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Laboratory of translational fertility preservation – Kenny Rodriguez-Wallberg's group

Our research focuses on the impact of cancer treatment on fertility potential and the prevention of infertility through fertility preservation strategies. We investigate the safety and efficacy of assisted reproduction and fertility preservation in an oncological context, but also other aspects of fertility, eg: The impact of gynecological surgery for malign and benign disease. The development and treatment of infertility in men and women. Psychological aspects of infertility after cancer.

Portrait of Kenny Rodriguez Wallberg.
Kenny Rodriguez Wallberg, Photo: Anders Norderman

Short Biography

Dr. Kenny A. Rodriguez Wallberg completed her ̽ѡ education and her residency in obstetrics and gynecology in her home country, Colombia. As specialist, Dr Rodriguez-Wallberg was then awarded a fellowship from the Groupement Français de Gynécologie de l’Enfant et de l’Adolescence and completed her training in Pediatric Gynecology at Hôpital Necker Enfant Malades in Paris, as well as in Reproductive Endocrinology, Infertility and Assisted Reproduction at Cochin-Baudelocque. In 2005 she earned her PhD degree at Uppsala University in Sweden and since 2007, she is a Senior Consultant in Reproductive Medicine at Karolinska Hospital in Stockholm and Head of the Program for Fertility Preservation. Dr Rodriguez-Wallberg is currently adjunct professor at the department of Oncology-Pathology at ̽ѡ and is sharing her clinical work with both clinical and translational research.

About our research

Our specific area of interest and expertise focuses on the impact of cancer treatment on fertility potential and the prevention of infertility through fertility preservation strategies. This new ̽ѡ field has been recently recognized and is usually named “Reproductive Oncology”. In the U.S. the term “Oncofertility” has become popular. As several methods are available for fertility preservation and those are currently used for cancer patients, we consider it of outmost importance the investigation of their safety in the oncological context.

Our research also encompasses the impact of several variables and interventions, such as the performance of ovarian surgery, even conservative and for benign diseases, in the development of infertility, as well as the treatment of infertility, in particular by using assisted reproductive techniques in both men and women. Psychological aspects of infertility after cancer, ethics in health care provision and a better understanding of specific patient groups’ access and barriers to healthcare are also subject of my research.

Our research activity is clinically oriented and integrated into Dr Rodriguez-Wallberg clinical work as senior consultant at the Reproductive Medicine clinic of Karolinska University Hospital, where she has been the clinical responsible for the Program for Fertility Preservation since 2007. Our projects have developed into both clinical and experimental research and thus our current research network includes clinicians and basic science researchers. Our research results have contributed to the improvement of potentially safer stimulation protocols for female patients with hormone-sensitive tumors including breast cancer, one of the most challenging patient groups in the field of fertility preservation. Dr Rodriguez-Wallberg have introduced the use of aromatase inhibitors for stimulation protocols of patients with breast cancer at Karolinska University Hospital in 2010 and shared her experience with colleagues of several Swedish hospitals, who have thereafter implemented those protocols at their hospitals successfully. Several of our current projects in fertility preservation are prospective and of national coverage. Those projects include the evaluation of safety and efficacy of fertility preservation by surgical methods, such as in the case of gynecological cancer, and by the performance of assisted reproductive technologies.

Our research is supported by:

  • The Swedish Research Council
  • The Swedish Cancer Foundation
  • The Swedish Childhood Cancer Foundation
  • Radiumhemmets Research Fonds
  • Stockholm County Council

Publications

Selected publications

  • Article: JAMA ONCOLOGY. 2021;7(1):86-91
    Marklund A; Lundberg FE; Eloranta S; Hedayati E; Pettersson K; Rodriguez-Wallberg KA
  • Article: BMC CANCER. 2020;20(1):1009
    Johansen G; Dahm-Kahler P; Staf C; Floter Radestad A; Rodriguez-Wallberg KA
  • Article: HUMAN REPRODUCTION OPEN. 2020;2020(4):hoaa052
    Anderson RA; Amant F; Braat D; D'Angelo A; Lopes SMCDS; Demeestere I; Dwek S; Frith L; Lambertini M; Maslin C; Moura-Ramos M; Nogueira D; Rodriguez-Wallberg K; Vermeulen N
  • Editorial comment: FERTILITY AND STERILITY. 2020;114(4):725-738
    Dolmans M-M; Taylor HS; Rodriguez-Wallberg KA; Blumenfeld Z; Lambertini M; von Wolff M; Donnez J
  • Article: PEDIATRIC BLOOD AND CANCER. 2020;67(9):e28507
    Borgstrom B; Fridstrom M; Gustafsson B; Ljungman P; Rodriguez-Wallberg KA
  • Editorial comment: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2020;99(5):569-570
    Rodriguez-Wallberg KA; Wikander I
  • Article: HUMAN REPRODUCTION OPEN. 2020;2020(3):hoaa016
    Goossens E; Jahnukainen K; Mitchell RT; van Pelt AMM; Pennings G; Rives N; Poels J; Wyns C; Lane S; Rodriguez-Wallberg KA; Rives A; Valli-Pulaski H; Steimer S; Kliesch S; Braye A; Andres MM; Medrano J; Ramos L; Kristensen SG; Andersen CY; Bjarnason R; Orwig KE; Neuhaus N; Stukenborg JB
  • Article: JOURNAL OF WOMEN'S HEALTH. 2018;27(7):939-945
    Marklund A; Nasiell J; Berger A-S; Fagerberg A; Rodriguez-Wallberg KA
  • Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;167(3):761-769
    Rodriguez-Wallberg KA; Eloranta S; Krawiec K; Lissmats A; Bergh J; Liljegren A
  • Article: HUMAN REPRODUCTION. 2018;33(2):238-247
    Lind T; Holte J; Olofsson JI; Hadziosmanovic N; Gudmundsson J; Nedstrand E; Lood M; Berglund L; Rodriguez-Wallberg K
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2017;96(12):1423-1429
    Feichtinger M; Karlstrom PO; Olofsson JI; Rodriguez-Wallberg KA
  • Article: MOLECULAR HUMAN REPRODUCTION. 2017;23(12):827-841
    Anastacio A; Rodriguez-Wallberg KA; Chardonnet S; Pionneau C; Federici C; Santos TA; Poirot C
  • Article: HUMAN REPRODUCTION. 2016;31(12):2856-2864
    Li J; Eriksson M; Czene K; Hall P; Rodriguez-Wallberg KA
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2016;95(9):1015-1026
    Rodriguez-Wallberg KA; Tanbo T; Tinkanen H; Thurin-Kjellberg A; Nedstrand E; Kitlinski ML; Macklon KT; Ernst E; Fedder J; Tiitinen A; Morin-Papunen L; Einarsson S; Jokimaa V; Hippelainen M; Lood M; Gudmundsson J; Olofsson JI; Andersen CY
  • Article: GYNECOLOGICAL ENDOCRINOLOGY. 2016;32(9):745-748
    Lind T; Lampic C; Olofsson JI; Rodriguez-Wallberg KA
  • Article: FERTILITY AND STERILITY. 2016;106(2):261-266
    Brannstrom M; Bokstrom H; Dahm-Kahler P; Diaz-Garcia C; Ekberg J; Enskog A; Hagberg H; Johannesson L; Kvarnstrom N; Molne J; Olausson M; Olofsson JI; Rodriguez-Wallberg K
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(14):1573-1579
    Papakonstantinou A; Foukakis T; Rodriguez-Wallberg KA; Bergh J
  • Letter: ANNALS OF ONCOLOGY. 2016;27(2):357
    Rodriguez-Wallberg K; Turan V; Munster P; Oktay K
  • Review: GYNECOLOGIC ONCOLOGY RESEARCH AND PRACTICE. 2016;3:8
    Feichtinger M; Rodriguez-Wallberg KA
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2016;95(1):38-44
    Wennberg A-L; Rodriguez-Wallberg KA; Milsom I; Brannstrom M
  • Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2015;372(23):2268-2269
    Oktay K; Rodriguez-Wallberg K; Munster P
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2015;94(3):324-328
    Rodriguez-Wallberg KA; Karlstrom P-O; Rezapour M; Castellanos E; Hreinsson J; Rasmussen C; Sheikhi M; Ouvrier B; Bozoky B; Olofsson JI; Lundqvist M; Hovatta O
  • Article: ACTA ONCOLOGICA. 2015;54(2):243-252
    Armuand GM; Wettergren L; Rodriguez-Wallberg KA; Lampic C
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2015;94(2):183-190
    Lind T; Hammarstrom M; Lampic C; Rodriguez-Wallberg K
  • Article: SUPPORTIVE CARE IN CANCER. 2014;22(10):2805-2812
    Armuand GM; Wettergren L; Rodriguez-Wallberg KA; Lampic C
  • Review: CANCER MANAGEMENT AND RESEARCH. 2014;6:105-117
    Rodriguez-Wallberg KA; Oktay K
  • Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2013;92(11):1290-1296
    Lind T; Lampic C; Hammarstrom M; Rodriguez-Wallberg K
  • Journal article: BREAST CANCER MANAGEMENT. 2013;2(2):135-147
    Rodriguez-Wallberg K; Oktay K
  • Article: ONCOLOGIST. 2012;17(11):1409-1417
    Rodriguez-Wallberg KA; Oktay K
  • Review: CANCER TREATMENT REVIEWS. 2012;38(5):354-361
    Rodriguez-Wallberg KA; Oktay K
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(17):2147-2153
    Armuand GM; Rodriguez-Wallberg KA; Wettergren L; Ahlgren J; Enblad G; Hoglund M; Lampic C
  • Article: BEST PRACTICE AND RESEARCH: CLINICAL OBSTETRICS AND GYNAECOLOGY. 2012;26(3):391-405
    Rodriguez-Wallberg KA; Oktay K
  • Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2012;732:1-8
    Rodriguez-Wallberg KA
  • Editorial comment: FERTILITY AND STERILITY. 2011;95(2):804.e7-804.10
    Oktay K; Tuerkcueoglu I; Rodriguez-Wallberg KA
  • Editorial comment: FERTILITY AND STERILITY. 2010;94(2):753.e15-753.e19
    Oktay K; Rodriguez-Wallberg KA; Sahin G
  • Article: REPRODUCTIVE BIOMEDICINE ONLINE. 2010;20(6):783-788
    Oktay K; Turkcuoglu I; Rodriguez-Wallberg KA
  • Article: REPRODUCTIVE BIOMEDICINE ONLINE. 2010;20(5):634-638
    Oktay K; Buyuk E; Rodriguez-Wallberg KA; Sahin G
  • Review: SEMINARS IN ONCOLOGY NURSING. 2009;25(4):268-277
    Rosen A; Rodriguez-Wallberg KA; Rosenzweig L
  • Show more

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