探花精选

Reza Zandi Shafagh

Reza Zandi Shafagh

Research Specialist
Visiting address: Solnav盲gen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och l盲kemedelsutveckling, 171 77 Stockholm

About me

  • Ph.D in Micro and Nanosystems
    Head of Biofabrication and Tissue Engineering core Facility (Biofab)


    Reza is a research specialist and currently the head of Biofabrication and Tissue Engineering core Facility (Biofab) at the Department of Physiology  and Pharmacology, karolinska institutet (KI). He holds Ph.D degree in Micro and Nanosystems from Royal Institute of Technology (), Micro and Nanosystems department (), Stockholm, Sweden. Reza's expertise lies in nanoengineering, microfluidics, lab-on-a-chip, and biomicroelectromechanical systems (BioMEMS) for bio探花精选 applications. More specifically during his Ph.D studies, he made the following contributions: 

    1. Establishing novel micro-and nanofabrication methods (micro and nano reaction injection molding- 渭RIM and NanoRIM), as well as implementing the standard ones (Electron beam lithography and Nanoimprint lithography), for high-resolution structuring of polymer materials (down to 20 nm) and scalable manufacturing of microfluidic devices.
    2. Introducing facile back-end processing techniques, including direct bonding and sealing, 3D surface energy patterning, and seamless integration of microfluidic devices and sensors.
    3. Presenting high-resolution protein patterning techniques.
    4. Developing ultrasensitive biosensing methods.

     
    He was also previously involved in three European IMI and EU FP7 projects , "" and "" and "":

    •  Within the framework of the RAPP-ID project, the research included technologies for rapid and ultrasensitive detection of Influenza
      virus directly from human breath.
    •  Within the framework of the Norosensor project, the research included technologies for the rapid and ultrasensitive detection of Norovirus in ambient air.
    •  POSITIVE project aimed at the diagnosis of food allergies via porous silicon-based lab-on-a-chip devices.


    Reza is currently the head of Biofabrication and Tissue Engineering core Facility (Biofab) at KI. Biofab aims to bridge the gap between engineering and biology at 探花精选 and provide common grounds with respect to suitable material of use of modular design and tunable structures for bio探花精选 purposes.

Research

    • Microphysiological systems to mimic organ-to-organ crosstalk: Microphysiological systems, also coined as Organ-on-a-Chip devices, offer exciting possibilities to bioengineer tissue-tissue interaction for disease modeling or drug development purposes. Reza's research interest lies in developing suitable materials and engineering solutions in the noted research field.
    • Mechanobiological control of human cells using bioinspired nanostructures: Development of suitable platforms for 3D cell culture and manipulation of different cell behaviors on a broad range of nanotopographies to alter mechanosensing of human cells are some other examples of the intended research efforts.

Articles

  • Article: MICROORGANISMS. 2025;13(3):534
    Ova A脰; Joffre E; Zandi Shafagh R; Assun莽茫o MFG; Sidorov RY; Santos LMA; Lauschke VM; R枚mling U
  • Article: ADVANCED MATERIALS INTERFACES. 2024;11(14)
    Harris P; Kaveh J; Kemas AM; Mikaelsson H; Fielden M; Lauschke VM; Shafagh RZ
  • Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(11):e2303561
    Kemas AM; Shafagh RZ; Taebnia N; Michel M; Preiss L; Hofmann U; Lauschke VM
  • Article: ADVANCED SCIENCE. 2022;9(34):e2203368
    Shafagh RZ; Youhanna S; Keulen J; Shen JX; Taebnia N; Preiss LC; Klein K; Buettner FA; Bergqvist M; van der Wijngaart W; Lauschke VM
  • Article: ADVANCED SCIENCE. 2021;8(16):e2100106
    Shen JX; Couchet M; Dufau J; de Castro Barbosa T; Ulbrich MH; Helmstadter M; Kemas AM; Zandi Shafagh R; Marques M-A; Hansen JB; Mejhert N; Langin D; Ryden M; Lauschke VM
  • Article: FASEB JOURNAL. 2021;35(3):e21305
    Kemas AM; Youhanna S; Shafagh RZ; Lauschke VM
  • Article: ACS APPLIED BIO MATERIALS. 2020;3(12):8757-8767
    Shafagh RZ; Shen JX; Youhanna S; Guo W; Lauschke VM; van der Wijngaart W; Haraldsson T
  • Article: MICROSYSTEMS & NANOENGINEERING. 2019;5:25
    Shafagh RZ; Decrop D; Ven K; Vanderbeke A; Hanusa R; Breukers J; Pardon G; Haraldsson T; Lammertyn J; van der Wijngaart W
  • Article: ACS NANO. 2018;12(10):9940-9946
    Shafagh RZ; Vastesson A; Guo W; van der Wijngaart W; Haraldsson T
  • Article: JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2017;27(12):124001
    Sandstrom N; Shafagh RZ; Gylfason KB; Haraldsson T; van der Wijngaart W
  • Article: ACS APPLIED MATERIALS & INTERFACES. 2017;9(36):30267-30272
    Marinins A; Shafagh RZ; van der Wijngaart W; Haraldsson T; Linnros J; Veinot JGC; Popov S; Sychugov I
  • Article: OPTICS LETTERS. 2017;42(11):2157-2160
    Lobov GS; Marinins A; Shafagh RZ; Zhao Y; van der Wijngaart W; Wosinski L; Thylen L; Toprak MS; Haraldsson T; Ostling M; Popov S
  • Article: ACS APPLIED MATERIALS & INTERFACES. 2017;9(12):10418-10426
    Decrop D; Pardon G; Brancato L; Kil D; Shafagh RZ; Kokalj T; Haraldsson T; Puers R; van der Wijngaart W; Lammertyn J
  • Article: PLOS ONE. 2016;11(12):e0166330
    Rajabi M; Roxhed N; Shafagh RZ; Haraldson T; Fischer AC; van der Wijngaart W; Stemme G; Niklaus F
  • Article: JOURNAL OF MICROMECHANICS AND MICROENGINEERING. 2015;25(7):075002
    Sandstrom N; Shafagh RZ; Vastesson A; Carlborg CF; van der Wijngaart W; Haraldsson T
  • Article: OPTICS EXPRESS. 2013;21(18):21293-21298
    Errando-Herranz C; Saharil F; Mola Romero A; Sandstrom N; Shafagh RZ; van der Wijngaart W; Haraldsson T; Gylfason KB

All other publications

  • Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206
    Youhanna S; Kemas AM; Preiss L; Zhou Y; Shen JX; Cakal SD; Paqualini FS; Goparaju SK; Shafagh RZ; Lind JU; Sellgren CM; Lauschke VM
  • Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(1):38-60
    Shen JX; Youhanna S; Shafagh RZ; Kele J; Lauschke VM
  • Review: BIOTECHNOLOGY JOURNAL. 2019;14(7):e1800347
    Lauschke VM; Shafagh RZ; Hendriks DFG; Ingelman-Sundberg M

Grants

  • KI Infrastructure grant
    1 January 2025 - 31 December 2028
  • KI Forskningsbidrag
    1 January 2025 - 31 December 2026
  • KI core-facility grant
    1 January 2022 - 1 January 2024
  • An 鈥渙n-chip鈥 platform for 3D cell co-culture, tissue-tissue interaction and 鈥渋n-situ鈥 drug screening
    TORE NILSON'S FOUNDATION FOR MEDICAL RESEARCH
    1 January 2021 - 1 January 2022

Employments

  • Research specialist, 探花精选, 2023-
  • Research Specialist, Department of Physiology and Pharmacology, 探花精选, 2023-
  • Postdoctoral researcher, Department of Physiology and Pharmacology, 探花精选, 2019-2023
  • Research assistant, Department of Physiology and Pharmacology, 探花精选, 2018-2019

Leadership and responsibility assignments

  • Head of Biofabrication and tissue engineering core facility at 探花精选, 探花精选, 2019-

Supervision

  • Jibbe Keulen
  • Chen Xing

Committee work

  • Svenska Institutet f枚r standarder, 2025-

Other expert reviewer/evaluation assignment

  • Reviewer or advisor for other scientific bodies, Member of topical advisory board for Micromachines journal, Micromachines Journal, 2021

Conference/event participation

  • Poster presenter of own accepted abstract, The 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (碌TAS 2024), , MANIPULATION OF CELL MORPHOLOGY AND ATTACHMENT ON NANOIMPRINTED THIOL-ENE-EPOXY TOPOGRAPHIES, 2024
  • Oral presenter of own accepted abstract, The 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2017), NANORIM: SUB-MICRON STRUCTURING WITH REACTION INJECTION MOLDING, , 2017

News from KI

Events from KI