̽ѡ

Vasco Sousa

Vasco Sousa

Senior Forskningsinfrastrukturspecialist
E-postadress: vasco.sousa@ki.se
Telefon: +46852483254
ö: BioClinicum J5:20, Akademiska stråket 1, Karolinska universitetssjukh, 17164 Solna
Postadress: K8 Klinisk neurovetenskap, K8 Imaging CF ARG, 171 77 Stockholm
Del av:

Om mig

  • Jag är enhetschef/chef för Autoradiography Core Facility. Vårt uppdrag är att hjälpa till att utveckla nya läkemedel och PET radioligander med klinisk betydelse. Tillsammans med de andra anläggningarna i vår division och Centre for Imaging Research (CIR) utgör vi en internationellt erkänd spjutspetsforskningshub.
    Jag har arbetat på ̽ѡ sedan slutet av 2010. Jag har över 7 års erfarenhet som senior lab manager, och i 5 år som koordinator för det strategiska forskningsområdet neurovetenskap (StratNeuro). Mellan 2011 och 2014 var jag postdoktor.

    Education:
    2010 - PhD in Neuroscience from the Faculty of Medicine, University of Lisbon (PT).
    2005 - BSc Hon degree in Neuroscience from the University of Glasgow (UK).

    Grants:
    2018- Core facility anslag (SLL/KI) (co-applicant in the core facility grant that was awarded 2019-2021: #SLL20180816)
    2013- Grant from the Rut and Arvid Wolff Memorial Foundation
    2012- Postdoctoral stipend from Wenner-Gren Stiftelserna
    2010- Research network grant from the European Cooperation in Science and Technology (COST)
    2006 - PhD grant from the Portuguese Foundation for Science and Technology (FCT)

Forskningsbeskrivning

  • Autoradiography Core Facility (ARG CF) är en central resurs inom Imaging Core Facilities-divisionen vid Institutionen för klinisk neurovetenskap på ̽ѡ. Vår anläggning är fullt utrustad och bemannad för att stödja studier som involverar radioligandbindning och autoradiografi. Vi erbjuder omfattande tjänster, konsultation, samt utbildning och tillgång till utrustning för att möjliggöra att våra användare kan utföra sin forskning.
    Vår anläggning specialiserar sig på metoder som är avgörande inom farmakologi och forskning om cellulära signaler, samt inom utvecklingen och valideringen av radioligander för positronemissionstomografi (PET) avbildning.

    Radioligandbindning används för att undersöka bindningsegenskaperna hos en radioaktivt märkt substans (radioligand) till ett specifikt mål, såsom en receptor eller enzym.
    Autoradiografi används för att visualisera lokaliseringen och distributionen av en radioligand i ett prov, vilket möjliggör bedömning av dess målspecifikhet.

Undervisning

  • @ Department of Clinical Neuroscience, ̽ѡ (Stockholm, SE),
    • 2011-present: course co-organizer, teaching and examiner in the doctoral course “Neuropsychopharmacology” (course #2526).
    • 2017: Taught “Behavioral tests for measuring depression” in the doctoral course “Making the most of Behavioral Methods in Rat and Mouse (course #CFK 2946).
    • 2011-2013: Taught “pre-clinical models of major depressive disorder” on the “Frontiers in Translational Medicine” course within the KI MSc. program.
    • Doctoral students advised
    . 2014: Tiberiu Loredan Stan (as co-supervisor)
    • Master’s students advised
    . 2013-2014 co-supervised 3 students from University of Milan, through the Erasmus program, 6 month projects.

    @ Faculty of Medicine &
  • Faculty of Science, University of Lisbon (Lisbon, PT)
    • 2008-2010: Taught “cannabinoid pharmacology” on the Biochemistry Msc program (Faculty of Science) and the Neuroscience Msc program (Faculty of Medicine).
    • 2007-2010: Taught "measuring neurotransmitter release” on the practical course “Neuroscience”, which was part of the 3rd year Medical degree program at the Faculty of Medicine.

Artiklar

  • Article: BRAIN. 2024;:awae373
    Akkuratov EE; Sorrell F; Picton L; Sousa VC; Paucar M; Jans D; Svensson L-B; Lindskog M; Fritz N; Liebmann T; Sillar KT; Rosewich H; Svenningsson P; Brismar H; Miles GB; Aperia A
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;23(1):410
    Veenit V; Zhang X; Ambrosini A; Sousa V; Svenningsson P
  • Article: MOLECULAR PSYCHIATRY. 2021;26(7):3253-3265
    Sousa VC; Mantas I; Stroth N; Hager T; Pereira M; Jiang H; Jabre S; Paslawski W; Stiedl O; Svenningsson P
  • Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2020;374(1):126-133
    Becanovic K; de Donno MV; Sousa VC; Tedroff J; Svenningsson P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(28):7906-7911
    Bigio B; Mathe AA; Sousa VC; Zelli D; Svenningsson P; McEwen BS; Nasca C
  • Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(10):1714-1722
    Stan TL; Sousa VC; Zhang X; Ono M; Svenningsson P
  • Article: NEUROBIOLOGY OF AGING. 2014;35(7):1680-1685
    Sousa VC; Vital J; Costenla AR; Batalha VL; Sebastiao AM; Ribeiro JA; Lopes LV
  • Article: TRANSLATIONAL PSYCHIATRY. 2014;4(6):e395
    Stan TL; Alvarsson A; Branzell N; Sousa VC; Svenningsson P
  • Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2014;121:82-87
    Schijven D; Sousa VC; Roelofs J; Olivier B; Olivier JDA
  • Article: PURINERGIC SIGNALLING. 2014;10(2):251-267
    Assaife-Lopes N; Sousa VC; Pereira DB; Ribeiro JA; Sebastiao AM
  • Journal article: JOURNAL OF CAFFEINE AND ADENOSINE RESEARCH. 2013;3(2):85-95
    Sousa VC; Ribeiro JA; Sebastião AM
  • Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(9):1823-1836
    Diogenes MJ; Costenla AR; Lopes LV; Jeronimo-Santos A; Sousa VC; Fontinha BM; Ribeiro JA; Sebastiao AM
  • Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(2):472-487
    Sousa VC; Assaife-Lopes N; Ribeiro JA; Pratt JA; Brett RR; Sebastiao AM

Alla övriga publikationer

  • Conference publication: GASTROENTEROLOGY. 2024;166(5):s-605
    MacKay J; Jucaite A; Cselényi Z; Johnström P; Dahl K; Schou M; Stenkrona P; Sousa VC; Högnäsbacka A; Gonzalez MAC; Giffen P; Bouma G; Nys J; Brülls M; Duncan M; Larsson J; Lundahl A; Les KA; Bergare J; Elmore CS; Kiraga J; Blé F-X; Fowler A; Belvisi MG; Marks DJ
  • Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2024;18(Supplement_1):i263
    MacKay J; Jucaite A; Cselényi Z; Johnström P; Dahl K; Schou M; Stenkrona P; Sousa V; Gonzalez MC; Giffen P; Bouma G; Nys J; Brülls M; Duncan M; Larsson J; Lundahl A; Les K; Bergare J; Elmore C; Kiraga J; Blé FX; Fowler A; Belvisi M; Marks D
  • Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2024;18:I260
    MacKay J; Jucaite A; Cselenyi Z; Johnstrom P; Dahl K; Schou M; Stenkrona P; Sousa V; Gonzalez MC; Giffen P; Bouma G; Nys J; Brulls M; Duncan M; Larsson J; Lundahl A; Les K; Bergare J; Elmore C; Kiraga J; Ble FX; Fowler A; Belvisi M; Marks D
  • Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108437
    Högnäsbacka A; Gonzalez MAC; Cselenyi Z; Jucaite A; Dahl K; Johnstrom P; Sousa V; Bergare J; Nys J; Gardiner P; Brülls M; Gehrmann U; Ble F-X; Les K; Elmore C; Mackay J; Halldin C; Marks D; Schou M
  • Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023;50(SUPPL 1):S254
    Schou M; Pike A; Jucaite A; Johnstrom P; Gonzalez MC; Hognasbacka A; Dahl K; Ghosh A; Johannes J; Staniszewska A; Leo E; Hamerlik P; Davies B; Cosulich S; Swales J; Lawrence R; Squatrito M; Mueller N; Sousa V; Bartek J; Stragliotto G; Stenkrona P; Farde L; Halldin C; Cselenyi Z
  • Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S31-S32
    Hognasbacka A; Gonzalez MAC; Cselenyi Z; Jucaite A; Dahl K; Johnstrom P; Sousa V; Bergare J; Nys J; Gardiner P; Brulls M; Gehrmann U; Ble F-X; Les K; Elmore C; Mackay J; Halldin C; Marks D; Schou M
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26:S371-S372
    Mathe AA; Nikosjkov A; Sousa V; Weide-Fischer C; Lennartsson A; Wegener G; Svenningsson P
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2015;40:S152-S153
    Mathe A; Nikosjkov A; Sousa V; Weide-Fischer C; Lennartsson A; Wegener G; Svenningsson P
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25:S97-S98
    Pereira M; Sousa V; Svenningsson P
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:S259
    Pereira M; Sousa VC; Stan T; Fischer CW; Wegener G; Olivier JDA; Mathe AA; Svenningsson P
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2013;38:S553-S554
    Mathe A; Sousa V; Fischer CW; Stan TL; Wegener G; Lennartsson A; Svenningsson P
  • Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:155
    Stan TL; Sousa V; Zhang X; Alvarsson A; Ono M; Svenningssson P
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S408-S409
    Sousa VC; Zhang X; Qi H; El Yacoubi M; Vaugeois JM; Svenningsson P

Forskningsbidrag

  • Autoradiography Core facility
    Core facility anslag (SLL/KI)
    1 January 2019 - 31 December 2021
  • “Mechanisms of HPA axis and circadian rhythm dysregulation, with implications for sleep disorders and major depression”
    Rut and Arvid Wolff Memorial Foundation
    18 November 2013 - 30 November 2014
  • “Investigation of gene-environment interactions and biochemical mechanisms in the onset and development of major depression”
    Wenner-Gren Stiftelserna
    1 January 2012 - 31 March 2014
  • short term grant for collaborative work at Strathclyde University
    European Cooperation in Science and Technology (COST)
    1 April 2010 - 30 June 2010
  • “Cross-talk mechanisms between adenosine and endocannabinoids”
    The Portuguese Foundation for Science and Technology (FCT)
    1 March 2006 - 31 March 2010

ԲäԾԲ

  • Senior Forskningsinfrastrukturspecialist, Klinisk neurovetenskap, ̽ѡ, 2024-
  • Co-ordinator for StratNeuro, Karolinska Institute, 2019-2023
  • Post-doctoral researcher, Neuropsychopharmacology, Department of Clinical Neuroscience, Karolinska Institute, 2011-2014
  • Visiting Researcher, Neuropsychopharmacology, Department of Clinical Neuroscience, Karolinska Institute, 2010-2011

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