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Yana Ruchiy

Yana Ruchiy

Phd Student
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm
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About me

  • I am a PhD student within the research group of Prof. Klas Blomgren, studying
    the effects of radiotherapy on tumour microenvironment in paediatric brain
    tumours.
    I have a Bachelor's Degree in Biological Sciences with Honours from
    Lancaster University, and a Master's Degree in Molecular Medicine from the
    Charité, Medical University of Berlin.

Research

  • During my PhD studies, my research is mainly focused on two projects:
    1. The effects of lithium on tumour progression in a mouse model of Group 3
    medulloblastoma.
    In the course of this project, I have created an in vivo model of Group 3
    medulloblastoma through an orthotopic injection of medulloblastoma cells. I
    then used this model to study the effects of lithium and irradiation on
    tumour growth and analysed it through whole-brain immunostaining and volume
    imaging techniques.
    2. Studies of inter- and intra- tumoural heterogeneity and tumour
    microenvironment in medulloblastoma.
    In the course of this project, I analysed single-cell datasets from Swedish
    medulloblastoma patients, comprising all four medulloblastoma subtypes. The
    main goal of this study was to look into the individual genomic landscapes of
    these tumours and the interactions between the tumour cells and their
    microenvironment, to provide a more detailed characterisation of
    different medulloblastoma subtypes and try to identify potential therapeutic
    targets.

Articles

  • Journal article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
    Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
  • Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1677
    Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
  • Article: EMBO MOLECULAR MEDICINE. 2021;13(10):e14123
    Uhlitz F; Bischoff P; Peidli S; Sieber A; Trinks A; Luethen M; Obermayer B; Blanc E; Ruchiy Y; Sell T; Mamlouk S; Arsie R; Wei T-T; Klotz-Noack K; Schwarz RF; Sawitzki B; Kamphues C; Beule D; Landthaler M; Sers C; Horst D; Bluethgen N; Morkel M

All other publications

  • Conference publication: NEURO-ONCOLOGY. 2023;25:i62
    Ruchiy Y; Tsea I; Verhoeven BM; Sinha I; Preka E; Olsen TK; Mei S; Blomgren K; Johnsen JI; Carlson L-M; Dyberg C; Baryawno N
  • Conference publication: BRAIN TUMOR RESEARCH AND TREATMENT. 2022;10(Suppl):s99
    Ruchiy Y; Zhao M; Rosen G; Swartling F; Blomgren K; Carlson L-M
  • Conference publication: CANCER RESEARCH. 2022;82(12)
    Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N

Grants

  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2023 - 31 December 2023
  • Barncancerfonden
    1 January 2022 - 31 December 2022

Employments

  • Phd Student, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2024-2025

Degrees and Education

  • Molecular Medicine MSc, Charité - University Medicine Berlin, 2020
  • Biological Sciences BSc, Lancaster University, 2016

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