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Our interest is central nervous system lesions including spinal cord injury and treatment strategies to counteract neurodegenerative processes. We develop and utilize novel and unique model systems to evaluate specifically human spinal cord injury processes and repair strategies. In addition, we study host donor interactions including allogeneic responses to human neural cell therapy.

We perform organotypic spinal cord slice cultures as well as co-cultures including human neural cells, glial cell populations and/or human peripheral blood mononuclear cells to follow spinal cord injury processes and interactions between the injured spinal cord and potential donor neural cells.

Clinical research focus

We also perform clinical research in the field of nervous system lesions, neurodegenerative disorders, rehabilitation as well as primary care. We participate in the international clinical trial TransEuro & BOOSTB4.

Clinical rehabilitation research is ongoing at Stiftelsen Stockholms Sjukhem where Elisabet Åkesson is Head of R&D as well as clinical physician at Rehabilitation, Stockholms Sjukhem.

Examples of clinical research studies at Rehabilitation Care,  and

• Make My Day: Value Based Client Centered and ICT-supported primary and secondary stroke prevention and rehabilitation after stroke, PI Eric Asaba, Ann-Helen Patomella & Susanne Guidetti
• Stroke, Rehabilitative training and tactile massage, PI Elisabet Åkesson
• Implementation of HiBalance training/ Förbättrad balans och fysisk aktivitet hos äldre - implementering av ett utmanande och progressivt träningsprogram, PI Erika Franzén
• Oral screens in post stroke training: a randomized clinical trial, PI, Gunilla Sandborgh Englund, KI
• Etablering av långsiktigt stöd efter förvärvad hjärnskada: Implementering och erfarenheter av Hjärna Tillsammans, PI Lena von Koch, Malin Tistad, Susanne Guidetti, Elisabet Åkesson
• DISKO: An interactive distance solution for stroke rehabilitation in the home setting, PIs E Åkesson & Susanne Palmcrants, Danderyds Hospital, Rehabilitation Medicine Clinic.

Selected scientific publications

Xiaofei Li, Zaneta Andrusivova, Paulo Czarnewski, Alma Andersson, Christoffer Mattsson Langseth, Daniel Gyllborg, Emelie Braun; Ludvig Larsson, Lijuan Hu, Zjanna Alekseenko, Helena Kopp Kallner, Elisabet Åkesson, Igor Adameyko, Mats Nilsson, Sten Linnarsson, Joakim Lundeberg and Erik Sundström. Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin". Nature Neuroscience. 2022 Nov 25. Accepted. BioRxiv: doi: 

Asaba E, Farias L, Åkesson E
PLoS One 2022 ;17(12):e0279000

Mingardo E, Beaman G, Grote P, Nordenskjöld A, Newman W, Woolf AS, Eckstein M, Hilger AC, Dworschak GC, Rösch W, Ebert AK, Stein R, Brusco A, Di Grazia M, Tamer A, Torres FM, Hernandez JL, Erben P, Maj C, Olmos JM, Riancho JA, Valero C, Hostettler IC, Houlden H, Werring DJ, Schumacher J, Gehlen J, Giel AS, Buerfent BC, Arkani S, Åkesson E, Rotstein E, Ludwig M, Holmdahl G, Giorgio E, Berettini A, Keene D, Cervellione RM, Younsi N, Ortlieb M, Oswald J, Haid B, Promm M, Neissner C, Hirsch K, Stehr M, Schäfer FM, Schmiedeke E, Boemers TM, van Rooij IALM, Feitz WFJ, Marcelis CLM, Lacher M, Nelson J, Ure B, Fortmann C, Gale DP, Chan MMY, Ludwig KU, Nöthen MM, Heilmann S, Zwink N, Jenetzky E, Odermatt B, Knapp M, Reutter H
Commun Biol 2022 Nov;5(1):1203

Mak JKL, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L, Boström AM, Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C, Olsson M, Cederholm T, Hägg S, Religa D, Jylhävä J
Gerontology 2022 Nov;():1-10

Asaba Eric, Michael Sy, Roi Charles Pineda, Rebecca Aldrich, Tetsuya Anzai, Peter Bontje, Ursa Bratun, Lisette Farias, Maria Kapanadze, Lea Suc and Elisabet Åkesson. Return to work after COVID-19: an international perspective, World Federation of Occupational Therapists Bulletin.  2022

Mak JKL, Hägg S, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L, Boström AM, Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C, Olsson M, Cederholm T, Jylhävä J, Religa D
J Gerontol A Biol Sci Med Sci 2022 Nov;77(11):2311-2319

Mälstam E, Asaba E, Åkesson E, Guidetti S, Patomella AH
Scand J Occup Ther 2022 Feb;29(2):152-164

Kananen L, Eriksdotter M, Boström AM, Kivipelto M, Annetorp M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C, Hägg S, Religa D, Jylhävä J, Cederholm T
Clin Nutr 2022 Dec;41(12):2973-2979

Xu H, Garcia-Ptacek S, Annetorp M, Cederholm T, Engel G, Engström M, Erlandsson H, Julius C, Kivipelto M, Lundberg LG, Metzner C, Sandberg L, Skogö Nyvang J, Sühl Öberg C, Åkesson E, Religa D, Eriksdotter M
J Am Med Dir Assoc 2021 Aug;22(8):1565-1573.e4

Lin C, Ekblad-Nordberg Å, Michaëlsson J, Götherström C, Hsu CC, Ye H, Johansson J, Rising A, Sundström E, Åkesson E
Cells 2021 Jul;10(7):

Oliver E, Alves-Lopes JP, Harteveld F, Mitchell RT, Åkesson E, Söder O, Stukenborg JB
BMC Biol 2021 Sep;19(1):212

Xu N, Xu T, Mirasol R, Holmberg L, Vincent PH, Li X, Falk A, Benedikz E, Rotstein E, Seiger Å, Åkesson E, Falci S, Sundström E
Neurotherapeutics 2021 Apr;18(2):1257-1272

Kurek M, Åkesson E, Yoshihara M, Oliver E, Cui Y, Becker M, Alves-Lopes JP, Bjarnason R, Romerius P, Sundin M, Norén Nyström U, Langenskiöld C, Vogt H, Henningsohn L, Petersen C, Söder O, Guo J, Mitchell RT, Jahnukainen K, Stukenborg JB
Cells 2021 Jan;10(2):

Lin C, Calzarossa C, Fernandez-Zafra T, Liu J, Li X, Ekblad-Nordberg Å, Vazquez-Juarez E, Codeluppi S, Holmberg L, Lindskog M, Uhlén P, Åkesson E
Stem Cell Res Ther 2020 Jul;11(1):320

Seiger Cronfalk B, Åkesson E, Nygren J, Nyström A, Strandell AM, Ruas J, von Euler M
Nurs Open 2020 Sep;7(5):1446-1452

Thunborg, C., Åkesson, E., Leavy, B., Håkansson, K., Sindi, S., Solomon, A., Levak, N. and Kivipelto, M. (2020), STRONGER 60+ Adaption of the multimodal FINGER model to prevent cognitive decline in a Swedish primary care rehabilitation unit: An effectiveness-implementation hybrid design. Alzheimer's Dement., 16: e042029. 

Wahman K, Nilsson E, Antepohl W, Samuelsson K, Åkesson E, Kuhlefelt Sandberg A, Augutis M
Spinal Cord Ser Cases 2019 ;5():105

Patomella AH, Guidetti S, Mälstam E, Eriksson C, Bergström A, Åkesson E, Kottorp A, Asaba E
BMJ Open 2019 Nov;9(11):e031984

Asp M, Giacomello S, Larsson L, Wu C, Fürth D, Qian X, Wärdell E, Custodio J, Reimegård J, Salmén F, Österholm C, Ståhl PL, Sundström E, Åkesson E, Bergmann O, Bienko M, Månsson-Broberg A, Nilsson M, Sylvén C, Lundeberg J
Cell 2019 Dec;179(7):1647-1660.e19

Dahlström M, Nordvall G, Sundström E, Åkesson E, Tegerstedt G, Eriksdotter M, Forsell P
Eur J Neurosci 2019 Nov;50(9):3487-3501

Vikan JK, Nilsson MI, Bushnik T, Deng W, Elessi K, Frost-Bareket Y, Kovrigina E, Shahwan J, Snekkevik H, Åkesson E, Stanghelle JK, Fugl-Meyer KS
J Rehabil Med 2019 May;51(5):361-368

Sancho P, Bartesaghi L, Miossec O, García-García F, Ramírez-Jiménez L, Siddell A, Åkesson E, Hedlund E, Laššuthová P, Pascual-Pascual SI, Sevilla T, Kennerson M, Lupo V, Chrast R, Espinós C
Hum Mol Genet 2019 May;28(10):1629-1644

Albalushi H, Sahlin L, Åkesson E, Kurek M, Kjartansdóttir KR, Lindh R, Söder O, Rotstein E, Hovatta O, Stukenborg JB
Endocrinology 2019 Jan;160(1):133-142

Hoeber J, König N, Trolle C, Lekholm E, Zhou C, Pankratova S, et al
Stem Cells Dev 2017 07;26(14):1065-1077

Joseph C, Andersson N, Bjelak S, Giesecke K, Hultling C, Nilsson Wikmar L, et al
J Rehabil Med 2017 May;49(5):431-436

Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, et al
Cell Transplant 2015 ;24(9):1799-812

Emgård M, Piao J, Aineskog H, Liu J, Calzarossa C, Odeberg J, et al
Exp Neurol 2014 Mar;253():138-45

Liu J, Hjorth E, Zhu M, Calzarossa C, Samuelsson EB, Schultzberg M, et al
J Cell Mol Med 2013 Nov;17(11):1434-43

Liu J, Götherström C, Forsberg M, Samuelsson EB, Wu J, Calzarossa C, et al
Stem Cell Res 2013 May;10(3):325-37

Wallman L, Åkesson E, Ceric D, Andersson PH, Day K, Hovatta O, et al
Lab Chip 2011 Oct;11(19):3241-8

Akesson E, Wolmer-Solberg N, Cederarv M, Falci S, Odeberg J
Stem Cell Res 2009 Jan;2(1):56-67

Akesson E, Sandelin M, Kanaykina N, Aldskogius H, Kozlova EN
Cell Transplant 2008 ;17(10-11):1115-23

Akesson E, Piao JH, Samuelsson EB, Holmberg L, Kjaeldgaard A, Falci S, et al
Physiol Behav 2007 Sep;92(1-2):60-6

Odeberg J, Piao JH, Samuelsson EB, Falci S, Akesson E
J Neuroimmunol 2005 Apr;161(1-2):1-11

Akesson E, Holmberg L, Jönhagen ME, Kjaeldgaard A, Falci S, Sundström E, et al
Exp Neurol 2001 Aug;170(2):305-16

Akesson E, Markling L, Kjaeldgaard A, Falci S, Ringdén O
J Neuroimmunol 2000 Nov;111(1-2):210-4

Akesson E, Kjaeldgaard A, Seiger A
Exp Neurol 1998 Jan;149(1):262-76

Falci S, Holtz A, Akesson E, Azizi M, Ertzgaard P, Hultling C, et al
J Neurotrauma 1997 Nov;14(11):875-84

Dissertations

Tingting Xu, 2022, Neural stem cell therapy and inflammation status of post-traumatic syringomyelia,

Chenhong Lin, 2021, Human spinal cord models for development of spinal cord injury repair strategies,

Halima Albalushi, 2018, In vitro models aiming for fertility preservation,

Ning Xu, 2015, Assesment of rat spinal cord injury models, 

Jia Liu, 2013, Host responses to human neural cell therapy in spinal cord injury,

Junghua Piao, 2007, Human neural precursor cells in spinal cord repair,