探花精选

Pernilla Stridh

Pernilla Stridh

Researcher
Visiting address: L8:05, CMM Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 Neuro Kockum, 171 77 Stockholm
Part of:

About me

  • I am an assistant professor in Genetic Epidemiology of Multiple Sclerosis at
    the Department of Clinical Neuroscience. My scientific work aims to
    understand the pathomechanisms of neuroinflammation, particularly multiple
    Sclerosis (MS), by identifying the genetic architecture and understanding how
    functional effects of genetic variants contribute to disease. I have trained
    in sequence-based analysis to identify causative genetic variants (Wellcomme
    Trust Center for Human Genetics), and am experienced and skilled in human
    genetics. I have trained in advanced genetic analyses during three research
    visits at deCODE Genetics, Iceland, and have identified MS-risk variants by
    developing approaches that go beyond traditional genome-wide association.
    Since 2018, I have extended the human genetic MS studies to include
    low-frequency and rare variants and quantitative traits describing severity
    and progression of MS. My work is funded by Horizon2020 /MultipleMS, / the
    Margaretha af Ugglas Foundation, and Neurofonden.d treatment of persons with
    MS.
    Max and Edit Follins Foundation award
    Lennmalms Prize and silver medal for research in neurology
    Bachelor of Science in Psychology with cognitive neuroscience emphasis.
    Department of Psychology, Boise State University, USA.
    Bachelor of Science in Biology with human biology emphasis. Department of
    Biology, Boise State University, USA.
    Honors Thesis i Cognitive Neuroscience. /The effects of neural insult on
    awareness level and cognitive processing during stroke/. Department of
    Psychology, Boise State University, USA.
    Short Term Fellow (EU FP6). Oxford University, Wellcome Trust Centre for
    Human Genetics, UK.
    PhD in Experimental Neuroscience. /Inheritance of autoimmune
    neuroinflammation/. Dep Clinical Neuroscience, 探花精选, Sweden.
    Short Term Fellow (EU FP7). Oxford University, Wellcome Trust Centre for
    Human Genetics, UK.
    Research Exchange Fellow (探花精选). deCODE Genetics, Iceland.

Research

  • MS is a leading cause of incurable progressive disability in young adults,
    characterized by autoimmune destruction of myelin and neurons by inflammatory
    cells that periodically enter the central nervous system. The exact cause of
    MS is unknown, but environmental exposures likely trigger disease in those
    who are genetically predisposed. MS is highly heterogeneous with respect to
    paraclinical findings, clinical outcomes, and response to treatment, making
    the prognosis of both severity and progression essentially impossible at the
    time of diagnosis. The challenge of identifying disease-modifying factors and
    understanding their combined roles in a single individual is hampering the
    full potential of personalized medicine. The difficulty in making reliable
    prognosis of MS severity and progression leaves persons with MS with
    substantial uncertainty for years. A key aim of my work is to search for
    outcome predictors to ultimately increase the ability to offer prognosis.
    My previous work has investigated the genetic architecture and functional
    genomics of neuroinflammation in experimental models and in patients.
    Genome-wide association (GWA) data from large case-control (1, 2) and within
    case cohorts (3) have been used to identify genetic determinants of MS
    susceptibility and severity, including rare variants (4), complemented by
    sequence-based approaches to elucidate causal MS variants in experimental
    models (5). The functional relevance of these genes and the mechanism by
    which they drive severity remains to be determined.
    A primary purpose of my current work is to detect patients that are at higher
    risk of developing severe disability and then improve their long term
    outcomes by making individualized predictions regarding prognosis, rate of
    acceleration, and treatment responses possible. I propose to cluster MS
    patients based on genetic and environmental exposures to identify subsets of
    patients that capture different disease trajectories. I further propose to
    characterize the biological processes that drive disease acceleration in that
    specific patient group and determine the genetic burden, environmental
    exposures, clinical outcomes and biomarkers distinguishing each cluster.
    Furthermore, to support early initiation and selection of the most effective
    and relevant disease modifying treatments (DMTs) I will identify biomarkers
    of future disability accumulation that distinguish subgroups with fast
    disease acceleration. Translating the genetic architecture into a greater
    understanding of the mechanisms that cause and shape MS, and knowing which
    mechanisms are preventable or modifiable, will constitute a breakthrough for
    the clinical management and treatment of persons with MS.
    1. Olafsson, S., et al., Fourteen sequence variants that associate with
    multiple sclerosis discovered by meta-analysis informed by genetic
    correlations. NPJ Genom Med, 2017. 2: p. 24.
    2. International Multiple Sclerosis Genetics, C., Multiple sclerosis genomic
    map implicates peripheral immune cells and microglia in susceptibility.
    Science, 2019. 365(6460).
    3. International Multiple Sclerosis Genetics Consortium, MultipleMS., Genetic
    analysis of multiple sclerosis severity identifies a novel locus and
    implicates CNS resilience as a major determinant of outcome. Research Square,
    2022.
    4. Consortium, I.M.S.G., Low-Frequency and Rare-Coding Variation Contributes
    to Multiple Sclerosis Risk. Cell, 2018. 175(6): p. 1679-1687 e7.
    5. Rat Genome, S., et al., Combined sequence-based and genetic mapping
    analysis of complex traits in outbred rats. Nat Genet, 2013. 45(7): p.
    767-75.

Teaching

  • I organize and run one doctoral course at 探花精选: Clinical and
    Experimental Neuroimmunology, 3200 (formerly 1627), 1.5hp (part of doctoral
    programmes allergy, immunology and inflammation (AII) and Neuroscience). This
    includes designing the course curriculum, ILOs, assignments and examinations,
    selecting external lecturers, and taking an active role as a lecturer,
    supervisor, demonstrator and examiner. I have organized this course 2013,
    2015, and 2019.
    I have also organized a course for Junior Faculty at 探花精选 in
    collaboration with Career Services, 鈥淎 practical guide to becoming an
    independent researcher at KI鈥, in 2015.
    Besides that, I actively teach at other courses at undergraduate
    (l盲karprogrammet termin 11), master (Master鈥檚 programme in biomedicine
    鈥淔rontiers of Translational Medicine鈥) and doctoral levels (Cytokines in
    inflammation, 1626) at 探花精选. The types of teaching include:
    lecturing (鈥淢ilj枚- epidemiologi vid MS鈥 45min, 鈥淢S genetik鈥 45min,
    鈥淕enetic studies and epigenetics in neuroinflammation鈥 2x45min, 鈥淎nimal
    Models鈥 2x45min, 鈥淔orward genetics鈥 1x45min and 鈥滻ntroduction to
    qPCR鈥 2x45min), designing and performing practical demonstrations,
    supervising students鈥 seminars and discussions, and designing and
    supervising individual research projects.

Articles

  • Article: MULTIPLE SCLEROSIS JOURNAL. 2024;30(14):1765-1774
    Jiang Y; Cesta CE; Liu Q; Kingwell E; Stridh P; Shchetynsky K; Olsson T; Kockum I; Stener-Victorin E; Jiang X; Manouchehrinia A
  • Article: JOURNAL OF NEUROLOGY. 2024;271(11):7250-7263
    Clarelli F; Corona A; Paakkonen K; Sorosina M; Zollo A; Piehl F; Olsson T; Stridh P; Jagodic M; Hemmer B; Gasperi C; Harroud A; Shchetynsky K; Mingione A; Mascia E; Misra K; Giordano A; Mazzieri MLT; Priori A; Saarela J; Kockum I; Filippi M; Esposito F; Boneschi FGM
  • Article: SLEEP. 2024;47(10):zsae156
    Johansson E; Olsson T; Strid P; Kockum I; Alfredsson L; Hedstrom AK
  • Article: BRAIN. 2024;147(10):3573-3582
    Huang J; Tengvall K; Lima IB; Hedstroem AK; Butt J; Brenner N; Gyllenberg A; Stridh P; Khademi M; Ernberg I; Al Nimer F; Manouchehrinia A; Hillert J; Alfredsson L; Andersen O; Sundstroem P; Waterboer T; Olsson T; Kockum I
  • Article: EUROPEAN JOURNAL OF NEUROLOGY. 2024;31(10):e16387
    Ingvarsson J; Grut V; Bistrom M; Berg LP; Stridh P; Huang J; Hillert J; Alfredsson L; Kockum I; Olsson T; Waterboer T; Nilsson S; Sundstrom P
  • Article: JOURNAL OF AUTOIMMUNITY. 2024;148:103294
    Liu Q; Jiang Y; Frisell T; Stridh P; Shchetynsky K; Alfredsson L; Kockum I; Manouchehrinia A; Jiang X
  • Article: ANNALS OF NEUROLOGY. 2024;96(2):302-305
    Grut V; Bistrom M; Salzer J; Stridh P; Jons D; Gustafsson R; Huang J; Bergstrom T; Kockum I; Waterboer T; Olsson T; Sundstrom P
  • Article: NATURE COMMUNICATIONS. 2024;15(1):6419
    Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
  • Article: ANNALS OF NEUROLOGY. 2024;95(6):1112-1126
    Neidhart S; Vlad B; Hilty M; Hogelin KA; Ziegler M; Berenjeno-Correa E; Reichen I; Stridh P; Jelcic I; Khademi M; Kockum I; Sospedra M; Al Nimer F; Martin R; Jelcic I
  • Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2024;95(6):554-560
    Johansson E; Alfredsson L; Strid P; Olsson T; Kockum I; Hedstrom AK
  • Journal article: NEUROLOGY. 2024;102(7_supplement_1)
    Giordano A; Needhamsen M; Shchetynsky K; Stridh P; Harroud A; Gasperi C; Zinevych I; Paakkonen K; Lahermo P; D'Alfonso S; Barizzone N; Cavalla P; Gallo A; Chinni E; Hemmer B; Flaskamp MC; Uibel P; Piehl F; Esposito F; Mascia E; Sorosina M; Filippi M; Gustavsen S; Olsson A; S酶ndergaard HB; Oturai A; Dubois B; Harbo HCF; Berge T; Bos SD; Villoslada P; Llufriu S; Boneschi FM; Liblau R; Pignolet B; Kockum I; Beck S; Saarela J; Jagodic M
  • Article: BRAIN. 2024;147(1):177-185
    Grut V; Bistrom M; Salzer J; Stridh P; Jons D; Gustafsson R; Fogdell-Hahn A; Huang J; Butt J; Lindam A; Alonso-Magdalena L; Bergstrom T; Kockum I; Waterboer T; Olsson T; Zetterberg H; Blennow K; Andersen O; Nilsson S; Sundstroem P
  • Article: CURRENT PROTOCOLS. 2024;4(1):e972
    Huang J; Kockum I; Stridh P
  • Article: ANNALS OF NEUROLOGY. 2023;94(6):1080-1085
    Gasperi C; Wiltgen T; Mcginnis J; Cerri S; Moridi T; Ouellette R; Pukaj A; Voon C; Bafligil C; Lauerer M; Andlauer TFM; Held F; Aly L; Shchetynsky K; Stridh P; Harroud A; Wiestler B; Kirschke JS; Zimmer C; Baras A; Piehl F; Berthele A; Granberg T; Kockum I; Hemmer B; Muehlau M
  • Article: NATURE. 2023;619(7969):323-331
    Harroud A; Stridh PJ; McCauley JH; Saarela J; van den Bosch AMR; Engelenburg H; Beecham A; Alfredsson L; Alikhani K; Amezcua L; Andlauer TFM; Ban M; Barcellos L; Barizzone N; Berge T; Berthele A; Bittner S; Bos S; Briggs FBS; Caillier S; Calabresi P; Caputo D; Carmona-Burgos D; Cavalla P; Celius E; Cerono G; Chinea A; Chitnis T; Clarelli F; Comabella M; Comi G; Cotsapas C; Cree BCA; D'Alfonso S; Dardiotis E; De Jager P; Delgado S; Dubois B; Engel S; Esposito F; Fabis-Pedrini M; Filippi M; Fitzgerald K; Gasperi C; Gomez L; Gomez R; Hadjigeorgiou G; Hamann J; Held F; Henry R; Hillert J; Huang J; Huitinga I; Islam T; Isobe N; Jagodic M; Kermode AL; Khalil M; Kilpatrick T; Konidari I; Kreft K; Lechner-Scott J; Leone M; Luessi F; Malhotra S; Manouchehrinia A; Manrique C; Martinelli-Boneschi F; Martinez A; Martinez-Maldonado V; Mascia E; Metz L; Midaglia L; Montalban X; Oksenberg J; Olsson T; Oturai A; Paakkonen K; Parnell GP; Patsopoulos N; Pericak-Vance M; Piehl F; Rubio J; Santaniello A; Santoro S; Schaefer C; Sellebjerg F; Shams H; Shchetynsky K; Silva C; Siokas V; Sondergaard H; Sorosina M; Taylor B; Vandebergh M; Vasileiou E; Vecchio D; Voortman M; Weiner H; Wever D; Yong VW; Hafler D; Stewart G; Compston A; Zipp F; Harbo H; Hemmer B; Goris A; Smolders J; Hauser S; Kockum I; Sawcer S; Baranzini S; Jonsdottir I; Blanco Y; Llufriu S; Madireddy L; Saiz A; Villoslada P; Stefansson K; Harbo HF; Hemmer B; Goris A; Kockum I; Sawcer SJ; Baranzini SE
  • Article: NATURE COMMUNICATIONS. 2023;14(1):3453
    Oddsson A; Sulem P; Sveinbjornsson G; Arnadottir GM; Steinthorsdottir V; Halldorsson G; Atlason BO; Oskarsson G; Helgason H; Nielsen HS; Westergaard DA; Karjalainen J; Katrinardottir H; Fridriksdottir RB; Jensson B; Tragante VA; Ferkingstad E; Jonsson H; Gudjonsson S; Beyter D; Moore KHS; Thordardottir H; Kristmundsdottir S; Stefansson O; Rantapaa-Dahlqvist S; Sonderby IE; Didriksen MA; Stridh P; Haavik J; Tryggvadottir L; Frei O; Walters GB; Kockum I; Hjalgrim H; Olafsdottir T; Selbaek G; Nyegaard M; Erikstrup C; Brodersen T; Saevarsdottir S; Olsson T; Nielsen KR; Haraldsson A; Bruun MT; Hansen TF; Steingrimsdottir T; Jacobsen RLT; Lie R; Djurovic S; Alfredsson L; Lopez de Lapuente Portilla A; Brunak S; Melsted PV; Halldorsson B; Saemundsdottir J; Magnusson OT; Padyukov L; Banasik K; Rafnar T; Askling J; Klareskog L; Pedersen OB; Masson G; Havdahl A; Nilsson BA; Andreassen O; Daly M; Ostrowski SR; Jonsdottir I; Stefansson H; Holm H; Helgason A; Thorsteinsdottir U; Stefansson KF; Gudbjartsson D
  • Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2023;52(3):703-714
    Hedstrom AK; Segersson D; Hillert J; Stridh P; Kockum I; Olsson T; Bellander T; Alfredsson L
  • Article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2023;94(5):337-348
    Smith KA; Piehl F; Olsson T; Alfredsson L; Hillert J; Kockum I; Strid P; Montgomery S
  • Article: CURRENT PROTOCOLS. 2023;3(4):e727
    Kockum I; Huang J; Stridh P
  • Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2022;68:104250
    Huang J; Kockum I; Stridh P
  • Show more

All other publications

  • Letter: MULTIPLE SCLEROSIS JOURNAL. 2024;30(10):1385-1386
    Stridh P; Huang J; Kockum I
  • Preprint: MEDRXIV. 2024
    Giordano A; Stridh P; Preziosa P; Pisa M; Sorosina M; Mascia E; Santoro S; Misra K; Clarelli F; Ferr猫 L; Needhamsen M; Manouchehrinia A; Cannizzaro M; Moridi T; Shchetynsky K; Ouellette R; Harroud A; Sandberg E; Kuttikkatte SB; Piehl F; Alfredsson L; Hillert J; Olsson T; Fugger L; Attfield K; Granberg T; Jagodic M; DeLuca GC; Rocca M; Filippi M; Kockum I; Esposito F
  • Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):3923
    Oddsson AR; Sulem P; Sveinbjornsson G; Arnadottir G; Steinthorsdottir VM; Halldorsson G; Atlason B; Oskarsson GO; Helgason H; Nielsen HS; Westergaard D; Karjalainen JA; Katrinardottir H; Fridriksdottir R; Jensson BB; Tragante V; Ferkingstad EA; Jonsson H; Gudjonsson S; Beyter D; Moore KHS; Thordardottir H; Kristmundsdottir S; Stefansson O; Rantapaeae-Dahlqvist S; Sonderby IE; Didriksen M; Stridh PA; Haavik J; Tryggvadottir L; Frei O; Walters GB; Kockum I; Hjalgrim H; Olafsdottir T; Selbaek G; Nyegaard M; Erikstrup C; Brodersen T; Saevarsdottir S; Olsson T; Nielsen KR; Haraldsson A; Bruun MT; Hansen TF; Steingrimsdottir TT; Jacobsen RL; Lie R; Djurovic S; Alfredsson L; Lopez de Lapuente Portilla A; Brunak SV; Melsted P; Halldorsson B; Saemundsdottir J; Magnusson OT; Padyukov L; Banasik K; Rafnar T; Askling J; Klareskog L; Pedersen OB; Masson G; Havdahl AA; Nilsson B; Andreassen O; Daly M; Ostrowski SR; Jonsdottir I; Stefansson H; Holm H; Helgason A; Thorsteinsdottir UF; Stefansson K; Gudbjartsson D
  • Editorial comment: NATURE. 2023
    Beecham AH; Stridh P
  • Conference publication: NEUROLOGY. 2023;100(17)
    Giordano A; Santoro S; Sorosina M; Mascia E; Clarelli F; Cannizzaro M; Ferre L; Moridi T; Stridh P; Shchetynsky K; Needhamsen M; Piehl F; Alfredsson L; Hillert J; Olsson T; Kockum I; Jagodic M; Filippi M; Esposito F
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:105
    Alfredsson L; Huang J; Brenner N; Butt J; Strid P; Kockum I; Waterboer T; Olsson T; Hedstrom AK
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:99
    Alfredsson L; Segersson D; Hillert J; Kockum I; Strid P; Olsson T; Bellander T; Olsson T; Hedstrom AK
  • Preprint: MEDRXIV. 2022
    Kakhki MP; Cucuzza CS; Giordano A; Badam TV; Strid P; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Kockum I; Hillert J; Olsson T; Kular L; Jagodic M
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):223
    Ewing E; Al Nimer F; Fernandes SJ; Kular L; Stridh P; Noori P; Gomez-Cabrero D; Tegner J; Khademi M; Olsson T; Piehl F; Jagodic M
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):506-507
    Huang J; Stridh P; Manouchehrinia A; Gyllenberg A; Alfredsson L; Hillert J; Olsson T; Kockum I
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):663
    Smith KA; Piehl F; Olsson T; Alfredsson L; Hillert J; Kockum I; Stridh P; Montgomery S
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):763-764
    Stridh P; Shchetynsky K; James T; Kockum I; Fink K
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(1_SUPPL):114
    Alfredsson L; Hedstrom A; Hillert J; Brenner N; Butt J; Waterboer T; Strid P; Kockum I; Olsson T
  • Preprint: MEDRXIV. 2021
    Stridh P; Kockum I; Huang J
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):762-763
    Dal Maschio VP; Corona A; Paakkonen K; Piehl F; Shchetynsky K; Cotsapas C; Saarela J; Hemmer B; Harbo H-CF; Jagodic M; Clarelli F; Filippi M; Esposito F; Stridh P; Olsson T; Kockum I; Boneschi FM
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):368
    Alfredsson L; Hedstrom A; Hillert J; Brenner N; Butt J; Waterboer T; Strid P; Kockum I; Olsson T
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):340-341
    Moridi T; Stridh P; Shchetynsky K; Manouchehrinia A; Kuhle J; Hillert J; Piehl F; Olsson T; Kockum I
  • Corrigendum: CELL. 2020;180(2):403
    International Multiple Sclerosis Genetics Consorti; International Multiple Sclerosis Genetics Consorti
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2020;26(3_SUPPL):368
    Ewing E; Al Nimer F; Kular L; Carlstrom K; Stridh P; Olsson T; Khademi M; Gomez-Cabrero D; Piehl F; Jagodic M
  • Preprint: BIORXIV. 2019
    Engdahl E; Gustafsson R; Huang J; Bistr枚m M; Bomfim IL; Stridh P; Khademi M; Brenner N; Butt J; Michel A; Jons D; Hortlund M; Alonso-Magdalena L; Hedstr枚m AK; Flamand L; Ihira M; Yoshikawa T; Andersen O; Hillert J; Alfredsson L; Waterboer T; Sundstr枚m P; Olsson T; Kockum I; Fogdell-Hahn A
  • Show more

Employments

  • Researcher, Department of Clinical Neuroscience, 探花精选, 2019-

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, 探花精选, 2010

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