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Immundesign – Team Leo Hanke

Vi är intresserade av patogener och de immunsvar de framkallar, med ett särskilt fokus på nya och återkommande virus. Vi utvecklar molekylära verktyg som gör det möjligt att utforska grundläggande aspekter av infektion och immunitet. Vårt mål är att använda dessa insikter för att vägleda utformningen av vacciner och riktade terapier.

VÃ¥r forskning

VÃ¥rt labb kombinerar olika metoder inom virologi, beräkningsmetoder, strukturbiologi och biokemi för att studera patogener och de immunsvar de framkallar. Vi använder smÃ¥ molekylära hämmare, sÃ¥som nano-antikroppar och AI-designade proteiner, för att fokusera pÃ¥ specifika patogener och fÃ¥ nya mekanistiska insikter som annars är svÃ¥ra att fÃ¥ fram i stor skala. 

Genom riktad protein engineering tillsammans med utvalda kemiska och enzymatiska strategier, modifierar vi våra proteiner för biomedicinska tillämpningar som kan förbättra detektion, möjliggöra spårning eller underlätta immunsvar. Vårt arbete syftar till att fördjupa den grundläggande förståelsen av infektioner och i slutändan vägleda designen av effektiva vaccinantigen och riktade terapier.

Publikationer

Alla gruppmedlemmars publikationer

  • Preprint: BIORXIV. 2024
    Pascha M; Ballegeer M; van Haperen R; Kooij A; van Miltenburg D; Smits A; Schipper J; Cui H; Albulescu I; Bosch BJ; Grosveld F; van Kuppeveld FJM; Saelens X; Drabek D; de Haan CAM
  • Article: NATURE COMMUNICATIONS. 2024;15(1):6338
    Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Castro Dopico X; Fischbach J; Kim S; Guryleva MV; Adori M; Chernyshev M; Stalmarck A; Hanke L; Mcinerney GM; Sheward DJ; Corcoran M; Haellberg BM; Murrell B; Karlsson Hedestam GB
  • Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(14):7672
    Strandberg H; Hagstromer CJ; Werin B; Wendler M; Johanson U; Tornroth-Horsefield S
  • Article: CELL REPORTS MEDICINE. 2024;5(6):101577
    Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
  • Journal article: NPJ VACCINES. 2024;9(1):97
    Pascha MN; Ballegeer M; Roelofs MC; Meuris L; Albulescu IC; van Kuppeveld FJM; Hurdiss DL; Bosch BJ; Zeev-Ben-Mordehai T; Saelens X; de Haan CAM
  • Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590
    Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E
  • Preprint: RESEARCH SQUARE. 2024
    Pascha M; Ballegeer M; Roelofs M; Meuris L; Albulescu I; Kuppeveld FV; Hurdiss D; Bosch B-J; Zeev-Ben-Mordehai T; Saelens X; de Haan C
  • Journal article: BIOCHEMICAL JOURNAL. 2024;481(1):17-32
    Kreida S; Roche JV; Missel JW; Al-Jubair T; Hagstromer CJ; Wittenbecher V; Linse S; Gourdon P; Tornroth-Horsefield S
  • Journal article: CHEMICAL SCIENCE. 2023;14(38):10561-10569
    Liu M; Morewood R; Yoshisada R; Pascha MN; Hopstaken AJP; Tarcoveanu E; Poole DAIII; de Haan CAM; Nitsche C; Jongkees SAK
  • Article: JCI INSIGHT. 2023;8(17):e167656
    Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
  • Journal article: SCIENTIFIC REPORTS. 2023;13(1):14674
    Hagstroemer CJ; Hyld Steffen J; Kreida S; Al-Jubair T; Frick A; Gourdon P; Toernroth-Horsefield S
  • Article: NANO LETTERS. 2023;23(9):3701-3707
    Schlegel J; Porebski B; Andronico L; Hanke L; Edwards S; Brismar H; Murrell B; McInerney GM; Fernandez-Capetillo O; Sezgin E
  • Article: OPEN BIOLOGY. 2023;13(5):220369
    Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-A; Anderson P; Achour A; McInerney GM
  • Article: EUROSURVEILLANCE. 2023;28(13):2200432
    Bystrom JW; Vikstrom L; Rosendal E; Groning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Hedestam GBK; Thunberg T; Monsen T; Elgh F; Evander M; Johansson AF; Overby AK; Ahim C; Normark J; Forsell MNE
  • Journal article: CHEMISTRY-A EUROPEAN JOURNAL. 2023;29(14):e202203923
    Liu M; Yoshisada R; Amedi A; Hopstaken AJP; Pascha MN; de Haan CAM; Geerke DP; Poole DAIII; Jongkees SAK
  • Article: IMMUNITY. 2023;56(1):193-206.e7
    Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
  • Article: FRONTIERS IN IMMUNOLOGY. 2023;14:941281
    Christensen D; Polacek C; Sheward DJ; Hanke L; McInerney G; Murrell B; Hartmann KT; Jensen HE; Zimmermann J; Jungersen G; Illigen KE; Isling LK; Fernandez-Antunez C; Ramirez S; Bukh J; Pedersen GK
  • Article: EBIOMEDICINE. 2022;84:104248
    Christensen D; Polacek C; Sheward DJ; Hanke L; Moliner-Morro A; McInerney G; Murrell B; Hartmann KT; Jensen HE; Jungersen G; Illigen K; Isling LK; Jensen RF; Hansen JS; Rosenkrands I; Fernandez-Antunez C; Ramirez S; Follmann F; Bukh J; Pedersen GK
  • Journal article: ACS CHEMICAL BIOLOGY. 2022;17(9):2425-2436
    Pascha MN; Thijssen V; Egido JE; Linthorst MW; van Lanen JH; van Dongen DAA; Hopstaken AJP; van Kuppeveld FJM; Snijder J; de Haan CAM; Jongkees SAK
  • Review: JOURNAL OF GENERAL VIROLOGY. 2022;103(5)
    Moliner-Morro A; McInerney GM; Hanke L
  • Preprint: MEDRXIV. 2022;MEDRXIV
    Byström JW; Vikström L; Rosendal E; Gröning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Karlsson Hedestam GB; Thunberg T; Monsen T; Elgh F; Evander M; Johansson A; Överby AK; Ahlm C; Normark J; Forsell MN
  • Article: SCIENCE ADVANCES. 2022;8(12):eabm0220
    Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekstrom S; Coquet JM; McInerney GM; Murrell B
  • Article: NATURE COMMUNICATIONS. 2022;13(1):155
    Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
  • Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232
    Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
  • Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379
    Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
  • Article: CELL REPORTS MEDICINE. 2021;2(11):100450
    Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
  • Journal article: VIRUSES-BASEL. 2021;13(10):2097
    Fibriani A; Stephanie R; Alfiantie AA; Siregar ALF; Pradani GAP; Yamahoki N; Purba WS; Alamanda CNC; Rahmawati E; Rachman RW; Robiani R; Ristandi RB
  • Journal article: JOURNAL OF NEUROSCIENCE. 2021;41(39):8249-8261
    Raoof R; Gil CM; Lafeber FPJG; de Visser H; Prado J; Versteeg S; Pascha MN; Heinemans ALP; Adolfs Y; Pasterkamp J; Wood JN; Mastbergen SC; Eijkelkamp N
  • Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676
    Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
  • Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(17):9213
    Chivasso C; Hagstromer CJ; Rose KL; Lhotellerie F; Leblanc L; Wang Z; Moscato S; Chevalier C; Zindy E; Martin M; Vanhollebeke B; Gregoire F; Bolaky N; Perret J; Baldini C; Soyfoo MS; Mattii L; Schey KL; Tornroth-Horsefield S; Delporte C
  • Article: NATURE COMMUNICATIONS. 2021;12(1):3695
    Roxhed N; Bendes A; Dale M; Mattsson C; Hanke L; Dodig-Crnkovic T; Christian M; Meineke B; Elsasser S; Andrell J; Havervall S; Thalin C; Eklund C; Dillner J; Beck O; Thomas CE; McInerney G; Hong M-G; Murrell B; Fredolini C; Schwenk JM
  • Article: CELL REPORTS MEDICINE. 2021;2(4):100252
    Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
  • Article: SCIENCE. 2021;371(6530):eabe6230
    Koenig P-A; Das H; Liu H; Kuemmerer BM; Gohr FN; Jenster L-M; Schiffelers LDJ; Tesfamariam YM; Uchima M; Wuerth JD; Gatterdam K; Ruetalo N; Christensen MH; Fandrey CI; Normann S; Toedtmann JMP; Pritzl S; Hanke L; Boos J; Yuan M; Zhu X; Schmid-Burgk JL; Kato H; Schindler M; Wilson IA; Geyer M; Ludwig KU; Hallberg BM; Wu NC; Schmidt FI
  • Article: SCIENTIFIC REPORTS. 2021;11(1):3125
    Szurgot I; Hanke L; Sheward DJ; Vidakovics LP; Murrell B; McInerney GM; Liljestrom P
  • Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312
    Hober S; Hellstrom C; Olofsson J; Andersson E; Bergstrom S; Jernbom Falk A; Bayati S; Mravinacova S; Sjoberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingstrom J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Muhr LS; Eklund C; Lagheden C; Dillner J; Sivertsson A; Havervall S; Thalin C; Tegel H; Pin E; Manberg A; Hedhammar M; Nilsson P
  • Journal article: FRONTIERS IN IMMUNOLOGY. 2021;12:786617
    Creytens S; Pascha MN; Ballegeer M; Saelens X; de Haan CAM
  • Article: EBIOMEDICINE. 2021;63:103197
    Worzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GBK; Murrell B; Christensen D; Pedersen GK
  • Article: BIOMOLECULES. 2020;10(12):E1661-1661
    Moliner-Morro A; J. Sheward D; Karl V; Perez Vidakovics L; Murrell B; McInerney GM; Hanke L
  • Article: NATURE COMMUNICATIONS. 2020;11(1):5588
    Custodio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Haellberg BM; Loew C
  • Article: NATURE COMMUNICATIONS. 2020;11(1):5064
    Rudberg A-S; Havervall S; Manberg A; Jernbom Falk A; Aguilera K; Ng H; Gabrielsson L; Salomonsson A-C; Hanke L; Murrell B; McInerney G; Olofsson J; Andersson E; Hellstrom C; Bayati S; Bergstrom S; Pin E; Sjoberg R; Tegel H; Hedhammar M; Phillipson M; Nilsson P; Hober S; Thalin C
  • Article: NATURE COMMUNICATIONS. 2020;11(1):4420
    Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
  • Article: EMBO REPORTS. 2017;18(6):1027-1037
    Hanke L; Schmidt FI; Knockenhauer KE; Morin B; Whelan SPJ; Schwartz TU; Ploegh HL
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(2):E152-E160
    Truttmann MC; Zheng X; Hanke L; Damon JR; Grootveld M; Krakowiak J; Pincus D; Ploegh HL
  • Article: JOURNAL OF IMMUNOLOGY. 2016;197(12):4838-4847
    Duarte JN; Cragnolini JJ; Swee LK; Bilate AM; Bader J; Ingram JR; Rashidfarrokhi A; Fang T; Schiepers A; Hanke L; Ploegh HL
  • Article: MBIO. 2016;7(6):e01569-e01516
    Hanke L; Knockenhauer KE; Brewer RC; van Diest E; Schmidt FI; Schwartz TU; Ploegh HL
  • Article: NATURE MICROBIOLOGY. 2016;1(8):16080
    Schmidt FI; Hanke L; Morin B; Brewer R; Brusic V; Whelan SPJ; Ploegh HL
  • Article: JOURNAL OF VIROLOGY. 2015;89(5):2792-2800
    Ashour J; Schmidt FI; Hanke L; Cragnolini J; Cavallari M; Altenburg A; Brewer R; Ingram J; Shoemaker C; Ploegh HL
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  • An, Yaxin
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Nyckelord:
Immunologi inom det medicinska området Infektionsmedicin Virologi
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2025-04-02