探花精选

Silvia Maioli

Silvia Maioli

Senior Research Specialist | Docent
Visiting address: Bioclinicum J10:20, Akademiska str氓ket 1, 17164 Huddinge
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 Neurogeriatrik Maioli, 171 77 Stockholm
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About me

  • I am research group leader and Docent (Associate Professor).

    With a PhD from the University of Bologna and a postdoc at KI, I have been immersed in the field of neuroscience, particularly Alzheimer鈥檚 Disease (AD), since 2011. My research focuses on investigating the mechanisms for risk factors for Alzheimer's Disease, with a specific emphasis on ApoE, cholesterol metabolism, and oxysterols.

    I am currently the main supervisor for 2 PhD students in my lab and a co-supervisor for 3 PhD students. I have directed two PhD theses as the main supervisor.

    I have extensive knowledge of mouse behavior and mouse models of neurodegenerative disease, and I am Facility Coordinator for the Animal Behavior Core Facility (ABCF) at KI. In addition, I work with different molecular biology techniques.

Research

  • My research is focused on understanding the biological mechanisms behind risk factors for neurodegenerative diseases like Alzheimer's Disease (AD), with a focus on sex-differences.

    Changes in brain cholesterol metabolism occurs in early stages of the disease and are considered important drivers of the neurodegenerative cascades in AD. AD risk factors such as hypercholesterolemia, hypertension, lifestyle, affect brain cholesterol metabolism. I study the role of cholesterol metabolites and transporters in the brain during neurodegenerative processes by using in vitro and in vivo models, as well as human samples. In addition, I am interested in the connection between cholesterol metabolism and sex hormones. Sex hormones, including estrogen and testosterone, originate from cholesterol and promote neuroprotective functions in the brain. Both cholesterol and sex hormones are shaped by genes and the environment (for example medications, diet), serving as potential preventive and therapeutic targets for AD.

    Another topic in the lab is multi-medication therapies and related sex-differences. We study the effects of different combinations of drugs commonly used in AD comorbidities using mouse models and human data from different clinical cohorts

Teaching

  • I am course director for the PhD Course 5239 Behavioral Analysis in Rodents: Classic and Novel Approaches, Neuroscience Programme, 探花精选.

    I teach in courses/study programmes at 探花精选:
    - Clinical Research School in Molecular Medicine.
    - PhD course 5539: Alzheimer鈥檚 Disease 鈥 Clinical features and pathogenic mechanisms.
    - Advanced course in Alzheimer鈥檚 Disease and other dementias.
    - Frontiers in Biomedicine (4Bi107) Master鈥檚 Programme in Biomedicine.

    Until now I have been supervisor for 15 master students .

Selected publications

  • Article: SCIENCE ADVANCES. 2024;10(4):eadj1354
    Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S

Articles

  • Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;119:286-300
    Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
  • Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535
    Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Alvarez-Jimenez L; Piras A; Gomez-Galan M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):220
    Petek B; Habel H; Xu H; Villa-Lopez M; Kalar I; Hoang MT; Maioli S; Pereira JB; Mostafaei S; Winblad B; Gregoric Kramberger M; Eriksdotter M; Garcia-Ptacek S
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387
    Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
  • Article: JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2023;18(3):529-550
    Sola-Sevilla N; Mesa-Lombardo A; Aleixo M; Exposito S; Diaz-Perdigon T; Azqueta A; Zamani F; Suzuki T; Maioli S; Eroli F; Matton A; Ramirez MJ; Solas M; Tordera RM; Martin ED; Puerta E
  • Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228
    Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):141
    Ghorbani M; Ferreira D; Maioli S
  • Article: GLIA. 2023;71(6):1414-1428
    Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
  • Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245
    Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2022;14(1):37
    Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
  • Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076
    Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
  • Article: AGING. 2021;13(11):14729-14744
    Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
  • Article: AGING. 2020;12(11):10147-10161
    Eroli F; Johnell K; Leal ML; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
  • Article: SCIENTIFIC REPORTS. 2019;9(1):3965
    Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
  • Article: CEREBRAL CORTEX. 2019;29(1):429-446
    Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
  • Article: PLOS ONE. 2018;13(3):e0194892
    Wastesson JW; Minguez AC; Fastbom J; Maioli S; Johnell K
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2017;214(3):699-717
    Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyas B; Olof-Wahlund L; Winblad B; Savitcheva I; Bjorkhem I; Cedazo-Minguez A
  • Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328
    Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Ronnback A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
  • Article: JOURNAL OF ALZHEIMER'S DISEASE. 2017;56(2):601-617
    Persson T; Lattanzio F; Calvo-Garrido J; Rimondini R; Rubio-Rodrigo M; Sundstrom E; Maioli S; Sandebring-Matton A; Cedazo-Minguez A
  • Article: JOURNAL OF ALZHEIMER'S DISEASE. 2016;53(1):349-361
    Tajeddinn W; Persson T; Calvo-Garrido J; Ahmed MS; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
  • Show more

All other publications

  • Preprint: BIORXIV. 2024
    Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garc铆a LE
  • Preprint: BIORXIV. 2022
    Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
  • Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925
    Maioli S; Leander K; Nilsson P; Nalvarte I
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):10139
    Loera-Valencia R; Eroli F; Garcia-Ptacek S; Maioli S
  • Preprint: BIORXIV. 2021
    Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Bj枚rkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
  • Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:104-114
    Loera-Valencia R; Goikolea J; Parrado-Fernandez C; Merino-Serraisa P; Maioli S

Grants

  • The cholesterol-CYP46A1 axis: a promising therapeutic target to protect women at risk of Alzheimer鈥檚 disease.
    Swedish Research Council
    1 January 2025 - 31 December 2028
  • Finansieringsf枚rslag f枚r en kryostat inom inom Avdelningen f枚r Neurogeriatrik
    Olle Engkvists Stiftelse
    1 January 2024
  • Swedish Research Council
    1 January 2024 - 31 December 2026
  • Cholesterol metabolism and sex hormones in Alzheimer鈥檚 Disease: from basic mechanisms to precision medicine.
    The private initiative 鈥淚nnovative ways to fight Alzheimer鈥檚 disease - Leif Lundblad Family and others鈥
    1 November 2023 - 31 October 2026
  • King Gustaf V:s and Queen Victorias Foundation
    1 January 2023 - 31 December 2024
  • Sex specific effects of CYP46A1 up regulation in brain: roles and implication for cholesterol turnover in neurodegenerative diseases.
    KID funding
    1 January 2022 - 31 December 2025
  • Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease risk.
    National Institutes of Health
    30 September 2020 - 31 May 2024

Employments

  • Senior Research Specialist, Department of Neurobiology, Care Sciences and Society, 探花精选, 2022-

Degrees and Education

  • Docent, 探花精选, 2023

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