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Oxygenation, early resuscitation in trauma and drug treatment in cardiac arrest – Team Malin Jonsson Fagerlund

Our research group study oxygenation, early resuscitation in trauma and drug treatment in cardiac arrest. We do translational research and clinical trials based on clinical problems and with the aim to improve patient care.

Part of the:

Oxygenation

Yearly, 10% of the population (almost 1 million Swedes) go through surgery. Hypoxia remains the main ultimate cause of anesthesia-related death and morbidity and most of these events occurs during induction of anesthesia or due to residual effects of anesthetics in high-risk patients.

In this project we generate and implement novel approaches for the prevention of acute hypoxia in the perioperative period that occur as a result of anesthesia. Novel technology for pre-oxygenation and oxygenation will be evaluated in clinical trials, state-of-the-art patient-centred physiological monitoring and experimental studies. This project will bring novel innovative technology to patient care and will ultimately have the potential to reduce perioperative respiratory complications and to increase patient safety. 

We have recently published promising results within the field of both pre-oxygenation and apneic oxygenation, and are currently conducting several studies in this area. The results from our studies are starting to become a game changer in the field of anesthesia and will serve as a basis for a safer perioperative patient management, an improved quality of care and a reduction of the costs, when the use of high-flow nasal oxygen is implemented within the coming years.

Trauma

This project evaluate pathophysiology, biomarker patterns and novel treatments in the early resuscitation phase of patients with severe bleeding and hemorrhagic shock following trauma. This research project will address factors important for survival and will bring potential new treatment strategies into the clinic and could ultimately improve outcomes for a patient group with low survival.

Cardiac arrest

This project investigate the potential of levosimendan as a therapeutic intervention for cardiac arrest with STEMI, with a focus on understanding its underlying mechanisms. We have demonstrated that levosimendan improve survival and improves cardiac performance in an experimental model. Introduction of levosimendan as a potential pharmacological intervention to patients with cardiac arrest has the potential to dramatically change the care and outcome for these patients.

Other projects that the research group is involved in included perioperative care of patients with obstructive sleep apnea, control of ventilation, COVID-19 and emergency laparotomy project.

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Your support means a lot to the success of research. This allows us to go further in our efforts to improve human health through research and education.

 

 

Group members

 MD, Research Group Leader

MD, Senior Consultant

Post-Docs

Ida-Maria Forsberg, Consultant ( ida-maria.forsberg@regionstockholm.se)

Erik von Oelreich, Consultant (erik.von.oelreich@regionstockholm.se)

Susanne Rysz, Senior Consultant (Susanne.rysz@regionstockholm.se)

PhD-students

, Resident

, Consultant

, Consultant

, Consultant

, Consultant

Anesthesia nurse

Consultant

In collaboration with Therese Djärv, Jessica Kåhlin, Emma Larsson, Johan Lundberg

Funding

ALF, Region Stockholm

Oxygenation


  1. Forsberg IM, Al-Saadi J, Sjöblom A, Grape L, Petersson J, Lundberg J, Lodenius A, Eriksson LI, Fagerlund MJ
    Eur J Anaesthesiol 2023 Aug;40(8):568-577
     

  2. Sjöblom A, Hedberg M, Johansson S, Henningsson R, Soumpasis I, Lafrenz H, Törnberg D, Lodenius Å, Fagerlund MJ
    Acta Anaesthesiol Scand 2023 Sep;67(8):1028-1036
     

  3. Rosén J, von Oelreich E, Fors D, Jonsson Fagerlund M, Taxbro K, Skorup P, Eby L, Campoccia Jalde F, Johansson N, Bergström G, Frykholm P, 
    Crit Care 2021 Jun;25(1):209
     

  4. Forsberg IM, Mkrtchian S, Ebberyd A, Ullman J, Eriksson LI, Lodenius Ã…, Jonsson Fagerlund M
    Acta Anaesthesiol Scand 2021 Oct;65(9):1276-1284
     

  5. Rosén J, von Oelreich E, Fors D, Jonsson Fagerlund M, Taxbro K, Frykholm P
    Crit Care 2021 Aug;25(1):273
     

  6. Spyckerelle I, Jonsson Fagerlund M, Holmgren E, Johansson G, Sahlin C, Thunberg J, Franklin KA
    Ann Surg Open 2021 Dec;2(4):e101
     

  7. Sjöblom A, Broms J, Hedberg M, Lodenius Å, Furubacke A, Henningsson R, Wiklund A, Nabecker S, Theiler L, Jonsson Fagerlund M
    Anaesthesia 2021 Sep;76(9):1176-1183
     

  8. Sjöblom A, Lodenius Å, Hedberg M, Fagerlund MJ
    Anaesthesia 2021 Sep;76(9):1275
     

  9. Sjöblom A, Hedberg M, Lodenius Å, Jonsson Fagerlund M
    Anaesthesia 2021 Sep;76(9):1277-1278
     

  10. Lodenius Ã…, Jonsson Fagerlund M
    Anesthesiology 2020 Jun;132(6):1609-1610
     

  11. Forsberg IM, Ullman J, Hoffman A, Eriksson LI, Lodenius Ã…, Fagerlund MJ
    Acta Anaesthesiol Scand 2020 Nov;64(10):1491-1498
     

  12. Mkrtchian S, Kåhlin J, Gómez-Galán M, Ebberyd A, Yoshitake T, Schmidt S, Kehr J, Hildenborg M, Jonsson Fagerlund M, Erlandsson Harris H, Eriksson LI
    Exp Physiol 2020 Sep;105(9):1634-1647
     

  13. Lodenius Å, Piehl J, Östlund A, Ullman J, Jonsson Fagerlund M
    Anaesthesia 2018 May;73(5):564-571
     

  14. Gustafsson IM, Lodenius Ã…, Tunelli J, Ullman J, Jonsson Fagerlund M
    Br J Anaesth 2017 Apr;118(4):610-617

Trauma


  1. Ohlén D, Hedberg M, Martinsson P, von Oelreich E, Djärv T, Jonsson Fagerlund M
    Scand J Trauma Resusc Emerg Med 2022 Oct;30(1):54

Cardiac arrest

 


  1. Sundelin A, Fagerlund MJ, Flam B, Djärv T
    Resusc Plus 2023 Sep;15():100413
     

  2. Flam B, Andersson Franko M, Skrifvars MB, Djärv T, Cronhjort M, Jonsson Fagerlund M, Mårtensson J
    Crit Care Med 2023 Sep;():
     

  3. Rysz S, Fagerlund MJ, Lundberg J, Ringh M, Hollenberg J, Lindgren M, Jonsson M, Djärv T, Nordberg P
    J Clin Med 2022 May;11(9):
     

  4. Rysz S, Lundberg J, Nordberg P, Eriksson H, Wieslander B, Lundin M, Fyrdahl A, Pernow J, Ugander M, Djärv T, Jonsson Fagerlund M
    Resuscitation 2020 May;150():113-12

Obstructive sleep apnea

 


  1. Berezin L, Nagappa M, Wong J, Clivatti J, Singh M, Auckley D, Charchaflieh JG, Jonsson Fagerlund M, Gali B, Joshi GP, Overdyk FJ, Margarson M, Mokhlesi B, Moon T, Ramachandran SK, Ryan CM, Schumann R, Weingarten TN, Won CHJ, Chung F
    Anesth Analg 2021 May;132(5):1223-1230
     

  2. Jonsson Fagerlund M, Franklin KA
    Anesth Analg 2021 May;132(5):1306-1313
     

  3. Christensson E, Mkrtchian S, Ebberyd A, Österlund Modalen Å, Franklin KA, Eriksson LI, Jonsson Fagerlund M
    Respir Physiol Neurobiol 2021 Dec;294():103746
     

  4. Christensson E, Ebberyd A, Hårdemark Cedborg A, Lodenius Å, Österlund Modalen Å, Franklin KA, Eriksson LI, Jonsson Fagerlund M
    Anaesthesia 2020 Mar;75(3):338-347
     

  5. Christensson E, Fagerlund MJ
    Anaesthesia 2020 Apr;75(4):553
     

  6. Christensson E, Franklin KA, Sahlin C, Palm A, Ulfberg J, Eriksson LI, Lindberg E, Hagel E, Jonsson Fagerlund M
    Anesth Analg 2018 Sep;127(3):736-743

COVID-19


  1. Rysz S, Jonsson Fagerlund M, Rimes-Stigare C, Larsson E, Campoccia Jalde F, MÃ¥rtensson J
    Acta Anaesthesiol Scand 2022 Jan;66(1):48-55
     

  2. Rysz S, Al-Saadi J, Sjöström A, Farm M, Campoccia Jalde F, Plattén M, Eriksson H, Klein M, Vargas-Paris R, Nyrén S, Abdula G, Ouellette R, Granberg T, Jonsson Fagerlund M, Lundberg J
    Nat Commun 2021 Apr;12(1):2417
     

  3. Wong DJN, El-Boghdadly K, Owen R, Johnstone C, Neuman MD, Andruszkiewicz P, Baker PA, Biccard BM, Bryson GL, Chan MTV, Cheng MH, Chin KJ, Coburn M, Jonsson Fagerlund M, Lobo CA, Martinez-Hurtado E, Myatra SN, Myles PS, Navarro G, O'Sullivan E, Pasin L, Quintero K, Shallik N, Shamim F, van Klei WA, Ahmad I
    Anesthesiology 2021 Aug;135(2):292-303
     

  4. El-Boghdadly K, Wong DJN, Owen R, Neuman MD, Pocock S, Carlisle JB, Johnstone C, Andruszkiewicz P, Baker PA, Biccard BM, Bryson GL, Chan MTV, Cheng MH, Chin KJ, Coburn M, Jonsson Fagerlund M, Myatra SN, Myles PS, O'Sullivan E, Pasin L, Shamim F, van Klei WA, Ahmad I
    Anaesthesia 2020 Nov;75(11):1437-1447
     

  5. Rysz S, Jalde FC, Oldner A, Eriksson LI, Lundberg J, Fagerlund MJ
    Crit Care 2020 Sep;24(1):546

Other


  1. Fuchs-Buder T, Brull SJ, Fagerlund MJ, Renew JR, Cammu G, Murphy GS, Warlé M, Vested M, Fülesdi B, Nemes R, Columb MO, Damian D, Davis PJ, Iwasaki H, Eriksson LI
    Acta Anaesthesiol Scand 2023 Sep;67(8):994-1017
     

  2. Danielson M, Wiklund A, Granath F, Blennow K, Mkrtchian S, Nellgård B, Oras J, Fagerlund MJ, Granström A, Schening A, Rasmussen LS, Harris HE, Zetterberg H, Ricksten SE, Eriksson LI
    Br J Anaesth 2021 Feb;126(2):467-476
     

  3. Danielson M, Wiklund A, Granath F, Blennow K, Mkrtchian S, Nellgård B, Oras J, Jonsson Fagerlund M, Granström A, Schening A, Rasmussen LS, Erlandsson Harris H, Zetterberg H, Ricksten SE, Eriksson LI
    Ann Neurol 2020 Mar;87(3):370-382
     

  4. Lundström N, Henriksson G, Börjesson O, Jonsson Fagerlund M, Petersson J
    Case Rep Crit Care 2019 ;2019():2921819
     

  5. Kirmeier E, Eriksson LI, Lewald H, Jonsson Fagerlund M, Hoeft A, Hollmann M, Meistelman C, Hunter JM, Ulm K, Blobner M, 
    Lancet Respir Med 2019 Feb;7(2):129-140
     

  6. Lodenius Ã…, Maddison KJ, Lawther BK, Scheinin M, Eriksson LI, Eastwood PR, Hillman DR, Fagerlund MJ, Walsh JH
    Anesthesiology 2019 Nov;131(5):962-973
     

  7. Lodenius Ã…, Jonsson Fagerlund M
    Anaesthesia 2018 Aug;73(8):1039-1040
     

  8. Mkrtchian S, Lee KL, KÃ¥hlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI
    Adv Exp Med Biol 2018 ;1071():25-33
     

  9. Mkrtchian S, Lee KL, KÃ¥hlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI
    Exp Cell Res 2017 Mar;352(2):412-419
     

  10. Szakmany T, Ditai J, Kirov M, Protsenko D, Osinaike B, Venara A, Demartines N, Hubner M, Pearse RM, Prowle JR, 
    Eur J Surg Oncol 2017 Dec;43(12):2324-2332
     

  11. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI
    Ann Neurol 2017 Apr;81(4):572-582
     

  12. Ahmad T, Bouwman RA, Grigoras I, Aldecoa C, Hofer C, Hoeft A, Holt P, Fleisher LA, Buhre W, Pearse RM, 
    Br J Anaesth 2017 Aug;119(2):258-266
     


  13. Br J Anaesth 2016 Oct;117(5):601-609
     

  14. Fagerlund MJ, Fink H, Baumüller E, Ulm K, Hollmann MW, Meistelman C, Hunter J, Leva B, Damster S, Eriksson LI, Blobner M
    Eur J Anaesthesiol 2016 May;33(5):381-3
     

  15. Jonsson Fagerlund M, Krupp J, Dabrowski MA
    Pharmaceuticals (Basel) 2016 Feb;9(1):
     

  16. Lodenius Ã…, Ebberyd A, HÃ¥rdemark Cedborg A, Hagel E, Mkrtchian S, Christensson E, Ullman J, Scheinin M, Eriksson LI, Jonsson Fagerlund M
    Anesthesiology 2016 Oct;125(4):700-15
     

  17. Flam B, Bendz E, Jonsson Fagerlund M, Höjer J
    Clin Toxicol (Phila) 2015 Nov;53(9):917
     

  18. KÃ¥hlin J, Mkrtchian S, Ebberyd A, Eriksson LI, Fagerlund MJ
    Adv Exp Med Biol 2015 ;860():371-7
     

  19. KÃ¥hlin J, Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, Kehr J, Prabhakar N, Poellinger L, Fagerlund MJ, Eriksson LI
    Exp Physiol 2014 Aug;99(8):1089-98
     

  20. Wiklund A, Gustavsson D, Ebberyd A, Sundman E, Schulte G, Jonsson Fagerlund M, Eriksson LI
    Acta Anaesthesiol Scand 2012 May;56(5):608-15
     

  21. Jonsson Fagerlund M, Sjödin J, Dabrowski MA, Krupp J
    Eur J Pharmacol 2012 Nov;694(1-3):13-9
     

  22. Mkrtchian S, KÃ¥hlin J, Ebberyd A, Gonzalez C, Sanchez D, Balbir A, Kostuk EW, Shirahata M, Fagerlund MJ, Eriksson LI
    J Physiol 2012 Aug;590(16):3807-19
     

  23. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M
    Ann Neurol 2011 Dec;70(6):986-995
     

  24. Dilger JP, Steinbach JH
    Anesthesiology 2010 Jan;112(1):247-9; author reply 249-50
     

  25. KÃ¥hlin J, Eriksson LI, Ebberyd A, Fagerlund MJ
    Respir Physiol Neurobiol 2010 Jul;172(3):122-8
     

  26. Jonsson Fagerlund M, Sjödin J, Krupp J, Dabrowski MA
    Br J Anaesth 2010 Apr;104(4):472-81
     

  27. Fagerlund MJ, KÃ¥hlin J, Ebberyd A, Schulte G, Mkrtchian S, Eriksson LI
    Anesthesiology 2010 Dec;113(6):1270-9
     

  28. Martyn JA, Fagerlund MJ, Eriksson LI
    Anaesthesia 2009 Mar;64 Suppl 1():1-9
     

  29. Fagerlund MJ, Eriksson LI
    Br J Anaesth 2009 Jul;103(1):108-14
     

  30. Jonsson Fagerlund M, Dabrowski M, Eriksson LI
    Anesthesiology 2009 Jun;110(6):1244-52
     

  31. Akada S, Fagerlund MJ, Lindahl SG, Sakamoto A, Prabhakar NR, Eriksson LI
    Respir Physiol Neurobiol 2008 Feb;160(3):284-8
     

  32. Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI
    Anesthesiology 2006 Apr;104(4):724-33
     

  33. Jonsson M, Gurley D, Dabrowski M, Larsson O, Johnson EC, Eriksson LI
    Anesthesiology 2006 Sep;105(3):521-33
     

  34. Jonsson MM, Lindahl SG, Eriksson LI
    Anesthesiology 2005 Jan;102(1):110-6
     

  35. Jonsson M, Wyon N, Lindahl SG, Fredholm BB, Eriksson LI
    Eur J Pharmacol 2004 Aug;497(2):173-80
     

  36. Jonsson M, Lindahl SG, Eriksson LI
    Adv Exp Med Biol 2003 ;536():135-40
     

  37. Jonsson M, Kim C, Yamamoto Y, Runold M, Lindahl SG, Eriksson LI
    Acta Anaesthesiol Scand 2002 May;46(5):488-94
Keywords:
Anesthesiology and Intensive Care
Content reviewer:
Malin Jonsson Fagerlund
29-01-2025