Britta Wahren Project
We have designed small DNA constructs to be used for immunotherapy and propylaxis in human immunodeficiency virus disease and in colorectal carcinoma.
Research project
The resulting vaccines have been used in human trials in four different countries in Europe and Africa. They appear to be very effective in priming for immune responses against a variety of HIV strains because they stimulate both innate, humoral and cell-mediated immunities. Genetic vaccines have several advantages: they make the person produce the vaccine protein in his own cells, and the vaccine thus becomes tailor-made for the immune responses of the vaccinated individual. 2020-2021 the HIV DNA vaccine will be studied for decrease of viral reservoir in children born to HIV-infected mothers in South Africa, Thailand and Italy. In a consortium involving European countries we hold a PhD school for learning on HIV and now also Covid-19 immunology and vaccines.
Research networks
Collaborators
- Merlin Robb, for clinical HIV studies internationally, Military HIV research program and National Institutes of Health, USA.
- Paolo Rossi and Paolo Palma for pediatric HIV vaccine studies, Tor Vergata University and Bambino Gesu Hospital, Italy. &
- Margaret A. Liu, honorary doctor and foreign adjunct professor, Protherimmune and ̽»¨¾«Ñ¡, USA and SE.
- Joan Joseph Munne, for PhD education in EU project EAVI2020, University Hospital Vall d´Hebron, Spain.
- Athina Kilpeläinen, PhD examination Barcelona 2020, IrsiCaixa, Barcelona, .
- Jorma Hinkula, for animal research.
- At the ̽»¨¾«Ñ¡ primarily Pontus Blomberg, Maria Isaguliants, Stefan Petkov, Karl Ljungberg (now Eurocine), Gunnel Biberfeld, Eric Sandström, and the Francesca Chiodi group.
Publications
Wahren B.
Hum Vaccin Immunother. 2022 Feb 25:1-4.
Joachim A, Msafiri F, Onkar S, Munseri P, Aboud S, Lyamuya EF, et al
Vaccines (Basel) 2020 Nov;8(4):
Viegas EO, Kroidl A, Munseri PJ, Missanga M, Nilsson C, Tembe N, et al
PLoS One 2018 ;13(11):e0206838
Hinkula J, Petkov S, Ljungberg K, Hallengärd D, Bråve A, Isaguliants M, et al
Heliyon 2017 Jun;3(6):e00339
Stenler S, Lundin KE, Hansen L, Petkov S, Mozafari N, Isaguliants M, et al
Hum Vaccin Immunother 2017 12;13(12):2849-2858
Nilsson C, Hejdeman B, Godoy-Ramirez K, Tecleab T, Scarlatti G, Bråve A, et al
PLoS One 2015 ;10(6):e0131748
Klein N, Palma P, Luzuriaga K, Pahwa S, Nastouli E, Gibb DM, et al
Lancet Infect Dis 2015 Sep;15(9):1108-1114
Palma P, Gudmundsdotter L, Finocchi A, Eriksson LE, Mora N, Santilli V, et al
Vaccines (Basel) 2014 Jul;2(3):563-80
Chissumba RM, Luciano A, Namalango E, Bauer A, Bhatt N, Wahren B, et al
Immunobiology 2018 12;223(12):792-801
Petkov S, Starodubova E, Latanova A, Kilpeläinen A, Latyshev O, Svirskis S, et al
PLoS One 2018 ;13(6):e0197902
Latanova AA, Petkov S, Kilpelainen A, Jansons J, Latyshev OE, Kuzmenko YV, et al
Sci Rep 2018 05;8(1):8078
Joachim A, Munseri PJ, Nilsson C, Bakari M, Aboud S, Lyamuya EF, et al
AIDS Res Hum Retroviruses 2017 08;33(8):880-888
Joachim A, Bauer A, Joseph S, Geldmacher C, Munseri PJ, Aboud S, et al
PLoS One 2016 ;11(5):e0155702
Klein N, Palma P, Luzuriaga K, Pahwa S, Nastouli E, Gibb DM, et al
Lancet Infect Dis 2015 Sep;15(9):1108-1114
Nilsson C, Hejdeman B, Godoy-Ramirez K, Tecleab T, Scarlatti G, Bråve A, et al
PLoS One 2015 ;10(6):e0131748
Joachim A, Nilsson C, Aboud S, Bakari M, Lyamuya EF, Robb ML, et al
PLoS One 2015 ;10(4):e0118486
Kilpeläinen A, Axelsson Robertson R, Leitner T, Sandström E, Maeurer M, Wahren B
AIDS Res Hum Retroviruses 2014 Nov;30(11):1065-71
Stenler S, Wiklander OP, Badal-Tejedor M, Turunen J, Nordin JZ, Hallengärd D, et al
Mol Ther Nucleic Acids 2014 Jan;2():e140
Palma P, Romiti ML, Montesano C, Santilli V, Mora N, Aquilani A, et al
PLoS One 2013 ;8(11):e79957
Nilsson C, Godoy-Ramirez K, Hejdeman B, Bråve A, Gudmundsdotter L, Hallengärd D, et al
AIDS Res Hum Retroviruses 2014 Mar;30(3):299-311
Hallengärd D, Bråve A, Isaguliants M, Blomberg P, Enger J, Stout R, et al
Genet Vaccines Ther 2012 Aug;10(1):5
Chang CH, Hinkula J, Loo M, Falkeborn T, Li R, Cardillo TM, et al
PLoS One 2012 ;7(7):e41235
Other references
Professor Britta Wahren has been interviewed by Swedish National Radio (SverigesRadio P4) to mark World Aids Day on December 1st, 2016 .The interview looks at how far research has progressed with the development of an HIV vaccine. .
After receiving the KI Silver medal 2015 for outstanding achievement in the field of ̽»¨¾«Ñ¡ research, Britta Wahren talks about her research past and present. .
- Wahren B & Wahren P. Framtidens farliga smitta – hur kan vi skydda oss. Britta Wahren, Patrik Wahren, KI University Press 2007.
- In 2015 Britta Wahren received the Grand Silver Medal Award of ̽»¨¾«Ñ¡ for outstanding ̽»¨¾«Ñ¡ research.
- Britta Wahren participates in a interview with the Swedish Radio (SR) called "".
- Contributing to KI essay pages and documentation project on the history of ̽»¨¾«Ñ¡ and /om-ki/essasamling.