探花精选

Xinsong Chen

Xinsong Chen

Research Specialist
Visiting address: CCK R8:04, 17176 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Hartman, 171 77 Stockholm

About me

  • A researcher with years of experience and verifiable achievements in oncology, experimental pathology, cell and molecular biology, tumor biology, and virology from leading laboratories at 探花精选 (KI). Currently, I am working as a research specialist (senior scientist) at the Oncology-Pathology department of KI and Karolinska University Hospital, with the main focus on studying breast cancer biomarkers, establishing novel diagnostic approaches for improving patient segmentation, precision oncology using various sequencing base tools, and developing various cancer patient biopsies-based IVD assays for better prediction of treatment response and facilitate drug development. I also participated in the preparation and management of several clinical trial translational studies.

Research

  • My primary research interests are studying intra-tumoral heterogeneity using multi-omics datasets and multi-modality approaches, integration of computational pathology image analysis approaches with spatial transcriptomic and proteomic analysis, precision medicine & diagnostics for breast cancer patients, as well as translational medicine studies from clinical trials or patient cohorts.

     

Teaching

  • Course supervisor and thesis examiner for eight bachelor's and master鈥檚 students at the Biomedicine program KI.

    Co-supervisor for 3 Ph.D. students at Dept. Oncology-Pathology, KI.

    Lecturing undergraduate to Ph.D. level courses at KI, including Basic Tumor Biology, Basic Tumor Histopathology, Molecular Pathology, Molecular Medicine - Oncology, etc.

Articles

  • Journal article: NATURE COMMUNICATIONS. 2025;16(1):2801
    Shafighi S; Geras A; Jurzysta B; Sahaf Naeini A; Filipiuk I; R膮czkowska A; Toosi H; Koperski 艁; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
  • Article: NATURE COMMUNICATIONS. 2024;15(1):9343
    Shafighi S; Geras A; Jurzysta B; Sahaf Naeini A; Filipiuk I; Raczkowska A; Toosi H; Koperski L; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
  • Article: GENOME BIOLOGY. 2024;25(1):214
    Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
    Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
  • Article: BIOINFORMATICS. 2024;40(5):btae284
    Kurt S; Chen M; Toosi H; Chen X; Engblom C; Mold J; Hartman J; Lagergren J
  • Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107
    Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
  • Article: BREAST CANCER RESEARCH. 2024;26(1):24
    Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
  • Article: SCIENCE. 2023;382(6675):1137
    Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
  • Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537
    Collodet C; Blust K; Gkouma S; Stahl E; Chen X; Hartman J; Hedhammar M
  • Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088
    Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL
  • Article: NATURE COMMUNICATIONS. 2023;14(1):982
    Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
    Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
  • Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592
    Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354
    Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
  • Article: BREAST CANCER RESEARCH. 2020;22(1):80
    Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
  • Article: CANCER RESEARCH. 2020;80(7):1538-1550
    Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
    Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
  • Article: ONCOGENE. 2016;35(29):3807-3816
    Chen X; Kamranvar SA; Masucci MG
  • Article: ONCOGENE. 2013;32(49):5522-5530
    Kamranvar SA; Chen X; Masucci MG
  • Article: PLOS PATHOGENS. 2013;9(10):e1003664
    Gastaldello S; Chen X; Callegari S; Masucci MG

All other publications

  • Conference publication: CANCER RESEARCH. 2024;84(9):po4-01-05-po4-01-05
    Ronnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
  • Conference publication: VIRCHOWS ARCHIV. 2024;485:S206
    Steen S; Karlsson E; Chen X; Acs B; Hartman J
  • Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859
    Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
  • Meeting abstract: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02
    Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
  • Preprint: BIORXIV. 2022
    Collodet C; Blust K; Gkouma S; St氓hl E; Chen X; Hartman J; Hedhammar M
  • Preprint: BIORXIV. 2022
    Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Mantovani G; Hagemann-Jensen M; Saarenp盲盲 S; Jangard M; Micha毛lsson J; Hartman J; Lagergren J; Mold J; Lundeberg J; Fris茅n J
  • Preprint: BIORXIV. 2022
    Shafighi SD; Geras A; Jurzysta B; Naeini AS; Filipiuk I; R膮czkowski 艁; Toosi H; Koperski 艁; Thrane K; Engblom C; Mold J; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
  • Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S1306
    Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
  • Preprint: BIORXIV. 2022
    Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Fris茅n J; St氓hl PL
  • Preprint: BIORXIV. 2021
    Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O鈥橣lanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
  • Conference publication: VIRCHOWS ARCHIV. 2018;473:S30
    Schagerholm C; Robertson S; Govindasamy-Muralidharan K; Lovrot J; Chen X; Hartman J
  • Doctoral thesis: 2015
    Chen X
  • Review: SEMINARS IN CANCER BIOLOGY. 2014;26:43-51
    Chen X; Kamranvar SA; Masucci MG

Selected grants

  • Multimodal analysis of breast tumors during ongoing neoadjuvant therapy
    探花精选 Foundations
    1 January 2025 - 31 December 2026
  • Investigating intratumoral heterogeneity to improve treatment outcome
    Cancerfonden
    1 January 2024 - 31 December 2026
  • Precision pathology - prediction of patient specific drug response
    Region Stockholm (Health, Medicine and Technic)
    1 January 2022 - 31 December 2024
  • Treatment Prediction and heterogeneity studies on breast cancer using ex vivo models
    探花精选 Foundations
    20 October 2020 - 20 October 2022

Employments

  • Research Specialist, Department of Oncology-Pathology, 探花精选, 2022-

Degrees and Education

  • PhD Of Medical Science, Department of Cell and Molecular Biology, 探花精选, 2015

Journal reviewing

  • npj Precision Oncology, Nature Portfolio, Anonymous peer review
  • Advanced Science, Wiley, Anonymous peer review

News from KI

Events from KI