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Key results

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  Marking U, Havervall S, Norin NG, Bladh O, Christ W, Gordon M, Ng H, Blom K, Phillipson M, Mangsbo S, Alm JJ, Smed-Sörensen A, Nilsson P, Hober S, Åberg M, Klingström J, Thålin C
  Nat Commun 2023 Mar;14(1):1577
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  Marking U, Bladh O, Aguilera K, Yang Y, Greilert Norin N, Blom K, Hober S, Klingström J, Havervall S, Åberg M, Sheward DJ, Thålin C
  Lancet Infect Dis 2024 Feb;24(2):e80-e81
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  Aguilera K, Bladh O, Marking U, Norin NG, Rihani A, Ujvari D, Ning FC, Klingström J, Havervall S, Åberg M, Blom K, Alm JJ, Thålin C
  Lancet Reg Health Eur 2024 Mar;38():100872
• Symptomatic infection with SARS-CoV-2 variant BA.2.86 induces a stronger mucosal IgA response to wild-type and BA.5 spike proteins as compared with serum IgG binding to these same proteins
  
  Bladh O, Greilert-Norin N, Havervall S, Marking U, Aguilera K, Alm JJ, Blom K, Åberg M, Klingström J, Thålin C
  N Engl J Med 2023 Oct;389(17):1626-1628
• A fourth mRNA vaccine dose against SARS-CoV-2 increases serum and nasal IgG levels but fails to enhance mucosal IgA responses, regardless of prior infection status. 
  
  Bladh O, Marking U, Havervall S, Norin NG, Aguilera K, Hober S, Smed-Sörensen A, Gordon M, Blom K, Åberg M, Klingström J, Thålin C
  Lancet Microbe 2023 Jul;4(7):e488
• Mucosal IgA antibodies are strongly correlated with protection against infection with SARS-CoV-2 BQ.1 and BQ.1.1 variants, while serum IgG levels show no significant association with protection in multivariate analysis.
  
  Marking U, Bladh O, Havervall S, Greilert-Norin N, Gordon M, Alm JJ, Blom K, Åberg M, Klingström J, Thålin C
  Lancet Infect Dis 2023 Aug;23(8):e272-e273
• Ongoing SARS-CoV-2 Omicron transmission was observed among highly vaccinated healthcare workers in Sweden in 2023, emphasizing the importance of continued surveillance for seasonal effects and emerging virus variants.
  
  Blom K, Bladh O, Havervall S, Marking U, Greilert Norin N, Alm JJ, Klingström J, Thålin C
  Lancet Reg Health Eur 2023 Oct;33():100725
• High levels of mucosal IgA antibodies in the airways provides protection from SARS-CoV-2 infection for a period of at least eight months. . Ulrika Marking, Oscar Bladh, Sebastian Havervall, Julia Svensson, Nina Greilert-Norin, Katherina Aguilera, Martha Kihlgren, Ann-Cristin Salomonsson, Maja Månsson, Radiosa Gallini, Cecilia Kriegholm, Philip Bacchus, Sophia Hober, Max Gordon, Kim Blom, Anna Smed-Sörensen, Mikael Åberg, Jonas Klingström, Charlotte Thålin. The Lancet Infectious Diseases, correspondence, online January 12 2023, doi: 
• High levels of mucosal IgA antibodies in the airways reduce the risk of being infected by omicron, but many did not receive detectable antibodies in the airways despite three doses of the SARS-CoV-2 vaccine. These findings shed light on the potential utility of novel nasal vaccines. ””, Sebastian Havervall, Ulrika Marking, Julia Svensson, Nina Greilert Norin, Philip Bacchus, Peter Nilsson, Sophia Hober, Max Gordon, Kim Blom, Jonas Klingström, Mikael Åberg, Anna Smed-Sörensen, Charlotte Thålin. The New England Journal of Medicine (NEJM), Letter to the Editor, online 14 september 2022, doi: 10.1056/NEJMc2209651
•  Healthcare workers are at increased risk of SARS-CoV-2 infection. Most people who became infected with SARS-CoV-2 experienced mild or no symptoms. Early on, we were able to establish the correlation between loss of smell, taste and COVID-19. SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.
  Rudberg AS, Havervall S, Månberg A, Jernbom Falk A, Aguilera K, Ng H, Gabrielsson L, Salomonsson AC, Hanke L, Murrell B, McInerney G, Olofsson J, Andersson E, Hellström C, Bayati S, Bergström S, Pin E, Sjöberg R, Tegel H, Hedhammar M, Phillipson M, Nilsson P, Hober S, Thålin C
  Nat Commun 2020 10;11(1):5064
• One in ten participants with mild COVID-19 report a diversity of long-term symptoms which disrupt work, social, and home life. Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.
  Havervall S, Rosell A, Phillipson M, Mangsbo SM, Nilsson P, Hober S, Thålin C
  JAMA 2021 05;325(19):2015-2016
• Broad and efficient SARS-CoV-2 immunity 8 months post mild infection. Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
  Havervall S, Ng H, Jernbom Falk A, Greilert-Norin N, Månberg A, Marking U, Laurén I, Gabrielsson L, Salomonsson AC, Aguilera K, Kihlgren M, Månsson M, Rosell A, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Lord M, Åberg M, Hedhammar M, Tegel H, Dönnes P, Phillipson M, Nilsson P, Klingström J, Mangsbo S, Hober S, Thålin C
  J Intern Med 2022 01;291(1):72-80
• T cells are an important part of our immune system, but T cell tests remain of limited value in individual diagnostics. An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
  Mangsbo SM, Havervall S, Laurén I, Lindsay R, Jernbom Falk A, Marking U, Lord M, Buggert M, Dönnes P, Christoffersson G, Nilsson P, Hober S, Phillipson M, Klingström J, Thålin C
  PLoS One 2021 ;16(9):e0258041
• A single dose adenovirus-vectored ChAdOx1 nCoV-19 elicits strong humoral immune responses in SARS-CoV-2 recovered study participants. Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.
  Havervall S, Marking U, Greilert-Norin N, Ng H, Gordon M, Salomonsson AC, Hellström C, Pin E, Blom K, Mangsbo S, Phillipson M, Klingström J, Hober S, Nilsson P, Åberg M, Thålin C
  EBioMedicine 2021 Aug;70():103523
• Considerable decline in neutralizing antibodies after both BNT162b2 and ChAdOx1 nCoV-19 vaccination over 3-7 months. Neutralizing antibody titers against all ten tested SARS-CoV-2 variants were at least 2 respectively 3-fold higher in SARS-CoV-2 recovered as compared to naive vaccinees following BNT162b2 and ChAdOx1 nCoV-19, respectively. Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.
  Havervall S, Marking U, Greilert-Norin N, Gordon M, Ng H, Christ W, Phillipson M, Nilsson P, Hober S, Blom K, Klingström J, Mangsbo S, Åberg M, Thålin C
  Clin Transl Immunology 2022 ;11(4):e1388
• High rate of omicron breakthrough infections among triple vaccinated healthcare workers. High viral replication despite three vaccine doses and mild symptoms. MedRxiv (DOI: 10.1101/2022.04.02.22273333) and Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022.
  Blom K, Havervall S, Marking U, Norin NG, Bacchus P, Groenheit R, Bråve A, Thålin C, Klingström J
  Emerg Infect Dis 2022 Aug;28(10):
• Serological responses to Omicron breakthrough infection in triple vaccinated healthcare workers are hampered by prior infection. Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.
  Blom K, Marking U, Havervall S, Norin NG, Gordon M, García M, Tecleab T, Christ W, Forsell M, Phillipson M, Nilsson P, Mangsbo S, Hober S, Åberg M, Klingström J, Thålin C
  Lancet Infect Dis 2022 07;22(7):943-945

The COMMUNITY project is financed by , Region Stockholm, Folkhälsomyndigheten, Lundblad Family Foundation, Hjärtlung fonden, and

The COMMUNITY study team

Ann-Christine Salomonsson, Bio̽����ѡ Laboratory Scientist

Katherina Aguilera, Bio̽����ѡ Laboratory Scientist

Martha Kihlgren, Bio̽����ѡ Laboratory Scientist

Lena Gabrielsson, Research Nurse

Maja Månsson, Research Nurse

KTH:

Uppsala Universitet:

Karolinska institutet / Public health agency of Sweden: