探花精选

Theo Gulen

Theo Gulen

Affiliated to Research | Docent
Visiting address: BioClinicum, J7:30, Akademiska str氓ket 1, 17164 Stockholm
Postal address: K2 Medicin, Solna, K2 Imm o lung Nilsson G, 171 77 Stockholm
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About me

  • I am an Associate Professor of Allergy and affiliated to 探花精选. In addition, I am a board certified physician in the fields of Internal Medicine, Clinical Immunology and Allergology and currently serve as a Senior Consultant in the Respiratory Diseases and Allergy Clinic, Karolinska University Hospital, Huddinge. In 2014, I earned my PhD from the 探花精选 on a project focusing on the intriguing association of Mastocytosis and Anaphylactic reactions.

Research

  • *Allergy, Anaphylaxis and Mastocytosis: Disorders Manifesting with Mast Cell Activation*

    My ongoing research aims to gain a comprehensive understanding of the mechanisms causing systemic mast cell activation and associated symptoms. This will be achieved by exploring distinct clinical and biological features observed in patients with 鈥淢ast Cell Activation Disorders鈥, such as patients with severe anaphylaxis, mast cell activation syndrome (MCAS), and mastocytosis. Furthermore, my research also focuses on identifying biomarkers of mast cell hyperreactivity and endotypes. The objective is to elucidate the mechanisms causing inherent increase in reactivity and releasability of mast cells, which serves as the primary perturbation leading to severe and uncontrolled mast cell activation in these patients.

    Anaphylaxis is a rapidly developing and serious hypersensitivity reaction that can concurrently affect multiple organ systems. It remains as a clinical entity and the diagnosis is based on constellation of different signs and symptoms according to the World Allergy Organization (WAO) diagnostic criteria, which involves two or more organs including skin/mucosal membranes, airways, cardiovascular, and/or gastrointestinal systems. These criteria enabled clinicians across the world to 'speak the same language' and facilitated tremendously patients and acute care physician to recognize and treat it promptly. It also made possible for scientist to report meaningful, comparable data. However, despite significant progresses in allergology and immunology during the last 2-3 decades, understanding of anaphylaxis for an allergist is fairly limited at present with respect to factors determining severity, underlying intracellular effector mechanisms within mast cells, co-factor influence, and immune mechanisms involving in mast cell activation syndromes (MCAS) and disorders (MCAD).

    To investigate this, future studies should approach anaphylaxis in a concerted manner with detailed phenotyping/endotyping by exploring the role of mast cell activation biomarkers in plasma and urine. In this context, patients with MCAD, such as mastocytosis are of great relevance to study patients with severe anaphylaxis, as these patients usually develop recurrent, severe anaphylaxis. Therefore, the main focus of the current project will be exploring clinical and biological features of MCAD patients to better understand mechanisms of anaphylaxis by screening specific diagnostic and prognostic biomarkers in patients with mastocytosis. We also aim to identify novel biomarkers of severe anaphylaxis.

    Ultimately, understanding these regulatory mechanisms might help to predict patients with severe anaphylaxis as well as to develop personalized treatment options for individual patients with mastocytosis and other mast cell disorders, such as severe allergies.

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Teaching

  • I have been actively involving in teaching activities in the 探花精选 education at KI for the graduate, post-graduate students as well as professional levels.
    My teaching duties are focused on allergic disorders including anaphylaxis, mast cell disorders, asthma, and mechanisms leading to allergies at the graduate level for third-year 探花精选 students in form of cathedral lectures, practical applications in form of PBL and direct clinical tutorship at the departments of Medicine Solna and Huddinge, 探花精选.
    I am Director of post-graduate training for Allergy Residents/Fellows in Karolinska University Hospital. This task requires planning and ascertaining of quality in training of allergy residents
    Teaching about Allergic diseases in broad for residents/specialist of Internal Medicine, Allergy and Pneumatology as well as general practitioners and doctoral students.

    *PhD supervisor*
    *On-going*
    Principal supervisor for Ilia Brooke.

    *Completed*
    Jennine Grootens, PhD 2019, KI, Co-supervisor

Selected publications

  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(3):753-761
    Zaghmout T; Maclachlan L; Bedi N; Guelen T
  • Review: DIAGNOSTICS. 2023;13(24):3662
    Beyens M; Toscano A; Ebo D; Guelen T; Sabato V
  • Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 2023;43(4):681-698
    Gulen T
  • Review: DIAGNOSTICS. 2023;13(21):3307
    Gulen T
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(10):3010-3020
    Valent P; Hoermann G; Bonadonna P; Hartmann K; Sperr WR; Broesby-Olsen S; Brockow K; Niedoszytko M; Hermine O; Chantran Y; Butterfield JH; Greiner G; Carter MC; Sabato V; Radia DH; Siebenhaar F; Triggiani M; Guellen T; Alvarez-Twose I; Staudinger T; Traby L; Sotlar K; Reiter A; Horny H-P; Orfao A; Galli SJ; Schwartz LB; Lyons JJ; Gotlib J; Metcalfe DD; Arock M; Akin C
  • Article: DIAGNOSTICS. 2023;13(13):2241
    Jarkvist J; Gulen T
  • Article: BLOOD ADVANCES. 2023;7(9):1713-1724
    Kennedy VE; Perkins C; Reiter A; Jawhar M; Luebke J; Kluin-Nelemans HC; Shomali W; Langford C; Abuel J; Hermine O; Niedoszytko M; Gorska A; Mital A; Bonadonna P; Zanotti R; Tanasi I; Mattsson M; Hagglund H; Triggiani M; Yavuz AS; Panse J; Christen D; Heizmann M; Shoumariyeh K; Mueller S; Elena C; Malcovati L; Fiorelli N; Wortmann F; Vucinic V; Brockow K; Fokoloros C; Papageorgiou SG; Breynaert C; Bullens D; Doubek M; Ilerhaus A; Angelova-Fischer I; Solomianyi O; Varkonyi J; Sabato V; Ruefer A; Schug TD; Hermans MAW; Fortina AB; Caroppo F; Bumbea H; Gulen T; Hartmann K; Elberink HO; Schwaab J; Arock M; Valent P; Sperr WR; Gotlib J
  • Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2022;88(11):4845-4853
    Kowalik A; de Monestrol I; Sorjonen K; Brockow K; Gulen T
  • Article: CANCERS. 2022;14(16):3942
    Ungerstedt J; Ljung C; Klimkowska M; Gulen T
  • Article: ALLERGY. 2022;77(8):2292-2312
    Barbaud A; Garvey LH; Arcolaci A; Brockow K; Mori F; Mayorga C; Bonadonna P; Atanaskovic-Markovic M; Moral L; Zanoni G; Pagani M; Soria A; Jost M; Caubet J-C; Carmo A; Mona A-A; Alvarez-Perea A; Bavbek S; Benedetta B; Bilo MB; Blanca-Lopez N; Bogas HG; Buonomo A; Calogiuri G; Carli G; Cernadas J; Cortellini G; Celik G; Demir S; Dona I; Dursun AB; Eberlein B; Faria E; Fernandes B; Garcez T; Garcia-Nunez I; Gawlik R; Gelincik A; Gomes E; Gooi JHC; Grosber M; Gulen T; Hacard F; Hoarau C; Janson C; Johnston SL; Joerg L; Ozdemir SK; Klimek L; Kosnik M; Kowalski ML; Kuyucu S; Kvedariene V; Laguna JJ; Lombardo C; Marinho S; Merk H; Meucci E; Morisset M; Munoz-Cano R; Murzilli F; Nakonechna A; Popescu F-D; Porebski G; Radice A; Regateiro FS; Rockmann H; Romano A; Sargur R; Sastre J; Hofmeier KS; Sedlackova L; Sobotkova M; Terreehorst I; Treudler R; Walusiak-Skorupa J; Wedi B; Wohrl S; Zidarn M; Zuberbier T; Agache I; Torres MJ
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):1941-1950
    Valent P; Hartmann K; Bonadonna P; Gulen T; Brockow K; Alvarez-Twose I; Hermine O; Niedoszytko M; Carter MC; Hoermann G; Butterfield JH; Lyons JJ; Sperr WR; Greiner G; Sotlar K; Kluin-Nelemans HC; Schwaab J; Lange M; George TI; Siebenhaar F; Broesby-Olsen S; Jawhar M; Nedoszytko B; Castells M; Orfao A; Gotlib J; Reiter A; Horny H-P; Triggiani M; Arock M; Metcalfe DD; Akin C
  • Letter: ALLERGY. 2022;77(6):1909-1911
    Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T; Nilsson G
  • Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(5):1377-1379
    Lazarinis N; Bossios A; Gulen T
  • Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 2022;42(1):45-63
    Gulen T; Akin C
  • Article: FRONTIERS IN ALLERGY. 2022;3:1071807
    Bonadonna P; Olivieri F; Jarkvist J; Nalin F; Zanotti R; Maclachlan L; Gulen T
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2021;9(11):3918-3928
    Gulen T; Akin C; Bonadonna P; Siebenhaar F; Broesby-Olsen S; Brockow K; Niedoszytko M; Nedoszytko B; Elberink HNGO; Butterfield JH; Sperr WR; Alvarez-Twose I; Horny H-P; Sotlar K; Schwaab J; Jawhar M; Zanotti R; Nilsson G; Lyons JJ; Carter MC; George TI; Hermine O; Gotlib J; Orfao A; Triggiani M; Reiter A; Hartmann K; Castells M; Arock M; Schwartz LB; Metcalfe DD; Valent P
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):889-894
    Gulen T; Teufelberger A; Ekoff M; Westerberg CM; Lyberg K; Dahlen S-E; Dahlen B; Nilsson G
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2021;9(6):2139-2144
    Bonadonna P; Brockow K; Niedoszytko M; Elberink HO; Akin C; Nedoszytko B; Butterfield JH; Alvarez-Twose I; Sotlar K; Schwaab J; Jawhar M; Castells M; Sperr WR; Hermine O; Gotlib J; Zanotti R; Reiter A; Broesby-Olsen S; Bindslev-Jensen C; Schwartz LB; Horny H-P; Radia D; Triggiani M; Sabato V; Carter MC; Siebenhaar F; Orfao A; Grattan C; Metcalfe DD; Arock M; Gulen T; Hartmann K; Valent P
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2020;8(9):3093-3101
    Jarkvist J; Brockow K; Gulen T
  • Article: ALLERGY. 2020;75(1):169-177
    Jarkvist J; Salehi C; Akin C; Gulen T
  • Show more

Articles

  • Journal article: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2025;:S1081-1206(25)00044-4
    G眉len T; Akin C
  • Journal article: LEUKEMIA. 2025;39(3):675-683
    Ruefer A; Nilius H; Hermine O; Niedoszytko M; Oude Elberink JNG; Bonadonna P; Shoumariyeh K; Gulen T; Hartmann K; Sabato V; Angelova-Fischer I; Baffoe D; Christen D; Belloni Fortina A; Breynaert C; Brockow K; von Bubnoff N; Bumbea H; van Daele P; Doubek M; Dybedal I; Elena C; Fokoloros C; Gorska A; Heizmann M; Jentzsch M; Klein S; Luebke J; Mattsson M; Mulder A; Panse J; Schug TD; Sciume M; Stefan A; Sztormowska M; Varkonyi J; Wortmann F; Yavuz AS; Sperr M; Gotlib J; Reiter A; Triggiani M; Sperr WR; Valent P
  • Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(12):3250-3260.e5
    Valent P; Hartmann K; Hoermann G; Reiter A; Alvarez-twose I; Brockow K; Bonadonna P; Hermine O; Niedoszytko M; Carter MC; Butterfield JH; Siebenhaar F; Zanotti R; Radia DH; Castells M; Sperr WR; Broesby-Olsen S; Triggiani M; Schwartz LB; George TI; Gulen T; Sotlar K; Gotlib J; Galli SJ; Horny H-P; Metcalfe DD; Orfao A; Arock M; Akin C
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(7):1850-1862.e1
    Beyens M; Sabato V; Ebo DG; Zaghmout T; Gulen T
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(6):1706-1717
    Valent P; Hartmann K; Bonadonna P; Sperr W; Niedoszytko M; Kluin-Nelemans HC; Hermine O; Sotlar K; Hoermann G; Nedoszytko B; Broesby-Olsen S; Zanotti R; Lange M; Doubek M; Brockow K; Alvarez-Twose I; Varkonyi J; Yavuz S; Nilsson G; Radia D; Grattan C; Schwaab J; Gillen T; Elberink HNGO; Haegglund H; Siebenhaar F; Hadzijusufovic E; Sabato V; Mayer J; Reiter A; Orfao A; Horny H-P; Triggiani M; Arock M
  • Journal article: JOURNAL OF CYSTIC FIBROSIS. 2022;21:s108
    Kowalik A; de Monestrol I; Sorjonen K; G眉len T
  • Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(5):602-612
    Broesby-Olsen S; Dybedal I; Gulen T; Kristensen TK; Moller MB; Ackermann L; Saaf M; Karlsson M; Agertoft L; Brixen K; Hermann P; Stylianou E; Mortz CG; Torfing T; Havelund T; Sander B; Bergstrom A; Bendix M; Garvey LH; Weis Bjerrum O; Valent P; Bindslev-Jensen C; Nilsson G; Vestergaard H; Hagglund H
  • Article: ACTA DERMATO-VENEREOLOGICA. 2014;94(5):583-584
    Hagglund H; Sander B; Gulen T; Lindelof B; Nilsson G
  • Article: MEDICAL ONCOLOGY. 2014;31(8):123
    Hagglund H; Sander B; Ahmadi A; Gulen T; Nilsson G
  • Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2013;3(1):22
    G眉len T; Dahl茅n B; Sander B; H盲gglund H; Nilsson G
  • Article: MEDICAL ONCOLOGY. 2012;29(5):3540-3546
    Gulen T; Sander B; Nilsson G; Palmblad J; Sotlar K; Horny H-P; Hagglund H
  • Article: LAKARTIDNINGEN. 2007;104(24-25):1881-1882
    Shemais H; Hot-Bjelak A; Pavlakovic ST; G眉len T

All other publications

  • Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2024;24(2):39-51
    Gulen T
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):2015-2024
    Pyatilova P; Akin C; Alvarez-Twose I; Arock M; Bonadonna P; Brockow K; Butterfield JH; Broesby-Olsen S; Carter MC; Castells M; George TI; Gotlib J; Greiner G; Gulen T; Hartmann K; Hermine O; Horny H-P; Jawhar M; Lange M; Lyons JJ; Maurer M; Metcalfe DD; Nedoszytko B; Niedoszytko M; Orfao A; Reiter A; Schwaab J; Sotlar K; Sperr WR; Triggiani M; Valent P; Siebenhaar F
  • Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(4):1128
    Gulen T; Akin C; Metcalfe DD; Valent P
  • Preprint: AUTHOREA PREPRINTS. 2021
    Nilsson G; Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T
  • Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(2):11
    Gulen T; Akin C
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1454
    Romantowski J; Gorska A; Niedoszytko M; Gulen T; Gruchala-Niedoszytko M; Nedoszytko B; Lange M; Brockow K; Arock M; Akin C; Valent P
  • Book chapter: MASTOCYTOSIS. 2020;p. 141-155
    G眉len T; Oude Elberink JNG; Brockow K
  • Conference publication: ALLERGY. 2020;75:195-196
    Jarkvist J; Brockow K; Gulen T
  • Conference publication: ALLERGY. 2019;74:670
    Jarkvist J; Bonadonna P; Gulen T
  • Editorial comment: ACTA DERMATO-VENEREOLOGICA. 2018;98(1):149-150
    Guelen T; Akin C
  • Conference publication: ALLERGY. 2018;73:69
    Salehi C; Jarkvist J; Nilsson G; Akin C; Gulen T
  • Conference publication: ALLERGY. 2017;72:445
    Gulen T; Lyberg K; Westerberg MC; Ekoff M; Alexeyenko A; Dahlen B; Nilsson G
  • Review: LAKARTIDNINGEN. 2016;113:D7CI
    G眉len T; Bj枚rkander J
  • Review: LAKARTIDNINGEN. 2016;113:DTED
    G眉len T; Wickman M
  • Conference publication: ALLERGY. 2016;71:77
    Ljung C; Nilsson G; Akin C; Gulen T
  • Conference publication: ALLERGY. 2015;70:72
    Gulen T; Moller-Westerberg C; Lyberg K; Kolmert J; Bood J; Dahlen S-E; Dahlen B; Nilsson G
  • Editorial comment: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(9):1099
    Zhang X-Y; Ziyab A; Guelen T
  • Review: LAKARTIDNINGEN. 2012;109(9-10):474-477
    G眉len T; Gottberg L; Dahl茅n B; Nilsson G; H盲gglund H
  • Review: LAKARTIDNINGEN. 2008;105(46):3341-3347
    H盲gglund H; G眉len T; S盲盲f M; Sander B; Nilsson G
  • Review: LAKARTIDNINGEN. 2007;104(26-27):1982-1986
    G眉len T; Gottberg L

Employments

  • Affiliated to Research, Department of Medicine, Huddinge, 探花精选, 2024-2027
  • Affiliated to Research, Department of Medicine, 探花精选, 2023-2026

Degrees and Education

  • Docent, Allergology, 探花精选, 2023
  • Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, 探花精选, 2014

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