Pia Dosenovic team
Studies B cells for the development of new vaccines.
Research focus
B cell responses are a critical component for the protection against infections provided by vaccines. The activation of B cells is however highly regulated, to make sure the body does not mount immune responses to self-antigens, or develop un-controllable cell division, which could lead to cancer.
To generate vaccines that elicit protective and long-lasting immune responses against pathogens such as HIV-1, influenza and other emerging viruses, we use genetically modified mouse models with B cells expressing human antibodies that enable us to define the trajectory and quality of antigen-specific B cells after immunization.
We are also testing novel approaches for vaccine design such as using anti-idiotypic antibodies to stimulate a pathogen-specific B cell response.
Collectively, our research aims to study B cell responses on the molecular and cellular levels to provide information on B cell regulation that can help develop new vaccines against HIV-1 as well as other genetically variable- and emerging pathogens.
Members
Pia Dosenovic
Principal ResearcherSof铆a Garc铆a Hern谩ndez
Research assistantManon Termote
Phd StudentErik Hyllner
Phd StudentLaura Eiben
PhD studentSelected publications
Dosenovic P, Pettersson AK, Wall A, Thientosapol ES, Feng J, Weidle C, et al
J. Exp. Med. 2019 Oct;216(10):2316-2330
Dosenovic P, Kara EE, Pettersson AK, McGuire AT, Gray M, Hartweger H, et al
Proc. Natl. Acad. Sci. U.S.A. 2018 05;115(18):4743-4748
Escolano A, Dosenovic P, Nussenzweig MC
J. Exp. Med. 2017 01;214(1):3-16
Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, et al
Immunity 2016 09;45(3):483-496
Escolano A, Steichen JM, Dosenovic P, Kulp DW, Golijanin J, Sok D, et al
Cell 2016 Sep;166(6):1445-1458.e12
McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, et al
Nat Commun 2016 Feb;7():10618
Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, et al
Cell 2015 Jun;161(7):1505-15
Klein F, Mouquet H, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC
Science 2013 Sep;341(6151):1199-204
Dosenovic P, Soldemo M, Scholz JL, O'Dell S, Grasset EK, Pelletier N, et al
J. Immunol. 2012 Jun;188(12):6018-26
Dosenovic P, Chakrabarti B, Soldemo M, Douagi I, Forsell MN, Li Y, et al
J. Immunol. 2009 Sep;183(5):3373-82
Funding
Current funding:
- 探花精选
- The Swedish Research Council (VR)
- The European Research Council (ERC starting grant 2019)
- Knut och Alice Wallenberg Foundation (Wallenberg Academy Fellow)
Previous funding:
- K99 Pathway to Independence Award (NIH)
- The Swedish Research Council (VR)
- 探花精选