Elisabeth Norin Project
Elisabeth Norin & Tore Midtvedt work with an anaerobic cultivated human intestinal microbiota (Achim) and they have succeeded in re-cultivating – under strict conditions - ex vivo for more than 20 years - a diverse ecosystem of human intestinal microbiota from a single healthy donor.
Anaerobic cultivated human intestinal microbiota (Achim)
In patients with recurrent Clostridium difficile infection (RCDI) this ecosystem is an excellent treatment option to reestablish a functional microbiota.
The study is still ongoing at the General Hospital in Gävle and in Oslo, where patients, after several treatment periods with different antimicrobials, were randomly admitted to one of the two arms ”ACHIM TRANSPLANTATION” or ”VANCOMYCIN TREATMENT”.
Most of the patients with RCDI so far included and thus treated have recovered.
Project members
Elisabeth Norin, Associate Professor
Tore Midtvedt, Professor emeritus
Bo Tjellström, PhD, MD
News
A published book: "Gastrointestinal Microbiology"
Editors; Arthur C. Ouwehand Health and Nutrition, Danisco Finland, Finland, Elaine E. Vaughan Wageningen University, Vlaardingen, Netherlands.
Elisabeth Norin & Tore Midtvedt have written a chapter; "Born germ-free - microbial dependent"
Read the introduction
Publications
Fecal Microbiota Transplantation for Primary Clostridium difficile Infection.
The New England Journal of Medicine June2018. DOI: 10.1056/NEJMc1803103
Benno P, Dahlgren AL, Befrits R, Norin E, Hellström PM, Midtvedt T
J Investig Med High Impact Case Rep ;4(2):2324709616648458
Tjellström B, Högberg L, Stenhammar L, Magnusson KE, Midtvedt T, Norin E, et al
Dig. Dis. Sci. 2016 07;61(7):2140-1
Benno P, Befrits R, Berstad A, Dahlgren AL, Norin E, Midtvedt T
Lakartidningen 2015 Jun;112():
Norin E
Microb. Ecol. Health Dis. 2015 ;26():27638
Benno P, Befrits R, Norin E, Berstad A, Dahlgren AL, Midtvedt T, et al
Microb. Ecol. Health Dis. 2015 ;26():27637
Tjellström B, Stenhammar L, Magnusson KE, Midtvedt T, Norin E, Sundqvist T, et al
J. Pediatr. Gastroenterol. Nutr. 2015 Jul;61(1):e4
Tjellström B, Stenhammar L, Sundqvist T, Fälth-Magnusson K, Hollén E, Magnusson KE, et al
Aliment. Pharmacol. Ther. 2014 May;39(10):1156-60
Midtvedt T, Norin E, Benno P, Dahlgren AL
Am. J. Gastroenterol. 2013 Dec;108(12):1931-2
Tjellström B, Högberg L, Stenhammar L, Fälth-Magnusson K, Magnusson KE, Norin E, et al
Microb. Ecol. Health Dis. 2013 ;24():
Midtvedt T, Zabarovsky E, Norin E, Bark J, Gizatullin R, Kashuba V, et al
PLoS ONE 2013 ;8(6):e66074
Tjellström B, Högberg L, Stenhammar L, Magnusson KE, Midtvedt T, Norin E, et al
Scand. J. Gastroenterol. 2012 Dec;47(12):1454-9
Jorup-Rönström C, Håkanson A, Sandell S, Edvinsson O, Midtvedt T, Persson AK, et al
Scand. J. Gastroenterol. 2012 May;47(5):548-52
Benno P, Bark J, Collinder E, Hellström PM, Midtvedt T, Norin E
Scand. J. Gastroenterol. 2012 Feb;47(2):251-2
Fallani M, Amarri S, Uusijarvi A, Adam R, Khanna S, Aguilera M, et al
Microbiology (Reading, Engl.) 2011 May;157(Pt 5):1385-1392
Valeur J, Norin E, Midtvedt T, Berstad A
Neurogastroenterol. Motil. 2010 Oct;22(10):1147
Tjellström B, Stenhammar L, Högberg L, Fälth-Magnusson K, Magnusson KE, Midtvedt T, et al
Scand. J. Gastroenterol. 2010 Sep;45(9):1059-62
Fallani M, Young D, Scott J, Norin E, Amarri S, Adam R, et al
J. Pediatr. Gastroenterol. Nutr. 2010 Jul;51(1):77-84