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Oliver Mortusewicz

Oliver Mortusewicz

Principal Researcher
Visiting address: Scilifelab, Alpha Building Level 4, Tomtebodav盲gen 23a, 17165 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Helleday Mortusewicz, 171 77 Stockholm
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About me

  • Principal Researcher, Team leader and Project leader at the Department of Oncology-Pathology & SciLifeLab

Research

  • A deep understanding of the molecular mechanisms of DNA repair and nucleotide metabolism is the cornerstone of our drug discovery approach.
    To be able to efficiently and successfully target proteins involved in these pathways for the treatment of cancer and other diseases, we need a detailed view of their biological functions and interactions in live cells.

    We have the unique ability to use small molecule Inhibitors and Activators developed by our excellent medicinal chemistry team as probes in our advanced molecular and cell biology assays to uncover new important biology.

    We regularly employ advanced live cell confocal microscopy in combination with laser microirradiation, Fluorescence recovery after photobleaching (FRAP) and Fluorescence loss in photobleaching (FLIP) to visualize high spatio-temporal details and highly coordinated processes of DNA repair, cell division and genome duplication in live cells. This is complemented by traditional antibody-based immunofluorescence assays in tumors and cells, allowing visualization of endogenous protein distribution and post-translational modifications after perturbation with drugs. Besides high-resolution confocal microscopy we use plate-reader microscopes for quantitative image based cytometry (QIBC), enabling us to test many different experimental settings and perturbations on a high number of cells.

Teaching

  • 鈥 Co-Supervison of four PhD Students to date
    鈥 Supervision of undergraduate & MSc thesis projects

Articles

  • Article: NATURE COMMUNICATIONS. 2025;16(1):1741
    Luttens A; Vo DD; Scaletti ER; Wiita E; Almlof I; Wallner O; Davies J; Kosenina S; Meng L; Long M; Mortusewicz O; Masuyer G; Ballante F; Michel M; Homan E; Scobie M; Kalderen C; Berglund UW; Tarnovskiy AV; Radchenko DS; Moroz YS; Kihlberg J; Stenmark P; Helleday T; Carlsson J
  • Article: NATURE COMMUNICATIONS. 2024;15(1):10347
    Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires MJ; Stigsdotter H; Rasti A; Langelier M-F; Rehling D; Throup A; Purewal-Sidhu O; Desroses M; Onireti J; Wakchaure P; Almloef I; Bostrom J; Bevc L; Benzi G; Stenmark P; Pascal JM; Helleday T; Page BDG; Altun M
  • Article: MOLECULAR ONCOLOGY. 2024;18(9):2179-2195
    Marttila P; Bonagas N; Chalkiadaki C; Stigsdotter H; Schelzig K; Shen J; Farhat CM; Hondema A; Albers J; Wiita E; Rasti A; Warpman Berglund U; Slipicevic A; Mortusewicz O; Helleday T
  • Journal article: MOLECULAR CANCER THERAPEUTICS. 2023;22(12_Supplement):b109
    Martilla P; Green AC; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernhardin F; Long M; Jemth A-S; Mortusewicz O; Homan E; Bonagas N; Ramos L; Sanjiv K; Mancina EG; Pham T; Slipicevic A; Henriksson M; Meiser J; Helleday T
  • Article: ONCOGENE. 2023;42(16):1282-1293
    Walter M; Mayr F; Hanna BMF; Cookson V; Mortusewicz O; Helleday T; Herr P
  • Article: NATURE METABOLISM. 2023;5(4):642-659
    Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
  • Article: SCIENCE. 2022;376(6600):1471-1476
    Michel M; Ben铆tez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Casta帽eda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; M眉ller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Sch枚mberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalder茅n C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
  • Article: NATURE COMMUNICATIONS. 2022;13(1):1015
    Bergstrand S; O'Brien EM; Coucoravas C; Hrossova D; Peirasmaki D; Schmidli S; Dhanjal S; Pederiva C; Siggens L; Mortusewicz O; O'Rourke JJ; Farnebo M
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4542
    Hanna BMF; Michel M; Helleday T; Mortusewicz O
  • Article: NUCLEIC ACIDS RESEARCH. 2020;48(21):12234-12251
    Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
  • Article: BIOMOLECULES. 2020;10(11):E1483-1483
    Hanna BMF; Helleday T; Mortusewicz O
  • Journal article: CANCER RESEARCH. 2020;80(17):3530-3541
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
  • Article: NUCLEIC ACIDS RESEARCH. 2019;47(14):7418-7429
    Tepper S; Mortusewicz O; Czlonka E; Bello A; Schmidt A; Jeschke J; Fischbach A; Pfeil I; Petersen-Mahrt SK; Mangerich A; Helleday T; Leonhardt H; Jungnickel B
  • Journal article: HEMASPHERE. 2019;3(S1):67
    Jagdhane P; Garg S; Xia J; He L; Misiak D; Mortusewicz O; Helleday T; M眉ller鈥怲idow C; Koehn M; Pabst C
  • Article: NUCLEUS. 2019;10(1):231-253
    Chagin VO; Reinhart B; Becker A; Mortusewicz O; Jost KL; Rapp A; Leonhardt H; Cardoso MC
  • Article: SCIENCE. 2018;362(6416):834-839
    Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
  • Article: ONCOTARGET. 2017;8(14):23713-23726
    Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
  • Article: CELL CYCLE. 2017;16(2):189-199
    Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vaharautio A; Bjorklund M; Taipale M; Helleday T; Taipale J
  • Article: ONCOGENESIS. 2016;5(12):e280
    Tanikawa M; Sanjiv K; Helleday T; Herr P; Mortusewicz O
  • Article: CANCER RESEARCH. 2016;76(5):1078-1088
    Ying S; Chen Z; Medhurst AL; Neal JA; Bao Z; Mortusewicz O; McGouran J; Song X; Shen H; Hamdy FC; Kessler BM; Meek K; Helleday T
  • Show more

All other publications

  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Str枚m CE; Mortusewicz O; Berglund UW; Helleday T
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Str枚m CE; Mortusewicz O; Berglund UW; Helleday T
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Str枚m CE; Mortusewicz O; Berglund UW; Helleday T
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2025
    Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Str枚m CE; Mortusewicz O; Berglund UW; Helleday T
  • Other: JOURNAL OF CELL SCIENCE. 2022;135(21):jcs260709
    Perucca P; Cazzalini O; Mortusewicz O; Necchi D; Savio M; Nardo T; Stivala LA; Leonhardt H; Cardoso MC; Prosperi E
  • Preprint: BIORXIV. 2022
    Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires M; Stigsdotter H; Rasti A; Langelier M-F; Langelier M-F; Rehling D; Throup A; Desroses M; Onireti J; Wakchaure P; Alml枚f I; Bostr枚m J; Bevc L; Benzi G; Stenmark P; Pascal J; Helleday T; Page BDG; Altun M
  • Conference publication: 2021;:9213
    Helleday T; Hanna BMF; Visnes T; Benitez-Buelga C; Cazares-K枚rner A; Sanjiv K; Mortusewicz O; Masuyer G; Wallner O; Michel M; Loseva O; Jemth A-S; Kalderen C; Stenmark P; Berglund UW
  • Meeting abstract: CANCER RESEARCH. 2020;80(16):5204
    Benitez-Buelga C; Visnes T; Sanjiv K; Mortusewicz O; Berglund UW; Helleday T
  • Meeting abstract: CANCER RESEARCH. 2019;79(13):105
    Sanjiv K; Gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kalderen C; Jemth A-S; Almlof I; Visnes T; Schultz N; Bostrom J; Montano JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Strom C; Scobie M; Bastians H; Berglund UW; Helleday T
  • Preprint: BIORXIV. 2019
    Gad H; Mortusewicz O; Rudd S; Stolz A; Amaral N; Brautigham L; Pudelko L; Sanjiv K; Kald茅ren C; Jemth A-S; Alml枚f I; Visnes T; Schultz N; Bostr枚m J; Calderon Montano JM; Hagenkort A; Groth P; Loseva O; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Str枚m C; Scobie M; Bastians H; Berglund UW; Helleday T
  • Preprint: BIORXIV. 2019
    Rudd S; Gad H; Amaral N; Hagenkort A; Groth P; Str枚m C; Mortusewicz O; Berglund UW; Helleday T
  • Corrigendum: CELL REPORTS. 2016;17(12):3407-3416
    Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
  • Corrigendum: MOLECULAR CELL. 2016;61(1):181
    Xie S; Mortusewicz O; Ma HT; Herr P; Poon RYC; Helleday T; Qian C
  • Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:81
    Sanjiv K; Hagenkort A; Reaper PM; Koolmeister T; Mortusewicz O; Schultz N; Scobie M; Berglund UW; Charlton PA; Pollard JR; Helleday T
  • Editorial comment: EMBO JOURNAL. 2013;32(4):493-495
    Mortusewicz O; Herr P; Helleday T

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