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Luca Jovine

Luca Jovine

Professor
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 BioNut Jovine, 171 77 Stockholm
Part of:

About me

  • I am a professor of structural biology and my research group studies the molecular basis of egg-sperm interaction at fertilization, a topic that is directly relevant to both understanding human infertility and identifying potential new methods of non-hormonal contraception. In parallel, we investigate a set of proteins that contain the same zona pellucida (ZP) module found in egg coat subunits but perform completely different biological functions. This part of our work has implications for the treatment of urinary tract infections - the most common type of non-epidemic bacterial infection in humans -, as well as kidney and vascular diseases.

    More information on our research may be found on my research group's page ().

Selected publications

  • Article: CELL. 2024;187(6):1440-1459.e24
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
  • Article: NATURE COMMUNICATIONS. 2022;13(1):3880
    Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Grana M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
  • Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193
    Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
  • Article: EMBO JOURNAL. 2020;39(24):e106807
    Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
  • Article: NATURE COMMUNICATIONS. 2019;10(1):3086
    Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
  • Article: CELL. 2017;169(7):1315-1326.e17
    Raj I; Al Hosseini HS; Dioguardi E; Nishimura K; Han L; Villa A; de Sanctis D; Jovine L
  • Article: CELL REPORTS. 2017;19(9):1917-1928
    Saito T; Bokhove M; Croci R; Zamora-Caballero S; Han L; Letarte M; de Sanctis D; Jovine L
  • Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662
    Nishimura K; Han L; Bianchi E; Wright GJ; de Sanctis D; Jovine L
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557
    Bokhove M; Nishimura K; Brunati M; Han L; de Sanctis D; Rampoldi L; Jovine L
  • Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101
    Han L; Nishimura K; Al Hosseini HS; Bianchi E; Wright GJ; Jovine L
  • Article: CELL. 2010;143(3):404-415
    Han L; Monne M; Okumura H; Schwend T; Cherry AL; Flot D; Matsuda T; Jovine L
  • Article: NATURE. 2008;456(7222):653-657
    Monne M; Han L; Schwend T; Burendahl S; Jovine L

Articles

  • Article: BLOOD. 2024;143(22):2314-2331
    Bernabeu-Herrero ME; Patel D; Bielowka A; Zhu J; Jain K; Mackay IS; Guerrero PC; Emanuelli G; Jovine L; Noseda M; Marciniak SJ; Aldred MA; Shovlin CL
  • Article: HUMAN MUTATION. 2024;2024:1-13
    DeMille D; McDonald J; Bernabeu C; Racher H; Olivieri C; Cantarini C; Sbalchiero A; Thompson BA; Jovine L; Shovlin CL; Dupuis-Girod S; Lesca G; Tusseau M; Ganguly A; Kasthuri RS; Jessen J; Massink MPG; Ichikawa S; Bayrak-Toydemir P
  • Journal article: ELIFE. 2024;13:RP93131
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Journal article: ELIFE. 2024;13
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129
    Furrow E; Rampoldi L; Jovine L; Wesson JA; Treeful AE; Jayachandran M; Lieske JC; Romero MF; Lulich JP
  • Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568
    Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
  • Article: NATURE COMMUNICATIONS. 2023;14(1):3506
    Gert KRB; Panser K; Surm J; Steinmetz BS; Schleiffer A; Jovine L; Moran Y; Kondrashov F; Pauli A
  • Article: PROTEIN SCIENCE. 2022;31(6):e4333
    Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740
    Nogueira E; Tirpak F; Hamilton LE; Zigo M; Kerns K; Sutovsky M; Kim J; Volkmann D; Jovine L; Taylor JF; Schnabel RD; Sutovsky P
  • Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693
    Jovine L
  • Article: BLOOD. 2020;136(17):1907-1918
    Shovlin CL; Simeoni I; Downes K; Frazer ZC; Megy K; Bernabeu-Herrero ME; Shurr A; Brimley J; Patel D; Kell L; Stephens J; Turbin IG; Aldred MA; Penkett CJ; Ouwehand WH; Jovine L; Turro E
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735
    Balbach M; Hamzeh H; Jikeli JF; Brenker C; Schiffer C; Hansen JN; Neugebauer P; Troetschel C; Jovine L; Han L; Florman HM; Kaupp UB; Struenker T; Wachten D
  • Article: SCIENTIFIC REPORTS. 2019;9(1):11601
    Schaeffer C; Izzi C; Vettori A; Pasqualetto E; Cittaro D; Lazarevic D; Caridi G; Gnutti B; Mazza C; Jovine L; Scolari F; Rampoldi L
  • Article: GENE. 2019;696:33-39
    Ruiz-Llorente L; Chiapparino E; Plumitallo S; Danesino C; Bayrak-Toydemir P; Pagella F; Manfredi G; Bernabeu C; Jovine L; Olivieri C
  • Article: IUCRJ. 2019;6(Pt 2):317-330
    Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Guevara T; Karmilin K; Kuske M; Olf M; Dietzel E; Yiallouros I; de Sanctis D; Goulas T; Weiskirchen R; Jahnen-Dechent W; Floehr J; Stoecker W; Jovine L; Gomis-Rueth FX
  • Article: SCIENTIFIC REPORTS. 2016;6:32556
    Algarra B; Han L; Soriano-Ubeda C; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
  • Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7
    Bokhove M; Al Hosseini HS; Saito T; Dioguardi E; Gegenschatz-Schmid K; Nishimura K; Raj I; de Sanctis D; Han L; Jovine L
  • Article: ELIFE. 2015;4:e08887
    Brunati M; Perucca S; Han L; Cattaneo A; Consolato F; Andolfo A; Schaeffer C; Olinger E; Peng J; Santambrogio S; Perrier R; Li S; Bokhove M; Bachi A; Hummler E; Devuyst O; Wu Q; Jovine L; Rampoldi L
  • Journal article: REPRODUCTION ABSTRACTS. 2014
    Algarra B; Han L; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
  • Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
    Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
  • Show more

All other publications

  • Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: EMDB. 2024
    Jovine L
  • Dataset: EMDB. 2024
    Jovine L
  • Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:742
    Demille D; Sbalchiero A; Cantarini C; Thompson B; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri R; Olivieri C; van Amstel JKP; Racher H; Shovlin C; Bayrak-Toydemir P
  • Preprint: ELIFE. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Preprint: BIORXIV. 2023
    Elofsson A; Han L; Bianchi E; Wright G; Jovine L
  • Preprint: BIORXIV. 2023
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge R; Komondor K; Carlson A; Landreh M; de Sanctis D; Yasumasu S; Ikawa M; Jovine L
  • Conference publication: ANGIOGENESIS. 2023;26(1):S18
    DeMille D; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri RS; Olivieri C; van Amstel PHK; Racher H; Shovlin CL; Bayrak-Toydemir P
  • Preprint: ELSEVIER BV. 2023
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
  • Dataset: PDB. 2022
    Jovine L; Nishio S; Tunyasuvunakool K; Jumper J; De Sanctis D
  • Preprint: BIORXIV. 2022
    Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
  • Dataset: 2022
    Jovine L
  • Dataset: PDB. 2022
    Jovine L; Xu C; Stsiapanava A; Carroni M; Tunyasuvunakool K; Jumper J
  • Show more

Grants

  • Leveraging integrative structural biology discoveries to unravel key molecular interactions in fertilization and antibacterial defense
    Swedish Research Council
    1 January 2025 - 31 December 2028
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • Deutsche Forschungsgemeinschaft
    1 January 2018 - 31 December 2019
  • Deutsche Forschungsgemeinschaft
    1 January 2018 - 31 December 2019
  • Knut and Alice Wallenberg Foundation
    1 January 2018 - 1 January 2023
  • Swedish Research Council
    1 January 2017 - 31 December 2020
  • Egg-sperm interaction at fertilization and Hedgehog (Hh) signaling
    Center for Innovative Medicine (CIMED)
    1 January 2015 - 31 December 2019
  • Japan Society for the Promotion of Science
    1 April 2013 - 31 March 2016
  • Molecular Basis of Mammalian Egg-Sperm Interaction at Fertilization
    Göran Gustafssons Stiftelse
    1 January 2013 - 31 December 2015
  • Swedish Research Council
    1 January 2013 - 31 December 2016
  • Swedish Research Council
    1 January 2013 - 31 December 2016
  • European Research Council
    1 January 2011 - 31 December 2015
  • Molecular basis of mammalian egg-sperm recognition
    European Molecular Biology Organization
    4 July 2010 - 4 July 2012
  • Swedish Research Council
    1 January 2010 - 31 December 2012
  • EMBO Young Investigators Award 2009
    Swedish Research Council
    1 January 2010 - 31 December 2012
  • Swedish Research Council
    1 January 2010 - 31 December 2012
  • Structural studies of zona pellucida domain proteins
    Swedish Research Council
    1 January 2008 - 31 December 2009
  • Cordis
    1 April 2006 - 31 March 2007
  • Structural studies of zona pellucida domain proteins
    Swedish Research Council
    1 January 2006 - 31 December 2007
  • Structural studies of mammalian fertilisation proteins
    International Human Frontier Science Program Organization
    1 May 2001 - 30 April 2004

Employments

  • Professor, Department of Medicine, Huddinge, ̽»¨¾«Ñ¡, 2024-
  • Professor, Department of Biosciences and Nutrition, ̽»¨¾«Ñ¡, 2013-2024
  • Assistant Professor, Department of Biosciences and Nutrition, ̽»¨¾«Ñ¡, 2005-2013

Degrees and Education

  • Ph.D, MRC Laboratory of Molecular Biology, University of Cambridge, 2000

Distinction and awards

  • Knut and Alice Wallenberg Foundation Project Grant, Knut and Alice Wallenberg Foundation, 2019
  • Center for Innovative Medicine Senior Investigator Grant, Karolinska Institute, 2015
  • Hugo Theorell Prize for Biophysics, Svenska Föreningen för Biokemi, Biofysik och Molekylärbiologi, 2013
  • Göran Gustafsson Prize for Chemistry, Göran Gustafsson Foundation, 2012
  • Erik K. Fernström Prize, Fernströmstiftelsen, 2011
  • ERC Starting Grant, European Union, 2011
  • EMBO Young Investigator, European Molecular Biology Organization, 2010
  • Sven och Ebba-Christina Hagberg Prize for Medical Research, Sven and Ebba-Christina Hagberg Foundation, 2010
  • Human Frontier Science Program Long-Term Fellow, International Human Frontier Science Program Organization, 2001
  • EMBO Long-Term Fellow, European Molecular Biology Organization, 2001

Committee work

  • Member, ClinGen HHT: Hereditary Hemorrhagic Telangiectasia Variant Curation Expert Panel, National Institutes of Health, , 2019-
  • Member, The Nobel Assembly at ̽»¨¾«Ñ¡, Karolinska Institute, , 2019-
  • Member, EMBO, European Molecular Biology Organization, , 2019-

Visiting research fellowships

  • Postdoctoral fellow, Icahn School of Medicine at Mount Sinai, New York, 2000-2005

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