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Konstantinos Meletis group

We are investigating the circuit mechanisms that shape motivated behaviours and the circuit imbalance that underlies core phenotypes of mood disorders.

Latest news and activities

Research focus

Meletis laboratory research focus
Image: Dinos Meletis

A key to this investigation is the development and use of advanced technologies to probe the organization and function of candidate circuits, focusing on the basal ganglia, hypothalamus, habenula, and the serotonin system. The investigation of neurons and circuit is based on genetic access to neuron types in combination with technologies to record or manipulate neuronal activity with high temporal and spatial precision during behavioral tasks. 

The Meletis laboratory has developed and applied a number of methods to map circuit organization and function, ranging from advanced molecular methods to determine gene expression patterns in cells and tissue – to in vivo approaches to define the role of neurons in aversion and motivation. Functional circuit mapping as well as molecular definitions of cell types and brain regions are central to establish a comprehensive understanding of how neurons and circuits generate motivated behaviors.

  1. Optogenetic control of a Parvalbumin-expressing GABAergic interneuron.
  2. Circuit and behavior control through electronic interface board with LED and gyroscope.
  3. Corticostriatal circuit dissection with genetically modified viruses.

Publications

Selected publications

  • Article: SCIENCE ADVANCES. 2020;6(26):eabb3446
    Ortiz C; Navarro JF; Jurek A; Martin A; Lundeberg J; Meletis K
  • Preprint: BIORXIV. 2020
    Weglage M; Wärnberg E; Lazaridis I; Tzortzi O; Meletis K
  • Article: CELL REPORTS. 2019;29(13):4320-4333.e5
    Martin A; Calvigioni D; Tzortzi O; Fuzik J; Warnberg E; Meletis K
  • Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368
    Lazaridis I; Tzortzi O; Weglage M; Martin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Furth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlen M; Meletis K
  • Article: NATURE NEUROSCIENCE. 2019;22(4):657-668
    Ahrlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Dorocic IP; Meletis K; Carlen M
  • Article: NATURE NEUROSCIENCE. 2018;21(1):139-149
    Furth D; Vaissiere T; Tzortzi O; Xuan Y; Martin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlen M; Miller CA; Rumbaugh G; Meletis K
  • Article: NEURON. 2014;83(3):663-678
    Dorocic IP; Furth D; Xuan Y; Johansson Y; Pozzi L; Silberberg G; Carlen M; Meletis K

All publications from group members

  • Journal article: CURRENT BIOLOGY. 2024;34(22):5263-5283.e8
    Lazaridis I; Crittenden JR; Ahn G; Hirokane K; Wickersham IR; Yoshida T; Mahar A; Skara V; Loftus JH; Parvataneni K; Meletis K; Ting JT; Hueske E; Matsushima A; Graybiel AM
  • Preprint: BIORXIV. 2024
    Contesse T; Bektash BY; Graziano M; Forastieri C; Contestabile A; Hahne S; Jung F; Nikolakopoulou I; Cao X; Skara V; Mantas I; Giatrellis S; Carlén M; Sandberg R; Calvigioni D; Meletis K
  • Article: BIORXIV. 2024;:2023.09.27.559787
    Vaissiere T; Michaelson SD; Creson T; Goins J; Fürth D; Balazsfi D; Rojas C; Golovin R; Meletis K; Miller CA; O'Connor D; Fontolan L; Rumbaugh G
  • Journal article: NATURE COMMUNICATIONS. 2024;15(1):8176
    Mantas I; Flais I; Masarapu Y; Ionescu T; Frapard S; Jung F; Le Merre P; Saarinen M; Tiklova K; Salmani BY; Gillberg L; Zhang X; Chergui K; Carlen M; Giacomello S; Hengerer B; Perlmann T; Svenningsson P
  • Journal article: F1000RESEARCH. 2024;13:1017
    Siafis S; Nomura N; Schneider-Thoma J; Bighelli I; Bannach-Brown A; Ramage FJ; Tinsdeall F; Mantas I; Jauhar S; Natesan S; Vernon AC; de Bartolomeis A; Hölter SM; Drude NI; Tölch U; Hansen W-P; Chiocchia V; Howes OD; Priller J; Macleod MR; Salanti G; Leucht S
  • Preprint: BIORXIV. 2024;BIORXIV
    Lazaridis I; Crittenden JR; Ahn G; Hirokane K; Yoshida T; Wickersham IR; Mahar A; Skara V; Loftus JH; Parvataneni K; Meletis K; Ting JT; Hueske E; Matsushima A; Graybiel AM
  • Journal article: JOURNAL OF COMPARATIVE NEUROLOGY. 2024;532(7):e25651
    Tzanou A; Theodorou E; Mantas I; Dalezios Y
  • Article: ISCIENCE. 2024;27(5):109743
    Brunner H; Kim H; Ahrlund-Richter S; van Lunteren JA; Crestani AP; Meletis K; Carlen M
  • Journal article: ELIFE. 2024;12
    Yaghmaeian Salmani B; Lahti L; Gillberg L; Jacobsen JK; Mantas I; Svenningsson P; Perlmann T
  • Article: ELIFE. 2024;12:RP89482
    Salmani BY; Lahti L; Gillberg L; Jacobsen JK; Mantas I; Svenningsson P; Perlmann T
  • Journal article: WELLCOME OPEN RESEARCH. 2024;9:182
    Siafis S; Chiocchia V; Macleod MR; Austin C; Homiar A; Tinsdeall F; Friedrich C; Ramage FJ; Kennett J; Nomura N; Maksym O; Rutigliano G; Vano LJ; McCutcheon RA; Gilbert D; Ostinelli EG; Stansfield C; Dehdarirad H; Juma DO; Wright S; Simple O; Elugbadebo O; Tonia T; Mantas I; Howes OD; Furukawa TA; Milligan L; Moreno C; Elliott JH; Hastings J; Thomas J; Michie S; Sena ES; Seedat S; Egger M; Potts J; Cipriani A; Salanti G; Leucht S
  • Preprint: BIORXIV. 2023
    Csillag V; Noble J; Calvigioni D; Reinius B; Fuzik J
  • Preprint: BIORXIV. 2023
    Brünner H; Kim H; Ährlund-Richter S; van Lunteren J; Crestani AP; Meletis K; Carlén M
  • Preprint: BIORXIV. 2023
    Cinquina V; Calvigioni D; Piscitelli F; Keimpema E; Di Marzo V; Verkhratsky A; Harkany T
  • Preprint: BIORXIV. 2023
    Cui P; Song K; Mariatos-Metaxas D; Isla A; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis A
  • Article: NATURE NEUROSCIENCE. 2023;26(7):1245-1255
    Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlen M; Meletis K
  • Article: ENEURO. 2023;10(7):1-20
    Kondabolu K; Doig NM; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Koos T; Magil PJ
  • Preprint: BIORXIV. 2023
    Yaghmaeian Salmani B; Lahti L; Gillberg L; Jacobsen JK; Mantas I; Svenningsson P; Perlmann T
  • Article: NUCLEIC ACIDS RESEARCH (NAR). 2023;51(8):e47
    Lebrigand K; Bergenstrahle J; Thrane K; Mollbrink A; Meletis K; Barbry P; Waldmann R; Lundeberg J
  • Article: NPJ PARKINSON'S DISEASE. 2023;9(1):56
    Skiteva O; Yao N; Mantas I; Zhang X; Perlmann T; Svenningsson P; Chergui K
  • Show more

Staff and contact

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Postal address

Department of Neuroscience
Attn: Konstantinos Meletis group
̽»¨¾«Ñ¡, SE-171 77 Stockholm

Visiting address (visitors, couriers, etc.)

̽»¨¾«Ñ¡, Biomedicum, Quarter B4
Solnavägen 9, SE-171 65 Solna

Delivery address (goods, parcels, etc.)

Tomtebodavägen 16, SE-171 65 Solna

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̽»¨¾«Ñ¡, Biomedicum, Solnavägen 9