Sophia Schedin Weiss

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About me

We use innovative approaches to elucidate mechanisms behind Alzheimer disease
and other neurodegenerative disorders. The overall goal is to develop novel
diagnostic and treatment strategies.
I am a Docent (Associate Professor) in ̽��ѡ biochemistry and have
throughout my scientific career sought after biochemical and cellular
pathways that are dysregulated and causative in human neurological and
age-related diseases. Initially, as a PhD student, I investigated how
biosynthesis and transport of lipids are affected in the neurological
disorder Niemann-Pick type C disease, which displays a number of pathogenic
pathways similar to those found in AD. These first studies in my career were
published under my premarital name Sophia Schedin.
I have further studied protein biochemistry and molecular interactions
involved in the regulation of thrombosis, where I developed my expertise in
proteolytic pathways, including the protein C pathway and the blood
coagulation cascade.
I devoted the past ten years of my career to study molecular mechanisms
behind, and biomarkers involved in, AD.

Research

I am dedicated to study the molecular mechanisms behind and find biomarkers
for Alzheimer disease (AD) and other neurodegenerative diseases. I have
studied novel molecular interactions important for the regulation of
gamma-secretase, the last one of two enzymes that process the amyloid
precursor protein (APP) to generate the amyloid β-peptide (Aβ), which is
known as a toxic agent in AD, and the component of amyloid plaques in the
brains of AD patients. One of my main interests is to study the subcellular
localization of the Aβ processing machinery in neurons. To this end I have
set up super-resolution microscopy techniques and master and teach in the
techniques stimulated emission depletion (STED) microscopy and stochastic
optical reconstruction microscopy (STORM). By using these techniques we have
determined the synaptic localization of gamma-secretase and Aβ in neurons at
the nano-scale level.
I also have a great interest in studying the roles of glycans in
neurodegenerative diseases. We have in our research group shown that
asparagine-linked glycans have altered structural pattern in cerebrospinal
fluid and brain in AD and believe that understanding these alterations are
important for new diagnotics and treatment strategies.

Articles

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):3622

Axenhus M; Doeswijk T; Nilsson P; Matton A; Winblad B; Tjernberg L; Schedin-Weiss S
Article: BMC PUBLIC HEALTH. 2024;24(1):823

Axenhus M; Schedin-Weiss S; Tjernberg L; Winblad B
Article: ALZHEIMER'S AND DEMENTIA. 2023;19(7):3244-3249

Zhou RZ; Vetrano DL; Grande G; Duell F; Jonsson L; Laukka EJ; Fredolini C; Winblad B; Tjernberg L; Schedin-Weiss S
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2022;14(1):196

Sandberg A; Berenjeno-Correa E; Rodriguez RC; Axenhus M; Weiss SS; Batenburg K; Hoozemans JJM; Tjernberg LO; Scheper W
Journal article: EUROPEAN MEDICAL JOURNAL NEUROLOGY. 2022;10(1):29-30

Axenhus M; Schedin-Weiss S; Nilsson P; Winblad B; Tjernberg L
Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2022;50(6):748-755

Axenhus M; Schedin-Weiss S; Winblad B; Wimo A
Article: GLYCOBIOLOGY. 2022;32(6):506-517

Lin T; van Husen LS; Yu Y; Tjernberg LO; Schedin-Weiss S
Article: BMC GERIATRICS. 2022;22(1):365

Axenhus M; Schedin-Weiss S; Tjernberg L; Wimo A; Eriksdotter M; Bucht G; Winblad B
Article: SCIENTIFIC DATA. 2021;8(1):312

Haytural H; Benfeitas R; Schedin-Weiss S; Bereczki E; Rezeli M; Unwin RD; Wang X; Dammer EB; Johnson ECB; Seyfried NT; Winblad B; Tijms BM; Visser PJ; Frykman S; Tjernberg LO
Journal article: CHEMBIOCHEM. 2021;22(22):3108

van Husen LS; Katsori A; Meineke B; Tjernberg LO; Schedin‐Weiss S; Elsässer SJ
Article: CHEMBIOCHEM. 2021;22(22):3208-3213

van Husen LS; Katsori A-M; Meineke B; Tjernberg LO; Schedin-Weiss S; Elsasser SJ
Article: JOURNAL OF NEUROCHEMISTRY. 2021;159(2):292-304

Gaunitz S; Tjernberg LO; Schedin-Weiss S
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2021;83(2):833-852

Yu Y; Gao Y; Winblad B; Tjernberg L; Weiss SS
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4530

Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg LO
Article: CURRENT ALZHEIMER RESEARCH. 2021;17(9):858-867

Axenhus M; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334

Sandebring-Matton A; Axenhus M; Bogdanovic N; Winblad B; Schedin-Weiss S; Nilsson P; Tjernberg LO
Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH. 2020;1867(9):118737

Hromadkova L; Bezdekova D; Pala J; Schedin-Weiss S; Tjernberg LO; Hoschl C; Ovsepian SV
Article: THE FEBS JOURNAL. 2020;287(15):3221-3234

Schedin-Weiss S; Gaunitz S; Sui P; Chen Q; Haslam SM; Blennow K; Winblad B; Dell A; Tjernberg LO
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2020;75(1):321-335

Schedin-Weiss S; Nilsson P; Sandebring-Matton A; Axenhus M; Sekiguchi M; Saito T; Winblad B; Saido T; Tjernberg LO
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2019;72(2):537-548

van Husen LS; Schedin-Weiss S; Minh NT; Kazmi MA; Winblad B; Sakmar TP; Elsaesser SJ; Tjernberg LO
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(3):2103-2114

Bonito-Oliva A; Schedin-Weiss S; Younesi SS; Tiiman A; Adura C; Paknejad N; Brendel M; Romin Y; Parchem RJ; Graff C; Vukojevic V; Tjernberg LO; Terenius L; Winblad B; Sakmar TP; Graham WV
Journal article: US NEUROLOGY. 2019;15(1):14

Tjernberg L; Associate Professor at the Department of Neurobiol CSAS; Weiss SS
Article: LIFE SCIENCE ALLIANCE. 2018;1(3):e201800028

Yu Y; Jans DC; Winblad B; Tjernberg LO; Schedin-Weiss S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(52):21623-21630

Peeler JC; Schedin-Weiss S; Soula M; Kazmi MA; Sakmar TP
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2017;9(1):57

Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(1):352-358

Frykman S; Inoue M; Ikeda A; Teranishi Y; Kihara T; Lundgren JL; Yamamoto NG; Bogdanovic N; Winblad B; Schedin-Weiss S; Tjernberg LO
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4:29

Schedin-Weiss S; Caesar I; Winblad B; Blom H; Tjernberg LO
Article: MOLECULAR NEUROBIOLOGY. 2015;52(3):1077-1092

Lucotte B; Tajhizi M; Alkhatib D; Samuelsson E-B; Wiehager B; Schedin-Weiss S; Sundstrom E; Winblad B; Tjernberg LO; Behbahani H
Article: JOURNAL OF NEUROCHEMISTRY. 2015;135(3):606-615

Lundgren JL; Ahmed S; Schedin-Weiss S; Gouras GK; Winblad B; Tjernberg LO; Frykman S
Article: THE FEBS JOURNAL. 2015;282(17):3438-3451

Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO
Journal article: ALZHEIMER'S AND DEMENTIA. 2015;11(7S_Part_8):p363-p364

Winblad B; Lundgren J; Ahmed S; Schedin-Weiss S; Gouras GK; Tjernberg LO; Frykman S
Article: THE FEBS JOURNAL. 2015;282(14):2587-2599

Inoue M; Hur J-Y; Kihara T; Teranishi Y; Yamamoto NG; Ishikawa T; Wiehager B; Winblad B; Tjernberg LO; Schedin-Weiss S
Journal article: ALZHEIMER'S AND DEMENTIA. 2014;10(4S_Part_12):p491

Gaunitz S; Schedin‐Weiss S; Winblad B; Tjernberg L
Article: PLOS ONE. 2013;8(5):e63962

Schedin-Weiss S; Inoue M; Teranishi Y; Yamamoto NG; Karlstrom H; Winblad B; Tjernberg LO
Article: NEUROCHEMISTRY INTERNATIONAL. 2012;61(1):108-118

Frykman S; Teranishi Y; Hur J-Y; Sandebring A; Yamamoto NG; Ankarcrona M; Nishimura T; Winblad B; Bogdanovic N; Schedin-Weiss S; Kihara T; Tjernberg LO
Article: PLOS ONE. 2012;7(1):e29586

Sjölinder M; Altenbacher G; Hagner M; Sun W; Schedin-Weiss S; Sjölinder H
Article: MOLECULAR & CELLULAR PROTEOMICS. 2012;11(1):M111.008730

Clark GF; Grassi P; Pang P-C; Panico M; Lafrenz D; Drobnis EZ; Baldwin MR; Morris HR; Haslam SM; Schedin-Weiss S; Sun W; Dell A
Article: PLOS ONE. 2011;6(12):e29011

Sun W; Grassi P; Engström A; Sooriyaarachchi S; Ubhayasekera W; Hreinsson J; Wånggren K; Clark GF; Dell A; Schedin-Weiss S
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2010;504(2):169-176

Schedin-Weiss S; Richard B; Olson ST
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;403(2):198-202

Sun W; Parry S; Ubhayasekera W; Engström A; Dell A; Schedin-Weiss S
Article: THROMBOSIS AND HAEMOSTASIS. 2010;104(3):544-553

Zhu T; Ubhayasekera W; Nickolaus N; Sun W; Tingsborg S; Mowbray SL; Schedin-Weiss S
Article: BIOCHEMISTRY. 2009;48(5):1094-1098

Sun W; Eriksson AS; Schedin-Weiss S
Article: BIOCHEMISTRY. 2008;47(51):13610-13619

Schedin-Weiss S; Richard B; Hjelm R; Olson ST
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(27):18601-18611

Sun W; Parry S; Panico M; Morris HR; Kjellberg M; Engström A; Dell A; Schedin-Weiss S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14417-14429

Richard B; Swanson R; Schedin-Weiss S; Ramirez B; Izaguirre G; Gettins PGW; Olson ST
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(4):506-513

Turunen M; Schedin-Weiss S
Article: BIOCHEMISTRY. 2007;46(11):3378-3384

Hjelm R; Schedin-Weiss S
Article: BIOCHEMISTRY. 2004;43(3):675-683

Schedin-Weiss S; Desai UR; Bock SC; Olson ST; Björk I
Article: BIOCHEMISTRY. 2002;41(41):12369-12376

Schedin-Weiss S; Arocas V; Bock SC; Olson ST; Björk I
Article: BIOCHEMISTRY. 2002;41(15):4779-4788

Schedin-Weiss S; Desai UR; Bock SC; Gettins PGW; Olson ST; Björk I
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;297(3):607-614

Turunen M; Peters JM; Gonzalez FJ; Schedin S; Dallner G
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1394(2-3):177-186

Schedin S; Nilsson M; Chojnacki T; Dallner G
Article: BIOCHEMICAL PHARMACOLOGY. 1998;56(9):1195-1199

Schedin S; Pentchev P; Dallner G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(10):6245-6251

Schedin S; Sindelar PJ; Pentchev P; Brunk U; Dallner G
Article: JOURNAL OF NEUROCHEMISTRY. 1995;65(2):670-676

SCHEDIN S; PENTCHEV PG; BRUNK U; DALLNER G
Article: CARCINOGENESIS. 1995;16(3):599-605

OLSSON JM; SCHEDIN S; TECLEBRHAN H; ERIKSSON LC; DALLNER G
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All other publications

Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:68-69

Axenhus M; Schedin-Weiss S; Nilsson P; Winblad B; Tjernberg L
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:74

Winblad B; Schedin-Weiss S; Tjernberg L; Wimo A; Bucht G; Eriksdotter M; Axenhus M
Review: BIOMEDICINES. 2021;9(7):801

Lin T; Tjernberg LO; Schedin-Weiss S
Preprint: BIORXIV. 2021

van Husen L; Katsori A-M; Meineke B; Tjernberg L; Schedin-Weiss S; Elsässer S
Review: BIOMOLECULES. 2021;11(6):858

Gaunitz S; Tjernberg LO; Schedin-Weiss S
Preprint: PREPRINTS.ORG. 2021

Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg L
Review: THE FEBS JOURNAL. 2014;281(1):46-62

Schedin-Weiss S; Winblad B; Tjernberg LO
Review: BIOCHIMIE. 2010;92(11):1587-1596

Olson ST; Richard B; Izaguirre G; Schedin-Weiss S; Gettins PGW

Employments

Researcher, Department of Neurobiology, Care Sciences and Society, ̽��ѡ, 2011-

Degrees and Education

Docent, ̽��ѡ, 2024

̽��ѡ

Sophia Schedin Weiss

About me

Research

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI

̽����ѡ

Sophia Schedin Weiss

About me

Research

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI

̽��ѡ