̽»¨¾«Ñ¡

Yitian Zhou

Yitian Zhou

Postdoctoral Researcher
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm

Research

  • My research focuses on characterizing the variation on human pharmacogenome, with particular interest in CYP genes, drug transporters and HLA genes. I studied distribution of clinically relevant variant alleles across different populations and ethnicities to infer their consequence on drug response phenotype. By leveraging AI/ML-based computational tools, I developed methods to interpret functional impact of pharmacogenetic variants, including rare variants as the majority identified from next-generation sequencing projects.

Teaching

  • Pharmacogenomics sessions for the , KI

Articles

  • Article: JOURNAL OF GENETICS AND GENOMICS. 2024;51(11):1228-1236
    Gonzalez-Padilla D; Camara MD; Lauschke VM; Zhou Y
  • Article: PHARMACOGENOMICS JOURNAL. 2024;24(3):17
    Zhou Y; Pirmann S; Lauschke VM
  • Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(5):e01390-e01323
    Camara MD; Zhou Y; Dara A; Tekete MM; de Sousa TN; Sissoko S; Dembele L; Ouologuem N; Togo AH; Alhousseini ML; Fofana B; Sagara I; Djimde AA; Gil PJ; Lauschke VM
  • Article: HUMAN GENOMICS. 2024;18(1):40
    Camara MD; Zhou Y; De Sousa TN; Gil JP; Djimde AA; Lauschke VM
  • Article: NPJ GENOMIC MEDICINE. 2023;8(1):24
    Tremmel R; Zhou Y; Schwab M; Lauschke VM
  • Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2023;113(3):712-723
    Khor CC; Winter S; Sutiman N; Muerdter TE; Chen S; Lim JSL; Li Z; Li J; Sim KS; Ganchev B; Eccles D; Eccles B; Tapper W; Zgheib NKK; Tfayli A; Ng RCH; Yap YS; Lim E; Wong M; Wong NS; Ang PCS; Dent R; Tremmel R; Klein K; Schaeffeler E; Zhou Y; Lauschke VMM; Eichelbaum M; Schwab M; Brauch HBB; Chowbay B; Schroth W
  • Article: HUMAN GENOMICS. 2023;17(1):15
    Zhou Y; Nevosadova L; Eliasson E; Lauschke VMM
  • Article: THE LANCET. 2023;401(10374):347-356
    Swen JJ; van der Wouden CH; Manson LEN; Abdullah-Koolmees H; Blagec K; Blagus T; Boehringer S; Cambon-Thomsen A; Cecchin E; Cheung K-C; Deneer VHM; Dupui M; Ingelman-Sundberg M; Jonsson S; Joefield-Roka C; Just KS; Karlsson MO; Konta L; Koopmann R; Kriek M; Lehr T; Mitropoulou C; Rial-Sebbag E; Rollinson V; Roncato R; Samwald M; Schaeffeler E; Skokou M; Schwab M; Steinberger D; Stingl JC; Tremmel R; Turner RM; van Rhenen MH; Fajardo CLD; Dolzan V; Patrinos GP; Pirmohamed M; Sunder-Plassmann G; Toffoli G; Guchelaar H-J
  • Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2023;280:237-260
    Zhou Y; Lauschke VM
  • Article: ISCIENCE. 2022;25(12):105506
    Xun D; Chen D; Zhou Y; Lauschke VM; Wang R; Wang Y
  • Article: PHARMACOGENOMICS JOURNAL. 2022;22(5-6):284-293
    Zhou Y; Lauschke VM
  • Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;154:113644
    De Mattia E; Silvestri M; Polesel J; Ecca F; Mezzalira S; Scarabel L; Zhou Y; Roncato R; Lauschke VM; Calza S; Spina M; Puglisi F; Toffoli G; Cecchin E
  • Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091
    Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
  • Article: PHARMACEUTICS. 2022;14(5):944
    Dagli-Hernandez C; Borges JB; Rodrigues Marcal EDS; Costa de Freitas RC; Mori AA; Goncalves RM; Faludi AA; de Oliveira VF; Ferreira GM; Bastos GM; Zhou Y; Lauschke VM; Cerda A; Hirata MH; Crespo Hirata RD
  • Article: PHARMACOLOGICAL RESEARCH. 2022;176:106087
    Siamoglou S; Koromina M; Hishinuma E; Yamazaki S; Tsermpini E-E; Kordou Z; Fukunaga K; Chantratita W; Zhou Y; Lauschke VM; Mushiroda T; Hiratsuka M; Patrinos GP
  • Article: GENETICS IN MEDICINE. 2022;24(1):157-169
    Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
  • Article: SCIENCE ADVANCES. 2021;7(36):eabi6856
    Zhou Y; Arribas GH; Turku A; Juergenson T; Mkrtchian S; Krebs K; Wang Y; Svobodova B; Milani L; Schulte G; Korabecny J; Gastaldello S; Lauschke VM
  • Journal article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2021;77(8):1095-1111
    Wang T; Zhou Y; Cao G
  • Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(7):e0027521-10.1128/aac.00221
    Pernaute-Lau L; Adegnika AA; Zhou Y; Zinsou JF; Gil JP; Krishna S; Kremsner PG; Lauschke VM; Velavan TP
  • Journal article: PHARMACOGENOMICS RESEARCH AND PERSONALIZED MEDICINE. 2021;0(0):0
    Zhou Y; Lauschke VM
  • Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;109(1):160-174
    Zhou Y; Krebs K; Milani L; Lauschke VM
  • Article: BRITISH JOURNAL OF CANCER. 2020;123(12):1782-1789
    Zhou Y; Dagli Hernandez C; Lauschke VM
  • Article: HUMAN GENETICS. 2020;139(5):623-646
    Xiao Q; Zhou Y; Lauschke VM
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2020;146(9):2475-2487
    Xiao Q; Zhou Y; Winter S; Buettner F; Schaeffeler E; Schwab M; Lauschke VM
  • Article: MOLECULAR PHARMACEUTICS. 2020;17(4):1170-1181
    Russell LE; Zhou Y; Lauschke VM; Kim RB
  • Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:52-58
    Zhou Y; Lauschke VM
  • Article: PHARMACOGENOMICS. 2019;20(15):1085-1092
    Lauschke VM; Nordling A; Zhou Y; Fontalva S; Barragan I; Ingelman-Sundberg M
  • Article: PHARMACOGENOMICS JOURNAL. 2019;19(2):115-126
    Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke VM
  • Article: JOURNAL OF LIPID RESEARCH. 2018;59(10):1987-2000
    Zhou Y; Magi R; Milani L; Lauschke VM
  • Article: JOURNAL OF MEDICAL GENETICS. 2018;55(9):617-627
    Zhou Y; Lauschke VM
  • Article: TOXICOLOGICAL SCIENCES. 2018;163(2):655-665
    Vorrink SU; Zhou Y; Ingelman-Sundberg M; Lauschke VM
  • Article: HUMAN GENOMICS. 2018;12(1):26
    Ingelman-Sundberg M; Mkrtchian S; Zhou Y; Lauschke VM
  • Journal article: PROCEEDINGS FOR ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY. 2018;WCP2018(0):po4-9-16
    Vorrink SU; Zhou Y; Ingelman-Sundberg M; Lauschke VM
  • Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2017;102(4):688-700
    Zhou Y; Ingelman-Sundberg M; Lauschke VM
  • Article: SCIENTIFIC REPORTS. 2014;4:6978
    Zhou Y; Zhou P; Xin Y; Wang J; Zhu Z; Hu J; Wei S; Ma H
  • Article: ACS APPLIED MATERIALS & INTERFACES. 2014;6(11):8313-8319
    Lv B; Zhou Y; Cha W; Wu Y; Hu J; Li L; Chi L; Ma H
  • Show more

All other publications

  • Review: EXPERT REVIEW OF CLINICAL PHARMACOLOGY. 2024;17(3):213-223
    Zhou Y; Lauschke VM
  • Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2024;64:33-51
    Lauschke VM; Zhou Y; Ingelman-Sundberg M
  • Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2023
    Tremmel R; Pirmann S; Zhou Y; Lauschke VM
  • Conference publication: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2023;396:S52
    Tremmel R; Zhou Y; Nevosadova L; Laarif S; Eliasson E; Lauschke VM
  • Conference publication: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2023;396:S52
    Klein K; Nies AT; Haag M; Hofmann U; Artursson P; Handin N; Burk O; Tremmel R; Winter S; Zhou Y; Schaeffeler E; Zanger UM; Lauschke VM; Schwab M
  • Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2022;10(23):1293-0
    Zhou Y; Lauschke VM
  • Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2022;131(6):452-464
    Zhou Y; Koutsilieri S; Eliasson E; Lauschke VM
  • Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2022;43(10):852-865
    Zhou Y; Tremmel R; Schaeffeler E; Schwab M; Lauschke VM
  • Conference publication: 2022;:30-35
    Sun Y; Zhou Y
  • Review: HUMAN GENETICS. 2022;141(6):1113-1136
    Zhou Y; Lauschke VM
  • Review: PHARMACOLOGICAL REPORTS. 2022;74(1):47-66
    Dagli-Hernandez C; Zhou Y; Lauschke VM; Genvigir FDV; Hirata TDC; Hirata MH; Hirata RDC
  • Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206
    Youhanna S; Kemas AM; Preiss L; Zhou Y; Shen JX; Cakal SD; Paqualini FS; Goparaju SK; Shafagh RZ; Lind JU; Sellgren CM; Lauschke VM
  • Review: ENDOCRINE, METABOLIC AND IMMUNE DISORDERS - DRUG TARGETS. 2022;22(13):1263-1275
    Genvigir FDV; Dagli-Hernandez C; Hirata TDC; Zhou Y; Lauschke VM; Hirata MH; Hirata RDC
  • Book chapter: COMPREHENSIVE PHARMACOLOGY. 2022;p. 53-83
    Zhou Y; Lauschke VM
  • Preprint: BIORXIV. 2021
    Xun D; Chen D; Zhou Y; Lauschke V; Wang R; Wang Y
  • Review: MOLECULAR DIAGNOSIS AND THERAPY. 2021;25(6):735-755
    Crespo Hirata TD; Dagli-Hernandez C; Dalla Vecchia Genvigir F; Lauschke VM; Zhou Y; Hirata MH; Crespo Hirata RD
  • Thesis / dissertation: 2021
    Zhou, Yitian
  • Review: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;110(3):626-636
    Zhou Y; Lauschke VM
  • Review: DRUG METABOLISM REVIEWS. 2021;53(2):253-278
    Russell LE; Zhou Y; Almousa AA; Sodhi JK; Nwabufo CK; Lauschke VM
  • Editorial comment: FRONTIERS IN GENETICS. 2021;12:736626
    Hiratsuka M; Zhou Y; Lauschke VM
  • Review: PHARMACOGENOMICS. 2020;21(18):1299-1310
    Xiao Q; Zhou Y; Lauschke VM
  • Review: PHARMACOLOGY AND THERAPEUTICS. 2019;197:122-152
    Lauschke VM; Zhou Y; Ingelman-Sundberg M
  • Review: FRONTIERS IN PHARMACOLOGY. 2019;10:1093
    Zhou Y; Shen JX; Lauschke VM
  • Review: FRONTIERS IN PHARMACOLOGY. 2018;9:1437
    Zhou Y; Fujikura K; Mkrtchian S; Lauschke VM
  • Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2018;123:5
    Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke V
  • Show more

Grants

  • Precision Medicine by personalized dosing of capecitabine and tamoxifen in breast cancer – advanced pharmacogene sequencing, phenotype markers and modeling of patient-unique genetic variants
    Cancerfonden

Employments

  • Postdoctoral Researcher, Department of Physiology and Pharmacology, ̽»¨¾«Ñ¡, 2023-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, ̽»¨¾«Ñ¡, 2021
  • Degree Of Master Of Medical Science 120 Credits, ̽»¨¾«Ñ¡, 2017

News from KI

Events from KI