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Translational Pharmacology – Kent Jardemark's team

Our research aims at understanding the mechanisms of action of novel biological pharmaceuticals on tumor cells.

Our research

We are focusing on extra- and intracellularly functional antibodies, and fragments to tailor the antibody-target interaction, as well as to widen the druggable proteome for antibody therapeutics.

We also aim at developing new drug delivery technologies to target tumors that for one reason or another are difficult to reach by drugs because of, for example, low exposure levels, metabolism, or adverse toxicity.

A third research interest concerns a novel proteomics methodology for characterization of membrane proteins aimed at epitope discovery for antibody therapeutics targeting ion channels, and GPCRs.

Publications

Selected publications

  • Article: SCIENCE ADVANCES. 2021;7(16):eabe6397
    Trkulja CL; Jungholm O; Davidson M; Jardemark K; Marcus MM; Hagglund J; Karlsson A; Karlsson R; Bruton J; Ivarsson N; Srinivasa SP; Cavallin A; Svensson P; Jeffries GDM; Christakopoulou M-N; Reymer A; Ashok A; Willman G; Papadia D; Johnsson E; Orwar O
  • Article: JOURNAL OF NEUROSCIENCE METHODS. 2015;241:132-136
    Ahemaiti A; Wigstrom H; Ainla A; Jeffries GDM; Orwar O; Jesorka A; Jardemark K
  • Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2014;136(42):14875-14882
    Trkulja CL; Jansson ET; Jardemark K; Orwar O
  • Article: JOURNAL OF NEUROSCIENCE METHODS. 2013;219(2):292-296
    Ahemaiti A; Ainla A; Jeffries GDM; Wigstrom H; Orwar O; Jesorka A; Jardemark K
  • Article: MOLECULAR PAIN. 2013;9:1
    Jansson ET; Trkulja CL; Ahemaiti A; Millingen M; Jeffries GDM; Jardemark K; Orwar O

Staff and contact

Team leader

All members of the group