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The most common project types carried out by CBCS and research groups in collaboration involve assay development and subsequent small molecule screening. Also, follow-up work after a high-throughput screen with medicinal- or synthetic chemistry support can be carried out by or in collaboration with CBCS.

Services

We offer a range of services in the are of chemical biology field.

Assay Development

Our highly experienced team works with a broad range of bioassay formats, with extensive knowledge in the intricate process of adapting novel bioassays from low-throughput to microtiter-based high-throughput formats. We are equipped with multiple (liquid handling) workstations and readout systems to accommodate a broad range of screening technologies and sizes. Our screens range from isolated biochemical targets to advanced primary cellular systems, phenotypic and high-content screens, plant biology, and whole-organism screening in infectious diseases and cancer.

Assay development and screening in BLS-3

The BSL3 Biomedicum Core Facility is a fully equipped facility performing a wide range of research activities with any pathogens that require a biosafety level 3 laboratory. The facility is equipped with state-of-the-art equipment such as liquid-handling robotics, plate reader, and flow cytometry and expertise staff specialized in high-throughput screening.

Synthetic Organic and Medicinal Chemistry

Access to is a central component of chemical biology and critical for further developing primary screening hits. Our chemistry teams consist of highly experienced, senior synthetic chemists and computational chemists with a background in academia and the pharmaceutical industry, providing each project with unique insight into the molecular basis of the system being studied.

Computational chemistry support

CBCS provides valuable support in Computational Chemistry, enabling researchers to leverage computational tools and techniques to advance their drug discovery projects. With a focus on accelerating the identification and subsequent optimization of potential hits, CBCS offers expertise in both ligand- and structure-based virtual screening. This is a computational approach to identify potential hit candidates, and analogues or derivatives of hit compounds that may exhibit enhanced activity or pharmacological properties, in order to prioritize compounds for further experimental evaluation.