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Yanbo Pan

Yanbo Pan

Senior Research Specialist
Visiting address: SciLifeLab, Tomtebodavägen 23A, 17121 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Lehtiö, 171 77 Stockholm
Part of:

Research

  • *Mass spectrometry (MS)-based quantitative proteomics and its clinical applications*
    Proteomics is a field aiming for systems-level analysis of proteins in an organism or system. This generates new knowledge in biology to discover clinical biomarkers and drug targets. With cutting-edge MS-based quantitative proteomics (label-based and label-free), we can decipher the molecular phenotypes of different patients at the protein level. The ultimate aim is to develop differential tests to be used as clinical evaluation tools.

    *Temporal spatial proteomics to improve understanding of protein level signaling in anti-cancer treatment*
    Protein localization and re-localization in the different compartments of cells is an essential control mechanism for cellular functions as well as intercellular communication in multicellular organisms. we are developing methods for protein subcellular localization analysis (/Molecular Cell 2019,
    Nature Reviews Methods Primers 2021, Nature Protocols 2022/) and trying to understand how proteins shuttle between different subcellular compartments in response to drug treatments and ultimately how this affects the drug sensitivity in cancer treatment.

    *Functional proteomics and proteogenomics for personalized medicine*
    Proteogenomics links DNA, RNA, and protein measurements into a central-dogma perspective and has the potential to improve our understanding of cancer biology. By using robust quantitative proteomics and proteogenomics to generate information about protein activity, protein complex formation, and genetic aberrant results in cancer cells and clinical tumors (/Oncogene 2019, Nature Cancer 2021/). we are generating new information to suggest novel biomarkers and drug combinations for improved cancer therapy.

Articles

  • Article: NATURE PROTOCOLS. 2022;17(8):1832-1867
    Arslan T; Pan Y; Mermelekas G; Vesterlund M; Orre LM; Lehtio J
  • Article: NATURE CANCER. 2021;2(11):1224-1242
    Lehtio J; Arslan T; Siavelis I; Pan Y; Socciarelli F; Berkovska O; Umer HM; Mermelekas G; Pirmoradian M; Jonsson M; Brunnstrom H; Brustugun OT; Purohit KP; Cunningham R; Asl HF; Isaksson S; Arbajian E; Aine M; Karlsson A; Kotevskaz M; Hansen CG; Haakensen VD; Helland A; Tamborero D; Johansson HJ; Branca RM; Planckz M; Staaf J; Orre LM
  • Article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):32
    Christopher JA; Stadler C; Martin CE; Morgenstern M; Pan Y; Betsinger CN; Rattray DG; Mahdessian D; Gingras A-C; Warscheid B; Lehtio J; Cristea IM; Foster LJ; Emili A; Lilley KS
  • Article: ONCOGENE. 2019;38(43):6881-6897
    Fotouhi O; Kjellin H; Juhlin CC; Pan Y; Vesterlund M; Ghaderi M; Yousef A; Andersson-Sand H; Kharaziha P; Caramuta S; Kjellman M; Zedenius J; Larsson C; Orre LM
  • Article: MOLECULAR CELL. 2019;73(1):166-182.e7
    Orre LM; Vesterlund M; Pan Y; Arslan T; Zhu Y; Woodbridge AF; Frings O; Fredlund E; Lehtio J
  • Article: CHEMICAL COMMUNICATIONS. 2016;52(40):6689-6692
    Zhang Y; Pan Y; Liu W; Zhou YJ; Wang K; Wang L; Sohail M; Ye M; Zou H; Zhao ZK
  • Article: ANALYTICAL CHEMISTRY. 2015;87(22):11353-11360
    Yao Y; Huang J; Cheng K; Pan Y; Qin H; Ye M; Zou H
  • Article: PROTEOMICS. 2015;15(21):3613-3616
    Pan Y; Mao J; Deng Z; Dong M; Bian Y; Ye M; Zou H
  • Article: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY. 2015;43(10):1452-1458
    Liu F-J; Ye M-L; Pan Y-B; Zou H-F
  • Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2014;406(25):6247-6256
    Pan Y; Cheng K; Mao J; Liu F; Liu J; Ye M; Zou H
  • Article: ANALYTICAL CHEMISTRY. 2014;86(14):6786-6791
    Liu F; Ye M; Pan Y; Zhang Y; Bian Y; Sun Z; Zhu J; Cheng K; Zou H
  • Article: CHINESE JOURNAL OF CHROMATOGRAPHY (SE PU). 2014;32(4):376-380
    Zheng H; Mao J; Pan Y; Liu Z; Liu Z; Ye M; Zou H
  • Article: ANALYTICAL CHEMISTRY. 2014;86(2):1170-1177
    Pan Y; Ye M; Zheng H; Cheng K; Sun Z; Liu F; Liu J; Wang K; Qin H; Zou H
  • Article: SCIENTIFIC REPORTS. 2013;3:3460
    Bian Y; Ye M; Wang C; Cheng K; Song C; Dong M; Pan Y; Qin H; Zou H
  • Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2013;52(35):9205-9209
    Pan Y; Ye M; Zhao L; Cheng K; Dong M; Song C; Qin H; Wang F; Zou H
  • Article: CHEMBIOCHEM. 2013;14(12):1438-1443
    Zhang Y; Pan Y; Yang W; Liu W; Zou H; Zhao ZK
  • Article: JOURNAL OF PROTEOME RESEARCH. 2012;11(9):4673-4681
    Dong M; Ye M; Cheng K; Song C; Pan Y; Wang C; Bian Y; Zou H
  • Article: CARBOHYDRATE RESEARCH. 2009;344(6):801-807
    Wang X-L; Huang Y; Zhu J; Pan Y-B; He R; Wang Y-Z
  • Article: CARBOHYDRATE POLYMERS. 2008;74(4):862-867
    Liu G-Y; Zhai Y-L; Wang X-L; Wang W-T; Pan Y-B; Dong X-T; Wang Y-Z

All other publications

  • Letter: NATURE METHODS. 2014;11(3):220-222
    Ye M; Pan Y; Cheng K; Zou H

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2026
  • Prenylation proteome profiling of childhood leukemia
    Dr Ã…ke Olsson Foundation
    1 January 2022 - 31 December 2022
  • Swedish Cancer Society
    1 July 2018 - 30 June 2021

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