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Thomas Perlmann

Thomas Perlmann

Professor
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Perlmann, 171 77 Stockholm
Part of:

About me

  • Professor in Molecular Developmental Biology

    My research group is localized at the department of Cell and Molecular Biology and at the Stockholm Branch of the Ludwig Institute for Cancer Research, where I am also the director.

    Education
    - Ph.D., ̽»¨¾«Ñ¡, 1991
    - M.Sc., Stockholm University, Chemistry and Biology, 1987

    Academic honours, awards and prizes
    - 2011 Nicholson Lecturer award at Rockefeller Rockefeller University
    - 2008 Member of the Royal Academy of Sciences, Sweden
    - 2006 Member of the Nobel Assembly, ̽»¨¾«Ñ¡

    1999 Göran Gustafsson Prize in Molecular Biology

    1997 Eric K. Fernström, Young Investigator Prize

Research

  • The vast complexity of the central nervous system raises challenging questions concerning the specification and differentiation of specific types of neurons. Dopamine neurons are clinically important cells that degenerate in patients with Parkinson’s disease and are also implicated in other neurological and psychiatric conditions.

    My group is interested in unraveling the signaling and transcriptional regulation that govern the specification, differentiation and maintenance of these cells. The studies have resulted in the identification of several transcription factors with key roles in these processes. The projects are focused on understanding functions in both early specification events and in maintenance of dopamine neurons in the adult brain. Moreover, we are also interested in regenerative medicine in relation to Parkinson’s disease and other brain disorders.

Selected publications

  • Article: NATURE NEUROSCIENCE. 2015;18(6):826-835
    Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
  • Article: CELL REPORTS. 2014;8(4):1018-1025
    Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2360-2365
    Kadkhodaei B; Alvarsson A; Schintu N; Ramskold D; Volakakis N; Joodmardi E; Yoshitake T; Kehr J; Decressac M; Bjorklund A; Sandberg R; Svenningsson P; Perlmann T
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(163):163ra156
    Decressac M; Kadkhodaei B; Mattsson B; Laguna A; Perlmann T; Bjorklund A
  • Review: NATURE REVIEWS GENETICS. 2012;13(6):429-439
    Holmberg J; Perlmann T
  • Article: GENES & DEVELOPMENT. 2011;25(19):2031-2040
    Malewicz M; Kadkhodaei B; Kee N; Volakakis N; Hellman U; Viktorsson K; Leung CY; Chen B; Lewensohn R; van Gent DC; Chen DJ; Perlmann T
  • Article: CELL STEM CELL. 2011;8(6):663-675
    Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T

Articles

  • Article: EMBO JOURNAL. 2022;41(17):e108780
    Kastriti ME; Faure L; Von Ahsen D; Bouderlique TG; Bostroem J; Solovieva T; Jackson C; Bronner M; Meijer D; Hadjab S; Lallemend F; Erickson A; Kaucka M; Dyachuk V; Perlmann T; Lahti L; Krivanek J; Brunet J-F; Fried K; Adameyko I
  • Article: SCIENCE ADVANCES. 2022;8(34):eabo1543
    Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Sodersten E; Svenningsson P; Chergui K; Ringner M; Perlmann T; Holmberg J
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(13):6961
    Pulcrano S; De Gregorio R; De Sanctis C; Lahti L; Perrone-Capano C; Ponti D; di Porzio U; Perlmann T; Caiazzo M; Volpicelli F; Bellenchi GC
  • Article: DEVELOPMENT. 2022;149(5):dev200076
    Salmani BY; Balderson B; Bauer S; Ekman H; Starkenberg A; Perlmann T; Piper M; Boden M; Thor S
  • Article: PLOS GENETICS. 2021;17(9):e1009822
    Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
  • Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021;14:763777
    Tiklova K; Gillberg L; Volakakis N; Lunden-Miguel H; Dahl L; Serrano GE; Adler CH; Beach TG; Perlmann T
  • Article: NATURE COMMUNICATIONS. 2020;11(1):2898
    Hagey DW; Topcic D; Kee N; Reynaud F; Bergsland M; Perlmann T; Muhr J
  • Article: NATURE COMMUNICATIONS. 2020;11(1):2434
    Tiklova K; Nolbrant S; Fiorenzano A; Bjorklund AK; Sharma Y; Heuer A; Gillberg L; Hoban DB; Cardoso T; Adler AF; Birtele M; Lunden-Miguel H; Volakakis N; Kirkeby A; Perlmann T; Parmar M
  • Article: NATURE COMMUNICATIONS. 2019;10(1):581
    Tiklova K; Bjorklund AK; Lahti L; Fiorenzano A; Nolbrant S; Gillberg L; Volakakis N; Yokota C; Hilscher MM; Hauling T; Holmstrom F; Joodmardi E; Nilsson M; Parmar M; Perlmann T
  • Article: NATURE COMMUNICATIONS. 2018;9(1):1226
    Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringner M; Perlmann T; Holmberg J
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(10):2735-2740
    Green H; Zhang X; Tiklova K; Volakakis N; Brodin L; Berg L; Greengard P; Perlmann T; Svenningsson P
  • Article: CELL STEM CELL. 2017;20(1):29-40
    Kee N; Volakakis N; Kirkeby A; Dahl L; Storvall H; Nolbrant S; Lahti L; Bjorklund AK; Gillberg L; Joodmardi E; Sandberg R; Parmar M; Perlmann T
  • Article: CELL STEM CELL. 2017;20(1):135-148
    Kirkeby A; Nolbrant S; Tiklova K; Heuer A; Kee N; Cardoso T; Ottosson DR; Lelos MJ; Rifes P; Dunnett SB; Grealish S; Perlmann T; Parmar M
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396
    Doucet-Beaupre H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguere N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Levesque M
  • Article: DEVELOPMENT. 2016;143(14):2616-2628
    Gross S; Garofalo DC; Balderes DA; Mastracci TL; Dias JM; Perlmann T; Ericson J; Sussel L
  • Article: SCIENTIFIC REPORTS. 2016;6:26448
    Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
  • Article: JOURNAL OF NEUROSCIENCE. 2015;35(42):14370-14385
    Volakakis N; Tiklova K; Decressac M; Papathanou M; Mattsson B; Gillberg L; Nobre A; Bjorklund A; Perlmann T
  • Article: JOURNAL OF NEUROSCIENCE. 2015;35(41):14057-14069
    Alvarsson A; Zhang X; Stan TL; Schintu N; Kadkhodaei B; Millan MJ; Perlmann T; Svenningsson P
  • Article: STEM CELLS. 2014;32(3):609-622
    Mong J; Panman L; Alekseenko Z; Kee N; Stanton LW; Ericson J; Perlmann T
  • Article: STEM CELLS AND DEVELOPMENT. 2014;23(1):5-15
    Marklund U; Alekseenko Z; Andersson E; Falci S; Westgren M; Perlmann T; Graham A; Sundstrom E; Ericson J
  • Show more

All other publications

  • Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):3630
    Tiklová K; Nolbrant S; Fiorenzano A; Björklund ÅK; Sharma Y; Heuer A; Gillberg L; Hoban DB; Cardoso T; Adler AF; Birtele M; Lundén-Miguel H; Volakakis N; Kirkeby A; Perlmann T; Parmar M
  • Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):4639
    Sodersten E; Toskas K; Rraklli V; Tiklova K; Bjorklund AK; Ringer M; Perlmanni T; Holmberg J
  • Editorial comment: DEVELOPMENT. 2016;143(16):2877-2881
    Kirkeby A; Perlmann T; Pereira C-F
  • Review: EXPERIMENTAL CELL RESEARCH. 2014;329(1):94-100
    Malewicz M; Perlmann T
  • Review: NATURE REVIEWS NEUROLOGY. 2013;9(11):629-636
    Decressac M; Volakakis N; Bjorklund A; Perlmann T
  • Editorial comment: BMC BIOLOGY. 2011;9:51
    Panman L; Perlmann T
  • Review: JOURNAL OF INTERNAL MEDICINE. 2009;266(4):358-371
    Hedlund E; Perlmann T
  • Meeting abstract: DEVELOPMENTAL BIOLOGY. 2007;306(1):430
    Applequist JM; Karlen M; Jordi E; Perlmann T; Ericson J
  • Review: PHARMACOLOGICAL REVIEWS. 2006;58(4):798-836
    Benoit G; Cooney A; Giguere V; Ingraham H; Lazar M; Muscat G; Perlmann T; Renaud J-P; Schwabe J; Sladek F; Tsai M-J; Laudet V
  • Published conference paper: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2005;16(10):1631-1640
    Lengqvist J; Alvélius G; Jörnvall H; Sjövall J; Perlmann T; Griffiths WJ
  • Review: CELL AND TISSUE RESEARCH. 2004;318(1):45-52
    Perlmann T; Wallén-Mackenzie A
  • Review: TRENDS IN CELL BIOLOGY. 2004;14(7):369-376
    Benoit G; Malewicz M; Perlmann T
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;991:48-60
    Wallén Å; Perlmann T
  • Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2003;364:463-475
    Mata de Urquiza A; Perlmann T
  • Letter: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2002;16(20):2003-2006
    Lengqvist J; Griffiths WJ; Perlmann T; Sjövall J
  • Editorial comment: NATURE GENETICS. 2002;31(1):7-8
    Perlmann T
  • Letter: CELL. 1999;97(2):161-163
    Auwerx J; Baulieu E; Beato M; Becker-Andre M; Burbach PH; Camerino G; Chambon P; Cooney A; Dejean A; Dreyer C; Evans RM; Gannon F; Giguere V; Gronemeyer H; Gustafson JA; Laudet V; Lazar MA; Mangelsdorf DJ; Milbrandt J; Milgrom E; Moore DD; O'Malley B; Parker M; Parker K; Perlmann T; Pfahl M; Rosenfeld MG; Samuels H; Schütz G; Sladek FM; Stunnenberg HG; Spedding M; Thummel C; Tsai MJ; Umesono K; Vennstrom B; Wahli W; Weinberger C; Willson TM; Yamamoto K
  • Published conference paper: BRAIN RESEARCH REVIEWS. 1998;26(2-3):302-305
    Olson L; Cheng H; Zetterström RH; Solomin L; Jansson L; Giménez-Llort L; Hoffer BJ; Perlmann T
  • Review: CELL. 1997;90(3):391-397
    Perlmann T; Evans RM
  • Editorial comment: NATURE. 1995;377(6548):387-388
    PERLMANN T; VENNSTROM B

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