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Neuropsychology of music – Fredrik Ullén group

Our research is performed in tight collaboration with the Max Planck Institute for Empirical Aesthetics, where Fredrik Ullén also is the Director of the Department of Cognitive Neuropsychology.

Decorative image representing a musical DNA spiral that is used in presentations of the research group's work on the genetics of music.

Research focus

Brain anatomy of adult monozygotic twins that differed in their musical experience.
Musically active monozygotic twins have thicker cortex in auditory-motor areas than their non-playing co-twins. Image: Fredrik Ullén

Scientific goal

Our scientific goal is to increase our understanding of the brain mechanisms that underpin human expertise, skill learning and creativity. In most of this work, we use music as a model. 

Indeed, music has proved very useful as a tool, or window, through which we can study questions of broad relevance for cognitive neuropsychology.

Engaging in music – whether as performers, listeners or creators - requires a stunningly complex interaction between numerous brain systems, which are involved in functions ranging from multisensory perception and motor coordination, to emotional processing and social interaction. Acquiring new musical skills, in turn, places extraordinary demands on neural plasticity, and the brain networks involved in learning and memory.

Brain anatomy of adult monozygotic twins that differed in their musical experience, i.e. one of the twins in the pair actively played the piano whereas the other had quit early in life. The playing twins showed a higher cortical thickness (CT) than their co-twins in several auditory and motor areas, including the inferior frontal cortex (IFG), premotor cortex (PMD, PMV), and the Sylvian parieto-temporal area (SPT).

Studying musicians and musical tasks can therefore provide important new knowledge not only about the musical brain as such, but also about fundamental principles for the neural control of behavior in general.

Finally, investigating musical engagement, its causes and consequences, is relevant from an applied perspective. Participating in musical activities, alone or together with others, may have effects on other things than our musical competence. In that context, we are particularly interested in the associations between cultural engagement, psychological well-being and health.

Schematic summary of main elements of the multifactorial gene.
Multifactoral Gene-Environment Interaction Model. Image: Fredrik Ullén

Schematic summary of main elements of the multifactorial gene– environment interaction model (MGIM) of expertise acquisition. At the phenotypic level (upper part), the MGIM assumes that psychological traits such as abilities, personality, interests, and motivation are associated with the domain and intensity of practice. Specific examples of variables that have been shown to be involved in various forms of expertise are provided in italics under each general heading. Practice will cause adaptations of neural mechanisms involved in expertise and can also influence relevant physical body properties. Furthermore, neural mechanisms related to trait differences may impact expertise independently of practice. Both genetic and nongenetic factors (lower part) influence the various variables that are involved in expertise at the phenotypic level. These influences are complex and involve different types of gene-environment interplay, i.e. gene-environment interaction as well as covariation.

Methodology

Methodologically, we employ a combination of techniques from experimental and differential psychology, behavior genetics, and structural and functional neuroimaging. This reflects our belief in the importance of integrating analyses at different levels, from the behavioral to the neurobiological, as well as that fact that we are equally interested in general mechanisms and processes that apply to all humans, and the neuropsychological basis of individual differences. Individual differences are the consequence of a complex interaction between genes and environment, and we believe that important insights about variation in musical behaviors can be gained by analyzing gene-environment interplay using the tools of behavior genetics. 

Publications

Selected publications

  • Article: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2023;152:105302
    Wesseldijk LW; Ullen F; Mosing MA
  • Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):15
    Wesseldijk LW; Lu Y; Karlsson R; Ullen F; Mosing MA
  • Article: NATURE HUMAN BEHAVIOUR. 2022;6(9):1292-1309
    Niarchou M; Gustavson DE; Sathirapongsasuti JF; Anglada-Tort M; Eising E; Bell E; McArthur E; Straub P; McAuley JD; Capra JA; Ullen F; Creanza N; Mosing MA; Hinds DA; Davis LK; Jacoby N; Gordon RL
  • Article: SCIENTIFIC REPORTS. 2022;12(1):14658
    Wesseldijk LW; Abdellaoui A; Gordon RL; Ullen F; Mosing MA
  • Article: CEREBRAL CORTEX. 2020;30(10):5193-5203
    de Manzano O; Kuckelkorn KL; Strom K; Ullen F
  • Article: CEREBRAL CORTEX. 2018;28(1):387-394
    de Manzano O; Ullen F
  • Article: PSYCHOLOGICAL BULLETIN. 2016;142(4):427-446
    Ullen F; Hambrick DZ; Mosing MA
  • Article: NATURE NEUROSCIENCE. 2015;18(7):953-955
    Power RA; Steinberg S; Bjornsdottir G; Rietveld CA; Abdellaoui A; Nivard MM; Johannesson M; Galesloot TE; Hottenga JJ; Willemsen G; Cesarini D; Benjamin DJ; Magnusson PKE; Ullen F; Tiemeier H; Hofman A; Van Rooij FJA; Walters GB; Sigurdsson E; Thorgeirsson TE; Ingason A; Helgason A; Kong A; Kiemeney LA; Koellinger P; Boomsma DI; Gudbjartsson D; Stefansson H; Stefansson K
  • Article: CEREBRAL CORTEX. 2015;26(7):3052-3063
    Pinho AL; Ullen F; Castelo-Branco M; Fransson P; de Manzano O
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(16):7574-7579
    Karabanov A; Cervenka S; de Manzano O; Forssberg H; Farde L; Ullen F
  • Article: NATURE NEUROSCIENCE. 2005;8(9):1148-1150
    Bengtsson SL; Nagy Z; Skare S; Forsman L; Forssberg H; Ullén F

All publications from group members

  • Letter: CURRENT BIOLOGY. 2024;34(6):R233-R234
    Wesseldijk LW; Henechowicz TL; Baker DJ; Bignardi G; Karlsson R; Gordon RL; Mosing MA; Ullen F; Fisher SE
  • Article: PSYCHOLOGY OF AESTHETICS, CREATIVITY, AND THE ARTS. 2023;17(6):675-681
    Wesseldijk LW; Gordon RL; Mosing MA; Ullen F
  • Article: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2023;152:105302
    Wesseldijk LW; Ullen F; Mosing MA
  • Article: COGNITION. 2023;233:105362
    Merseal HM; Beaty RE; Kenett YN; Lloyd-Cox J; de Manzano Ö; Norgaard M
  • Article: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS. 2023;53(3):1034-1052
    Offermans JE; de BEI; Lange AMC; Middeldorp CM; Wesseldijk LW; Boomsma DI; Dieleman GC; Bogels SM; van Steensel FJA
  • Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1521(1):140-154
    Gustavson DE; Coleman PL; Wang Y; Nitin R; Petty LE; Bush CT; Mosing MA; Wesseldijk LW; Ullen F; Below JE; Cox NJ; Gordon RL
  • Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):15
    Wesseldijk LW; Lu Y; Karlsson R; Ullen F; Mosing MA
  • Article: SCIENTIFIC REPORTS. 2022;12(1):14658
    Wesseldijk LW; Abdellaoui A; Gordon RL; Ullen F; Mosing MA
  • Article: INTELLIGENCE. 2021;89:101584
    de Manzano O; Ullen F
  • Article: NEUROIMAGE. 2021;233:117962
    Manting CL; Gulyas B; Ullen F; Lundqvist D
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2021;173:110573
    Kuckelkorn KL; de Manzano O; Ullen F
  • Article: PSYCHOLOGICAL SCIENCE. 2021;32(1):3-13
    Wesseldijk LW; Mosing MA; Ullen F
  • Article: INTELLIGENCE. 2021;84:101516
    Sorjonen K; Madison G; Hemmingsson T; Melin B; Ullen F
  • Article: CEREBRAL CORTEX. 2020;30(10):5193-5203
    de Manzano O; Kuckelkorn KL; Strom K; Ullen F
  • Article: NEUROIMAGE. 2020;217:116930
    Manting CL; Andersen LM; Gulyas B; Ullen F; Lundqvist D
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2020;161:110001
    Wesseldijk LW; Ullen F; Mosing MA
  • Article: INTELLIGENCE. 2020;80:101454
    Sorjonen K; Madison G; Melin B; Ullen F
  • Article: PSYCHOPHARMACOLOGY. 2020;237(1):69-82
    Khemiri L; Steensland P; Guterstam J; de Manzano O; Franck J; Jayaram-Lindstrom N
  • Article: SCIENTIFIC REPORTS. 2019;9(1):12606
    Wesseldijk LW; Ullen F; Mosing MA
  • Article: DEVELOPMENTAL PSYCHOLOGY. 2019;55(7):1473-1479
    Wesseldijk LW; Mosing MA; Ullen F
  • Article: QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY. 2019;72(6):1308-1327
    Pliatsikas C; Verissimo J; Babcock L; Pullman MY; Glei DA; Weinstein M; Goldman N; Ullman MT
  • Article: NEUROIMAGE. 2019;189:307-315
    Forsberg L; Sigurdsson S; Launer LJ; Gudnason V; Ullen F
  • Article: PSYCHOLOGY OF AESTHETICS, CREATIVITY, AND THE ARTS. 2019;13(1):49-57
    Theorell T; Madison G; Ullen F
  • Article: INTELLIGENCE. 2018;69:123-133
    de Manzano O; Ullen F
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2018;1423(1):427-434
    Mosing MA; Ullen F
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2018;1423(1):284-295
    Hambrick DZ; Burgoyne AP; Macnamara BN; Ullen F
  • Article: JOURNAL OF AFFECTIVE DISORDERS. 2018;226:6-11
    Mosing MA; Butkovic A; Ullen F
  • Article: CEREBRAL CORTEX. 2018;28(1):387-394
    de Manzano O; Ullen F
  • Article: PLOS ONE. 2018;13(3):e0194054
    Furlan M; Babcock L; Vallesi A
  • Review: PROGRESS IN BRAIN RESEARCH. 2018;237:279-289
    Theorell T; Harmat L; Eriksson H; Ullen F
  • Article: BEHAVIOURAL BRAIN RESEARCH. 2017;335:167-173
    Vallesi A; Mazzonetto I; Ambrosini E; Babcock L; Capizzi M; Arbula S; Tarantino V; Semenza C; Bertoldo A
  • Article: MUSICAE SCIENTIAE. 2017;21(3):250-266
    Eriksson H; Harmat L; Theorell T; Ullen F
  • Article: EXPERIMENTAL BRAIN RESEARCH. 2017;235(3):787-798
    Holm L; Karampela O; Ullen F; Madison G
  • Article: BILINGUALISM: LANGUAGE AND COGNITION. 2017;20(2):403-417
    Babcock L; Vallesi A
  • Article: CREATIVITY RESEARCH JOURNAL. 2017;29(1):29-36
    Lennartsson A-K; Horwitz EB; Theorell T; Ullen F
  • Article: INTELLIGENCE. 2016;59:157-162
    Madison G; Mosing MA; Verweij KJH; Pedersen NL; Ullen F
  • Article: ARCHIVES OF SEXUAL BEHAVIOR. 2016;45(7):1799-1806
    Mosing MA; Verweij KJH; Abe C; de Manzano O; Ullen F
  • Article: INTELLIGENCE. 2016;57:33-40
    Mosing MA; Verweij KJH; Madison G; Ullen F
  • Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2016;44(4):354-360
    Theorell T; De Manzano O; Lennartsson A-K; Pedersen NL; Ullen F
  • Article: DEVELOPMENTAL SCIENCE. 2016;19(3):504-512
    Mosing MA; Madison G; Pedersen NL; Ullen F
  • Article: PSYCHOLOGICAL BULLETIN. 2016;142(4):427-446
    Ullen F; Hambrick DZ; Mosing MA
  • Article: TWIN RESEARCH AND HUMAN GENETICS. 2016;19(2):87-96
    Verweij KJH; Mosing MA; Ullen F; Madison G
  • Article: PSYCHOLOGY OF LEARNING AND MOTIVATION - ADVANCES IN RESEARCH AND THEORY. 2016;64:1-55
    Hambrick DZ; Macnamara BN; Campitelli G; Ullen F; Mosing MA
  • Article: EVOLUTION AND HUMAN BEHAVIOR. 2015;36(5):359-366
    Mosing MA; Vervveij KJH; Madison G; Pedersen NL; Zietsch BP; Ullen F
  • Article: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY. 2015;97(1):1-7
    Harmat L; de Manzano O; Theorell T; Hogman L; Fischer H; Ullen F
  • Article: NATURE NEUROSCIENCE. 2015;18(7):953-955
    Power RA; Steinberg S; Bjornsdottir G; Rietveld CA; Abdellaoui A; Nivard MM; Johannesson M; Galesloot TE; Hottenga JJ; Willemsen G; Cesarini D; Benjamin DJ; Magnusson PKE; Ullen F; Tiemeier H; Hofman A; Van Rooij FJA; Walters GB; Sigurdsson E; Thorgeirsson TE; Ingason A; Helgason A; Kong A; Kiemeney LA; Koellinger P; Boomsma DI; Gudbjartsson D; Stefansson H; Stefansson K
  • Article: CEREBRAL CORTEX. 2015;26(7):3052-3063
    Pinho AL; Ullen F; Castelo-Branco M; Fransson P; de Manzano O
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2015;1337:125-129
    Ullen F; Mosing MA; Madison G
  • Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2015;104(3):274-284
    Theorell T; Lennartsson A-K; Madison G; Mosing MA; Ullen F
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2015;74:133-138
    Butkovic A; Ullen F; Mosing MA
  • Article: FRONTIERS IN PSYCHOLOGY. 2015;6:1622
    Babcock L; Vallesi A
  • Article: FRONTIERS IN HUMAN NEUROSCIENCE. 2015;9:642
    Mussgens DM; Ullen F
  • Article: FRONTIERS IN PSYCHOLOGY. 2015;6:1096
    Horwitz EB; Lennartsson A-K; Theorell TPG; Ullen F
  • Article: NEUROPSYCHOLOGIA. 2015;67:91-99
    Babcock L; Vallesi A
  • Article: PSYCHOLOGICAL SCIENCE. 2014;25(9):1795-1803
    Mosing MA; Madison G; Pedersen NL; Kuja-Halkola R; Ullen F
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2014;63:87-93
    Ullen F; Mosing MA; Holm L; Eriksson H; Madison G
  • Article: JOURNAL OF NEUROSCIENCE. 2014;34(18):6156-6163
    Pinho AL; de Manzano O; Fransson P; Eriksson H; Ullen F
  • Article: FRONTIERS IN PSYCHOLOGY. 2014;5:774
    Theorell TP; Lennartsson A-K; Mosing MA; Ullen F
  • Article: PLOS ONE. 2014;9(11):e113874
    Mosing MA; Pedersen NL; Madison G; Ullen F
  • Article: ACTA PSYCHOLOGICA. 2013;143(1):119-128
    Madison G; Karampela O; Ullén F; Holm L
  • Article: JOURNAL OF EXPERIMENTAL PSYCHOLOGY: HUMAN PERCEPTION AND PERFORMANCE. 2013;39(2):365-380
    Holm L; Ullen F; Madison G
  • Article: NEUROIMAGE. 2013;67:1-6
    de Manzano O; Cervenka S; Jucaite A; Hellenas O; Farde L; Ullen F
  • Article: TWIN RESEARCH AND HUMAN GENETICS. 2013;16(1):317-329
    Magnusson PKE; Almqvist C; Rahman I; Ganna A; Viktorin A; Walum H; Halldner L; Lundström S; Ullén F; Långström N; Larsson H; Nyman A; Gumpert CH; Råstam M; Anckarsäter H; Cnattingius S; Johannesson M; Ingelsson E; Klareskog L; de Faire U; Pedersen NL; Lichtenstein P
  • Editorial comment: BEHAVIORAL AND BRAIN SCIENCES. 2012;35(6):440-441
    Madison G; Ullen F
  • Article: NEUROIMAGE. 2012;63(1):272-280
    de Manzano O; Ullen F
  • Article: BILINGUALISM: LANGUAGE AND COGNITION. 2012;15(4):820-840
    Babcock L; Stowe JC; Maloof CJ; Brovetto C; Ullman MT
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2012;53(5):699-704
    Mosing MA; Magnusson PKE; Pedersen NL; Nakamura J; Madison G; Ullen F
  • Article: INTELLIGENCE. 2012;40(2):100-106
    Ullen F; Soderlund T; Kaaria L; Madison G
  • Article: NEUROIMAGE. 2012;59(1):772-780
    de Manzano O; Ullen F
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2012;52(2):167-172
    Ullen F; de Manzano O; Almeida R; Magnusson PKE; Pedersen NL; Nakamura J; Csikszentmihalyi M; Madison G
  • Article: NEUROSCIENCE RESEARCH. 2012;72(1):59-67
    Forsman LJ; de Manzano O; Karabanov A; Madison G; Ullen F
  • Article: PLOS ONE. 2012;7(11):e47958
    Mosing MA; Pedersen NL; Cesarini D; Johannesson M; Magnusson PKE; Nakamura J; Madison G; Ullen F
  • Article: EXPERIMENTAL BRAIN RESEARCH. 2011;215(3-4):359-367
    Holmstrom L; de Manzano O; Vollmer B; Forsman L; Valero-Cuevas FJ; Ullen F; Forssberg H
  • Article: EXPERIMENTAL BRAIN RESEARCH. 2011;214(2):175-183
    Holm L; Ullen F; Madison G
  • Article: JOURNAL OF EXPERIMENTAL PSYCHOLOGY: HUMAN PERCEPTION AND PERFORMANCE. 2011;37(5):1578-1594
    Madison G; Gouyon F; Ullen F; Hornstrom K
  • Thesis / dissertation: 2010
    De Manzano, Örjan
  • Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2010;52(10):948-954
    Vollmer B; Holmstrom L; Forsman L; Krumlinde-Sundholm L; Valero-Cuevas FJ; Forssberg H; Ullen F
  • Article: EMOTION. 2010;10(3):301-311
    de Manzano O; Theorell T; Harmat L; Ullen F
  • Article: PLOS ONE. 2010;5(5):e10670
    de Manzano O; Cervenka S; Karabanov A; Farde L; Ullen F
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(16):7574-7579
    Karabanov A; Cervenka S; de Manzano O; Forssberg H; Farde L; Ullen F
  • Article: PERSONALITY AND INDIVIDUAL DIFFERENCES. 2009;47(3):229-232
    Forsman LJ; Madison G; Ullen F
  • Article: NEURON GLIA BIOLOGY. 2009;5(1-2):29-34
    Ullen F
  • Article: NEUROIMAGE. 2009;44(2):480-488
    Karabanov A; Blom O; Forsman L; Ullen F
  • Article: CORTEX. 2009;45(1):62-71
    Bengtsson SL; Ullen F; Ehrsson HH; Hashimoto T; Kito T; Naito E; Forssberg H; Sadato N
  • Article: INTELLIGENCE. 2009;37(1):68-75
    Madison G; Forsman L; Blom O; Karabanov A; Ullen F
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2008;100(2):733-739
    Karabanov A; Ullen F
  • Article: JOURNAL OF NEUROSCIENCE. 2008;28(16):4238-4243
    Ullen F; Forsman L; Blom O; Karabanov A; Madison G
  • Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):193-198
    Ullen F
  • Article: JOURNAL OF COGNITIVE NEUROSCIENCE. 2007;19(5):830-842
    Bengtsson SL; Csikszentmihalyi M; Ullen F
  • Article: NEUROIMAGE. 2006;30(1):272-284
    Bengtsson SL; Ullén F
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2005;1060:368-376
    Ullén F; Bengtsson SL; Ehrsson HH; Forssberg H
  • Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2005;22(12):3255-3265
    Bengtsson SL; Ehrsson HH; Forssberg H; Ullén F
  • Article: NATURE NEUROSCIENCE. 2005;8(9):1148-1150
    Bengtsson SL; Nagy Z; Skare S; Forsman L; Forssberg H; Ullén F
  • Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2004;19(9):2591-2602
    Bengtsson SL; Ehrsson HH; Forssberg H; Ullén F
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2003;90(6):3725-3735
    Ullén F; Bengtsson SL
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2003;89(2):1126-1135
    Ullén F; Forssberg H; Ehrsson HH
  • Article: BIOLOGICAL CYBERNETICS. 2002;86(1):1-14
    Kozlov AK; Ullén F; Fagerstedt P; Aurell E; Lansner A; Grillner S
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2001;86(5):2257-2265
    Fagerstedt P; Orlovsky GN; Deliagina TG; Grillner S; Ullén F
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2001;86(5):2246-2256
    Fagerstedt P; Ullén F
  • Published conference paper: NEUROCOMPUTING. 2001;38:1373-1378
    Kozlov AK; Fagerstedt P; Ullén F; Aurell E
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 1997;78(2):960-976
    Ullen F; Deliagina TG; Orlovsky GN; Grillner S
  • Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1996;8(11):2298-2307
    Ullen F; Deliagina TG; Orlovsky GN; Grillner S
  • Article: JOURNAL OF EXPERIMENTAL BIOLOGY. 1995;198(12):2581-2591
    DELIAGINA TG; ULLEN F; GONZALEZ MJ; EHRSSON HH; ORLOVSKY GN; GRILLNER S
  • Article: JOURNAL OF EXPERIMENTAL BIOLOGY. 1995;198(3):675-681
    ULLEN F; DELIAGINA TG; ORLOVSKY GN; GRILLNER S
  • Article: JOURNAL OF EXPERIMENTAL BIOLOGY. 1995;198(3):665-673
    ULLEN F; DELIAGINA TG; ORLOVSKY GN; GRILLNER S
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Group leader

All members of the group