELL STEM CELL. 2017;20(1):29-40
    Kee N; Volakakis N; Kirkeby A; Dahl L; Storvall H; Nolbrant S; Lahti L; Bjorklund AK; Gillberg L; Joodmardi E; Sandberg R; Parmar M; Perlmann T
  • Article: NATURE NEUROSCIENCE. 2015;18(6):826-U404
    Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
  • Article: CELL REPORTS. 2014;8(4):1018-1025
    Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2360-2365
    Kadkhodaei B; Alvarsson A; Schintu N; Ramskold D; Volakakis N; Joodmardi E; Yoshitake T; Kehr J; Decressac M; Bjorklund A; Sandberg R; Svenningsson P; Perlmann T
  • Article: CELL STEM CELL. 2011;8(6):663-675
    Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T

Staff and contact

Group leader

All members of the group