Mechanism of B and T cell death during HIV infection- Francesca Chiodi Group
The work of our group aims at understanding the mechanisms of cell damage during HIV infection.
Several cell types are damaged during the infection, through the direct effect of the virus and through indirect mechanisms of damage. In fact B lymphocytes which are not the direct targets for the infection, are severely impaired in number and function during HIV infection. The mechanisms underlying such dysfunctions are poorly understood but other mechanisms in addition to direct virus replication account for deletion of immune cells including T and B cells.
We and other groups have shown that T and B cells from infected subjects are primed for apoptosis. The expression of Fas and FasL (pivotal molecules in the regulation of apoptosis) is increased, indicating that this receptor-ligand pair may play a crucial role for loss of immune cells. One crucial question is the characterization of the molecular pathway leading to up-regulation of Fas and FasL during HIV infection. The expression of these molecules is increased on B and T cells in blood from the early stages of infection, already at the time of primary infection.
We found that memory B cells are lost in infected patients, likely due to terminal differentiation of memory B cells to plasma cells. The effector function of B cells is also impaired during HIV infection in that we found a decline of antibodies to previously met antigens either during childhood or through vaccination. Also, a limited amount of neutralizing antibodies, aimed at controlling virus infection, is produced in HIV infected subjects who progress to AIDS.
We believe that the understanding of the mechanisms leading to cell damage during AIDS may be important to design future anti-HIV therapies and vaccines. Studies which we conduct on additional groups of immunocompromised patients may help to through light on the mechanism of T and B cell depletion during HIV infection.
Project Groups within the Francesca Chiodi
Group members
Francesca Chiodi
Professor, SeniorBritta Wahren
Professor Emeritus/EmeritaContact
Mailing address
Department of Microbiology, Tumor and Cell Biology
̽»¨¾«Ñ¡
SE–171 77 Stockholm
Visiting address
Department of Microbiology, Tumor and Cell Biology
Biomedicum
Solnavägen 9, floor 9, Quarter 9C
Alumni
Alumni
Former PhD students *=main supervisor
Eva Björling* (1993)
Astrid Samuelsson, MD* (1997)
Maria Di Stefano* (1997)
Farideh Sabri* (2000)
Angelo De Milito* (2002)
Anna Nilsson, MD (2004)
Ann Atlas, MD* (2006)
Liv Eidsmo, MD (2006)
Kehmia Titanji (2006)
Caroline Fluur* (2007)
Frida Mowafi (2007)
Thi Thanh Ha, MD* (2008)
Alberto Cagigi (2009)
Nancy Vivar, MD (2009)
Linh Dang* (2011)
Hong Thang, MD* (2011)
Stefano Sammicheli (2011)
Nicolas Ruffin* (2012)
Miriam Kiene (2013)
Hanna Ingelman-Sundberg, MD (2015)
Rebecka Lantto* (2016)
Aikaterini Nasi (2016)
Yonas Bekele* (2018
Shanbhu Ganeshappa Araloguppe (2019)
Caroline Rönnberg, MD (2019)
Previous group members
Irina Elovaara, MD, PhD
Roberta Marenzi, MD
Bence Rethi, PhD
Simone Pensieroso, PhD
M Krzyzowska, PhD
Sylvie Amu, PhD
Collaborations
Sven Grützmeier, Ander Karlsson and Bo Heideman
The Gay Men's Health Clinic, South Hospital, Stockholm and Ann Atlas. Department of Medicine at Solna, Infectious Disease Unit. Clinical collaborator on several studies These doctors scientists are colloborating with us on issues of immunological relevance for AIDS.
Julie Fox, King’s College London
Carolina Herrera, Imperial College London
Emily Webb, London School of Hygiene and Tropical Medicine, UK
Clive Gray, Stellenbosch University, South Africa
Heather Jaspan, Seattle Children's Research Institute, Seattle and University of Cape Town
Publications
Lemma M, Bekele Y, Petkov S, Hägglund M, Petros B, Aseffa A, et al
Pathogens 2020 Feb;9(3):
Nilsson A, Chiodi F
J. Infect. Dis. 2019 Dec;():
Gray CM, O'Hagan KL, Lorenzo-Redondo R, Olivier AJ, Amu S, Chigorimbo-Murefu N, et al
Mucosal Immunol 2020 01;13(1):118-127
Dabee S, Barnabas S, Lennard K, Jaumdally S, Gamieldien H, Balle C, et al
PLoS ONE 2019 ;14(4):e0213975
Bekele Y, Lemma M, Bobosha K, Yibeltal D, Nasi A, Gebre M, et al
Vaccine 2019 Apr;37(17):2348-2355
Bekele Y, Lakshmikanth T, Chen Y, Mikes J, Nasi A, Petkov S, et al
JCI Insight 2019 Feb;4(3):
Petkov S, Starodubova E, Latanova A, Kilpeläinen A, Latyshev O, Svirskis S, et al
PLoS ONE 2018 ;13(6):e0197902
Latanova A, Petkov S, Kilpelainen A, Jansons J, Latyshev O, Kuzmenko Y, et al
Sci Rep 2018 May;8(1):8078
Barnabas S, Dabee S, Passmore J, Jaspan H, Lewis D, Jaumdally S, et al
Int J STD AIDS 2018 05;29(6):531-539
Bekele Y, Graham R, Soeria-Atmadja S, Nasi A, Zazzi M, Vicenti I, et al
Front Immunol 2017 ;8():1966
Nasi A, Chiodi F
J. Intern. Med. 2018 Mar;283(3):257-267
Bekele Y, Yibeltal D, Bobosha K, Andargie T, Lemma M, Gebre M, et al
Sci Rep 2017 08;7(1):8956
Chiodi F, Bekele Y, Lantto Graham R, Nasi A
Front Immunol 2017 ;8():451
Nasi A, Amu S, Göthlin M, Jansson M, Nagy N, Chiodi F, et al
Front Immunol 2017 ;8():244
Sabri F, Prados A, Muñoz-Fernández R, Lantto R, Fernandez-Rubio P, Nasi A, et al
Retrovirology 2016 09;13(1):61
Chiodi F
AIDS 2016 07;30(12):1991-3
Amu S, Lantto Graham R, Bekele Y, Nasi A, Bengtsson C, Rethi B, et al
Medicine (Baltimore) 2016 Jun;95(23):e3738
Lantto R, Nasi A, Sammicheli S, Amu S, Fievez V, Moutschen M, et al
AIDS 2015 Sep;29(14):1757-66
Bekele Y, Amu S, Bobosha K, Lantto R, Nilsson A, Endale B, et al
Medicine (Baltimore) 2015 Jul;94(27):e1125
Amu S, Lavy-Shahaf G, Cagigi A, Hejdeman B, Nozza S, Lopalco L, et al
Retrovirology 2014 Sep;11():76
Jahnmatz M, Amu S, Ljungman M, Wehlin L, Chiodi F, Mielcarek N, et al
Vaccine 2014 Jun;32(27):3350-6
Chiodi F, Kaufmann S
J. Intern. Med. 2014 May;275(5):442-3
Chiodi F, Weiss R
J. Intern. Med. 2014 May;275(5):444-55
Kiene M, Rethi B, Jansson M, Dillon S, Lee E, Lantto R, et al
PLoS ONE 2014 ;9(2):e88195
Amu S, Ruffin N, Rethi B, Chiodi F
AIDS 2013 Sep;27(15):2323-34
Cagigi A, Pensieroso S, Ruffin N, Sammicheli S, Thorstensson R, Pan-Hammarström Q, et al
Vaccine 2013 Apr;31(18):2231-7
Pensieroso S, Galli L, Nozza S, Ruffin N, Castagna A, Tambussi G, et al
AIDS 2013 May;27(8):1209-17
Rethi B, Sammicheli S, Amu S, Pensieroso S, Hejdeman B, Schepis D, et al
AIDS 2013 Jan;27(2):155-62
Kiene M, Marzi A, Urbanczyk A, Bertram S, Fisch T, Nehlmeier I, et al
Virology 2012 Nov;433(1):73-84
Spetz A, Chiodi F
J. Infect. Dis. 2013 Apr;207(8):1189-92
Ruffin N, Lantto R, Pensieroso S, Sammicheli S, Hejdeman B, Rethi B, et al
J. Intern. Med. 2012 Nov;272(5):492-503
Dang L, Nilsson A, Ingelman-Sundberg H, Cagigi A, Gelinck L, Titanji K, et al
J. Intern. Med. 2012 Mar;271(3):282-93
Sammicheli S, Ruffin N, Lantto R, Vivar N, Chiodi F, Rethi B
J. Autoimmun. 2012 Jun;38(4):304-14
Caridha R, Ha T, Gaseitsiwe S, Hung P, Anh N, Bao N, et al
AIDS Res. Hum. Retroviruses 2012 Aug;28(8):852-6
Albert J, Chiodi F
J. Intern. Med. 2011 Dec;270(6):502-8
Vivar N, Ruffin N, Sammicheli S, Hejdeman B, Rethi B, Chiodi F
J. Infect. Dis. 2011 Jun;203(11):1658-67
Ruffin N, Ahmed S, Osorio L, Wang X, Jackson G, Collin M, et al
Transplantation 2011 May;91(9):946-51
Krzyzowska M, Shestakov A, Eriksson K, Chiodi F
Cell Death Dis 2011 Mar;2():e132
Ruffin N, Ahmed S, Osorio L, Wang X, Jackson G, Collin M, et al
Transplantation 2011 May;91(9):946-51
Nilsson A, Chiodi F
PLoS Pathog. 2011 Feb;7(2):e1001241
Chiodi F
J. Clin. Invest. 2010 Nov;120(11):3810-3
Thang P, Ruffin N, Brodin D, Rethi B, Cam P, Hien N, et al
J. Intern. Med. 2010 Aug;268(2):181-93
Cagigi A, Nilsson A, Pensieroso S, Chiodi F
Lancet Infect Dis 2010 Jul;10(7):499-503
Cagigi A, Palma P, Nilsson A, Di Cesare S, Pensieroso S, Kakoulidou M, et al
AIDS 2010 Aug;24(13):2075-80
Gougeon M, Chiodi F
J. Intern. Med. 2010 May;267(5):502-14