Charlotte Rolny

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About me

Leading a research team that focuses on tumor immunology specifically to understand the underlying mechanisms that regulate the pro-tumoral phenotype of immune cells denoted Tumor-Associated Macrophages (TAMs). By employing state-of-art mouse models, cutting edge molecular biology techniques and patient samples, we have deciphered several mechanisms whereby pro-tumoral TAM phenotypes are regulated. By targeting these controlled pathways, pro-tumoral TAMs can be reprogrammed into an anti-tumoral phenotype leading to activation of cytotoxic immune cells and hampering tumor growth and metastatic dissemination. We work closely to clinicians assuring a bench-to-bedside link. Topics that we address:
i) Identifying novel targets that govern tumor-associated macrophage pro-tumoral functions by single-cell sequencing in, genome wide sequencing of total and ribosome- bound RNA, and proteomics.
ii) Identifying novel tumor microenvironment biomarkers in patient samples including TAM phenotypes and their spatial localization.
iii) Regulation of metastatic dissemination via the hematogenous route to secondary organs

Articles

Article: CELL REPORTS. 2023;42(12):113507

Banerjee K; Kerzel T; Bekkhus T; Ferreira SDS; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Ostman A; Squadrito ML; Rolny C
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308

Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(10):e2017089118

Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Article: GYNECOLOGIC ONCOLOGY. 2020;159(3):860-868

Corvigno S; Mezheyeuski A; De La Fuente LM; Westbom-Freme S; Carlson JW; Fernebro J; Avall-Lundqvist E; Kannisto P; Hedenfalk I; Malander S; Rolny C; Dahlstrand H; Ostman A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(44):27556-27565

Bartish M; Tong D; Pan Y; Wallerius M; Liu H; Ristau J; Ferreira SDS; Wallmann T; van Hoef V; Masvidal L; Kerzel T; Joly A-L; Goncalves C; Preston SEJ; Ebrahimian T; Seitz C; Bergh J; Pietras K; Lehoux S; Naldini L; Andersson J; Squadrito ML; del RSV; Larsson O; Rolny C
Article: CANCERS. 2019;11(10):E1479-1479

Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;200(3):348-358

Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Wendt CH; Larsson O
Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717

Sjoberg E; Meyrath M; Milde L; Herrera M; Lovrot J; Hagerstrand D; Frings O; Bartish M; Rolny C; Sonnhammer E; Andy CE; Augsten M; Ostman A
Journal article: PANCREATOLOGY. 2019;19:s28-s29

Li X; Wallmann T; Nania S; Hornung L; Kleiter I; Löhr J-M; Rolny C; Heuchel R
Journal article: ANNALS OF THE AMERICAN THORACIC SOCIETY. 2018;15(Supplement_4):s290-s291

Wendt CH; Sandri BJ; Masvidal L; Murie C; Bartish M; Avdulov S; Higgins L; Markowski T; Peterson M; Bergh J; Yang P; Rolny C; Limper AH; Griffin TJ; Bitterman PB; Larsson O
Article: ISCIENCE. 2018;9:71-83

Wallmann T; Zhang X-M; Wallerius M; Bolin S; Joly A-L; Sobocki C; Leiss L; Jiang Y; Bergh J; Holland EC; Enger PO; Andersson J; Swartling FJ; Miletic H; Uhrbom L; Harris RA; Rolny C
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(11):1417-1425

Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Wallmann T; Tufvesson-Stiller H; Chambers BJ; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
Article: ONCOIMMUNOLOGY. 2017;6(8):e1338238

Sarhan D; Leijonhufvud C; Murray S; Witt K; Seitz C; Wallerius M; Xie H; Ullen A; Harmenberg U; Lidbrink E; Rolny C; Andersson J; Lundqvist A
Article: CANCER RESEARCH. 2016;76(11):3166-3178

Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
Article: CELL REPORTS. 2016;15(9):2000-2011

Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: SCIENCE. 2015;347(6226):1138-1142

Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(1):249-257

Sarhan D; D'Arcy P; Wennerberg E; Lidén M; Hu J; Winqvist O; Rolny C; Lundqvist A
Article: CANCER RESEARCH. 2012;72(8):1953-1963

Tugues S; Honjo S; Konig C; Noguer O; Hedlund M; Botling J; Deschoemaeker S; Wenes M; Rolny C; Jahnen-Dechent W; Mazzone M; Claesson-Welsh L
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(7):2945

Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
Journal article: CANCER RESEARCH. 2011;71(8_Supplement):3268

Casazza A; Kigel B; Rolny C; Neufeld G; Tamagnone L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(4):741-749

Casazza A; Fu X; Johansson I; Capparuccia L; Andersson F; Giustacchini A; Squadrito ML; Venneri MA; Mazzone M; Larsson E; Carmeliet P; De Palma M; Naldini L; Tamagnone L; Rolny C
Article: CANCER CELL. 2011;19(1):31-44

Rolny C; Mazzone M; Tugues S; Laoui D; Johansson I; Coulon C; Squadrito ML; Segura I; Li X; Knevels E; Costa S; Vinckier S; Dresselaer T; Akerud P; De Mol M; Salomaki H; Phillipson M; Wyns S; Larsson E; Buysschaert I; Botling J; Himmelreich U; Van Ginderachter JA; De Palma M; Dewerchin M; Claesson-Welsh L; Carmeliet P
Article: DIABETES. 2010;59(10):2569-2578

Christoffersson G; Henriksnas J; Johansson L; Rolny C; Ahlstrom H; Caballero-Corbalan J; Segersvard R; Permert J; Korsgren O; Carlsson P-O; Phillipson M
Article: BLOOD. 2010;116(11):1924-1931

Massena S; Christoffersson G; Hjertstrom E; Zcharia E; Vlodavsky I; Ausmees N; Rolny C; Li J-P; Phillipson M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(8):2684-2698

Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
Article: CELL. 2010;141(1):178-190

Van de Veire S; Stalmans I; Heindryckx F; Oura H; Tijeras-Raballand A; Schmidt T; Loges S; Albrecht I; Jonckx B; Vinckier S; Van Steenkiste C; Tugues S; Rolny C; De Mol M; Dettori D; Hainaud P; Coenegrachts L; Contreres J-O; Van Bergen T; Cuervo H; Xiao W-H; Le Henaff C; Buysschaert I; Masouleh BK; Geerts A; Schomber T; Bonnin P; Lambert V; Haustraete J; Zacchigna S; Rakic J-M; Jimenez W; Noel A; Giacca M; Colle I; Foidart J-M; Tobelem G; Morales-Ruiz M; Vilar J; Maxwell P; Vinores SA; Carmeliet G; Dewerchin M; Claesson-Welsh L; Dupuy E; Van Vlierberghe H; Christofori G; Mazzone M; Detmar M; Collen D; Carmeliet P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(5):1155-1171

Rolny C; Capparuccia L; Casazza A; Mazzone M; Vallario A; Cignetti A; Medico E; Carmeliet P; Comoglio PM; Tamagnone L
Article: BLOOD. 2006;108(6):1877-1886

Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
Article: EXPERIMENTAL CELL RESEARCH. 2005;308(2):381-393

Rolny C; Lu LG; Ågren N; Nilsson I; Roe C; Webb GC; Welsh M
Article: FASEB JOURNAL. 2004;18(13):1507-1515

Nilsson I; Rolny C; Wu Y; Pytowski B; Hicklin D; Alitalo K; Claesson-Welsh L; Wennström S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(21):22267-22275

Holmqvist K; Cross MJ; Rolny C; Hägerkvist R; Rahimi N; Matsumoto T; Claesson-Welsh L; Welsh M
Article: JOURNAL OF CELL SCIENCE. 2004;117(8):1513-1523

Magnusson P; Rolny C; Jakobsson L; Wikner C; Wu Y; Hicklin DJ; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(22):19315-19321

Rolny C; Spillmann D; Lindahl U; Claesson-Welsh L
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1998;12(2):309-313

Andersson AC; Svensson AC; Rolny C; Andersson G; Larsson E
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All other publications

Review: NATURE REVIEWS CANCER. 2023;23(6):408-425

Bartish M; Abraham MJ; Goncalves C; Larsson O; Rolny C; Del Rincon SV
Meeting abstract: CANCER RESEARCH. 2023;83(5):p2-20-08-p2-20-08

Talkhoncheh MS; Sjolund J; Balbas PB; Kurzejamska E; Larsson S; Cordero E; Oudenaarden CR; Pantaleo J; Jonsson G; Rolny C; Bocci M; Pietras K
Preprint: BIORXIV. 2022

Banerjee K; Kerzel T; Bekkhus T; de Souza Ferreira S; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Östman A; Squadrito ML; Rolny C
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2117333118

Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Meeting abstract: CANCER IMMUNOLOGY RESEARCH. 2018;6(9):a77

Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Tufvesson-Stiller H; Ostling J; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2017;35:e23088

Zerdes I; Tsesmetzis N; Lovrot J; Rolny C; Bergh JCS; Rassidakis G; Foukakis T
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):312-313

Bartish M; Wallerius M; Wallmann T; Sanz LM; van Hoef V; Joly A-L; Andersson J; Larsson O; Rolny C
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):315

Bartish M; Wallerius M; Wallmann T; Sanz LM; Van Hoef V; Joly A-L; Andersson J; Rolny C; Larsson O
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):314-315

Wallerius M; Bartish M; Wallmann T; Andresson J; Rolny C
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):315-316

Wallmann T; Wallerius M; Landwehr L; Agardy D; Bartish M; Squadrito M; De Palma M; Rolny C
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):334

Witt K; Ligtenberg MA; Conti L; Lanzardo S; Tufvesson-Stiller H; Ostling J; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(12):5411

Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L
Review: EXPERIMENTAL CELL RESEARCH. 2013;319(11):1635-1643

Eissler N; Rolny C
Book chapter: HANDBOOK OF CELL SIGNALING. 2010;p. 1927-1937

Dimberg A; Rolny C; van Meeteren LA; Claesson-Welsh L
Conference publication: DIABETOLOGIA. 2010;53:S60

Christoffersson G; Henriksnas J; Johansson L; Rolny C; Ahlstrom H; Caballero-Corbalan J; Segersvard R; Permert J; Korsgren O; Carlsson P-O; Phillipson M

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About me

Articles

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̽����ѡ

Charlotte Rolny

About me

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI

̽��ѡ