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Role of T cells in human host defense – Johan Sandberg group

Innate and adaptive immune mechanisms work together to contain viral and bacterial infections. We investigate basic aspects of cell-mediated immunity as well as the immunopathogenesis of such infections. We do this with a basis in our solid understanding of fundamental immunology that we apply towards patient-based research and develop into translational approaches.

The group is part of the Center for Infectious Medicine (CIM).

About our research

The majority of T lymphocytes carry diverse T cell receptors (TCRs) that display classical MHC-restriction. However, the T cell compartment also includes unconventional T cell subsets that recognize antigens presented by non-classical MHC-like molecules. Several of these subsets are evolutionarily conserved, display innate-like characteristics, and play important roles in immune control of pathogens.

The group is particularly interested in the complementary roles that adaptive CD8 T cells, and the unconventional innate-like T cells such as the invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells play in host defense.

Keywords

T cells, NK cells, NKT cells, MAIT cells, CD1d, MR1

Open positions

We always want to get in touch with talented potential co-workers. If you are interested in doing research within our group, as a degree project or as a researcher, please contact the group leader Johan Sandberg.

Projects and collaborations

The group is involved in a multitude of projects together with many collaborators, as exemplified by the list of selected publications. Project objectives include investigations of:

  • The role of MAIT cells in human immune control of bacterial infections including antibiotic resistant bacteria.
  • Adaptive and innate T cell-mediated immunity in response to acute viral infection, including SARS-CoV-2 and HIV-1 infections.
  • Adaptive and innate T cell-mediated immunity in response to viral and bacterial vaccines.
  • Role of tissue-resident T cell populations in immunity and tissue homeostasis.
  • Viral (HIV-1, HSV) and bacterial (S. aureus) immune evasion mechanisms.
  • Mechanisms of viral immunopathogenesis.
  • Application of unconventional T cells in immunotherapy.

Collaboration at CIM

The group also collaborates with  postdoctoral researcher in Jakob Michaelsson's group at the Center for Infectious Medicine (CIM).

Research support

  • The Swedish Research Council
  • The Swedish Cancer Society
  • The Swedish Heart-Lung Foundation
  • Center for Innovative Medicine
  • SciLife Lab/Knut and Alice Wallenberg Foundation
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Publications

Selected publications

  • Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362
    Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
  • Journal article: SCIENCE ADVANCES. 2024;10(24):eadn6331
    Zheng Y; Han F; Wu Z; Wang B; Chen X; Boulouis C; Jiang Y; Ho A; He D; Sia WR; Mak JYW; Fairlie DP; Wang L-F; Sandberg JK; Lobie PE; Ma S; Leeansyah E
  • Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
    Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgard J; Maleki KT; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Bjorkstrom NK; Klingstrom J; Ljunggren H-G; Aleman S; Buggert M; Stralin K; Sandberg JK
  • Review: JOURNAL OF IMMUNOLOGY. 2023;211(4):511-517
    Sandberg JK; Leeansyah E; Eller MA; Shacklett BL; Paquin-Proulx D
  • Article: JOURNAL OF IMMUNOLOGY. 2022;208(5):1170-1179
    Boulouis C; Leeansyah E; Shambat SM; Norrby-Teglund A; Sandberg JK
  • Article: NATURE MEDICINE. 2022;28(3):472-476
    Gao Y; Cai C; Grifoni A; Muller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Osterborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2104721118
    Paquin-Proulx D; Lal KG; Phuang-Ngern Y; Creegan M; Tokarev A; Suhkumvittaya S; Alrubayyi A; Kroon E; Pinyakorn S; Slike BM; Bolton DL; Krebs SJ; Eller LA; Sajjaweerawan C; Pagliuzza A; Chomont N; Rerknimitr R; Chomchey N; Phanuphak N; de Souza MS; Michael NL; Robb ML; Ananworanich J; Sandberg JK; Eller MA; Schuetz A
  • Article: CELL REPORTS MEDICINE. 2021;2(3):100220
    Maleki KT; Tauriainen J; Garcia M; Kerkman PF; Christ W; Dias J; Bystrom JW; Leeansyah E; Forsell MN; Ljunggren H-G; Ahlm C; Bjorkstrom NK; Sandberg JK; Klingstrom J
  • Article: JCI INSIGHT. 2021;6(5):140074
    Parrot T; Healy K; Boulouis C; Sobkowiak MJ; Leeansyah E; Aleman S; Bertoletti A; Chen MS; Sandberg JK
  • Article: CELL. 2020;183(1):158-168.e14
    Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
  • Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
    Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
  • Article: PLOS BIOLOGY. 2020;18(6):e3000644
    Boulouis C; Sia WR; Gulam MY; Teo JQM; Png YT; Phan TK; Mak JYW; Fairlie DP; Poon IKH; Koh TH; Bergman P; Lim CM; Wang L-F; Kwa ALH; Sandberg JK; Leeansyah E
  • Article: NATURE COMMUNICATIONS. 2020;11(1):272
    Lal KG; Kim D; Costanzo MC; Creegan M; Leeansyah E; Dias J; Paquin-Proulx D; Eller LA; Schuetz A; Phuang-ngern Y; Krebs SJ; Slike BM; Kibuuka H; Maganga L; Nitayaphan S; Kosgei J; Sacdalan C; Ananworanich J; Bolton DL; Michael NL; Shacklett BL; Robb ML; Eller MA; Sandberg JK
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25923-25931
    Emgard J; Bergsten H; McCormick JK; Barrantes I; Skrede S; Sandberg JK; Norrby-Teglund A

Staff and contact

Group leader

All members of the group