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My research set out to investigate consequences of intra tumour cellular heterogeneity for the progression into refractory disease, with the objective to target residual disease and prevent metastasis. 

Our research aims to decipher the complicated spatial interplay between tumour cells and the tumour microenvironment using MULTIPLEX genomic, transcriptomic and proteomic profiles in order to investigate consequences of tumour heterogeneity for the progression into refractory disease. 

Neuroblastoma is the most common extra cranial solid tumor in pediatrics and accounts for 15% of cancer related deaths in children. Even though the overall survival has increased following implementation of novel therapeutics one third of high-risk patients will experience treatment failure. An outcome most likely influenced by the tumour microenvironment. Spatial multi-omics techniques enable better dissection of the tumour microenvironment through investigation of the spatial architecture. A combination of several novel multiparameter immunofluorescence analysis techniques is being used on patient biopsies. The single-cell approach allows us to investigate cell-cell interactions that might contributing to resistance. This is combined by targeted treatment in matched in vivo cell lines of neuroblastoma, in order to re-sensitize resistant tumour cells to therapy. An enhanced understanding of the intra-tumour heterogeneity and asynchronous therapy responsiveness are among the most important areas in tumour research and our work is anticipated to produce novel biological discoveries and encourage further development of therapies. 

Recent teaching
2024 and 2022 Course Leader - “Translational Paediatric Oncology in the Era of Immunotherapy and Omics”, KI PhD course
2021 Teacher - “Translational Paediatric Oncology in the Era of Immunotherapy and Omics”, KI PhD course
2020-2021 Teacher - Molecular Medicine and Oncology, KI Biomedicine program
2019-2020 Teacher - DFM 1 course, course module Development – from egg to embryo, KI Medicine program

Supervisor
2021 - ongoing (Co-supervisor) Ioanna Tsea PhD-student

2023 Master thesis, Yuwei Lin, MSc, KTH
2023 Master thesis, Alexandra Johansson, MSc, KTH
2022 Master thesis, Maja Lundström, MSc, KTH
2021 Master thesis, Mani Devaraj, MSc, KI
2021 Master thesis, Agnes Sorteberg, MSc, KTH
2021 Master thesis, Vesa Halipi, MSc, LTH
2020 Master thesis, Maryam Sahi, MSc, KTH
2020 Master thesis, Ximena Lopez Lorenzo, MSc, KTH
2019 Master thesis, Linnéa Ödborn Jönsson MSc, KTH
2018 Master thesis, Faye Keller MSc, Uppsala University