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Sean Rudd

Sean Rudd

Principal Researcher
Visiting address: SciLifeLab, Tomtebodavägen 23, 17165 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Rudd, 171 77 Stockholm
Part of:

About me

  • Group Leader at the Department of Oncology-Pathology &

  • SciLifeLab

Research

  • The Rudd Group aims to provide cancer patients with better treatment options. We believe one way this can be achieved in a timely manner is by focusing research efforts upon commonly used chemotherapeutic agents. These therapies, which form standard-of-care for many cancers, typically kill tumour cells by targeting pan-essential pathways, principally metabolism of the DNA molecule or its nucleotide building blocks (deoxynucleoside triphosphates, dNTPs). In our research program we aim to define the molecular underpinnings of why some cancers respond to these therapies whilst others do not. This information can provide the basis for rational therapy improvements through the identification of biomarkers and therapeutic targets together with the design of mechanism-based drug combinations. We employ a multidisciplinary approach in our research – centred upon biochemical, biophysical, and cell-based methods – and use both hypothesis-driven and hypothesis-free approaches in our efforts to define and exploit the molecular mechanisms underpinning clinical efficacy of chemotherapeutic agents.

Teaching

  • • Supervision of undergraduate &
  • MSc thesis projects
    • Lecturing on cancer biology, cancer drug discovery, and drug mechanism of action
    • Co-organise doctoral course on Genome Instability in Cancer Development and Therapy

Articles

  • Article: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2024;43(8):831-836
    Dirks C; Bwanika HC; Jemth A-S; Zhang SM; Rudd SG
  • Article: ISCIENCE. 2024;27(2):108907
    Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
  • Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
    Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
  • Article: CELL DEATH AND DISEASE. 2021;12(7):709
    Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
  • Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(170)
    Yague-Capilla M; Rudd SG
  • Article: BMC RESEARCH NOTES. 2021;14(1):27
    Makela P; Zhang SM; Rudd SG
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
    Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
  • Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
    Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
  • Article: CANCER RESEARCH. 2020;80(17):3530-3541
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
  • Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
    Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
  • Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
    Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
  • Article: BLOOD CANCER JOURNAL. 2018;8(11):98
    Rassidakis GZ; Herold N; Myrberg IH; Tsesmetzis N; Rudd SG; Henter J-I; Schaller T; Ng S-B; Chng WJ; Yan B; Ng CH; Ravandi F; Andreeff M; Kantarjian HM; Medeiros LJ; Xagoraris I; Khoury JD
  • Article: NATURE COMMUNICATIONS. 2018;9(1):250
    Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
  • Article: EXPERIMENTAL HEMATOLOGY. 2017;52:32-39
    Herold N; Rudd SG; Sanjiv K; Kutzner J; Myrberg IH; Paulin CBJ; Olsen TK; Helleday T; Henter J-I; Schaller T
  • Article: CELL CYCLE. 2017;16(11):1029-1038
    Herold N; Rudd SG; Sanjiv K; Kutzner J; Bladh J; Paulin CBJ; Helleday T; Henter J-I; Schaller T
  • Article: MOLECULAR & CELLULAR ONCOLOGY. 2017;4(2):e1287554
    Rudd SG; Schaller T; Herold N
  • Article: NATURE MEDICINE. 2017;23(2):256-263
    Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
  • Article: ONCOGENESIS. 2016;5(12):e275
    Eshtad S; Mavajian Z; Rudd SG; Visnes T; Bostrom J; Altun M; Helleday T
  • Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
    Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
  • Article: NUCLEIC ACIDS RESEARCH (NAR). 2015;43(2):1056-1068
    Guilliam TA; Jozwiakowski SK; Ehlinger A; Barnes RP; Rudd SG; Bailey LJ; Skehel JM; Eckert KA; Chazin WJ; Doherty AJ
  • Show more

All other publications

  • Review: DISEASE MODELS & MECHANISMS. 2024;17(8):dmm050775
    Yague-Capilla M; Rudd SG
  • Preprint: BIORXIV. 2024
    Wang J; Strauss R; Bartek J; Rudd SG
  • Review: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2023;92(4):241-251
    Rudd SG
  • Preprint: BIORXIV. 2023
    Zhang SM; Paulin CBJ; Michel M; Marttila P; Yagüe-Capilla M; Bwanika HC; Shu H; Vekatram RP; Wiita E; Jemth A-S; Almlöf I; Loseva O; Ortis F; Dirks C; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Strömberg K; Homan E; Scobie M; Lundbäck T; Helleday T; Rudd S
  • Review: MOLECULAR ONCOLOGY. 2022;16(21):3792-3810
    Helleday T; Rudd SG
  • Corrigendum: CELL DEATH AND DISEASE. 2022;13(8):672
    Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
  • Review: PEERJ. 2022;10:e13141
    Wang J; Hao S; Gu J; Rudd SG; Wang Y
  • Preprint: BIORXIV. 2020
    Mäkelä P; Zhang SM; Rudd S
  • Preprint: BIORXIV. 2020
    Zhang SM; Calderón-Montaño J; Rudd S
  • Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5050
    Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
  • Review: CANCERS. 2018;10(7):E240-240
    Tsesmetzis N; Paulin CBJ; Rudd SG; Herold N
  • Review: DNA REPAIR. 2016;44:193-204
    Rudd SG; Valerie NCK; Helleday T
  • Review: MOLECULAR & CELLULAR ONCOLOGY. 2014;1(2):e960754
    Rudd SG; Bianchi J; Doherty AJ

Grants

  • Swedish Cancer Society
    1 January 2024
  • Barncancerfonden
    1 January 2022 - 31 December 2022
  • Swedish Cancer Society
    1 January 2021
  • Swedish Research Council
    1 January 2019 - 31 December 2022

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