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Translational studies on tumor microenvironment – Arne Östman Group

The group focuses on tumor microenvironment, with discovery studies as well as biomarker and drug target identification. Special attention is given to cancer-associated fibroblasts. Many studies use novel methods for spatial tissue profiling of human tumors. Collaborations with clinical researchers, SciLifeLab experts, companies, and IP collection, are common defining project features. The ultimate goal is to contribute to the use of CAFs as drug targets and biomarkers of clinical utility.

Arne Östman
Professor Arne Östman. Photo: private

Our research

Projects commonly integrate experimental studies and profiling of clinical samples. Studies have been performed across a broad range of tumor types, including breast, prostate, ovarian, colorectal and kidney cancer. A series of ongoing studies take advantage of novel methods for high content tissue profiling, which are used both for tumor biology discovery and identification of drug targets and biomarkers.

The group actively encourage studies that take advantage of the complementary expertise of biologists, pathologists and oncologists. The group also has a longstanding track-record of studies performed in collaborations with pharma companies and biotech start-up companies.

Tumor microenvironment
Tumor microenvironment.

Publications

Selected publications

  • Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(1):71-82
    Pellinen T; Paavolainen L; Martin-Bernabe A; Araujo RP; Strell C; Mezheyeuski A; Backman M; La Fleur L; Bruck O; Sjolund J; Holmberg E; Valimaki K; Brunnstrom H; Botling J; Moreno-Ruiz P; Kallioniemi O; Micke P; Ostman A
  • Article: CLINICAL CANCER RESEARCH. 2021;27(12):3469-3477
    Strell C; Folkvaljon D; Holmberg E; Schiza A; Thurfjell V; Karlsson P; Bergh J; Bremer T; Akslen LA; Warnberg F; Ostman A
  • Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
    Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
  • Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717
    Sjoberg E; Meyrath M; Milde L; Herrera M; Lovrot J; Hagerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Andy CE; Augsten M; Ostman A
  • Article: CANCER RESEARCH. 2014;74(13):3408-3417
    Bruzzese F; Hagglof C; Leone A; Sjoberg E; Roca MS; Kiflemariam S; Sjoblom T; Hammarsten P; Egevad L; Bergh A; Ostman A; Budillon A; Augsten M
  • Article: CANCER RESEARCH. 2014;74(11):2999-3010
    Augsten M; Sjoberg E; Frings O; Vorrink SU; Frijhoff J; Olsson E; Borg A; Ostman A
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
    Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
  • Article: CANCER RESEARCH. 2013;73(7):2139-2149
    Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Ostman A; Eriksson U
  • Article: CANCER RESEARCH. 2013;73(4):1287-1297
    Pena C; Virtudes Cespedes M; Lindh MB; Kiflemariam S; Mezheyeuski A; Edqvist P-H; Hagglof C; Birgisson H; Bojmar L; Jirstrom K; Sandstrom P; Olsson E; Veerla S; Gallardo A; Sjoblom T; Chang AC-M; Reddel RR; Mangues R; Augsten M; Ostman A
  • Editorial comment: NATURE MEDICINE. 2012;18(9):1332-1334
    Ostman A

Staff and contact

Group leader

All members of the group

Keywords:
Cancer and Oncology Cell and Molecular Biology Immunology in the Medical Area
Content reviewer:
24-03-2025