̽»¨¾«Ñ¡

Nitrate-nitrite-NO pathway in health and disease – Eddie Weitzberg's research group

Our research focuses on mortality and morbidity following major surgical procedures and critical illness.

Our research

We focus on exploring the role of the nitrate-nitrite-NO pathway for the generation of nitric oxide (NO) and other reactive nitrogen intermediates in mammals.

The inorganic anions nitrate (NO³¯) and nitrite (NO²¯) can recycle in vivo to form NO and other bioactive nitrogen oxides. This represents an important alternative source of NO, especially during hypoxia/ischemia when the classical L-arginine/NO synthase pathway may be dysfunctional. A picture is now emerging suggesting important biological functions of the nitrate-nitrite-NO pathway with provocative implications in relation to the diet and cardiovascular homeostasis. In addition, an expanding number of studies suggest a therapeutic potential for nitrate and nitrite in cardiovascular and metabolic diseases.

In a translational approach our research spans from experimental in vitro studies to human clinical trials.

Publications

Selected publications

  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(1):217-226
    Cordero-Herrera I; Kozyra M; Zhuge Z; Haworth SM; Moretti C; Peleli M; Caldeira-Dias M; Jahandideh A; Han H; Cruz JDC; Kleschyov AL; Montenegro MF; Ingelman-Sundberg M; Weitzberg E; Lundberg JO; Carlstrom M
  • Review: CELL METABOLISM. 2018;28(1):9-22
    Lundberg JO; Carlstrom M; Weitzberg E
  • Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2018;75:16-26
    Eriksson KE; Yang T; Carlstrom M; Weitzberg E
  • Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:87-98
    Hezel M; Peleli M; Liu M; Zollbrecht C; Jensen BL; Checa A; Giulietti A; Wheelock CE; Lundberg JO; Weitzberg E; Carlstrom M
  • Review: JOURNAL OF INTERNAL MEDICINE. 2016;279(4):315-336
    Omar SA; Webb AJ; Lundberg JO; Weitzberg E
  • Review: NATURE REVIEWS DRUG DISCOVERY. 2015;14(9):623-641
    Lundberg JO; Gladwin MT; Weitzberg E
  • Article: REDOX BIOLOGY. 2015;5:234-242
    Hezel MP; Liu M; Schiffer TA; Larsen FJ; Checa A; Wheelock CE; Carlstrom M; Lundberg JO; Weitzberg E
  • Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2015;44:88-97
    Uusijarvi J; Eriksson K; Larsson AC; Nihlen C; Schiffer T; Lindholm P; Weitzberg E
  • Review: ANNUAL REVIEW OF NUTRITION. 2013;33:129-159
    Weitzberg E; Lundberg JO
  • Article: CELL METABOLISM. 2011;13(2):149-159
    Larsen FJ; Schiffer TA; Borniquel S; Sahlin K; Ekblom B; Lundberg JO; Weitzberg E
  • Review: ANESTHESIOLOGY. 2010;113(6):1460-1475
    Weitzberg E; Hezel M; Lundberg JO

Funding

  • (VR)
  • (ALF)