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Ralf Morgenstern

Ralf Morgenstern

Professor Emeritus/Emerita
Telephone: +46852487131
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Dreij, 171 77 Stockholm
Part of:

Research

  • tatic drugs and we are investigating inhibitors that could increase treatment efficiency.

    Prostaglandin E (PGE) is very important in pathophysiology related to fever pain and inflammation. In collaboration with Per-Johan Jakobssons group we are investigating a membrane bound enzyme that catalyses the formation of PGE regarding active site location, chemical and kinetic mechanism. Recently the structure of MPGES1 was solved in collaboration with Professor Hans Heberts group at KI which forms the basis for studies on the molecular level. This information is vital to develop new and hopefully safer alternatives to NSAIDs like aspirin. Such development is underway in collaboration with NovaSaid, a company formed together with KI innovations.

    Antioxidant supplements at high levels are increasingly recognised as harmful. The mechanism of the harmful effects have not been elucidated. We have proposed the hypothesis that antioxidants cause a redox dysregulation that lowers endogenous protective enzyme levels. We will investigate this hypothesis initially in cellular systems and later in more complex settings.

    Financing

    The Swedish Cancer Society / Cancerfonden

Selected publications

  • Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2009;487(1):42-48
    Alander J; Lengqvist J; Holm PJ; Svensson R; Gerbaux P; van den Heuvel RHH; Hebert H; Griffiths WJ; Armstrong RN; Morgenstern R
  • Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224
    Samuelsson B; Morgenstern R; Jakobsson P-J
  • Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;360(5):934-945
    Holm PJ; Bhakat P; Jegerschold C; Gyobu N; Mitsuoka K; Fujiyoshi Y; Morgenstern R; Hebert H

Articles

  • Journal article: BIOMOLECULES. 2024;14(6):641
    Morgenstern R
  • Article: PHARMACOLOGICAL RESEARCH. 2023;196:106899
    Zhang J; Ye Z-W; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(8):104920
    Zhang J; Ye Z-W; Braeutigam L; Chakraborty P; Luo Z; Culpepper J; Aslam M; Zhang L; Johansson K; Haeggstrom JZ; Xu J; Olsson M; Townsend DM; Mehrotra S; Morgenstern R; Tew KD
  • Article: THE FEBS JOURNAL. 2023;290(13):3448-3460
    Cebula M; Morgenstern R
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638
    Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J
  • Article: REDOX BIOLOGY. 2018;17:171-179
    Brautigam L; Zhang J; Dreij K; Spahiu L; Holmgren A; Abe H; Tew KD; Townsend DM; Kelner MJ; Morgenstern R; Johansson K
  • Article: SCIENTIFIC REPORTS. 2017;7(1):7897
    Kuang Q; Purhonen P; Alander J; Svensson R; Hoogland V; Winerdal J; Spahiu L; Ottosson-Wadlund A; Jegerschold C; Morgenstern R; Hebert H
  • Article: BRITISH JOURNAL OF NUTRITION. 2017;118(2):154-160
    Selin JZ; Lindblad BE; Bottai M; Morgenstern R; Wolk A
  • Article: BIOCHEMISTRY. 2017;56(24):3089-3098
    Spahiu L; Alander J; Ottosson-Wadlund A; Svensson R; Lehmer C; Armstrong RN; Morgenstern R
  • Article: BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES. 2017;1859(2):238-244
    Shimoji M; Figueroa RA; Neve E; Maksel D; Imreh G; Morgenstern R; Hallberg E
  • Article: SCIENTIFIC REPORTS. 2016;6:38316
    Cebula M; Turan IS; Sjodin B; Thulasingam M; Brock J; Chmyrov V; Widengren J; Abe H; Mannervik B; Haeggstrom JZ; Rinaldo-Matthis A; Akkaya EU; Morgenstern R
  • Article: MOLECULAR PHARMACEUTICS. 2016;13(6):2010-2025
    van Gisbergen MW; Cebula M; Zhang J; Ottosson-Wadlund A; Dubois L; Lambin P; Tew KD; Townsend DM; Haenen GRMM; Drittij-Repders M-J; Saneyoshi H; Araki M; Shishido Y; Ito Y; Arner ESJ; Abe H; Morgenstern R; Johansson K
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977
    Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
  • Article: PLOS ONE. 2016;11(9):e0163600
    Raouf J; Rafique N; Goodman MC; Idborg H; Bergqvist F; Armstrong RN; Jakobsson P-J; Morgenstern R; Spahiu L
  • Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(10):1365-1371
    Ahmad S; Thulasingam M; Palombo I; Daley DO; Johnson KA; Morgenstern R; Haeggstrom JZ; Rinaldo-Matthis A
  • Article: ANTIOXIDANTS AND REDOX SIGNALING. 2014;21(5):700-704
    Selin JZ; Lindblad BE; Rautiainen S; Michaelsson K; Morgenstern R; Bottai M; Basu S; Wolk A
  • Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;69:167-171
    Kelner MJ; Diccianni MB; Yu AL; Rutherford MR; Estes LA; Morgenstern R
  • Article: JAMA OPHTHALMOLOGY. 2014;132(3):247-252
    Rautiainen S; Lindblad BE; Morgenstern R; Wolk A
  • Article: FEBS OPEN BIO. 2014;4:886-891
    Bjorkhem-Bergman L; Johansson M; Morgenstern R; Rane A; Ekstrom L
  • Journal article: THE ANALYST. 2014;139(17):4382
    Shibata A; Nakano Y; Ito M; Araki M; Zhang J; Yoshida Y; Shuto S; Mannervik B; Morgenstern R; Ito Y; Abe H
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All other publications

  • Book chapter: REFERENCE MODULE IN BIOMEDICAL SCIENCES. 2024;p.
    Mannervik B; Morgenstern R
  • Review: ADVANCES IN CANCER RESEARCH. 2023;160:107-132
    Zhang J; Ye Z-W; Morgenstern R; Townsend DM; Tew KD
  • Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1099
    Edenius C; Ekstrom G; Kolmert J; Morgenstern R; Stenberg P; Jakobsson PJ; Tornling G
  • Review: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2020;147:106383
    Bergqvist F; Morgenstern R; Jakobsson P-J
  • Conference publication: CANCER RESEARCH. 2019;79(13):881
    Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
  • Conference publication: 2019;:881
    Zhang J; Ye Z-W; Townsend DM; Morgenstern R; Tew KD
  • Book chapter: GLUTATHIONE. 2018;p. 215-226
    Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
  • Book chapter: GLUTATHIONE. 2018;p. 215-226
    Morgenstern R; Haeggström JZ; Jakobsson P-J; Flohé L
  • Book chapter: COMPREHENSIVE TOXICOLOGY. 2018;p. 326-362
    Armstrong RN; Morgenstern R; Board PG
  • Published conference paper: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS. 2014;262:244-260
    Chaudhry QA; Hanke M; Morgenstern R; Dreij K
  • Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S60-S61
    Dreij K; Chaudhry QA; Zhang J; Sundberg K; Jernstrom B; Hanke M; Morgenstern R
  • Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2012;244
    Ito M; Shibata A; Abe H; Zhang J; Morgenstern R; Shuto S; Ito Y
  • Review: DRUG METABOLISM REVIEWS. 2011;43(2):300-306
    Morgenstern R; Zhang J; Johansson K
  • Corrigendum: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(3):674
    Rautiainen S; Akesson A; Levitan EB; Morgenstern R; Mittleman MA; Wolk A
  • Thesis / dissertation: 2010
    Johansson, Katarina
  • Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2010;239
    Ito M; Abe H; Shibata A; Shimizu S; Alander J; Morgenstern R; Ito Y
  • Conference publication: 2009;:1-5
    Chaudhry QA; Hanke M; Morgenstern R
  • Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2009;65:S77
    Hebert H; Jegerschoeld C; Purhonen P; Bhakat P; Gheorghe K; Gyobu N; Mitsuoka K; Pawelzik S; Jakobsson P-J; Morgenstern R
  • Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35
    Staab CA; Alander J; Morgenstern R; Grafstrom RC; Hoog J-O
  • Conference publication: EUROPEAN HEART JOURNAL. 2008;29:353
    Gigante B; Zotova E; Lyrenas L; De Faire U; Morgenstern R; Bennet A
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Grants

  • Swedish Research Council
    1 January 2016 - 31 December 2019
  • Swedish Research Council
    1 January 2012 - 31 December 2014
  • From detection of single enzyme molecules to tumor treatment
    Swedish Foundation for Strategic Research
    1 May 2011 - 30 April 2015
  • Swedish Research Council
    1 January 2011 - 31 December 2013
  • Swedish Research Council
    1 January 2009 - 31 December 2011

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