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Defining the metabolic signatures of tissue resident human ILCs – Chris Tibbitt team

The current focus of the Chris Tibbitt team is understanding tissue ILC specific metabolism in the context of allergy and cancer.

The Chris Tibbitt team is part of the Jenny Mjösberg research group at the Center for Infectious Medicine (CIM).

About our research

Induction of any immune response requires metabolic changes. While a number of genes and pathways have been evaluated in T cells, the factors that link activation to alterations in metabolic state remains to be profiled in depth for human ILCs. Using the latest techniques in metabolic profiling and single cell mutli-omics, we aim to map the metabolic profiles of human ILCs across a range of tissues and inflammatory conditions. Our aim is to assess whether biological therapies can impact upon cell intrinsic metabolism. We are also seeking to determine how host metabolic state (e.g. obesity) can alter the ILC phenotypes during asthma. 

Publications

Selected publications


  1. Julian M. Stark, Jielu Liu, Christopher A. Tibbitt, Murray Christian, Junjie Ma, Anna Wintersand, Ben Murrell, Mikael Adner, Hans Grönlund, Guro Gafvelin, Jonathan M Coquet. Allergy 2022 Jun;(): PMID: 35657107
     

  2. Efthymia Kokkinou, Ram Vinay Pandey, Luca Mazzurana, Irene Gutierrez-Perez, Christopher A Tibbitt, Whitney Weigel, Tea Soini, Anna Carrasco, Anna Rao, Maho Nagasawa, Susanne Bal, Mats Jangard, Danielle Friberg, Ulrick Lindfoss, Caroline Nordenvall, Malin Ljunggren, Staffan Haapaniemi, Ã…sa Keita, Johan Söderholm, Charlotte Hedin, Hergen Spits, Yenan Bryceson, Jenny Mjösberg. Sci Immunol 2022 04;7(70):eabj8301 PMID: 35427178
     

  3. Cajsa H Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A Tibbitt, Julian M Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M Coquet, Susanne Nylén. Mucosal Immunol 2022 02;15(2):257-267 PMID: 34931000
     

  4. Junjie Ma*, Christopher A Tibbitt*, Susanna K Georén, Murray Christian, Ben Murrell, Lars-Olaf Cardell, Claus Bachert, Jonathan M Coquet.
    Sci Immunol 2021 08;6(62): PMID:34389612 *denotes joint authorship.
     

  5. Rohrbeck, Leona, Monika Adori, Shan Wang, Chenfei He, Christopher A Tibbitt, Mark Chernyshev, Madle Sirel, Ulf Ribacke, Mohammad Bohooly-Y, Mikael Karlsson, Gunilla Karlsson Hedstam, Jonathan M Coquet. Immunol Cell Biol 2021 02;99(2):234-243 PMID: 32888232
     

  6. Batyrova, Banu, Fien Luwaert, Panagiota Maravelia, Yuria Miyabayashi, Neha Vashist, Julian M. Stark, Sara Y. Soori, Christopher A Tibbitt, Paulo Reise, Jonthan M Coquet, Benedict Chambers. Immun Inflamm Dis 2020 03;8(1):8-23 PMID:31742928
     

  7. Christopher A Tibbitt*, Julian M Stark*, Liesbet Martens, Junjie Ma, Jeffrey E Mold, Kim Deswarte, Ganna Oliynk, Xiaogang Feng, Bart N Lambrecht, Pieter De Bleser, Susanne Nylén, Hamida Hammad, Marie Aresenian Henriksson, Yvan Saeys, Jonathan M Coquet. Immunity 2019 07;51(1):169-184.e5 PMID:31231035 *Denotes joint authorship.
     

  8. Julian M Stark, Jonathan M Coquet, Christopher A Tibbitt. Curr Allergy Asthma Rep 2021 10;21(11):45 PMID: 34697644
     

  9. Julian M Stark^, Christopher A Tibbitt^, Jonathan M Coquet. Front Immunol 2019 ;10():2318 PMID: 31611881 ^Denotes joint authorship.
     

  10. Ting Chen*, Christopher A Tibbitt*, Xiaogang Feng, Julian M Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael CI Karlsson, Bart N Lambrecht, Gunilla B Karlsson Hedestam, Rudi W Hendriks, Benedict J Chambers, Susanne Nylén, Jonathan M Coquet. Sci Immunol 2017 Mar;2(9): PMID: 28783701