Research group Aleksandra Antovic
The reserch group conducts clinical research primarily on systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) and ANCA associated vasculitis (AAV). The group consists of approximately 20 persons including clinical researchers, postdocs, doctoral students, students, research nurses and a research patient partner.
SLE/APS/Vasculitis group
Main research focus is clinical studies, which are often performed as translational projects in collaboration with molecular immunologists, geneticists, epidemiologists, but also patients' perceptions of symptoms and educational needs are addressed.
SLE
Since the mid-90s, we have characterized and collected samples from large cohorts of very well-characterized patients and matched controls that we follow longitudinally with careful cross-sectional studies approximately every 10 years.
- We have identified four autoantibody defined sub-groups among SLE patients. We are now performing further studies on how these sub-groups differ regarding symptoms, type of inflammation, and genetics.
- Studies on lupus nephritis including identification of biomarkers, histopathological studies and analysis of immune cell alterations following immunosuppressive and biologic therapy on renal SLE.
- Cardiac Magnetic Resonance studies (CMRI) to investigate microvascular function in the myocardium of SLE patients with and without chest symptoms.
- Autoantibody specificities in general and in circulating Immune complexes, collaboration with prof Johan R枚nnelid.
- MS proteomic study to further characterize the four SLE subgroups.
- We collaborate internationally in studies of the genetics of SLE.
- Molecular inflammatory process in SLE target organs: skin and kidneys.
APS
We have collected samples from patients with APS since 2008. We investigate risk factors for recurring thromboses and pregnancy morbidities. We also focus on the coagulation and complement systems. In APS. Another focus is on the contribution of antiphospholipid antibodies to myocardial infarctions in the general population.
AAV
Since 2008, we have characterized and collected samples from large cohorts (n=350) of well-characterized patients with AAV from the rheumatology and nephrology departements. Longitudinal follow-up has been performed in patients with active disease for up to 10 years (n=100). We perform clinical studies, experimental studies and participate in national and international studies on AAV genetics. Additionally, we are studying patients' perception of educational needs and support using questionnaires and interviews.
Group members
- Professor
- Assistant professor
- , Assistant professor
- , MD PhD
- MD PhD
- RN PhD
- MD PhD
- Post Doc: MD PhD
- , Post doc, MD, PhD
- , MD, PhD student
- , PhD student
- PhD student
- PhD student,
- PhD student
- , PhD student
- PhD student
- , PhD student
- , PhD student
- Visiting professor
- Sonia M枚ller, research nurse
- Hans Kling, research nurse
- Karin Sporre, research patient partner
Pre-PhD student:
- Enrico Fuzzi
Cooperations
We are part of the Swedish SLE network,
SLEuro and the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) group, Christian Lood University of Washington, Seattle USA, David Pisetsky, Duke University USA, Timothy Niewolds, University of Special Surgery USA.
Research support
- Swedish Research Council
- Swedish Heart-Lung foundation
- Swedish Society of Medicine and Ingegerd Johansson鈥檚 donation, Stockholm City council
- King Gustaf V鈥檚 80-year foundation
- Swedish Rheumatism Association
- 探花精选鈥檚 foundations
Selected publications
Antovic A, Bruchfeld A, Ekland J, L枚vstr枚m B, Hugelius A, B枚rjesson O, Knight A, Gunnarsson I
Scand J Rheumatol 2022 Sep;():1-6
Antovic A, Mobarrez F, Manojlovic M, Soutari N, De Porta Baggemar V, Nordin A, Bruchfeld A, Vojinovic J, Gunnarsson I
J Rheumatol 2020 May;47(5):714-721
Brolin S, Welin E, L枚vstr枚m B, Bruchfeld A, Gunnarsson I, Pettersson S
Rheumatol Adv Pract 2022 ;6(2):rkac062
Diaz-Gallo LM, Oke V, Lundstr枚m E, Elvin K, Ling Wu Y, Eketj盲ll S, Zickert A, Gustafsson JT, J枚nsen A, Leonard D, Birmingham DJ, Nordmark G, Bengtsson AA, R枚nnblom L, Gunnarsson I, Yu CY, Padyukov L, Svenungsson E
ACR Open Rheumatol 2022 Jan;4(1):27-39
Elbagir S, Grosso G, Mohammed NA, Elshafie AI, Elagib EM, Zickert A, Manivel VA, Pertsinidou E, Nur MAM, Gunnarsson I, R枚nnelid J, Svenungsson E
Lupus 2021 Jul;30(8):1289-1299
Faustini F, Dunn N, Kharlamova N, Ryner M, Bruchfeld A, Malmstr枚m V, Fogdell-Hahn A, Gunnarsson I
Arthritis Res Ther 2021 Aug;23(1):211
Faustini F, Sippl N, St氓lesen R, Chemin K, Dunn N, Fogdell-Hahn A, Gunnarsson I, Malmstr枚m V
Front Immunol 2022 ;13():826152
H盲yry A, Faustini F, Zickert A, Larsson A, Niewold TB, Svenungsson E, Oke V, Gunnarsson I
Lupus Sci Med 2022 Sep;9(1):
Jonasdottir AD, Antovic A, Qureshi AR, Nordin A, Malmstr枚m V, Gunnarsson I, Bruchfeld A
Scand J Rheumatol 2022 Apr;():1-9
Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hru拧kov谩 Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesa艡 V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG
N Engl J Med 2012 Jul;367(3):214-23
Svenungsson E, Antovic A
J Intern Med 2020 Apr;287(4):349-372
Oke V, Gunnarsson I, Dorschner J, Eketj盲ll S, Zickert A, Niewold TB, Svenungsson E
Arthritis Res Ther 2019 Apr;21(1):107
Grosso G, Sippl N, Kjellstr枚m B, Amara K, de Faire U, Elvin K, Lindahl B, N盲sman P, Ryd茅n L, Norhammar A, Svenungsson E
Ann Intern Med 2019 Feb;170(4):277-280
Zickert A, Sundelin B, Svenungsson E, Gunnarsson I
Lupus Sci Med 2014 ;1(1):e000018