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Luca Jovine

Luca Jovine

Professor
E-postadress: luca.jovine@ki.se
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: BlickagÃ¥ngen 16, 14152 Flemingsberg
Postadress: H7 Medicin, Huddinge, H7 BioNut Jovine, 171 77 Stockholm
Del av:

Om mig

  • Jag är professor i strukturbiologi och min forskargrupp studerar den molekylära grunden för interaktion mellan ägg och spermier vid befruktning, ett ämne som är direkt relevant för bÃ¥de att förstÃ¥ mänsklig infertilitet och identifiera potentiella nya metoder för icke-hormonella preventivmedel. Parallellt undersöker vi en uppsättning proteiner som innehÃ¥ller samma zona pellucida (ZP)-modul som finns i underenheter av äggskal men som utför helt andra biologiska funktioner. Denna del av vÃ¥rt arbete har implikationer för behandling av urinvägsinfektioner - den vanligaste typen av icke-epidemisk bakterieinfektion hos människor - samt även njur- och kärlsjukdomar.

    Mer information om vår forskning kan hittas på min forskargrupps sida ().

Utvalda publikationer

  • Article: CELL. 2024;187(6):1440-1459.e24
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Algarra B; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Sanctis DD; Yasumasu S; Ikawa M; Jovine L
  • Article: NATURE COMMUNICATIONS. 2022;13(1):3880
    Moi D; Nishio S; Li X; Valansi C; Langleib M; Brukman NG; Flyak K; Dessimoz C; de Sanctis D; Tunyasuvunakool K; Jumper J; Grana M; Romero H; Aguilar PS; Jovine L; Podbilewicz B
  • Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(3):190-193
    Stsiapanava A; Xu C; Nishio S; Han L; Yamakawa N; Carroni M; Tunyasuvunakool K; Jumper J; de Sanctis D; Wu B; Jovine L
  • Article: EMBO JOURNAL. 2020;39(24):e106807
    Stsiapanava A; Xu C; Brunati M; Zamora-Caballero S; Schaeffer C; Bokhove M; Han L; Hebert H; Carroni M; Yasumasu S; Rampoldi L; Wu B; Jovine L
  • Article: NATURE COMMUNICATIONS. 2019;10(1):3086
    Nishimura K; Dioguardi E; Nishio S; Villa A; Han L; Matsuda T; Jovine L
  • Article: CELL. 2017;169(7):1315-1326.e17
    Raj I; Al Hosseini HS; Dioguardi E; Nishimura K; Han L; Villa A; de Sanctis D; Jovine L
  • Article: CELL REPORTS. 2017;19(9):1917-1928
    Saito T; Bokhove M; Croci R; Zamora-Caballero S; Han L; Letarte M; de Sanctis D; Jovine L
  • Letter: CURRENT BIOLOGY. 2016;26(14):R661-R662
    Nishimura K; Han L; Bianchi E; Wright GJ; de Sanctis D; Jovine L
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(6):1552-1557
    Bokhove M; Nishimura K; Brunati M; Han L; de Sanctis D; Rampoldi L; Jovine L
  • Letter: CURRENT BIOLOGY. 2016;26(3):R100-R101
    Han L; Nishimura K; Al Hosseini HS; Bianchi E; Wright GJ; Jovine L
  • Article: CELL. 2010;143(3):404-415
    Han L; Monne M; Okumura H; Schwend T; Cherry AL; Flot D; Matsuda T; Jovine L
  • Article: NATURE. 2008;456(7222):653-657
    Monne M; Han L; Schwend T; Burendahl S; Jovine L

Artiklar

  • Article: BLOOD. 2024;143(22):2314-2331
    Bernabeu-Herrero ME; Patel D; Bielowka A; Zhu J; Jain K; Mackay IS; Guerrero PC; Emanuelli G; Jovine L; Noseda M; Marciniak SJ; Aldred MA; Shovlin CL
  • Article: HUMAN MUTATION. 2024;2024:1-13
    DeMille D; McDonald J; Bernabeu C; Racher H; Olivieri C; Cantarini C; Sbalchiero A; Thompson BA; Jovine L; Shovlin CL; Dupuis-Girod S; Lesca G; Tusseau M; Ganguly A; Kasthuri RS; Jessen J; Massink MPG; Ichikawa S; Bayrak-Toydemir P
  • Journal article: ELIFE. 2024;13:RP93131
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Journal article: ELIFE. 2024;13
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Journal article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2024;8(s1):129
    Furrow E; Rampoldi L; Jovine L; Wesson JA; Treeful AE; Jayachandran M; Lieske JC; Romero MF; Lulich JP
  • Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(11S):568
    Furrow E; Rampoldi L; Jovine L; Wesson J; Jayachandran M; Lieske JC; Romero MF; Lulich JP
  • Article: NATURE COMMUNICATIONS. 2023;14(1):3506
    Gert KRB; Panser K; Surm J; Steinmetz BS; Schleiffer A; Jovine L; Moran Y; Kondrashov F; Pauli A
  • Article: PROTEIN SCIENCE. 2022;31(6):e4333
    Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:872740
    Nogueira E; Tirpak F; Hamilton LE; Zigo M; Kerns K; Sutovsky M; Kim J; Volkmann D; Jovine L; Taylor JF; Schnabel RD; Sutovsky P
  • Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 2021;88(10):686-693
    Jovine L
  • Article: BLOOD. 2020;136(17):1907-1918
    Shovlin CL; Simeoni I; Downes K; Frazer ZC; Megy K; Bernabeu-Herrero ME; Shurr A; Brimley J; Patel D; Kell L; Stephens J; Turbin IG; Aldred MA; Penkett CJ; Ouwehand WH; Jovine L; Turro E
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:572735
    Balbach M; Hamzeh H; Jikeli JF; Brenker C; Schiffer C; Hansen JN; Neugebauer P; Troetschel C; Jovine L; Han L; Florman HM; Kaupp UB; Struenker T; Wachten D
  • Article: SCIENTIFIC REPORTS. 2019;9(1):11601
    Schaeffer C; Izzi C; Vettori A; Pasqualetto E; Cittaro D; Lazarevic D; Caridi G; Gnutti B; Mazza C; Jovine L; Scolari F; Rampoldi L
  • Article: GENE. 2019;696:33-39
    Ruiz-Llorente L; Chiapparino E; Plumitallo S; Danesino C; Bayrak-Toydemir P; Pagella F; Manfredi G; Bernabeu C; Jovine L; Olivieri C
  • Article: IUCRJ. 2019;6(Pt 2):317-330
    Cuppari A; Koerschgen H; Fahrenkamp D; Schmitz C; Guevara T; Karmilin K; Kuske M; Olf M; Dietzel E; Yiallouros I; de Sanctis D; Goulas T; Weiskirchen R; Jahnen-Dechent W; Floehr J; Stoecker W; Jovine L; Gomis-Rueth FX
  • Article: SCIENTIFIC REPORTS. 2016;6:32556
    Algarra B; Han L; Soriano-Ubeda C; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
  • Article: JOURNAL OF STRUCTURAL BIOLOGY. 2016;194(1):1-7
    Bokhove M; Al Hosseini HS; Saito T; Dioguardi E; Gegenschatz-Schmid K; Nishimura K; Raj I; de Sanctis D; Han L; Jovine L
  • Article: ELIFE. 2015;4:e08887
    Brunati M; Perucca S; Han L; Cattaneo A; Consolato F; Andolfo A; Schaeffer C; Olinger E; Peng J; Santambrogio S; Perrier R; Li S; Bokhove M; Bachi A; Hummler E; Devuyst O; Wu Q; Jovine L; Rampoldi L
  • Journal article: REPRODUCTION ABSTRACTS. 2014
    Algarra B; Han L; Aviles M; Coy P; Jovine L; Jimenez-Movilla M
  • Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2013;69(Pt 12):2563-2579
    Cherry AL; Finta C; Karlstrom M; Jin Q; Schwend T; Astorga-Wells J; Zubarev RA; Del Campo M; Criswell AR; de Sanctis D; Jovine L; Toftgard R
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Alla övriga publikationer

  • Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: PDB. 2024
    Jovine L
  • Dataset: EMDB. 2024
    Jovine L
  • Dataset: EMDB. 2024
    Jovine L
  • Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:742
    Demille D; Sbalchiero A; Cantarini C; Thompson B; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri R; Olivieri C; van Amstel JKP; Racher H; Shovlin C; Bayrak-Toydemir P
  • Preprint: ELIFE. 2024
    Elofsson A; Han L; Bianchi E; Wright GJ; Jovine L
  • Preprint: BIORXIV. 2023
    Elofsson A; Han L; Bianchi E; Wright G; Jovine L
  • Preprint: BIORXIV. 2023
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge R; Komondor K; Carlson A; Landreh M; de Sanctis D; Yasumasu S; Ikawa M; Jovine L
  • Conference publication: ANGIOGENESIS. 2023;26(1):S18
    DeMille D; McDonald J; Bernabeu C; Dupuis-Girod S; Ganguly A; Giraud S; Ichikawa S; Jessen J; Jovine L; Kasthuri RS; Olivieri C; van Amstel PHK; Racher H; Shovlin CL; Bayrak-Toydemir P
  • Preprint: ELSEVIER BV. 2023
    Nishio S; Emori C; Wiseman B; Fahrenkamp D; Dioguardi E; Zamora-Caballero S; Bokhove M; Han L; Stsiapanava A; Lu Y; Kodani M; Bainbridge RE; Komondor KM; Carlson AE; Landreh M; Daniele DS; Yasumasu S; Ikawa M; Jovine L
  • Dataset: PDB. 2022
    Jovine L; Nishio S; Tunyasuvunakool K; Jumper J; De Sanctis D
  • Preprint: BIORXIV. 2022
    Allison TM; Degiacomi MT; Marklund EG; Jovine L; Elofsson A; Benesch JLP; Landreh M
  • Dataset: 2022
    Jovine L
  • Dataset: PDB. 2022
    Jovine L; Xu C; Stsiapanava A; Carroni M; Tunyasuvunakool K; Jumper J
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Forskningsbidrag

  • Utnyttja integrativa strukturbiologiska upptäckter för att reda ut viktiga molekylära interaktioner i befruktning och antibakteriellt försvar
    ³Õ±ð³Ù±ð²Ô²õ°ì²¹±è²õ°ùÃ¥»å±ð³Ù
    1 January 2025 - 31 December 2028
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • Deutsche Forschungsgemeinschaft
    1 January 2018 - 31 December 2019
  • Deutsche Forschungsgemeinschaft
    1 January 2018 - 31 December 2019
  • Knut and Alice Wallenberg Foundation
    1 January 2018 - 1 January 2023
  • Swedish Research Council
    1 January 2017 - 31 December 2020
  • Egg-sperm interaction at fertilization and Hedgehog (Hh) signaling
    Center for Innovative Medicine (CIMED)
    1 January 2015 - 31 December 2019
  • Japan Society for the Promotion of Science
    1 April 2013 - 31 March 2016
  • Molecular Basis of Mammalian Egg-Sperm Interaction at Fertilization
    Göran Gustafssons Stiftelse
    1 January 2013 - 31 December 2015
  • Swedish Research Council
    1 January 2013 - 31 December 2016
  • Swedish Research Council
    1 January 2013 - 31 December 2016
  • European Research Council
    1 January 2011 - 31 December 2015
  • Molecular basis of mammalian egg-sperm recognition
    European Molecular Biology Organization
    4 July 2010 - 4 July 2012
  • Swedish Research Council
    1 January 2010 - 31 December 2012
  • EMBO Young Investigators Award 2009
    Swedish Research Council
    1 January 2010 - 31 December 2012
  • Swedish Research Council
    1 January 2010 - 31 December 2012
  • Structural studies of zona pellucida domain proteins
    Swedish Research Council
    1 January 2008 - 31 December 2009
  • Cordis
    1 April 2006 - 31 March 2007
  • Structural studies of zona pellucida domain proteins
    Swedish Research Council
    1 January 2006 - 31 December 2007
  • Structural studies of mammalian fertilisation proteins
    International Human Frontier Science Program Organization
    1 May 2001 - 30 April 2004

´¡²Ô²õ³Ùä±ô±ô²Ô¾±²Ô²µ²¹°ù

  • Professor, Medicin, Huddinge, ̽»¨¾«Ñ¡, 2024-
  • Professor, Institutionen för biovetenskaper och näringslära, ̽»¨¾«Ñ¡, 2013-2024
  • Senior Forskare, Institutionen för biovetenskaper och näringslära, ̽»¨¾«Ñ¡, 2005-2013

Examina och utbildning

  • Ph.D, MRC Laboratory of Molecular Biology, University of Cambridge, 2000

Priser och utmärkelser

  • Knut och Alice Wallenbergs Stiftelse Stipendium, Knut and Alice Wallenberg Foundation, 2019
  • Center for Innovative Medicine Senior Investigator Grant, Karolinska Institute, 2015
  • Hugo Theorell Prize for Biophysics, Svenska Föreningen för Biokemi, Biofysik och Molekylärbiologi, 2013
  • Göran Gustafsson Prize for Chemistry, Göran Gustafsson Foundation, 2012
  • Erik K. Fernström Prize, Fernströmstiftelsen, 2011
  • ERC Starting Grant, European Union, 2011
  • EMBO Young Investigator, European Molecular Biology Organization, 2010
  • Sven och Ebba-Christina Hagberg Prize for Medical Research, Sven and Ebba-Christina Hagberg Foundation, 2010
  • Human Frontier Science Program Long-Term Fellow, International Human Frontier Science Program Organization, 2001
  • EMBO Long-Term Fellow, European Molecular Biology Organization, 2001

Uppdrag i kommitté

  • Medlem, ClinGen HHT: Hereditary Hemorrhagic Telangiectasia Variant Curation Expert Panel, National Institutes of Health, , 2019-
  • Medlem, Nobelförsamlingen vid ̽»¨¾«Ñ¡, Karolinska Institute, , 2019-
  • Medlem, EMBO, European Molecular Biology Organization, , 2019-

Gästforskning och resestipendier

  • Postdoktor, Icahn School of Medicine at Mount Sinai, New York, 2000-2005

Nyheter från KI

Kalenderhändelser från KI