探花精选

Ninib Baryawno

Ninib Baryawno

Principal Researcher | Docent
Visiting address: Widerstr枚mska huset, Tomtebodav盲gen 18A, 17177 Stockholm
Postal address: K6 Kvinnors och barns h盲lsa, K6 Barnonkologi och barnkirurgi Baryawno, 171 77 Stockholm
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About me

  • The lab focus is to solve problems that limit the ability of cancer therapy 

  • to be used more effectively against deadly forms of pediatric cancers and 
  • adult cancers.

     

  • Dr Ninib Baryawno received his PhD diploma at 探花精选 under the supervision of associate professor John Inge Johnsen and professor Per 

  • Kogner. His thesis work focused on developing novel therapeutics based on 
  • better biological understanding of the childhood brain tumor medulloblastoma. 
  • A disorder of development, arising mostly in the cerebellum during 
  • embryogenesis and is largely dictated by events in stem cell regulatory 
  • signaling pathways. His research was published as a thesis 鈥淣ew Potential 
  • Targets in Medulloblastoma Therapy 鈥 Studies on Cellular Mechanisms and 
  • Mediators鈥, and defended in February 2010. It was the interest in stem cell based approaches to disease that brought Dr 
  • Baryawno together with professor David Scadden at Harvard University and 
  • Massachusetts General Hospital in 2011. Dr Baryawno was a postdoctoral fellow 
  • in the Scadden lab until 2017 where he applied single-cell RNA-sequencing to 
  • study how the hematopoietic stem cell niche supports the outgrowth of murine 
  • leukemia and human bone metastases.

     

  • Dr Baryawno became Assistant professor at 探花精选 in January 2018.

     

  • Research training:

    • 2001-2005, Biomedicine program, 探花精选.
    • 2005-2010, PhD training, 探花精选.
    • 2011-2017, Postdoc fellowship, Harvard University/Massachusetts General Hospital.
    • 2018, Assistant pProfessor, 探花精选.
    • 2023, Associate Professor (Docent), 探花精选.
    • 2023, Group leader, 探花精选.

Research

  • The lab's focus is to solve problems that limit the ability of cancer therapy to be used more effectively against deadly forms of pediatric cancers and adult cancers. We focus our research on pediatric tumors of the nervous system such as neuroblastoma and medulloblastoma, and bone metastases from different tumor origins.

     

  • Our research is balanced by a commitment to the value of basic and translational research. This effort is based on the integrated approach of single-cell technologies, computational modeling, and functional preclinical testing, directed at understanding the role of the tumor microenvironment in cancer development, tumor cell dissemination, and cancer resistance.

     

  • Read more about our work here at 

  • .

    Research expertise:

    • Childhood cancer (neuroblastoma, medulloblastoma)
    • Metastatic cancer (neuroblastoma, prostate cancer, renal cell carcinoma)
    • Tumor microenvironment (stroma, immune cells)
    • Basic and translational
    • Single-cell omics
    • Preclinical modeling (organoids/tumoroids, animals)

Teaching

  • Teaching at 探花精选, lectures and seminars:

    • Pediatric oncology course 2017, 2021 (graduates, 13h)
    • Medical Medicine 鈥 Oncology 2019, 2020, 2021, 2022 and current (undergraduates, 75 hours)
    • Tumor Biology Course 2018 (undergraduates/graduates
    • 20 hours, )
    • Advanced Course in Tumor Biology 2018 (graduates, 1h)
    • Vascular Cell Biology Course 2019 (graduates, 1h)
    • Regenerative Medicine (undergraduates, 1h)

Articles

  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(19):10517
    Woo S-Y; Shim W-S; Lee H; Baryawno N; Song P; Kim BS; Yoon S; Oh S-O; Lee D
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(19):10381
    Kang N; Kim J; Kwon M; Son Y; Eo S-K; Baryawno N; Kim BS; Yoon S; Oh S-O; Lee D; Kim K
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2024;134(21):e175310
    Nagarajan D; Parracho RT; Corujo D; Xie M; Kutkaite G; Olsen TK; Bedos MR; Salehi M; Baryawno N; Menden MP; Chen X; Buschbeck M; Mao Y
  • Article: MOLECULAR CANCER. 2024;23(1):180
    Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
  • Article: JCI INSIGHT. 2024;9(6):e173337
    Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickstrom M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
  • Article: CANCER CELL. 2024;42(2):283-300.e8
    Wienke J; Visser LL; Kholosy WM; Keller KM; Barisa M; Poon E; Munnings-Tomes S; Himsworth C; Calton E; Rodriguez A; Bernardi R; Ham FVD; Hooff SRV; Matser YAH; Tas ML; Langenberg KPS; Lijnzaad P; Borst AL; Zappa E; Bergsma FJ; Strijker JGM; Verhoeven BM; Mei S; Kramdi A; Restuadi R; Sanchez-Bernabeu A; Cornel AM; Holstege FCP; Gray JC; Tytgat GAM; Scheijde-Vermeulen MA; Wijnen MHWA; Dierselhuis MP; Straathof K; Behjati S; Wu W; Heck AJR; Koster J; Nierkens S; Janoueix-Lerosey I; Krijger RRD; Baryawno N; Chesler L; Anderson J; Caron HN; Margaritis T; Noesel MMV; Molenaar JJ
  • Article: GENOME MEDICINE. 2024;16(1):1
    Mei S; Alchahin AM; Tsea I; Kfoury Y; Hirz T; Jeffries NE; Zhao T; Xu Y; Zhang H; Sarkar H; Wu S; Subtelny AO; Johnsen JI; Zhang Y; Salari K; Wu C-L; Randolph MA; Scadden DT; Dahl DM; Shin J; Kharchenko PV; Saylor PJ; Sykes DB; Baryawno N
  • Article: ONCOIMMUNOLOGY. 2023;12(1):2184130
    Valind A; Verhoeven BM; Enoksson J; Karlsson J; Christensson G; Manas A; Aaltonen K; Jansson C; Bexell D; Baryawno N; Gisselsson D; Hagerling C
  • Article: JCI INSIGHT. 2023;8(17):e167858
    Massengale M; Massengale JL; Benson CR; Baryawno N; Oki T; Steinhauser ML; Wang A; Balani D; Oh LS; Randolph MA; Gill TJ; Kronenberg HM; Scadden DT
  • Article: NATURE COMMUNICATIONS. 2023;14(1):663
    Hirz T; Mei S; Sarkar H; Kfoury Y; Wu S; Verhoeven BM; Subtelny AO; Zlatev DV; Wszolek MW; Salari K; Murray E; Chen F; Macosko EZ; Wu C-L; Scadden DT; Dahl DM; Baryawno N; Saylor PJ; Kharchenko PV; Sykes DB
  • Article: CELL DEATH AND DISEASE. 2022;13(10):916
    Woo S-Y; Lee H; Park SM; Choi H-S; Kim J; Kwon M; Sohn J; Nam JH; Kim H-S; Song P; Baryawno N; Kim Y-H; Kim K; Lee D
  • Article: NATURE COMMUNICATIONS. 2022;13(1):5747
    Alchahin AM; Mei S; Tsea I; Hirz T; Kfoury Y; Dahl D; Wu C-L; Subtelny AO; Wu S; Scadden DT; Shin JH; Saylor PJ; Sykes DB; Kharchenko PV; Baryawno N
  • Article: JCI INSIGHT. 2022;7(17):e153836
    Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tummler C; Myrberg IH; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
  • Article: CELL REPORTS MEDICINE. 2022;3(6):100657
    Verhoeven BM; Mei S; Olsen TK; Gustafsson K; Valind A; Lindstrom A; Gisselsson D; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
  • Article: SCIENTIFIC REPORTS. 2022;12(1):7519
    Jo A; Kwak J-H; Woo S-Y; Kim B-Y; Son Y; Choi H-S; Kim J; Kwon M; Cho H-R; Eo S-K; Nam JH; Kim H-S; Baryawno N; Lee D; Kim K
  • Article: AMERICAN JOURNAL OF CANCER RESEARCH. 2022;12(12):5532-5551
    Lim DM; Kang J; Woo S-Y; Choi H-S; Kwon M; Kim J; Park HR; Jung K; Baryawno N; Kim H-S; Lee D; Kim YH
  • Article: ELIFE. 2021;10:e66512
    Fast EM; Sporrij A; Manning M; Rocha EL; Yang S; Zhou Y; Guo J; Baryawno N; Barkas N; Scadden D; Camargo F; Zon LI
  • Article: CANCER CELL. 2021;39(11):1464-1478.e8
    Kfoury Y; Baryawno N; Severe N; Mei S; Gustafsson K; Hirz T; Brouse T; Scadden EW; Igolkina AA; Kokkaliaris K; Choi BD; Barkas N; Randolph MA; Shin JH; Saylor PJ; Scadden DT; Sykes DB; Kharchenko PV
  • Article: CANCERS. 2021;13(21):5493
    Milosevic J; Fransson S; Gulyas M; Olsen TK; Gallo-Oller G; Treis D; Elfman LHM; Wilhelm M; Martinsson T; Baryawno N; Kogner P; Johnsen JI
  • Article: NATURE METHODS. 2021;18(8):912-920
    Andrews N; Serviss JT; Geyer N; Andersson AB; Dzwonkowska E; Sutevski I; Heijboer R; Baryawno N; Gerling M; Enge M
  • Show more

All other publications

  • Review: CANCERS. 2023;15(19):4734
    Alchahin AM; Tsea I; Baryawno N
  • Preprint: BIORXIV. 2022
    Alchahin AM; Mei S; Tsea I; Hirz T; Kfoury Y; Dahl D; Wu C-L; Subtelny AO; Wu S; Scadden DT; Shin JH; Saylor PJ; Sykes DB; Kharchenko PV; Baryawno N
  • Editorial comment: CELL STEM CELL. 2017;20(5):590-592
    Baryawno N; Severe N; Scadden DT
  • Thesis / dissertation: 2010
    Baryawno, Ninib

Grants

  • Swedish Research Council
    1 December 2023 - 30 November 2026
  • Swedish Research Council
    1 January 2022 - 31 December 2025
  • Barncancerfonden
    1 January 2022 - 31 December 2022
  • Dissecting the cellular and molecular landscape of human neuroblastoma as a tool for developing novel therapeutic targets
    Swedish Cancer Society
    1 January 2019
  • Swedish Research Council
    1 July 2012 - 30 June 2015

Employments

  • Principal Researcher, Department of Women's and Children's Health, 探花精选, 2022-

Degrees and Education

  • Docent, 探花精选, 2023
  • Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, 探花精选, 2010
  • Master Of Medical Science, 探花精选, 2007

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