探花精选

Pawe艂 Kozielewicz

Pawe艂 Kozielewicz

Assistant Professor | Team Leader
Visiting address: Solnav盲gen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Receptorbiologi, 171 77 Stockholm
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About me

  • I graduated with a Master鈥檚 of Pharmacy degree from the Medical University of Warsaw, Poland. Next, I did my PhD as a Marie Curie Fellow with Prof. Nicholas M. Barnes at the University of Birmingham and Celentyx Ltd., UK (immunological and neuropharmacological studies on therapeutical drugs and targets, including orphan G protein-coupled receptors, GPCRs).

    I had my first post-doctoral stay in the lab of Prof. Agnieszka Chacinska at the IIMCB, Warsaw, Poland (protein biogenesis in synaptoneurosomes). In August 2017, I joined Prof. Gunnar Schulte's lab for my second post-doc (pharmacology of class F Frizzleds GPCRs).

    In February 2022, I received a Higher doctorate in 探花精选 sciences from the Medical University of Lublin, Poland. 

    I am currently setting up my independent lab, please see Molecular pharmacology of GPCRs and

Research

  • In my post-doctoral research in the Schulte lab, I focused on exploring the pharmacology of class F (Frizzleds) GPCRs by employing structural-functional analysis. It can be argued that, given certain ambiguities which exist about the molecular mechanism of action of these proteins, Frizzleds are similar to another class of the seven transmembrane-spanning receptors: orphan GPCRs. As such, in my prospective research, I will investigate the role of orphan GPCRs in health and diseases. For several diseases, some previous findings about a few orphan GPCRs have not been followed up by more thorough reports. Hence, the precise nature of orphan GPCRs' signalling and its association with a diseased state at a molecular level remain largely unknown. I aim to address these gaps in knowledge to push novel opportunities for therapies.

    Please check Molecular pharmacology of GPCRs website for more information.

Teaching

  • All at 探花精选:

    2025 鈥 present: Deputy Programme Director, The Global Master鈥檚 Programme in Translational Physiology and Pharmacology

    2023 鈥 present: director of the elective Advanced Receptor Pharmacology course (4 hp); The Global Master鈥檚 Programme in Translational Physiology and Pharmacology

    2022 鈥 present: seminars on pharmacokinetics; Pharmacology and Toxicology course; Bachelor's Programme in Biomedicine
    2021 鈥 present: supervision of students in the project on a literature search of a public health-related question; BV1 course; L盲karprogrammet
    2019 鈥 2022: seminars on pharmacokinetics and pharmacology of receptors; DSM2.1 course, Gamla l盲karprogrammet

     

    2022 鈥 completion of a 鈥淭eaching and learning in higher education, distance鈥 course (Grundl盲ggande h枚gskolepedagogik, distant, 5 weeks).

Articles

  • Journal article: MOLECULAR PHARMACOLOGY. 2025;:100026
    Tsang CH; De Rosa A; Kozielewicz P
  • Journal article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024;7(12):4000-4009
    Tsang CH; Kozielewicz P
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024;181(20):3819-3835
    Gratz L; Sajkowska-Kozielewicz JJ; Wesslowski J; Kinsolving J; Bridge LJ; Petzold K; Davidson G; Schulte G; Kozielewicz P
  • Article: BIOORGANIC CHEMISTRY. 2024;151:107681
    Espinosa-Bustos C; Bertrand J; Villegas-Menares A; Guerrero S; Di Marcotullio L; Navacci S; Schulte G; Kozielewicz P; Bloch N; Villela V; Paulino M; Kogan MJ; Cantero J; Salas CO
  • Journal article: BRITISH JOURNAL OF PHARMACOLOGY. 2024
    Morales P; Scharf MM; Bermudez M; Egyed A; Franco R; Hansen OK; Jagerovic N; Jakubik J; Keseru GM; Kiss DJ; Kozielewicz P; Larsen O; Majellaro M; Mallo-Abreu A; Navarro G; Prieto-Diaz R; Rosenkilde MM; Sotelo E; Stark H; Werner T; Wingler LM
  • Journal article: SLAS DISCOVERY. 2024;29(6):100174
    Sajkowska JJ; Tsang CH; Kozielewicz P
  • Article: CELL REPORTS. 2024;43(2):113727
    Kinsolving J; Bous J; Kozielewicz P; Kosenina S; Shekhani R; Gratz L; Masuyer G; Wang Y; Stenmark P; Dong M; Schulte G
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180:S23-S144
    Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA; Abbracchio MP; Abraham G; Agoulnik A; Alexander W; Al-hosaini K; Back M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Brauner-Osborne H; Burnstock G; Calo G; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dent G; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gratz L; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Herr D; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; Ijzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Lolait SJ; Lupp A; Macrae R; Maguire J; Malfacini D; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy PM; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Singh KD; Smith CM; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Ye RD
  • Article: NATURE COMMUNICATIONS. 2023;14(1):4573
    Gratz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G
  • Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2023;2023(1)
    Arthofer E; Dijksterhuis J; Gr盲tz L; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
  • Article: SCIENCE SIGNALING. 2023;16(779):eabo4974
    Bowin C-F; Kozielewicz P; Gratz L; Kowalski-Jahn M; Schihada H; Schulte G
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2374:195-204
    Kozielewicz P; Schulte G
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178:S27-S156
    Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Pawson AJ; Southan C; Davies JA; Abbracchio MP; Alexander W; Al-hosaini K; Baeck M; Barnes NM; Bathgate R; Beaulieu J-M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Braeuner-Osborne H; Burnstock G; Calo G; Castano JP; Catt K; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Csaba Z; Dahlgren C; Dent G; Singh KD; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Williams TL; Lolait SJ; Lupp A; Macrae R; Maguire J; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy P; Nahon J-L; Ngo T; Norel X; Nyimanu D; Ocarroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PMWM; Tirupula K; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Woodruff TM; Yao C; Ye RD
  • Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)
    Arthofer E; Dijksterhuis J; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
  • Article: NATURE COMMUNICATIONS. 2021;12(1):3919
    Turku A; Schihada H; Kozielewicz P; Bowin C-F; Schulte G
  • Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(3):1235-1245
    Kozielewicz P; Shekhani R; Moser S; Bowin C-F; Wesslowski J; Davidson G; Schulte G
  • Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:101-115
    Kozielewicz P; Schihada H; Schulte G
  • Article: MOLECULES. 2020;26(1):E143-143
    Sajkowska-Kozielewicz JJ; Kozielewicz P; Makarova K; Stocki M; Barnes NM; Paradowska K
  • Journal article: FARMACJA POLSKA. 2020;76(10):592-599
    Kwas K; Mostowy M; Kozielewicz P; Sajkowska-Kozielewicz J
  • Article: EMBO REPORTS. 2020;21(8):e48882
    Kuzniewska B; Cysewski D; Wasilewski M; Sakowska P; Milek J; Kulinski TM; Winiarski M; Kozielewicz P; Knapska E; Dadlez M; Chacinska A; Dziembowski A; Dziembowska M
  • Show more

All other publications

  • Preprint: MEDRXIV. 2024
    Tsang CH; De Rosa A; Kozielewicz P
  • Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2024;45(5):419-429
    Schulte G; Scharf MM; Bous J; Voss JH; Gratz L; Kozielewicz P
  • Preprint: RESEARCH SQUARE. 2024
    Schulte G; Gr盲tz L; Turku A; Kozielewicz P; Bowin C-F; Scharf M; Voss J; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; K枚rber M; Lauschke V; L枚ber S; Gmeiner P
  • Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(4):479-480
    Kozielewicz P; Gratz L; Sajkowska-Kozielewicz J; Moser S; Davidson G; Schulte G
  • Preprint: BIORXIV. 2022
    Bowin C-F; Kozielewicz P; Gr盲tz L; Kowalski-Jahn M; Schihada H; Schulte G
  • Preprint: BIORXIV. 2022
    Gr盲tz L; Sajkowska-Kozielewicz J; Wesslowski J; Petzold K; Davidson G; Schulte G; Kozielewicz P
  • Letter: CELL RESEARCH. 2021;31(12):1311-1314
    Xu L; Chen B; Schihada H; Wright SC; Turku A; Wu Y; Han G-W; Kowalski-Jahn M; Kozielewicz P; Bowin C-F; Zhang X; Li C; Bouvier M; Schulte G; Xu F
  • Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2020;126:17-24
    Schulte G; Kozielewicz P
  • Review: MOLECULAR PHARMACOLOGY. 2020;97(2):62-71
    Kozielewicz P; Turku A; Schulte G
  • Preprint: BIORXIV. 2019
    Kuzniewska B; Cysewski D; Wasilewski M; Sakowska P; Milek J; Kulinski TM; Kozielewicz P; Dadlez M; Chacinska A; Dziembowski A; Dziembowska M
  • Preprint: BIORXIV. 2019
    Kozielewicz P; Bowin C-F; Schulte G
  • Editorial comment: LIFE SCIENCES. 2019;225:132
    Kozielewicz P
  • Conference publication: FEBS OPEN BIO. 2019;9:28-29
    Kuzniewska B; Cysewski D; Sakowska P; Milek J; Wasilewski M; Winiarski M; Kulinski TM; Kozielewicz P; Knapska E; Chacinska A; Dziembowski A; Dziembowska M
  • Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2016;164:98-105
    Kozielewicz P; Grafton G; Kutner A; Curnow SJ; Gordon J; Barnes NM
  • Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381
    Sajkowska-Kozielewicz JJ; Kozielewicz P; Makarova K; Wawer I; Paradowska K
  • Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381
    Sajkowska-Kozielewicz JJ; Kozielewicz P; Barnes NM; Wawer I; Paradowska K

Grants

  • Understanding the role of orphan GPCR GPR61 in obesity
    探花精选 Research Foundation
    25 November 2024 - 24 November 2026
  • Targeting G protein-coupled receptors in cancers
    探花精选
    10 October 2024 - 9 October 2027
  • GPR34, GPR65 and GPR183 as therapeutic targets in blood cancers
    Jeansson Foundation
    13 December 2023 - 12 December 2024
  • Swedish Research Council
    1 January 2023 - 31 December 2026

Employments

  • Assistant Professor, Department of Physiology and Pharmacology, 探花精选, 2023-2029
  • Researcher, Department of Physiology and Pharmacology, 探花精选, 2022-2023
  • Post-doctoral researcher, Department of Physiology and Pharmacology, 探花精选, 2017-2022

Degrees and Education

  • Habilitation in Medical Sciences, Medical University of Lublin, 2022
  • PhD in Clinical and Experimental Medicine, University of Birmingham, 2017
  • Master's of Pharmacy, Medical University of Warsaw, 2013

Leadership and responsibility assignments

  • Deputy Programme Director, The Global Master's Programme in Translational Physiology and Pharmacology, Department of Physiology and Pharmacology, 探花精选, 2025-
  • Team Leader, Molecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, 探花精选, 2024-

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