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Cardiometabolic diseases – Ping Chen research group

We work on data-driven research in human cardiometabolic diseases.

Research

We aim to integrate longitudinal patient data, cutting-edge multi-omics technologies, and novel computational approaches to monitor individual disease progression and dissect the underlying disease-driving mechanisms. In particular, we are interested in the roles of immune cells (macrophages, monocytes, dendritic cells, etc.) and RNA splicing-centric transcriptional regulation in disease progression.

Currently, we focus on obesity and its associated metabolic diseases, especially non-alcoholic fatty liver disease and diabetes.

Publications

Selected publications

  • Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(8):461-472
    Barreby E; Chen P; Aouadi M
  • Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
    Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
  • Article: NATURE COMMUNICATIONS. 2021;12(1):2141
    He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
  • Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714
    Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskold D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
    Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M

Research techniques

  • Single-cell omics, Spatial omics
  • Mass spectrometry
  • Bioinformatics
  • Artificial intelligence.
Keywords:
Bioinformatics and Systems Biology (methods development, see 10203) Cardiac and Cardiovascular Systems Endocrinology and Diabetes Gastroenterology and Hepatology Immunology in the ̽»¨¾«Ñ¡ area
PC
Content reviewer:
Ping Chen
Christina Sundqvist
22-03-2024