探花精选

Mikael Lindstr枚m

Mikael Lindstr枚m

Researcher | Docent
Visiting address: Tomtebodav盲gen 23A, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 Genome biology Bartek, 171 77 Stockholm

About me

  • PhD degree in Experimental Oncology 2004 and Docent in Experimental Pathology 

  • obtained 2012 at 探花精选 i Stockholm, Sweden.

Research

  • We are specifically interested in molecular mechanisms underlying the regulation of ribosome biogenesis, how the cell senses errors in the complex process of ribosome biogenesis and how these processes in turn can be used in the development of novel anti-cancer therapies. To investigate ribosome biogenesis and nucleolar structure, the team uses various microscopy technologies, ribosome profiling, rDNA assays, transcriptomics, translatomics, and proteomics. We also work a lot with small molecules and functional screens. Main lines and interests of research: 1. Characterization of ribosome biogenesis regulatory proteins and potential role in cancer development, biomarker discovery for precision / 


  • personalized cancer medicine. 2. Regulation of ribosome biogenesis and protein synthesis in normal CNS cells and in glioma, including heterogeneity of ribosome in relation to glioma cellular diversity. 3. Targeting of ribosome biogenesis or mature ribosome function in cancer. 4. Functional studies of ribosomal proteins.

     

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  • I have evaluated manuscripts for the following journals among others

     

  • Oncogene, Nature, EMBO Rep, EMBO J, Nature Cell Biology, J Biol Chem, Mol Cell Biol, Proteins, J. of Clinical Investigation, Mol Cell, Intl. J of Cancer, Int J Mol Sciences, Cancer, Cancers, J Cytology &

  • Histology, J Mol Biol, PLoS One, FEBS Letters, FEBS J, Future Oncology, Cell Proliferation, Biochem J, Scientific Reports, Tumor Biology, Current Drug Targets, Cytotherapy, Nature Communications, J Cell Science, Cell Reports, Cell Cycle, Chemistry Biology, Blood, Pharmaceuticals, Biochem Soc Trans, Cells, Oncotarget, Int J of Dev Neuroscience, Cellular Physiology and Biochemistry, BMC Biotechnology, BMC Molecular Biology, Bioscience Reports, Cancer Res, Elife, J Cellular Physiology, J Oncology, BBA Mol Cell, Comm Biol, Metabolites, Ebiomedicine, ACS Chemical Biology, BBA Molecular Res, Biomarkers, JCI Insight, BioEssays, Cell Death and Disease, Cell Death and Differentiation, Biomedicines, Breast Cancer Research, Pathogens, Signal Transduction and Targeted Therapies, Biomolecules and Biomedicine, Histology &
  • Histopathology, Epigenetics and Chromatin, Mol Oncol, Nucleic Acids Res Cancer, iScience, Int J Cancer, Discover Oncology, Trends Cell Biology, Cell Proliferation and many others

Teaching

  • Supervision

     

  • Co-supervisor: Dr Tamador Elsir, PhD 2010-06-04, KI 


  • Co-supervisor: Dr Inga Nazarenko, PhD 2011-09-30, KI
    Co-supervisor: Dr Karl Holmberg-Olausson, PhD 2015-06-01, KI

    Main supervisor: Dr Kaveh Moazemi Goudarzi, PhD 2018-04-27, KI
    Main supervisor: Dr Asimina Zisi, PhD 2022-10-28, KI

     

  • Service to the universities

     

  • Pre-examiner of doctoral dissertation: 16 (2009-2024)
    Half time review for PhD: 20 (2012-2024)
    Chairman of PhD defense: 8 (2015-2024)
    Examiner of MSc or BSc thesis 16 (2012-2018)
    Opponent: 1

     

  • Following courses I have taken

    Basic pedagogics for university lecturers GHPH09

    Postgraduate supervisor training course KI

    Leadership education UGL, KI

    Web courses for supervisors

     

  • I have over 1000 teaching hours in cell biology, oncology, and biochemistry for students at the 探花精选 and bio探花精选 programs, including molecular oncology and biostatistics (BioMed), and Molecular Medicine course, cell biology. At the 探花精选 program biochemistry in the DFM1 and BV2 courses. I have been teaching also at the postgraduate course level, at the Cancer Cell cycles and Cancer Cell metabolism courses. I have co-organized a course on Brain Tumors. I currently also teach biochemistry at the KI "prep course" for foreign (non EU) 探花精选 doctors that will take knowledge test for licence to practice medicine in Sweden. 

Articles

  • Article: NUCLEIC ACIDS RESEARCH (NAR). 2024;52(8):4151-4166
    Espinoza JA; Kanellis DC; Saproo S; Leal K; Martinez JF; Bartek J; Lindstrom MS
  • Journal article: CANCER RESEARCH. 2024;84(6):4526
    Saproo S; Papadaki S; Espinoza JA; Bartek J; Lindstrom MS
  • Journal article: CANCER RESEARCH. 2024;84(5):pr-002-pr-002
    Zisi A; Dratkiewicz E; Kanellis DC; Moussaud S; Karlsson I; Caren H; Brautigam L; Bartek J; Lindstrom MS
  • Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678
    Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Bjorkman A; Li X; Arampatzis S; Bartkova J; Andujar-Sanchez M; Fernandez-Capetillo O; Mistrik M; Lindstrom MS; Bartek J
  • Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072
    Zisi A; Kanellis DC; Moussaud S; Karlsson I; Caren H; Braeutigam L; Bartek J; Lindstrom MS
  • Article: ONCOGENE. 2021;40(32):5066-5080
    Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
  • Article: SCIENCE ADVANCES. 2021;7(32):eabf7561
    Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Bostrom J; Dyrskjot L; Broholm H; Altun M; Elsasser SJ; Lindstrom MS; Bartek J
  • Article: CANCER RESEARCH. 2020;80(7):1538-1550
    Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
  • Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789
    Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Huhn D; Watanabe K; Helleday T; Lindstrom MS; Bartek J
  • Article: NEURO-ONCOLOGY ADVANCES. 2020;2(1):vdaa061
    Guo M; van Vliet M; Zhao J; de Stahl TD; Lindstrom MS; Cheng H; Heller S; Nister M; Hagerstrand D
  • Article: CANCER RESEARCH. 2018;78(20):5901-5916
    Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nister M; Lindstrom MS; Hagerstrand D
  • Article: CELL CYCLE. 2018;17(17):2146-2163
    Bennetzen MV; Kosar M; Bunkenborg J; Payne MR; Bartkova J; Lindstrom MS; Lukas J; Andersen JS; Bartek J; Larsen DH
  • Article: ONCOTARGET. 2017;8(57):96536-96552
    Kostopoulou ON; Wilhelmi V; Raiss S; Ananthaseshan S; Lindstrom MS; Bartek J; Soderberg-Naucler C
  • Article: LEUKEMIA. 2017;31(1):213-221
    Jaako P; Ugale A; Wahlestedt M; Velasco-Hernandez T; Cammenga J; Lindstrom MS; Bryder D
  • Article: SCIENTIFIC REPORTS. 2015;5:16495
    Olausson KH; Elsir T; Goudarzi KM; Nister M; Lindstrom MS
  • Article: LEUKEMIA. 2015;29(11):2221-2229
    Jaako P; Debnath S; Olsson K; Zhang Y; Flygare J; Lindstrom MS; Bryder D; Karlsson S
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(50):34601-34619
    Olausson KH; Nister M; Lindstrom MS
  • Article: CANCER BIOLOGY & THERAPY. 2014;15(11):1499-1514
    Goudarzi KM; Nister M; Lindstrom MS
  • Article: GENES & DEVELOPMENT. 2014;28(1):58-70
    Kelly GL; Grabow S; Glaser SP; Fitzsimmons L; Aubrey BJ; Okamoto T; Valente LJ; Robati M; Tai L; Fairlie WD; Lee EF; Lindstrom MS; Wiman KG; Huang DCS; Bouillet P; Rowe M; Rickinson AB; Herold MJ; Strasser A
  • Article: CELLS. 2012;1(4):774-798
    Holmberg Olausson K; Nist茅r M; Lindstr枚m MS
  • Article: PLOS ONE. 2012;7(12):e52476
    Lindstrom MS
  • Article: BRITISH JOURNAL OF CANCER. 2011;104(11):1747-1754
    Elsir T; Qu M; Berntsson SG; Orrego A; Olofsson T; Lindstrom MS; Nister M; von Deimling A; Hartmann C; Ribom D; Smits A
  • Article: PLOS ONE. 2011;6(4):e18303
    Nazarenko I; Hedren A; Sjodin H; Orrego A; Andrae J; Afink GB; Nister M; Lindstrom MS
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;405(4):581-587
    Gadalla S-E; Alexandraki A; Lindstrom MS; Nister M; Ericsson C
  • Article: JOURNAL OF ONCOLOGY. 2011;2011:852970-11
    Hede S-M; Nazarenko I; Nist茅r M; Lindstr枚m MS
  • Article: BIOCHEMISTRY RESEARCH INTERNATIONAL. 2011;2011:195209-16
    Lindstr枚m MS
  • Article: CANCER CELL. 2010;18(3):231-243
    Macias E; Jin A; Deisenroth C; Bhat K; Mao H; Lindstrom MS; Zhang Y
  • Article: PLOS ONE. 2010;5(3):e9578-A129
    Lindstrom MS; Nister M
  • Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2010;69(2):129-138
    Elsir T; Eriksson A; Orrego A; Lindstrom MS; Nister M
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(23):15568-15576
    Lindstrom MS; Zhang Y
  • Article: CANCER CELL. 2007;12(4):355-366
    Itahana K; Mao H; Jin A; Itahana Y; Clegg HV; Lindstrom MS; Bhat KP; Godfrey VL; Evan GI; Zhang Y
  • Article: CELL CYCLE. 2007;6(4):434-437
    Lindstrom MS; Deisenroth C; Zhang Y
  • Article: MOLECULAR AND CELLULAR BIOLOGY. 2007;27(3):1056-1068
    Lindstrom MS; Jin A; Deisenroth C; Wolf GW; Zhang Y
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(27):18463-18472
    Enomoto T; Lindstrom MS; Jin A; Ke H; Zhang Y
  • Article: ACTA ONCOLOGICA. 2006;45(6):676-684
    Wang J-L; Andersson S; Li X; Hellstrom A-C; Auer G; Angstrom T; Lindstrom MS; Wallin K-L
  • Article: MODERN PATHOLOGY. 2005;18(5):629-637
    Wang JL; Zheng BY; Li XD; Nokelainen K; 脜ngstr枚m T; Lindstr枚m MS; Wallin KL
  • Article: CLINICAL CANCER RESEARCH. 2004;10(7):2407-2414
    Wang JL; Zheng BY; Li XD; 脜ngstr枚m T; Lindstr枚m MS; Wallin KL
  • Article: ONCOGENE. 2003;22(32):4993-5005
    Lindstr枚m MS; Wiman KG
  • Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):381-387
    Lindstr枚m MS; Wiman KG
  • Article: CANCER LETTERS. 2002;180(2):211-221
    Hashemi J; Lindstr枚m MS; Asker C; Platz A; Hansson J; Wiman KG
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(27):25336-25341
    Jackson MW; Lindstr枚m MS; Berberich SJ
  • Article: ONCOGENE. 2001;20(17):2171-2177
    Lindstr枚m MS; Klangby U; Wiman KG
  • Article: APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH. 2001;6(1-2):133-137
    Henriksson M; Selivanova G; Lindstr枚m M; Wiman KG
  • Article: EXPERIMENTAL CELL RESEARCH. 2000;256(2):400-410
    Lindstr枚m MS; Klangby U; Inoue R; Pisa P; Wiman KG; Asker CE
  • Show more

All other publications

  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstr枚m MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
  • Review: CELL DEATH AND DIFFERENTIATION. 2022;29(5):972-982
    Lindstrom MS; Bartek J; Maya-Mendoza A
  • Review: CANCERS. 2022;14(9):2126
    Zisi A; Bartek J; Lindstrom MS
  • Corrigendum: ONCOGENE. 2021;40(32):5153
    Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
  • Editorial comment: BIOSCIENCE REPORTS. 2019;39(7):BSR20190770
    Lindstrom MS
  • Review: ONCOGENE. 2018;37(18):2351-2366
    Lindstrom MS; Jurada D; Bursac S; Orsolic I; Bartek J; Volarevic S
  • Review: INTERNATIONAL JOURNAL OF ONCOLOGY. 2016;48(4):1313-1324
    Goudarzi KM; Lindstrom MS
  • Meeting abstract: CANCER RESEARCH. 2015;75:2082
    Goudarzi KM; Elsir T; Nister M; Lindstrom MS
  • Conference publication: EUROPEAN JOURNAL OF CANCER. 2014;50:S72
    Goudarzi KM; Nister M; Lindstrom MS
  • Book chapter: PROTEINS OF THE NUCLEOLUS. 2013;p. 251-273
    Lindstr枚m MS; Latonen L
  • Review: CANCER AND METASTASIS REVIEWS. 2012;31(3-4):793-805
    Elsir T; Smits A; Lindstrom MS; Nister M
  • Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2012;117(2):99-112
    Nazarenko I; Hede S-M; He X; Hedren A; Thompson J; Lindstrom MS; Nister M
  • Conference publication: CANCER RESEARCH. 2012;72:5560
    Eisir T; Qu M; Berntsson S; Olofsson T; Ribom D; Orrego A; Hedren A; Deimling AV; Hartmann C; Lindstrom M; Smits A; Nister M
  • Conference publication: NEURO-ONCOLOGY. 2010;12:51
    Elsir T; Qu M; Berntsson S; Orrego A; Olofsson T; Lindstrom M; Nister M; Ribom D; Smits A
  • Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;379(2):167-170
    Lindstrom MS
  • Review: CELL BIOCHEMISTRY AND BIOPHYSICS. 2006;46(1):79-90
    Lindstrom MS; Zhang Y
  • Thesis / dissertation: 2004
    Lindstr枚m, Mikael
  • Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.
    Lindstr枚m MS; Asker C; Wiman KG

Grants

  • Swedish Research Council
    1 January 2012 - 31 December 2014

Employments

  • Researcher, Department of Medical Biochemistry and Biophysics, 探花精选, 2015-

Degrees and Education

  • Docent, 探花精选, 2012
  • Doctor Of Philosophy, Department of Oncology-Pathology, 探花精选, 2004
  • Master Of Medical Science, 探花精选, 1999

Supervisor

  • Asimina Zisi, RNA Polymerase I inhibition: mechanism and exploitation in cancer treatment
  • Kaveh Goudarzi, Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors
  • Karl Holmberg Olausson, Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
  • Inga Nazarenko, Modeling PDGF-driven gliomagenesis in the mouse
  • Tamador Elsir, Transcription factors PROX1 and p53 in cancer development

Editorial work

  • Tumor Discovery, Editorial board member, 2024
  • Frontiers Biophysics, Section editor / academic editor, 2023
  • Precision Cancer Medicine, AME HONG KONG, Editorial board member, 2023
  • Cancers, Editorial board member, 2020

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