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Innate Immune Regulation – Quirin Hammer team

The team investigates molecular mechanisms that regulate innate immune cell responses.

Quirin Hammer team
Illustration of innate immune cells.
Illustration of the team's work on recognition of aberrant or virus-infected cells by innate immune cells. By: Quirin Hammer

The Quirin Hammer team is part of the Hans-Gustaf Ljunggren group at the Center for Infectious Medicine (CIM).

About our research

The team explores signals that regulate the activation of immune cells with a focus on cytotoxic effector cells of the innate immune system as well as innate-like cells of the adaptive immune systems. Innate and innate-like lymphocytes with cytolytic properties such as natural killer (NK) cells and unconventional T cells represent the first line of defense against virus infections and developing cancers. Innate cells respond to a broad range of viruses and tumor cells using partly overlapping and partly very distinct pathways.

Central aspects of our research are to delineate the molecular signals that allow innate and innate-like lymphocytes to recognize virus-infected cells and to study by which means these innate cells discriminate between healthy and tumor-transformed cells. For this, we employ a broad range of in silico, cellular, as well as molecular biology techniques and study samples from patients with ongoing disease. In parallel to understanding the signals that initiate and restrict innate immune cell activation, we aim at exploiting such recognition pathways for cell therapy against cancer.

Collaborations

  • Professor Chiara Romagnani, German Rheumatism Reserach Center, Berlin, Germany.
  • Assistant Professor Amir Horowitz, Icahn School of Medicine at Mount Sinai, New York City, United States of America.
  • Associate Professor Mattia Mori, University of Siena, Siena, Italy.
  • Assistant Professor Francesco Spallotta, Institute for Systems Analysis and Computer Science “A. Ruberti”, Rome, Italy.
  • Professor Martin Messerle, Hannover Medical School, Hannover, Germany.
  • Professor Karl-Johan Malmberg, ̽ѡ, Stockholm, Sweden.

Research support

  • Marie Skłodowska-Curie Actions (EU)
  • Hedlunds Stiftelse
  • Groschinsky Minnesfond
  • ̽ѡ Foundation for Virus Reserach
  • Region Stockholm
  • Stiftelsen Lars Hiertas Minne
  • Petrus och Augusta Hedlunds Stiftelse
  • Stiftelsen Tornspiran
  • KI Foundations (KI stiftelser och fonder)
  • Åke Wibergs Stiftelse
  • Jonas Söderquist Scholarship

Publications

2020-2022


Cuapio A, Boulouis C, Filipovic I, Wullimann D, Kammann T, Parrot T, Chen P, Akber M, Gao Y, Hammer Q, Strunz B, Pérez Potti A, Rivera Ballesteros O, Lange J, Muvva JR, Bergman P, Blennow O, Hansson L, Mielke S, Nowak P, Söderdahl G, Österborg A, Smith CIE, Bogdanovic G, Muschiol S, Hellgren F, Loré K, Sobkowiak MJ, Gabarrini G, Healy K, Sällberg Chen M, Alici E, Björkström NK, Buggert M, Ljungman P, Sandberg JK, Aleman S, Ljunggren HG
Mol Med 2022 02;28(1):20 


Hammer Q, Dunst J, Christ W, Picarazzi F, Wendorff M, Momayyezi P, Huhn O, Netskar HK, Maleki KT, García M, Sekine T, Sohlberg E, Azzimato V, Aouadi M, , , Degenhardt F, Franke A, Spallotta F, Mori M, Michaëlsson J, Björkström NK, Rückert T, Romagnani C, Horowitz A, Klingström J, Ljunggren HG, Malmberg KJ
Cell Rep 2022 03;38(10):110503


Palacios D, Momayyezi P, Huhn O, Ask EH, Dunst J, Malmberg KJ, Hammer Q
Eur J Immunol 2022 Apr;():


Vietzen H, Rückert T, Hartenberger S, Honsig C, Jaksch P, Geleff S, Hammer Q, Romagnani C, Segura-Wang M, Puchhammer-Stöckl E
mBio 2021 03;12(2):


Maucourant C, Filipovic I, Ponzetta A, Aleman S, Cornillet M, Hertwig L, Strunz B, Lentini A, Reinius B, Brownlie D, Cuapio A, Ask EH, Hull RM, Haroun-Izquierdo A, Schaffer M, Klingström J, Folkesson E, Buggert M, Sandberg JK, Eriksson LI, Rooyackers O, Ljunggren HG, Malmberg KJ, Michaëlsson J, Marquardt N, Hammer Q, Strålin K, Björkström NK,
Sci Immunol 2020 08;5(50):


Sekine T, Perez-Potti A, Nguyen S, Gorin JB, Wu VH, Gostick E, Llewellyn-Lacey S, Hammer Q, Falck-Jones S, Vangeti S, Yu M, Smed-Sörensen A, Gaballa A, Uhlin M, Sandberg JK, Brander C, Nowak P, Goepfert PA, Price DA, Betts MR, Buggert M
Sci Immunol 2020 07;5(49):


Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi MF, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers DR, Gagliani N, Huber S, Flavell RA, Polic B, Romagnani C
J Exp Med 2020 08;217(8):

2018-2019


Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ
Nat Commun 2019 01;10(1):514


Hammer Q, Rückert T, Romagnani C
Nat Immunol 2018 08;19(8):800-808


Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C
Nat Immunol 2018 05;19(5):453-463