探花精选

Sho Oasa

Assistant Professor
Visiting address: L8:01, CMM, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 CPF Vukojevic, 171 77 Stockholm
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About me

  • I completed my PhD in Life Science under the supervision of Prof. Masataka Kinjo at Laboratory of Molecular Cell Dynamics, Hokkaido University, Sapporo, Japan in 2016. I had a postdocotrall training at same laboratory in 2016-2017. I moved to Vladana Vukojevic and Lars Terenius's research group, Department of Clinical Neuroscience, 探花精选 (KI) as a research associate for 2017-2019 financially supported by the Nakatani Foundation for Advancement of measuring technologies in bio探花精选 engineering. Following the research associates, I was employed as the Postdoctoral fellowship in the same research group in KI for 2019-2021 financially supported by the postdoctoral funding by the Strategic Neuroscience. My career progresssed an Assistant Professor at 2021.

    I'm a Biophysist with an expetise on fluorescence microscopy techniques including live-cell confocal microscopy imaigng, fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

    Please feel free to contact me if you have any questions in the fluorescence microscopy.

    Our group organizes the fluorescence microscopy core facility in Center for Molecular Medicine and PhD course in fluorescence microscopy.

     

     

Research

  • I'm working on the sveral directions of researches in 探花精选.

     

    1) Scanning-free confocal fluorescence microscopy towards massively parallel fluorescence correlation spectroscopy and fluorescence lifetime imaging microscopy (mpFCS/FLIM).

    Fluorescence Correlation Spectroscopy (FCS) allows us to characterize the dynamic properties of fluorescently tagged proteins and its concentration in live cells. However, classical FCS based on a confocal microscopy focused laser in a selected position, being subjected to FCS analysis.

    We are developping with Dr. Alexsandar Krmpot and Dr. Stanko Nikolic (Institute of Physics Belgrade, University of Belgrade, Serbia) the 2D imaging FCS instrument to record fluorescence intensity in different positions of cells at the same time. Parallel computing calculated large number of autocorrelation curves in FCS analysis to quantitatively characterize the spatial heterogeneity of protein dynamics and density/concentration in live cells. This instrument allows us to high-throughput analysis in in vitro samples as well as sptially resolved analysis in live cells.

     

    2) Alcohol modulation on plasma membrane organization, opioid receptors dynamics/functionalities and opioid receptor antagonists' effect to the alocohol modulations.

    (Constructing)

     

    3) Development of small molecular decoys interfering with amyloid beta aggregation towards new medication to Alzheimer's disease

    (Constructing)

     

    4) Characterization of transcription factor dimerization inhibitor towards new medication for glioblastoma and medulloblastoma

    (Constructing)

     

    5) Glucocorticoid receptor (GR) transporting/dimerization kinetics coupling to the GR functionality.

    (Constructing)

     

     

     

     

     

Articles

  • Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2025;:130809
    Oasa S; Stoyanov B; Hamada Y; Nikoli膰 SN; Krmpot AJ; Kitamura A; Vukojevi膰 V
  • Article: NATURE COMMUNICATIONS. 2025;16(1):1091
    Li Y; Lim C; Dismuke T; Malawsky DS; Oasa S; Bruce ZC; Offenhaeuser C; Baumgartner U; D'Souza RCJ; Edwards SL; French JD; Ock LSH; Nair S; Sivakumaran H; Harris L; Tikunov AP; Hwang D; Alicea Pauneto CDM; Maybury M; Hassall T; Wainwright B; Kesari S; Stein G; Piper M; Johns TG; Sokolsky-Papkov M; Terenius L; Vukojevic V; Mcswain LF; Gershon TR; Day BW
  • Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):477
    Oasa S; Sezgin E; Ma Y; Horne DA; Radmilovic MD; Jovanovic-Talisman T; Martin-Fardon R; Vukojevic V; Terenius L
  • Article: SCIENTIFIC REPORTS. 2024;14(1):24846
    Min J-H; Sarlus H; Oasa S; Harris RA
  • Journal article: JOURNAL OF ALZHEIMERS DISEASE. 2024;101(3):787-796
    Oasa S; Chen G; Schultzberg M; Terenius L
  • Article: ANALYTICAL CHEMISTRY. 2023;95(41):15171-15179
    Nikolic SN; Oasa S; Krmpot AJ; Terenius L; Belic MR; Rigler R; Vukojevic V
  • Article: CELL AND BIOSCIENCE. 2023;13(1):142
    Johansson B; Oasa S; Soria AM; Tiiman A; Soderberg L; Amandius E; Moller C; Lannfelt L; Terenius L; Gimenez-Llort L; Vukojevic V
  • Article: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023;244:125312
    Radmilovic MD; Drvenica IT; Rabasovic MD; Ilic VL; Pavlovic D; Oasa S; Vukojevic V; Peric M; Nikolic SN; Krmpot AJ
  • Article: SCIENTIFIC REPORTS. 2023;13(1):11834
    Kitamura A; Oasa S; Kawaguchi H; Osaka M; Vukojevic V; Kinjo M
  • Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(9):1575-1584
    Oasa S; Kouznetsova VL; Tiiman A; Vukojevic V; Tsigelny IF; Terenius L
  • Journal article: FASEB JOURNAL. 2022;36(S1)
    Oasa S; Krmpot A; Nikolic S; Clayton A; Tsigelny I; Changeux J; Terenius L; Rigler R; Vukojevic V
  • Article: FASEB JOURNAL. 2021;35(12):e22055
    Li T; Oasa S; Ciruela F; Terenius L; Vukojevic V; Svenningsson P
  • Article: ANALYTICAL CHEMISTRY. 2021;93(35):12011-12021
    Oasa S; Krmpot AJ; Nikolic SN; Clayton AHA; Tsigelny IF; Changeux J-P; Terenius L; Rigler R; Vukojevic V
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(5):2683-2686
    Oasa S; Vukojevic V; Rigler R; Tsigelny IF; Changeux J-P; Terenius L
  • Article: ANALYTICAL CHEMISTRY. 2019;91(17):11129-11137
    Krmpot AJ; Nikolic SN; Oasa S; Papadopoulos DK; Vitali M; Oura M; Mikuni S; Thyberg P; Tisa S; Kinjo M; Nilsson L; Terenius L; Rigler R; Vukojevic V
  • Article: SCIENTIFIC REPORTS. 2018;8(1):7488
    Oasa S; Mikuni S; Yamamoto J; Kurosaki T; Yamashita D; Kinjo M
  • Article: SCIENTIFIC REPORTS. 2017;7(1):4336
    Tiwari M; Oasa S; Yamamoto J; Mikuni S; Kinjo M
  • Article: COLLOIDS AND SURFACES B-BIOINTERFACES. 2017;151:95-101
    Tanaka H; Oasa S; Kinjo M; Tange K; Nakai Y; Harashima H; Akita H
  • Article: FEBS LETTERS. 2015;589(17):2171-2178
    Oasa S; Sasaki A; Yamamoto J; Mikuni S; Kinjo M
  • Journal article: SEIBUTSU BUTSURI. 2014;54(5):280-282
    OASA S
  • Show more

All other publications

  • Preprint: AUTHOREA, INC.. 2025
    Li T; Vukojevi膰 V; Oasa S; Bai Y; Yang Y; Li H; Tang Y; Terenius L; H枚kfelt T; Svenningsson P; Xu Z
  • Corrigendum: SCIENTIFIC REPORTS. 2024;14(1):30574
    Min J-H; Sarlus H; Oasa S; Harris RA
  • Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(8):1658-1659
    Oasa S; Kouznetsova VL; Tsigelny IF; Terenius L
  • Preprint: RES SQ. 2023;RES SQ
    Terenius L; Oasa S; Sezgin E; Ma Y; Horne D; Radmikovi膰 M; Jovanovi膰-Talisman T; Martin-Fardon R; Vukojevic V
  • Preprint: RES SQ. 2023;RES SQ
    Li Y; Lim C; Dismuke T; Malawsky DS; Oasa S; Bruce ZC; Offenh盲user C; Baumgartner U; D'Souza RCJ; Edwards SL; French JD; Ock LSH; Nair S; Sivakumaran H; Harris L; Tikunov AP; Hwang D; Del Mar Alicea Pauneto C; Maybury M; Hassall T; Wainwright B; Kesari S; Stein G; Piper M; Johns TG; Sokolsky-Papkov M; Terenius L; Vukojevi膰 V; Gershon TR; Day BW
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S99
    Oasa S; Kouznetsova V; Masich S; Tiiman A; Vukojevic V; Tsigelny I; Terenius L
  • Preprint: BIORXIV. 2022
    Kitamura A; Oasa S; Kawaguchi H; Osaka M; Vukojevi膰 V; Kinjo M
  • Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):307A
    Oasa S; Krmpot A; Nikolic S; Terenius L; Rigler R; Vukojevic V
  • Conference publication: PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. 2015;9536:95360o-95360o-9-95360O
    Krmpot AJ; Nikolic SN; Vitali M; Papadopoulos DK; Oasa S; Thyberg P; Tisa S; Kinjo M; Nilsson L; Gehring WJ; Terenius L; Rigler R; Vukojevic V
  • Conference publication: 2015;:95360o
    Krmpot AJ; Nikoli膰 SN; Vitali M; Papadopoulos DK; Oasa S; Thyberg P; Tisa S; Kinjo M; Nilsson L; Gehring WJ; Terenius L; Rigler R; Vukojevi膰 V

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2026

Employments

  • Assistant Professor, Department of Clinical Neuroscience, 探花精选, 2021-2026
  • Postdoctoral Researcher, Department of Clinical Neuroscience, 探花精选, 2019-2021
  • Research Associate, Department of Clinical Neuroscience, 探花精选, 2017-2019
  • Postdoctoral Fellowship, Faculty of Advanced Life Science, Hokkaido University, 2016-2017

Degrees and Education

  • Ph.D., Study on homodimer of glucocorticoid receptor and transcriptional regulation in single-cell level using fluorescence correlation spectroscopy and microwells., Graduate School of Life Science, Hokkaido University, 2016
  • Msc, Graduate School of Life Science, Hokkaido University, 2013
  • Bsc, Department of Science, Hokkaido University, 2011

Journal reviewing

  • Cell Reports
  • Plant, Cell & Environment

Conference/event participation

  • Poster presenter of own accepted abstract, The 21st IUPAB, 2024
  • Invited speaker, Bio-optics meeting, 2024
  • Invited speaker, The 7th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2023
  • Poster presenter of own accepted abstract, EBSA satellite meeting 鈥淔luorescence fluctuation and single molecule spectroscopy鈥, 2023
  • Poster presenter of own accepted abstract, European Biophysics Society Association (EBSA), 2023
  • Poster presenter of own accepted abstract, Experimental Biology, Selected as oral 15 min talk as well, 2022
  • Poster presenter of own accepted abstract, Methods and Applications of Fluorescence, 2022
  • Invited speaker, The 6th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2021
  • Invited speaker, Photonica, 2021
  • Poster presenter of own accepted abstract, Annual meeting of Biophysics, 2020
  • Invited speaker, 5th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2019
  • Poster presenter of own accepted abstract, The annual meeting of Biophysics of Japan, 2019
  • Poster presenter of own accepted abstract, The 54th Annual meeting of the Biophysical Society of Japan, 2016
  • Oral presenter of own accepted abstract, The 3rd International International Life Life-Science Symposium for young scientists, 2015
  • Poster presenter of own accepted abstract, Single Protein Dynamics in Cellulo in Cellulo
  • SPDC2014, 2014
  • Poster presenter of own accepted abstract, The 52nd Annual meeting of Biophysical Society of Japan Annual meeting of Biophysical Society of Japan, 2014
  • Poster presenter of own accepted abstract, The 50th Annual meeting Annual meeting of the Biophysical Society of of the Biophysical Society of Japan, 2012

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Events from KI