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Renal glomerulus biology and diseases – Jaakko Patrakka group

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Publication accepted in Nature Communications

Publications

Selected publications

  • Article: NATURE COMMUNICATIONS. 2021;12(1):2141
    He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
  • Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2019;30(9):1573-1586
    Zambrano S; Moeller-Hackbarth K; Li X; Rodriguez PQ; Charrin E; Schwarz A; Nystrom J; Wernerson AO; Lal M; Patrakka J
  • Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2018;29(6):1679-1689
    Ma X; Schwarz A; Sevilla SZ; Levin A; Hultenby K; Wernerson A; Lal M; Patrakka J
  • Review: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(13):1387-1401
    Tryggvason K; Patrakka J; Wartiovaara J
  • Article: LANCET. 2002;359(9317):1575-1577
    Patrakka J; Martin P; Salonen R; Kestilä M; Ruotsalainen V; Männikkö M; Ryynänen M; Rapola J; Holmberg C; Tryggvason K; Jalanko H

Staff and contact

Group leader

All members of the group

Research techniques

  • Generation and characterization of transgenic mouse lines.
  • Morpholino and CRISPR/Cas-9 technology in zebrafish. Phenotypic analysis of zebrafish.
  • Cell culture.
  • RNA sequencing.
  • Expressional profiling by RNAscope, qPCR, immunohistochemistry, Western blot.
Keywords:
Cancer and Oncology Cell and Molecular Biology Kidney Diseases Nephrology
Content reviewer:
22-03-2024