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Ping Chen

Ping Chen

Principal Researcher
Visiting address: ,
Postal address: H5 Laboratoriemedicin, H5 Klin Kemi Chen, 171 77 Stockholm
Part of:

About me

  • As a computational biologist, I am dedicated to bridging the gap between data science and ̽»¨¾«Ñ¡ research. I earned my Ph.D. in Medical Systems Biology from the University of Helsinki in 2016, where my doctoral dissertation focused on the ‘Quantitative Study of Transcriptome Dynamics during Evolution and Treatment Resistance in Cancer’. Following my Phd, I pursued received postdoctoral research training on Smart-seq2/3 single cell methodology in Rickard Sandberg’s group, and on immunometabolism in Myriam Aouadi’s group at ̽»¨¾«Ñ¡, Sweden. Since 2022, I have been leading my independent research group at the Division of Clinical Chemistry in KI LABMED. Our team is deeply engaged in data-driven research on human cardiometabolic diseases, encompassing both computational method development and in-depth mechanistic studies. Additionally, since September 2023, I have started my second lab at the University of Helsinki in Finland. This lab is dedicated to investigating the regulation of alternative splicing in human metabolic diseases.

    *Research funding*
    My research has received funding from CIMED, Jeanssons Stiftelser, SRP Diabetes, Research Council of Finland and ̽»¨¾«Ñ¡.

    *Commission of trust*
    - Member of master thesis evaluation committee and member of doctoral student half-time review committee at ̽»¨¾«Ñ¡ (2023)
    - Doctoral education board member at the Department of Laboratory Medicine, ̽»¨¾«Ñ¡ (2022--)
    - Associate Editor of Journal of Translational Medicine (2020--)
    - Secretary of the Junior Faculty Steering Group leadership at ̽»¨¾«Ñ¡ (2022--) &
  • Member of the JF Communication Focus Group (2021--)
    - Organization committee member of Karolinska Liver Academy kick-off meeting (2022)
    - Junior Faculty and departmental representative for evaluating KI new Research Information Management System (2022)
    - Organization committee member of Karolinska Discovers seminar series (2021-2022)

Research

  • We study human obesity and related metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and diabetes. I am particularly enthusiastic about developing AI-driven tools to enhance our insights on disease diagnostics. Additionally, my focus includes advancing data-driven methodologies to explore the roles of immune cells and transcriptional regulation, with a special emphasis on RNA splicing, in these diseases.

    Since 2022, I have been leading my independent research group at the Division of Clinical Chemistry in KI LABMED. Our team is deeply engaged in data-driven research on human cardiometabolic diseases, encompassing both computational method development and in-depth mechanistic studies. Our data-driven research aims to develop new precise diagnosis and treatment strategies for patients and further dissect the cellular and molecular mechanisms driving disease pathogenesis . In close collaboration with multidisciplinary researchers, we integrate longitudinal patient data,
    multi-omics technologies as well as novel computational and experimental approaches in our research. Since September 2023, I have started a second lab in the University of Helsinki in Finland. This lab is dedicated to investigating the role of alternative splicing in human metabolic diseases.

Teaching

  • * Co-organiser of the Karolinska Basic Bioinformatics course for doctoral students (2022--)
    * Teaching in Basic Bioinformatics courses (2019-2022)
    * Teaching in LABMED courses (2022--)
    * Co-supervisor of two ongoing PhD students at KI MedH (2021--) and main supervisor of my lab members (2023--)
    * Karolinska professional pedagogy training (equivalent to five weeks of academic studies) (2020)

Articles

  • Article: NATURE METABOLISM. 2023;5(7):1188-1203
    Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
  • Article: AGING. 2023;15(12):5240-5265
    Salignon J; Faridani OR; Miliotis T; Janssens GE; Chen P; Zarrouki B; Sandberg R; Davidsson P; Riedel CG
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2212476120
    Tarnawski L; Shavva VS; Kort EJ; Zhuge Z; Nilsson I; Gallina AL; Martinez-Enguita D; Sahlgren BH; Weiland M; Caravaca AS; Schmidt S; Chen P; Abbas K; Wang F-H; Ahmed O; Eberhardson M; Farnert A; Weitzberg E; Gustafsson M; Kehr J; Malin SG; Hult H; Carlstrom M; Jovinge S; Olofsson PS
  • Article: SCIENTIFIC REPORTS. 2022;12(1):20519
    Holmer M; Hagstrom H; Chen P; Danielsson O; Aouadi M; Ryden M; Stal P
  • Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
    Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
  • Article: NATURE MEDICINE. 2021;27(11):1941-1953
    Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvonen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ; Kutschke M; Arifen N; Kramer N; Aouadi M; Knibbe C; Boucher J; Thorell A; Spalding KL
  • Article: IMMUNITY. 2021;54(9):2101-2116.e6
    Bleriot C; Barreby E; Dunsmore G; Ballaire R; Chakarov S; Ficht X; De Simone G; Andreata F; Fumagalli V; Guo W; Wan G; Gessain G; Khalilnezhad A; Zhang XM; Ang N; Chen P; Morgantini C; Azzimato V; Kong WT; Liu Z; Pai R; Lum J; Shihui F; Low I; Xu C; Malleret B; Kairi MFM; Balachander A; Cexus O; Larbi A; Lee B; Newell EW; Ng LG; Phoo WW; Sobota RM; Sharma A; Howland SW; Chen J; Bajenoff M; Yvan-Charvet L; Venteclef N; Iannacone M; Aouadi M; Ginhoux F
  • Article: NATURE COMMUNICATIONS. 2021;12(1):2141
    He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
  • Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714
    Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskold D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
    Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
  • Article: JOURNAL OF PATHOLOGY. 2020;250(2):159-169
    Kaipio K; Chen P; Roering P; Huhtinen K; Mikkonen P; Ostling P; Lehtinen L; Mansuri N; Korpela T; Potdar S; Hynninen J; Auranen A; Grenman S; Wennerberg K; Hautaniemi S; Carpen O
  • Article: TRANSLATIONAL ONCOLOGY. 2019;12(1):170-179
    Aakko S; Straume AH; Birkeland EE; Chen P; Qiao X; Lonning PE; Kallio MJ
  • Article: ONCOTARGET. 2016;7(11):12267-12285
    Tambe M; Pruikkonen S; Maki-Jouppila J; Chen P; Elgaaen BV; Straume AH; Huhtinen K; Carpen O; Lonning PE; Davidson B; Hautaniemi S; Kallio MJ
  • Article: ONCOGENE. 2016;35(7):867-877
    Wang L; Yang H; Lei Z; Zhao J; Chen Y; Chen P; Li C; Zeng Y; Liu Z; Liu X; Zhang H-T
  • Article: BIODATA MINING. 2016;9:20
    Icay K; Chen P; Cervera A; Rantanen V; Lehtonen R; Hautaniemi S
  • Article: CANCER RESEARCH. 2015;75(15):2987-2998
    Chen P; Huhtinen K; Kaipio K; Mikkonen P; Aittomaki V; Lindell R; Hynninen J; Auranen A; Grenman S; Lehtonen R; Carpen O; Hautaniemi S
  • Article: CELL REPORTS. 2015;10(12):1992-2005
    Merkin JJ; Chen P; Alexis MS; Hautaniemi SK; Burge CB
  • Article: PLOS ONE. 2014;9(3):e91031
    Taskinen M; Louhimo R; Koivula S; Chen P; Rantanen V; Holte H; Delabie J; Karjalainen-Lindsberg M-L; Bjorkholm M; Fluge O; Pedersen LM; Fjorden K; Jerkeman M; Eriksson M; Hautaniemi S; Leppa S
  • Article: JOURNAL OF CELL SCIENCE. 2013;126(11):2459-2469
    Ylivinkka I; Hu Y; Chen P; Rantanen V; Hautaniemi S; Nyman TA; Keski-Oja J; Hyytiainen M
  • Article: PLOS ONE. 2013;8(4):e60930
    Haapa-Paananen S; Chen P; Hellstrom K; Kohonen P; Hautaniemi S; Kallioniemi O; Perala M
  • Show more

All other publications

  • Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(8):461-472
    Barreby E; Chen P; Aouadi M

Employments

  • Principal Researcher, Department of Laboratory Medicine, ̽»¨¾«Ñ¡, 2025-
  • Assistant Professor, Department of Laboratory Medicine, ̽»¨¾«Ñ¡, 2023-2024

Degrees and Education

  • PhD, Faculty of Medicine, University of Helsinki, 2016
  • MSc, Faculty of Computer Science, University of Helsinki, 2009
  • BSc, Biology and Bioinformatics, Department of Biology and Basic Medical Sciences, Soochow University, 2007

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