探花精选

Peter Svensson

Peter Svensson

Principal Researcher | Docent
Telephone: +46852481051
Visiting address: Blickag氓ngen 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 CIM-CID Svensson, 171 77 Stockholm
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About me

  • The research of the group into the HIV cure field is focused on chromatin,
    and especially how transcription and chromatin states transitions
    interconnect.
    Docent (associate professor) in functional genomics at the Department of
    Biosciences and Nutrition.
    I completed my Ph.D. at Leiden University Medical Center and Uppsala
    University in 2006. After that I did a post-doc in the lab of Leona Samson at
    Massachusetts Institute of Technology. In 2010, I became a PI at Karolinska
    Institutet. Between 2015 and 2017 I was at the Gladstone Institute of
    Virology and Immunology (San Fransisco) as a Visiting scientist.

Research

  • HIV infection is a devastating disease affecting 35 million people worldwide.
    Current anti-retroviral treatment is highly effective and has made the HIV
    infection chronic. However, despite more effective treatments, the prospects
    of a cure are distant.
    The problem for an HIV cure is that, even though the virus particles are
    eradicated, the infected cells maintain the information of remake the virus.
    This information is integrated in the host cell as a provirus. The provirus
    switches between active and inactive states. Thereby, the infected cells
    evade both the immune system and death associated with massive viral
    production.
    In my lab we characterize the composition of proviral chromatin and how it
    connects with transcription and viral production. We are interested in the
    fate of the HIV-1 provirus from the time of infection until latency has
    been firmly established in resting primary CD4+T-cells. Whereas the
    proviruses encompassed in heterochromatin are refractory to activation, we
    have shown that latent proviruses with 鈥渆nhancer鈥 characteristics are
    readily activated. Our studies have provided key insights as to detect the
    remaining HIV-1 infected cells capable of reseeding the infection and the
    mechanisms whereby they are maintained.

Articles

  • Article: PLOS PATHOGENS. 2022;18(6):e1010555
    Lindqvist B; Jutte BB; Love L; Assi W; Roux J; Sonnerborg A; Tezil T; Verdin E; Svensson JP
  • Article: COMMUNICATIONS BIOLOGY. 2022;5(1):357
    Svensson Akusjarvi S; Krishnan S; Jutte BB; Ambikan AT; Gupta S; Rodriguez JE; Vegvari A; Sperk M; Nowak P; Vesterbacka J; Svensson JP; Sonnerborg A; Neogi U
  • Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1067767
    Milao JF; Love L; Gourgi G; Derhaschnig L; Svensson JP; Soennerborg A; van Domselaar R
  • Article: NATURE COMMUNICATIONS. 2021;12(1):4800
    Shoaib M; Chen Q; Shi X; Nair N; Prasanna C; Yang R; Walter D; Frederiksen KS; Einarsson H; Svensson JP; Liu CF; Ekwall K; Lerdrup M; Nordenskiold L; Sorensen CS
  • Article: NUCLEIC ACIDS RESEARCH. 2020;48(13):7154-7168
    Sanso M; Parua PK; Pinto D; Svensson JP; Pag V; Bitton DA; MacKinnon S; Garcia P; Hidalgo E; Bahler J; Tanny JC; Fisher RP
  • Article: EPIGENETICS. 2020;15(6-7):702-714
    Varnoosfaderani FS; Palau A; Dong W; Persson J; Durand-Dubief M; Svensson JP; Lennartsson A
  • Article: SCIENTIFIC REPORTS. 2020;10(1):6055
    Dong W; Oya E; Zahedi Y; Prasad P; Svensson JP; Lennartsson A; Ekwall K; Durand-Dubief M
  • Article: PLOS PATHOGENS. 2020;16(1):e1008264
    Lindqvist B; Akusjarvi SS; Sonnerborg A; Dimitriou M; Svensson JP
  • Article: LIFE SCIENCE ALLIANCE. 2019;2(5):e201900433
    Ait-Saada A; Khorosjutina O; Chen J; Kramarz K; Maksimov V; Svensson JP; Lambert S; Ekwall K
  • Article: ELIFE. 2018;7:e34655
    Battivelli E; Dahabieh MS; Abdel-Mohsen M; Svensson JP; Da Silva IT; Cohn LB; Gramatica A; Deeks S; Greene WC; Pillai SK; Verdin E
  • Article: CELL HOST & MICROBE. 2016;20(6):785-797
    Besnard E; Hakre S; Kampmann M; Lim HW; Hosmane NN; Martin A; Bassik MC; Verschueren E; Battivelli E; Chan J; Svensson JP; Gramatica A; Conrad RJ; Ott M; Greene WC; Krogan NJ; Siliciano RF; Weissman JS; Verdin E
  • Article: EMBO REPORTS. 2015;16(12):1673-1687
    Sadeghi L; Prasad P; Ekwall K; Cohen A; Svensson JP
  • Article: MOLECULAR CELL. 2015;59(6):984-997
    Zhao H; Sifakis EG; Sumida N; Millan-Arino L; Scholz BA; Svensson JP; Chen X; Ronnegren AL; de Lima CDM; Varnoosfaderani FS; Shi C; Loseva O; Yammine S; Israelsson M; Rathje L-S; Nemeti B; Fredlund E; Helleday T; Imreh MP; Gondor A
  • Article: GENOME RESEARCH. 2015;25(6):872-883
    Svensson JP; Shukla M; Menendez-Benito V; Norman-Axelsson U; Audergon P; Sinha I; Tanny JC; Allshire RC; Ekwall K
  • Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2014;21(3):236-243
    Sadeghi L; Siggens L; Svensson JP; Ekwall K
  • Article: LAB ON A CHIP. 2013;13(14):2754-2763
    Vahey MD; Pesudo LQ; Svensson JP; Samson LD; Voldman J
  • Article: PLOS ONE. 2013;8(9):e73736
    Svensson JP; Pesudo LQ; McRee SK; Adeleye Y; Carmichael P; Samson LD
  • Article: EMBO JOURNAL. 2012;31(23):4388-4403
    Pointner J; Persson J; Prasad P; Norman-Axelsson U; Stralfors A; Khorosjutina O; Krietenstein N; Svensson JP; Ekwall K; Korber P
  • Article: PLOS GENETICS. 2012;8(9):e1002985
    Choi ES; Stralfors A; Catania S; Castillo AG; Svensson JP; Pidoux AL; Ekwall K; Allshire RC
  • Article: MOLECULAR CELL. 2012;46(5):691-704
    Ryan CJ; Roguev A; Patrick K; Xu J; Jahari H; Tong Z; Beltrao P; Shales M; Qu H; Collins SR; Kliegman JI; Jiang L; Kuo D; Tosti E; Kim H-S; Edelmann W; Keogh M-C; Greene D; Tang C; Cunningham P; Shokat KM; Cagney G; Svensson JP; Guthrie C; Espenshade PJ; Ideker T; Krogan NJ
  • Show more

All other publications

  • Preprint: RESEARCH SQUARE. 2021
    Akusj盲rvi SS; Krishnan S; J眉tte B; Ambikan A; Gupta S; Rodriguez J; Vegvari A; Sperk M; Nowak P; Vesterbacka J; Svensson P; Sonnerborg A; Neogi U
  • Preprint: BIORXIV. 2021
    Lindqvist B; Assi W; Roux J; Love L; J眉tte B; S枚nnerborg A; Tezil T; Verdin E; Verdin E; Svensson P
  • Review: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:668637
    Svensson JP
  • Preprint: BIORXIV. 2018
    Sumida N; Sifakis E; Scholz B; Fernandez-Woodbridge A; Kiani N; Gomez-Cabrero D; Svensson P; Tegner J; G枚nd枚r A; Ohlsson R
  • Preprint: BIORXIV. 2018
    Battivelli E; Dahabieh M; Abdel-Mohsen M; Svensson P; Tojal Da Silva I; Cohn L; Gramatica A; Deeks S; Greene W; Pillai S; Verdin E
  • Preprint: BIORXIV. 2017
    Sans贸 M; Pinto D; Svensson P; Pag茅 V; Parua P; Bitton D; Mbogning J; Garcia P; Hidalgo E; Robert F; B盲hler J; Tanny J; Fisher R
  • Editorial comment: EPIGENOMICS. 2014;6(5):451-454
    Svensson JP; Ekwall K
  • Other: PERSONALIZED MEDICINE. 2008;5(6):561-563
    Fry RC; Svensson JP; Valiathan C
  • Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2008;49(7):578
    Quiros L; Svensson P; Wang E; Fry R; Samson LD
  • Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2008;49(7):578
    Svensson P; Rebecca FR; Samson LD
  • Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2004;1657:82
    Jahangir R; Svensson P; Janssen G; Szuhai K; Maassen JA; Raap A

Grants

  • Swedish Research Council
    1 January 2020 - 31 December 2022
  • Swedish Research Council
    1 January 2016 - 31 December 2018

Employments

  • Principal Researcher, Department of Medicine, Huddinge, 探花精选, 2024-

Degrees and Education

  • Docent, 探花精选, 2012

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