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Stephan Meinke

Stephan Meinke

Research Specialist
Visiting address: NEO Medicinaren 25, HERM plan 7, Hälsovägen 7C (lastkaj), 14157 Huddinge/Stockholm
Postal address: H7 Medicin, Huddinge, H7 Hematologi Höglund, 171 77 Stockholm
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About me

  • I am a research specialist in immunology, working both in the group of Petter Höglund and the group of Evren Alici at the Center for Hematology and Regenerative Medicine (HERM).
    I received my PhD from Heidelberg University, Germany, in 2010 for a thesis titled "Regulation of human lymphocytes by SLAM-related receptors" and I have worked at KI since 2011 when I came here for my postdoctoral studies.

Research

  • My research interests lie in two areas of immunology. One is the biology of Natural Killer (NK) cells and how they can be used in cancer immunotherapy. The other one is the immune system's reaction to platelet transfusions and how to help allo-immunized patients in need of platelet transfusions.

    NK cells can recognise virally infected or cancer cells through a large set of inhibitory and activating receptors. When activated, they can kill these cells and recruit other cells of the immune system and activate them. In patients with cancer this function of NK cells is often impaired. One aim of cancer immunotherapy is to restore and enhance the function of NK cells, so they can eliminate the malignant cells. This can be done by isolating NK cells from the patient's blood, grow and activate them in culture, and then infuse them back into the patient.
    I am interested in how these cells change in the culture and after they are infused and how their infusion affects the patient's immune system. Furthermore, I am also interested how NK cell function can be enhanced by genetic modification.

    Platelet transfusion are used to stop and prevent bleeding in patients with thrombocytopenia, e.g. patients with haematological malignancies. In some patients the transfused donor platelets are destroyed by the patients' immune system. This is often caused by antibodies against the human leukocyte antigens (HLA). It is common practice to use HLA-matched platelets for HLA-immunised patients, an approach requiring a large pool of HLA-typed donors and advanced logistics.
    I am interested in the alternative approach to remove HLA from donor platelets to make them suitable for immunised patients. One possibility is to use a low pH buffer to denature the antigens on the platelet surface. However, this treatment also affects platelet function and their persistence after transfusion. Balancing these factors is the challenge that we need to master before this approach can be of clinical use.

Teaching

  • Co-supervisor for three PhD students, one current, two have defended their theses.

Articles

  • Article: BLOOD ADVANCES. 2024;8(3):571-580
    Palmblad J; Sohlberg E; Nilsson CC; Lindqvist H; Deneberg S; Ratcliffe P; Meinke S; Mortberg A; Klimkowska M; Hoglund P
  • Article: SCIENCE SIGNALING. 2023;16(780):eabq0752
    Schmied L; Luu TT; Sondergaard JN; Hald SH; Meinke S; Mohammad DK; Singh SB; Mayer C; Casoni GP; Chrobok M; Schlums H; Rota G; Truong HM; Westerberg LS; Guarda G; Alici E; Wagner AK; Kadri N; Bryceson YT; Saeed MB; Hoglund P
  • Journal article: HEMASPHERE. 2022;6(Suppl):1318-1319
    Meinke S; Kadri N; Bi S; Bostancioglu B; Markey C; Breitmeyer JB; Hussain A; Krishnan R; Kaufmann GF; Alici E
  • Journal article: HEMASPHERE. 2022;6(Suppl ):1326-1327
    P1443: AUTOLOGOUS NK CELLS AS CONSOLIDATION AFTER FRONT-LINE STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA: A LONG-TERM FOLLOW-UP
    Lund J; Nahi H; Meinke S; Holmqvist P-H; Ljunggren H-G; Aschan J; Alici E
  • Article: CELL REPORTS MEDICINE. 2022;3(2):100508
    Nahi H; Chrobok M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Blomberg P; Holmqvist P-H; Walther-Jallow L; Mellstrom K; Liwing J; Gustafsson C; Mansson R; Klimkowska M; Gahrton G; Lund J; Ljungman P; Ljunggren H-G; Alici E
  • Article: BLOOD. 2022;139(5):704-716
    Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mortberg A; Hoglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
  • Article: FRONTIERS IN IMMUNOLOGY. 2022;13:854312
    Luu TT; Sondergaard JN; Pena-Perez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers BJ; Achour A; Kutter C; Hoglund P; Mansson R; Kadri N
  • Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;196(1):224-233
    Karlstrom C; Gryfelt G; Schmied L; Meinke S; Hoglund P
  • Article: HEMASPHERE. 2021;5(5):e564
    Mulder TA; Pena-Perez L; Berglof A; Meinke S; Estupinan HY; Heimersson K; Zain R; Mansson R; Smith CIE; Palma M
  • Article: LIFE SCIENCE ALLIANCE. 2021;4(4):e202000723
    Luu TT; Schmied L; Nguyen N-A; Wiel C; Meinke S; Mohammad DK; Bergo M; Alici E; Kadri N; Ganesan S; Hoglund P
  • Article: TRANSFUSION. 2021;61(4):1222-1234
    Mirlashari MR; Vetlesen A; Nissen-Meyer LSH; Naper C; Tjonnfjord GE; Njerve IU; Ezligini F; Landmark BF; Meinke S; Sandgren P; Hoglund P; Hetland G
  • Journal article: HEMASPHERE. 2021;5(5)
    Mulder TA; Pena-Perez L; Berglof A; Meinke S; Estupinan HY; Heimersson K; Zain R; Mansson R; Smith CIE; Palma M
  • Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(4):494-504
    Luu TT; Wagner AK; Schmied L; Meinke S; Freund JE; Kambayashi T; Ravens I; Achour A; Bernhardt G; Chambers BJ; Hoglund P; Kadri N
  • Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249
    Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Le Blanc K; Kadri N; Hoglund P
  • Article: TRANSFUSION. 2018;58(11):2657-2668
    Meinke S; Wikman A; Gryfelt G; Hultenby K; Uhlin M; Hoeglund P; Sandgren P
  • Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;183(2):212-224
    Palma M; Krstic A; Perez LP; Bergloef A; Meinke S; Wang Q; Blomberg KEM; Kamali-Moghaddam M; Shen Q; Jaremko G; Lundin J; De Paepe A; Hoeglund P; Kimby E; OEsterborg A; Mansson R; Smith CIE
  • Article: THROMBOSIS RESEARCH. 2018;162:69-76
    Refsum E; Meinke S; Gryfelt G; Wikman A; Hoglund P
  • Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(3):135-142
    Ganesan S; Luu TT; Chambers BJ; Meinke S; Brodin P; Vivier E; Wetzel DM; Koleske AJ; Kadri N; Hoglund P
  • Journal article: ISBT SCIENCE SERIES. 2017;12(1):148-153
    Meinke S; Karlström C; Gryfelt G; Wikman A; Höglund P
  • Article: TRANSFUSION MEDICINE. 2017;27(1):43-51
    Refsum E; Mortberg A; Dahl J; Meinke S; Auvinen M-K; Westgren M; Reilly M; Hoglund P; Wikman A
  • Show more

All other publications

  • Conference publication: BLOOD. 2022;140:12440-12441
    Susek KH; Flore VN; Karvouni M; Meinke S; Conner J; Powers C; Allen R; Wagner AK; Alici E
  • Preprint: BIORXIV. 2022
    Schmied L; Luu T; Søndergaard J; Meinke S; Mohammad D; Singh S; Mayer C; Casoni G; Chrobok M; Schlums H; Rota G; Truong H; Westerberg L; Guarda G; Alici E; Wagner A; Kadri N; Bryceson Y; Saeed M; Höglund P
  • Meeting abstract: BLOOD. 2021;138:4796
    Nahi H; Chrobook M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Walther-Jallow L; Liwing J; Klimkowska M; Gahrton G; Ljungman P; Ljunggren H-G; Alici E
  • Preprint: BIORXIV. 2021
    Luu T; Søndergaard JN; Peña-Pérez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers B; Achour A; Kutter C; Höglund P; Månsson R; Kadri N
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(6)
    Schmied L; Meinke S; Brandt L; Thanh TL; Karlstrom C; Sandgren P; Vidarsson G; Onfelt B; Hoglund P
  • Review: FRONTIERS IN IMMUNOLOGY. 2021;12:640578
    Schmied L; Hoglund P; Meinke S
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(6)
    Luu T; Schmied L; Sondergaard JN; Saeed MB; Meinke S; Mohammad D; Casoni GP; Schlums H; Truong HM; Westerberg L; Bryceson Y; Alici E; Wagner AK; Kadri N; Hoglund P
  • Conference publication: BLOOD. 2020;136:24-25
    Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Lorenz S; Meinke S; Hoglund P; Sundin M; Karlsson G; Palmblad J; Malmberg K-J
  • Review: TRANSFUSION MEDICINE REVIEWS. 2019;33(4):231-235
    Meinke S; Karlstrom C; Hoglund P
  • Conference publication: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2019;19(10):E169
    Susek KH; Meinke S; Wagner AK; Ljunggren H-G; Alici E
  • Preprint: SSRN ELECTRONIC JOURNAL. 2019
    Luu TT; Nguyen N-A; Ganesan S; Meinke S; Kadri N; Alici E; Höglund P
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):297
    Ganesan S; Thuy LT; Kadri N; Meinke S; Hoglund P
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):257-258
    Meinke S; Brandt L; Sandgren P; Onfelt B; Hoglund P
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):295
    Thuy TL; Vignesh S; Wagner AK; Chrobok M; Schlums H; Tornmalm J; Kadri N; Meinke S; Widengren J; Bryceson Y; Alici E; Johannsson S; Hoglund P
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):295
    Thuy TL; Ngoc AN; Ganesan S; Meinke S; Wagner AK; Chrobok M; Alici E; Hoglund P
  • Meeting abstract: BLOOD. 2016;128(22):3235
    Palma M; Krstic A; Berglof A; Wang Q; Blomberg E; Meinke S; Kamali-Moghaddam M; Shen Q; Jaremko G; Lundin J; Kimby E; Hoglund P; Mansson R; Osterborg A; Smith E
  • Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;82(3):208-217
    Berglof A; Hamasy A; Meinke S; Palma M; Krstic A; Mansson R; Kimby E; Osterborg A; Smith CIE
  • Conference publication: VOX SANGUINIS. 2013;105:143
    Sandgren PJK; Meinke S; Eckert E; Taune-Wikman A; Hoglund P
  • Preprint: NATURE PRECEDINGS.
    Meinke S; Böhm C; Durlanik S; Watzl C

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