Phillip Newton
Principal Researcher
E-mail: phillip.newton@ki.se
Visiting address: BioMedicum A4, Solnav盲gen 9, 17165 Solna
Postal address: K6 Kvinnors och barns h盲lsa, K6 Barnonkologi och Barnkirurgi Blomgren Newton, 171 77 Stockholm
About me
- I read Biochemistry as an undergraduate at University College London, and
have been studying long-bone growth since 2012 when I began my PhD at the
University of Manchester and Roslin Institute (Edinburgh, UK). I then moved
to Karolinska Institute and conducted postdoctoral research with Asst.
Professor Andrei Chagin (Department of Physiology and Pharmacology), during
which time I was also associated with Prof. Lars S盲vendahl's lab (Department
of Women's and Children's Health). Since January 2020, I moved to the
Department of Women's and Children's Health where I have started working as a
principle investigator in the group of Prof. Klas Blomgren.
Harold M. Frost Young Investigator Award (2019)
American Society for Bone and Mineral Research Young Investigator Award
(2016)
Research
- Until we reach our adult height, our long-bones are being continuously
lengthened because of the activity of narrow discs of cartilage in our
long-bones, called growth plates. Growth plates are very interesting tissues.
Each growth plate is made up of highly organised columns of cells
(chondrocytes), in which the last cell in the column is continually removed
and replaced by bone tissue. This process must be very tightly controlled so
that our bones continue to grow in proportion to each other and so that we
grow similarly to our peers. Long-bone growth is important as it ultimately
determines how tall we become.
My research aims to understand the fundamental aspects of long-bone growth at
the cellular level and to unravel the signaling pathways controlling this
process. By coupling clinical samples with basic research at the lab bench we
endeavour to have a patient-oriented approach.
*Selected publications:*
*(1)* A radical switch in clonality reveals a stem cell niche in the
epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow
L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A,
Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H,
Fried K, Kasper M, Hedlund E, Adameyko I, S盲vendahl L, Chagin AS
/Nature/ 567(7747):234-238 (2019)* *
*(2)* Superficial cells are self-renewing chondrocyte progenitors, which form
the articular cartilage in juvenile mice.
Li L*, Newton PT*, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie
M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B,
Adameyko I, Chagin AS
/FASEB// /31(3):1067-1084/ /(2016)
*(3)* Pharmacological inhibition of lysosomes activates the mTORC1 signaling
pathway in chondrocytes in an autophagy-independent manner.
Newton PT*, Vuppalapati KK*, Bouderlique T, Chagin AS
/Autophagy/ 11(9):1594-607 (2015)
*(4)* Clonal Genetic Tracing using the Confetti Mouse to Study Mineralized
Tissues.
Zhou B, Kaucka M, Chagin AS, Newton PT
/J. Vis. Exp./ (152), e60424, doi:10.3791/60424 (2019)
*(5)* New insights into niclosamide action: autophagy activation in
colorectal cancer (Commentary).
Newton PT
/Biochem J/. 476(5):779-781 (2019)
*(6)* Chondrogenic ATDC5 cells: an optimised model for rapid and
physiological matrix mineralization.
Newton PT*, Staines KA*, Spevak L, Boskey AL, Teixeira CC, Macrae VE,
Canfield AE, Farquharson C
/Int J Mol Med/ 30(5):1187-93 (2012)
*(7)* Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies.
Hammarsj枚 A, Wang Z, Vaz R, Taylan F, Sedghi M, Girisha KM, Chitayat D,
Neethukrishna K, Godoy R, Gowrishankar K, Lindstrand A, Nasiri J, Baktashian
M, Newton PT, Guo L, Hofmeister W, Petterson M, Chagin AS, Nishimura G, Yan
L, Matsumoto N, Shannon P, Nordgren A, Miyake N, Grigelioniene G, Ikegawa S
/Scientific Reports/ 7(1):15585 (2017)
* denotes shared first authorship.
Articles
- Journal article: BONE. 2024;188:117223
- Article: JOURNAL OF EXTRACELLULAR BIOLOGY. 2024;3(9):1-16
- Article: NATURE COMMUNICATIONS. 2024;15(1):2367
- Journal article: BLOOD. 2023;142:4076
- Article: NATURE COMMUNICATIONS. 2023;14(1):509
- Article: NATURE COMMUNICATIONS. 2022;13(1):6949
- Journal article: BONE REPORTS. 2022;16:101360
- Article: ELIFE. 2020;9:e55212
- Journal article: BONE REPORTS. 2020;13:100663
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2020;217(3):e20191306
- Article: REDOX BIOLOGY. 2020;28:101387
- Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(152)
- Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(152)
- Article: NATURE. 2019;567(7747):234-238
- Article: BRITISH JOURNAL OF ANAESTHESIA. 2019;122(3):350-360
- Article: BONE REPORTS. 2018;8:64-71
- Article: SCIENTIFIC REPORTS. 2017;7(1):15585
- Article: ELIFE. 2017;6:e25902
- Article: THE FASEB JOURNAL. 2017;31(3):1067-1084
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(3):627-631
- Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2016;145(1):67-79
- Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2015;30(12):2249-2261
- Article: AUTOPHAGY. 2015;11(9):1594-1607
- Article: MOLECULAR MEDICINE. 2015;20(1):667-675
- Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2012;30(5):1187-1193
- Journal article: BONE. 2010;47:s149
- Show more
All other publications
- Poster: JOURNAL OF EXTRACELLULAR VESICLES. 2024;:e12444
- Preprint: BIORXIV. 2024
- Preprint: RESEARCH SQUARE. 2023
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2023;38:140
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2023;38:132
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2023;38:213
- Preprint: BIORXIV. 2022
- Review: AUTOPHAGY. 2021;17(1):1-382
- Review: PEDIATRIC RESEARCH. 2020;87(6):986-990
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:592
- Preprint: BIORXIV. 2019
- Editorial comment: BIOCHEMICAL JOURNAL. 2019;476(5):779-781
- Meeting abstract: OSTEOARTHRITIS AND CARTILAGE. 2015;23:A309
- Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2014;29:S351
Grants
- Swedish Research Council1 January 2020 - 31 December 2023