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Ulla Stenius

Ulla Stenius

Professor | Docent
Telephone: +46852487510
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm
Part of:

About me

  • Ulla Stenius is a Professor of Occupational Toxicology since 2010 at the Institute of Environmental Medicine (IMM). 2014-2022 she was appointed Head/Director of the same department.

Research

  • Chemical carcinogenesis, prevention and risk assessment

    We analyze sex differences in response to carcinogens and the carcinogenic effects of silica. The goal of the projects is to improve the scientific base for risk assessment.

    The CRAB- and Lion-projects investigates a novel approach to cancer risk assessment and cancer discovery which could greatly assist risk assessors with the management of large textual data and aid knowledge discovery.



    Projects
    - Using text mining to aid cancer risk assessment
    - Gender differences in carcinogenesis
    - Cancer risk of low dose exposure for silica


    Project: Gender differences in carcinogenesis
    In this project we investigate sex differences in response to carcinogens. A main objective is to identify chemicals exhibiting sexual dimorphism in their response. Another objective is to identify mode of action for these chemicals. Of special interest is the role of androgen receptor for male susceptibility to carcinogens.
    Financed by Forte and Formas

    Project: Cancer risk associated with low dose silica exposure
    The overall aim of this project is to characterize mechanisms for silica-induced inflammation and silica-induced DNA damage at low doses.
    In cell studies we find that silica particles induce inflammation and DNA damage in lower doses than previously employed. The finding that this occurs in epithelial cells suggests that this may have a direct bearing on silica-related lung cancer. Our data challenges the mode of action for silica carcinogenesis suggested by IARC and suggests that cancer should be seen not as a sequel of silicosis but rather as process that develops in parallel with silicosis. In this project, an alternative type of DNA damage mechanism will be studied
  • quartz particles can cause double strand breaks and micronuclei through activation of endonuclease G. The mechanism will be further characterized in experimental models and its relevance to cancer development investigated. The project may lead to a simplified risk assessment of quartz and perhaps also to a lowering of occupational exposure limits.
    Financed by AFA försäkring

Selected publications

  • Article: CARCINOGENESIS. 2019;40(4):580-591
    Zheng H; Jarvis IWH; Bottai M; Dreij K; Stenius U
  • Article: BIOINFORMATICS. 2019;35(9):1553-1561
    Pyysalo S; Baker S; Ali I; Haselwimmer S; Shah T; Young A; Guo Y; Hogberg J; Stenius U; Narita M; Korhonen A
  • Article: BIOINFORMATICS. 2017;33(24):3973-3981
    Baker S; Ali I; Silins I; Pyysalo S; Guo Y; Hogberg J; Stenius U; Korhonen A
  • Article: CARCINOGENESIS. 2016;37(10):985-992
    Ali I; Hogberg J; Hsieh J-H; Auerbach S; Korhonen A; Stenius U; Silins I

Articles

  • Article: CANCERS. 2023;15(3):865
    Zheng H; Stenius U; Hoegberg J
  • Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(6):67008
    Ali I; Dreij K; Baker S; Hogberg J; Korhonen A; Stenius U
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021;548:91-97
    Wu R; Hogberg J; Adner M; Stenius U; Zheng H
  • Article: PARTICLE AND FIBRE TOXICOLOGY. 2020;17(1):39
    Wu R; Hogberg J; Adner M; Ramos-Ramirez P; Stenius U; Zheng H
  • Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;127:110112
    Ghalali A; Ye Z-W; Hogberg J; Stenius U
  • Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742
    Barron Cuenca J; Tirado N; Vikstrom M; Lindh CH; Stenius U; Leander K; Berglund M; Dreij K
  • Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2019;695:133942
    Cuenca JB; Tirado N; Barral J; Ali I; Levi M; Stenius U; Berglund M; Dreij K
  • Journal article: ENVIRONMENTAL EPIDEMIOLOGY. 2019;3(Supplement 1):22-23
    J B; N T; J B; C L; U S; M B; K D
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(9):E2054-2054
    Raasmaja A; Stenius U; Ghalali A
  • Article: JOURNAL OF BIOMEDICAL SEMANTICS. 2019;10(1):2
    Chiu B; Majewska O; Pyysalo S; Wey L; Stenius U; Korhonen A; Palmer M
  • Article: CANCER RESEARCH. 2019;79(1):47-60
    Nilchian A; Johansson J; Ghalali A; Asanin ST; Santiago A; Rosencrantz O; Sollerbrant K; Vincent CT; Sund M; Stenius U; Fuxe J
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2018;355:43-51
    Brostrom JM; Ghalali A; Zheng H; Hogberg J; Stenius U; Littorin M; Tinnerberg H; Broberg K
  • Article: CARCINOGENESIS. 2017;38(12):1196-1206
    Zheng H; Hogberg J; Stenius U
  • Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2017;51(15):8805-8814
    Dreij K; Mattsson A; Jarvis IWH; Lim H; Hurkmans J; Gustafsson J; Bergvall C; Westerholm R; Johansson C; Stenius U
  • Article: MOLECULAR CANCER RESEARCH. 2017;15(6):714-722
    Ghalali A; Martin-Renedo J; Hogberg J; Stenius U
  • Article: PLOS ONE. 2017;12(3):e0173132
    Larsson K; Baker S; Silins I; Guo Y; Stenius U; Korhonen A; Berglund M
  • Article: CARCINOGENESIS. 2016;37(12):1144-1151
    Ali I; Julin B; Glynn A; Hogberg J; Berglund M; Johansson J-E; Andersson S-O; Andren O; Giovannucci E; Wolk A; Stenius U; Akesson A
  • Article: BIOINFORMATICS. 2016;32(3):432-440
    Baker S; Silins I; Guo Y; Ali I; Hogberg J; Stenius U; Korhonen A
  • Article: TOXICOLOGY LETTERS. 2016;241:32-37
    Ali I; Guo Y; Silins I; Hogberg J; Stenius U; Korhonen A
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;287(3):222-231
    Brostrom JM; Ye Z-W; Axmon A; Littorin M; Tinnerberg H; Lindh CH; Zheng H; Ghalali A; Stenius U; Jonsson BAG; Hogberg J
  • Show more

All other publications

  • Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2022;32(5):782
    Barron Cuenca J; Tirado N; Vikstrom M; Lindh CH; Stenius U; Leander K; Berglund M; Dreij K
  • Book chapter: COMPUTATIONAL INTELLIGENCE METHODS FOR BIOINFORMATICS AND BIOSTATISTICS: LECTURE NOTES IN COMPUTER SCIENCE (INCLUDING SUBSERIES LECTURE NOTES IN ARTIFICIAL INTELLIGENCE AND LECTURE NOTES IN BIOINFORMATICS). 2015;p. 89-98
    Korhonen A; Guo Y; Baker S; Yetisgen-Yildiz M; Stenius U; Narita M; Liò P
  • Review: TOXICOLOGY. 2014;321:27-39
    Jarvis IWH; Dreij K; Mattsson Å; Jernström B; Stenius U
  • Review: BIOINFORMATICS. 2013;29(11):1440-1447
    Guo Y; Silins I; Stenius U; Korhonen A
  • Review: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART B: CRITICAL REVIEWS. 2009;12(2):107-123
    Smolders R; Schramm K-W; Stenius U; Grellier J; Kahn A; Trnovec T; Sram R; Schoeters G
  • Review: EXS. 2009;99:181-208
    Högberg J; Silins I; Stenius U
  • Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2008;28(4-5):392-401
    Mattsson A; Malmlof M; Seidel A; Stenius U; Jernstrom B
  • Meeting abstract: EPIDEMIOLOGY. 2006;17(6):S299
    Hogberg J; Stenius U; Paajarvi G
  • Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):537-548
    Pääjärvi G; Jernström B; Stenius U; Seidel A
  • Letter: HEPATOLOGY. 2001;33(2):480-481
    Högberg J; Stenius U
  • Letter: CARCINOGENESIS. 1999;20(1):181-182
    Stenius U; Högberg J
  • Published conference paper: TOXICOLOGY IN VITRO. 1998;12(5):607-610
    Lennartsson P; Stenius U; Hogberg J
  • Published conference paper: ATLA ALTERNATIVES TO LABORATORY ANIMALS. 1996;24(3):393-397
    Stenius U; Martens U; Hogberg J
  • Other: CARCINOGENESIS. 1995;16(8):1683-1686
    Stenius U; Högberg J
  • Book chapter: ANTICARCINOGENESIS AND RADIATION PROTECTION 2. 1991;p. 151-154
    Högberg J; Stenius U

Grants

  • New type of DNA damage can be crucial for silica-induced carcinogenesis
    AFA Försäkring
    1 July 2023 - 30 June 2026
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2023 - 31 December 2025
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2019 - 31 December 2021

Employments

  • Professor, Institute of Environmental Medicine, ̽»¨¾«Ñ¡, 2010-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 1999

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