Ingemar Ernberg Group
Our primary research interest is infection and cancer in humans. We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism.
Project Leaders in the Ingemar Ernberg Group
Barbro Ehlin-Henriksson Project
Research Summary
Our primary research interest is infection and cancer in humans. We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism.
Why is EBV of great bio̽»¨¾«Ñ¡ interest today?
EBV is the most common virus in the human population (>90% of adults carry the virus) which normally gives rise to an inconspicuous or benign infection, paradoxically, however, under rare circumstances it induces tumors. It is associated with ten different forms of cancer in humans out of which some epithelial ones are very common in certain regions, in particular nasopharyngeal carcinoma (NPC) and gastric cancer (5-10 % thereof). Furthermore, it is the 4th largest infectious cause of cancer in humans involved in approximately 200,000 new cases of cancer every year worldwide.
This virus also offers one of the most complete models for studying tumorigenesis in man, from molecule to patient, exploiting the viral infection of human B-lymphocytes. The foundations for multistep tumorigenesis in this biology can be partly explored in vivo in patient cohorts where the tumor development increases significantly, due to immunosuppression like in post-transplant patients and HIV-carriers. The EBV cell line models allow comparison of non-malignant versus malignant phenotypes of human cancer in vitro (lymphoblastoid cell lines, LCL vs Burkitt´s lymphoma cell line, BL). We are using this virus to study the initiating immortalizing process and switches between resting and proliferating phenotypes to better understand EBV protein – host cell interactions involved in tumorigenesis controlling the switch from cell arrest to proliferation and reprogramming of metabolism.
Leading the Personalized Cancer Medicine (PCM)
We are also leading the Personalized Cancer Medicine (PCM) at ̽»¨¾«Ñ¡, funded by Radiumhemmets´ Research Funds, with the aim to establish and develop PCM as a leading treatment concept in academic cancer healthcare in Stockholm. PCM is an interdisciplinary research field and the main focus is to strengthen the infrastructure for local, national and international team science addressing PCM. Some 30 colleagues are affiliated with us to the PCM program, out of which half are part-time employed.
Group Members
Former group members and PhD students
Anna Aleman
Jenny Almqvist
Ender Altiok
Anna Birgersdotter
Carl-Ivar Brändén
Henrik Brändén
Rozina Caridha
Joakim Cöster
Sun Di
Ziming Du
Anneka Ehrnst
Kerstin Falk
Anna Friis
Fu Chen
Anneka Ehrnst
Jan Willem Gratama
Elvira Grigorieva
Sven Grützmeier
Lars Holmgren
Qin Li
Uno Lindberg
Su Ling
Janos Minarovits
Ngyen van Do
Li-Sophie Rathje
Rickard Sandberg
JianYong Shao
Boris Troyanovsky
Maria Werner
Anita Westman
Gösta Winberg
Liang Wu
Xiangning Zhang
Xiaoying Zhou
Publications
Feng R, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, et al
Cancer Med 2019 04;8(4):1835-1844
Ernberg I
Mol Oncol 2019 03;13(3):648-652
Feng RM, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, et al
Oral Oncol. 2019 01;88():102-108
Calvo F, Apolone G, Baumann M, Caldas C, Celis JE, de Lorenzo F, et al
Eur. J. Cancer 2018 11;103():155-159
Meng Q, Valentini D, Rao M, Liu Z, Xie S, Morgell A, et al
Oncotarget 2018 Apr;9(32):22451-22459
Xiao X, Zhang Z, Chang ET, Liu Z, Liu Q, Cai Y, et al
Am. J. Epidemiol. 2018 10;187(10):2117-2125
Poiret T, Axelsson-Robertson R, Remberger M, Luo XH, Rao M, Nagchowdhury A, et al
Front Immunol 2018 ;9():760
Ye W, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, et al
Oncotarget 2017 Oct;8(50):87073-87085
Kashuba E, Dmitriev AA, Kamal SM, Melefors O, Griva G, Römling U, et al
Microb. Ecol. Health Dis. 2017 ;28(1):1345574
Gainullin MR, Zhukov IY, Zhou X, Mo Y, Astakhova L, Ernberg I, et al
Sci Rep 2017 08;7(1):9012
Wu L, Ehlin-Henriksson B, Zhou X, Zhu H, Ernberg I, Kis LL, et al
Immunology 2017 12;152(4):562-573
Liang J, Zheng S, Xiao X, Wei J, Zhang Z, Ernberg I, et al
Biol Open 2017 Jun;6(6):914-922
Liu Z, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, et al
Cancer 2017 Jul;123(14):2716-2725
Ernberg I, Kärre K, Wigzell H
Nature 2017 02;542(7641):296
Zhou J, Huang Z, Wang Z, Liu S, Grandien A, Ernberg I, et al
Oncotarget 2017 Jul;8(27):43853-43865
Grützmeier S, Porwit A, Schmitt C, Sandström E, Åkerlund B, Ernberg I
Infect. Agents Cancer 2016 ;11():46
Astakhova L, Ngara M, Babich O, Prosekov A, Asyakina L, Dyshlyuk L, et al
PLoS ONE 2016 ;11(7):e0154102
Liu Z, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, et al
Cancer Epidemiol. Biomarkers Prev. 2016 08;25(8):1201-7
Wang HY, Chang YL, To KF, Hwang JS, Mai HQ, Feng YF, et al
Chin J Cancer 2016 May;35():41
Li Q, Rane L, Poiret T, Zou J, Magalhaes I, Ahmed R, et al
Oncotarget 2016 May;7(21):30230-40
Li Q, Wennborg A, Aurell E, Dekel E, Zou JZ, Xu Y, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 Mar;113(10):2672-7
Ernberg I
J. Intern. Med. 2015 Dec;278(6):643-4
Zhou X, Wei J, Chen F, Xiao X, Huang T, He Q, et al
Oncotarget 2015 Dec;6(38):41077-91
Tsidulko AY, Matskova L, Astakhova LA, Ernberg I, Grigorieva EV
Oncotarget 2015 Dec;6(41):43529-39
Nawaz I, Hu LF, Du ZM, Moumad K, Ignatyev I, Pavlova TV, et al
Oncotarget 2015 Oct;6(31):31493-507
Nawaz I, Moumad K, Martorelli D, Ennaji MM, Zhou X, Zhang Z, et al
Clin Epigenetics 2015 ;7():89
Zhou X, Matskova L, Rathje LS, Xiao X, Gish G, Werner M, et al
Oncogene 2015 Aug;34(34):4491-9
Ahmed RK, Poiret T, Ambati A, Rane L, Remberger M, Omazic B, et al
J. Immunother. 2014 Oct;37(8):416-25
Nawaz I, Qiu X, Wu H, Li Y, Fan Y, Hu LF, et al
Epigenetics 2014 Aug;9(8):1138-48
Suhovskih AV, Tsidulko AY, Kutsenko OS, Kovner AV, Aidagulova SV, Ernberg I, et al
Front Oncol 2014 ;4():79
Friis A, Akerlund B, Christensson B, Gyllensten K, Aleman A, Zou JZ, et al
Infect. Agents Cancer 2013 Jul;8(1):28
Midtvedt T, Zabarovsky E, Norin E, Bark J, Gizatullin R, Kashuba V, et al
PLoS ONE 2013 ;8(6):e66074
Zhang X, Zhang Z, Zheng B, He Z, Winberg G, Ernberg I
Arch. Virol. 2013 Jul;158(7):1433-43
Wu L, Ehlin-Henriksson B, Zhu H, Ernberg I, Klein G
Int. J. Cancer 2013 Aug;133(3):766-70
Zhang Z, Sun D, Hutajulu SH, Nawaz I, Nguyen Van D, Huang G, et al
PLoS ONE 2012 ;7(11):e45908
Friis AM, Akerlund B, Gyllensten K, Aleman A, Bratt G, Sandström E, et al
Vaccine 2012 Sep;30(42):6093-8
Mostovich LA, Prudnikova TY, Kondratov AG, Gubanova NV, Kharchenko OA, Kutsenko OS, et al
Epigenetics 2012 Aug;7(8):930-9
Dmitriev AA, Kashuba VI, Haraldson K, Senchenko VN, Pavlova TV, Kudryavtseva AV, et al
Epigenetics 2012 May;7(5):502-13
Du ZM, Kou CW, Wang HY, Huang MY, Liao DZ, Hu CF, et al
Head Neck 2012 Oct;34(10):1456-64
Friis AM, Ã…kerlund B, Gyllensten K, Aleman A, Ernberg I
Scand. J. Infect. Dis. 2012 May;44(5):388-92
Wang HY, Sun BY, Zhu ZH, Chang ET, To KF, Hwang JS, et al
J. Clin. Oncol. 2011 Dec;29(34):4516-25
Du C, Huang T, Sun D, Mo Y, Feng H, Zhou X, et al
Cancer Lett. 2011 Oct;309(1):54-61
Shao JY, Cao Y, Miao XP, Huang MY, Deng L, Hao JJ, et al
Chin J Cancer 2011 Sep;30(9):620-6
Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, et al
Genome Med 2011 Jul;3(7):43
Du ZM, Hu LF, Wang HY, Yan LX, Zeng YX, Shao JY, et al
PLoS ONE 2011 Apr;6(4):e19137
Du C, Huang T, Sun D, Mo Y, Feng H, Zhou X, et al
Cancer Lett. 2011 Oct;309(1):54-61
Benno P, Ernberg I, Midtvedt T, Norin E, Zachrisson K
Lakartidningen ;107(13-14):907-9
Benno P, Blomquist L, Ernberg I, Midtvedt T, Möllby R, Norin E
Lakartidningen ;107(13-14):900-3
Fiskesund R, Thomas LV, Schobert M, Ernberg I, Lundt I, Yu S
J. Appl. Microbiol. 2009 Feb;106(2):624-33
Kashuba VI, Pavlova TV, Grigorieva EV, Kutsenko A, Yenamandra SP, Li J, et al
PLoS ONE 2009 May;4(5):e5231
Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, et al
Lancet Oncol. 2009 Apr;10(4):321-2
Ferreri AJ, Ernberg I, Copie-Bergman C
J. Intern. Med. 2009 Apr;265(4):421-38
Birgersdotter A, Baumforth KR, Porwit A, Sjöberg J, Wei W, Björkholm M, et al
Br. J. Cancer 2009 Oct;101(8):1393-401
Huang S, Ernberg I, Kauffman S
Semin. Cell Dev. Biol. 2009 Sep;20(7):869-76
Birgersdotter A, Baumforth KR, Wei W, Murray PG, Sjöberg J, Björkholm M, et al
Am. J. Clin. Pathol. 2010 Feb;133(2):271-80
Earlier Publications
Book release
Ingmar Ernberg, co-editor
Ernberg, I. Et al.
Vad är liv, i kosmos, i cellen i människan?
Karolinska Universitet
y Press, Stockholm, 2010.